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Christa Volkmar - One of the best experts on this subject based on the ideXlab platform.
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Field Monitoring and Efficacy of Entomopathogenic Nematodes Against Chamomile Stem Weevil Microplontus rugulosus and Chamomile Smooth Beetle Olibrus aeneus Under Greenhouse Conditions
Gesunde Pflanzen, 2016Co-Authors: Nawal Gaafar, Nabil El-wakeil, Abdellah S. H. Abdel-moniem, Christa VolkmarAbstract:Chamomile Matricaria recutita (L.) is an ancient healing plant; it is used for a sore stomach, a mild laxative, anti-inflammatory and a gentle sleep aid. Chamomile plants are infested by Chamomile stem-weevil Microplontus rugulosus (Col., Curculionidae) and Chamomile smooth beetle Olibrus aeneus (Col., Phalacridae), and can lead to a high reduction in Chamomile yield. This work aimed to survey M. rugulosus and O. aeneus by different monitoring methods as well as to manage them by using entomopathogenic nematodes.
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Efficiency of entomopathogenic nematodes on Chamomile smooth beetle Olibrus aeneus and Chamomile stem weevil Microplontus rugulosus under greenhouse conditions
ScienceOpen Posters, 2015Co-Authors: Nabil El-wakeil, Nawal Gaafar, Abdellah S. H. Abdel-moniem, Christa VolkmarAbstract:Chamomile Matricaria recutita (L) is an ancient healing plant; it is used for a sore stomach, a mild laxative, anti-inflammatory and a gentle sleep aid. Chamomile plants are infected by many insect pests. The flower heads are infested by Chamomile smooth beetle Olibrus aeneus (Fabricius 1792). The dangerous insect is infestation with Chamomile stem-weevil Microplontus rugulosus (Autumn 1795). Their infestations lead to a high reduction in Chamomile yield. This work aimed to determine the adequate management strategies of Microplontus rugulosus and Olibrus aeneus, especially using entomopathogenic nematodes. Management of Chamomile insects was conducted on plants moved from field to greenhouse using entomopathogenic nematodes; while the control plants were sprayed only with water. The efficiency of three types of entomopathogenic nematodes (EPNs) was evaluated; each strain replicated 3 times; each was 50 Chamomile plants (totally is 150 for each strain). Three treatment dates were carried out in May, June and July; the first one was mainly for controlling stem weevil, while the other two dates were for smooth beetle. Steinernema carpocapsae had more efficiency than S. feltiae and Heterorhabditis bacteriophora. The lived larvae were higher in the untreated than treated plants. EPNS could be one of the most effective management strategies to control such insects to keep the environment clean and should be one of the suitable control strategies for integrated insect management practices which would be developed with the ecological requirements of insects in different Chamomile fields.
Petr Solich - One of the best experts on this subject based on the ideXlab platform.
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development and application of uhplc ms ms method for the determination of phenolic compounds in Chamomile flowers and Chamomile tea extracts
Talanta, 2010Co-Authors: Lucie Nováková, Anna Vildová, Joana Patricia Mateus, Tiago Gonçalves, Petr SolichAbstract:UHPLC-MS/MS method using BEH C18 analytical column was developed for the separation and quantitation of 12 phenolic compounds of Chamomile (Matricaria recutita L.). The separation was accomplished using gradient elution with mobile phase consisting of methanol and formic acid 0.1%. ESI in both positive and negative ion mode was optimized with the aim to reach high sensitivity and selectivity for quantitation using SRM experiment. ESI in negative ion mode was found to be more convenient for quantitative analysis of all phenolics except of chlorogenic acid and kaempherol, which demonstrated better results of linearity, accuracy and precision in ESI positive ion mode. The results of method validation confirmed, that developed UHPLC-MS/MS method was convenient and reliable for the determination of phenolic compounds in Chamomile extracts with linearity >0.9982, accuracy within 76.7-126.7% and precision within 2.2-12.7% at three spiked concentration levels. Method sensitivity expressed as LOQ was typically 5-20 nmol/l. Extracts of Chamomile flowers and Chamomile tea were subjected to UHPLC-MS/MS analysis. The most abundant phenolic compounds in both Chamomile flowers and Chamomile tea extracts were chlorogenic acid, umbelliferone, apigenin and apigenin-7-glucoside. In Chamomile tea extracts there was greater abundance of flavonoid glycosides such as rutin or quercitrin, while the aglycone apigenin and its glycoside were present in lower amount.
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Development and application of UHPLC–MS/MS method for the determination of phenolic compounds in Chamomile flowers and Chamomile tea extracts
Talanta, 2010Co-Authors: Lucie Nováková, Anna Vildová, Joana Patricia Mateus, Tiago Gonçalves, Petr SolichAbstract:UHPLC-MS/MS method using BEH C18 analytical column was developed for the separation and quantitation of 12 phenolic compounds of Chamomile (Matricaria recutita L.). The separation was accomplished using gradient elution with mobile phase consisting of methanol and formic acid 0.1%. ESI in both positive and negative ion mode was optimized with the aim to reach high sensitivity and selectivity for quantitation using SRM experiment. ESI in negative ion mode was found to be more convenient for quantitative analysis of all phenolics except of chlorogenic acid and kaempherol, which demonstrated better results of linearity, accuracy and precision in ESI positive ion mode. The results of method validation confirmed, that developed UHPLC-MS/MS method was convenient and reliable for the determination of phenolic compounds in Chamomile extracts with linearity >0.9982, accuracy within 76.7-126.7% and precision within 2.2-12.7% at three spiked concentration levels. Method sensitivity expressed as LOQ was typically 5-20 nmol/l. Extracts of Chamomile flowers and Chamomile tea were subjected to UHPLC-MS/MS analysis. The most abundant phenolic compounds in both Chamomile flowers and Chamomile tea extracts were chlorogenic acid, umbelliferone, apigenin and apigenin-7-glucoside. In Chamomile tea extracts there was greater abundance of flavonoid glycosides such as rutin or quercitrin, while the aglycone apigenin and its glycoside were present in lower amount.
Sanjay Gupta - One of the best experts on this subject based on the ideXlab platform.
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Chamomile: A Herbal Agent for Treatment of Diseases of the Elderly
Foods and Dietary Supplements in the Prevention and Treatment of Disease in Older Adults, 2015Co-Authors: Janmejai K. Srivastava, Sanjay GuptaAbstract:Chamomile is a centuries-old established traditional medicinal herb popular in the Western world. It is available in two varieties, namely German Chamomile (Chamomilla recutita) and Roman Chamomile (Chamaemelum nobile). The dry flower of Chamomile contains approximately 120 secondary metabolites, comprising terpenoids and flavonoids, which contribute to its medicinal properties. Chamomile preparations are found to be beneficial in many human ailments. Chamomile is also well known for its essential oils with a pleasant aroma. It is used extensively for supplementing cosmetic products and in aromatherapy. Chamomile in the form of herbal tea is becoming increasingly popular, with more than a million cups of Chamomile tea consumed daily worldwide. Chamomile has gained significant attention as a health-promoting herb with demonstrable effects against several diseases of old age. Because of its longstanding widespread use in traditional medicine, Chamomile has attracted considerable attention in the field of biomedical research. This chapter discusses in detail the curative and preventive properties of Chamomile in health-promoting strategies that are safe and clinically useful in the elderly population.
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Chamomile confers protection against hydrogen peroxide induced toxicity through activation of nrf2 mediated defense response
Phytotherapy Research, 2013Co-Authors: Natarajan Bhaskaran, Janmejai K. Srivastava, Sanjeev Shukla, Sanjay GuptaAbstract:Oxidative stress plays an important role in the development of various human diseases. Aqueous Chamomile extract is used as herbal medicine, in the form of tea, demonstrated to possess antiinflammatory and antioxidant properties. We demonstrate the cytoprotective effects of Chamomile on hydrogen peroxide (H₂O₂)-induced cellular damage in macrophage RAW 264.7 cells. Pretreatment of cells with Chamomile markedly attenuated H₂O₂-induced cell viability loss in a dose-dependent manner. The mechanisms by which Chamomile-protected macrophages from oxidative stress was through the induction of several antioxidant enzymes including NAD(P)H:quinone oxidoreductase, superoxide dismutase, and catalase and increase nuclear accumulation of the transcription factor Nrf2 and its binding to antioxidant response elements. Furthermore, Chamomile dose-dependently reduced H₂O₂-mediated increase in the intracellular levels of reactive oxygen species. Our results, for the first time, demonstrate that Chamomile has protective effects against oxidative stress and might be beneficial to provide defense against cellular damage.
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Induction of heme oxygenase-1 by Chamomile protects murine macrophages against oxidative stress
Life Sciences, 2012Co-Authors: Natarajan Bhaskaran, Janmejai K. Srivastava, Sanjeev Shukla, Rajnee Kanwal, Sanjay GuptaAbstract:Aims: Protection of cells from oxidative insult may be possible through direct scavenging of reactive oxygen species, or through stimulation of intracellular antioxidant defense mechanisms by induction of antioxidant gene expression. In this study we investigated the cytoprotective effect of Chamomile and elucidated the underlying mechanisms. Main methods: The cytoprotective effect of Chamomile was examined on H2O2-induced cellular stress in RAW 264.7 murine macrophages. Key findings: RAW 264.7 murine macrophages treated with Chamomile were protected from cell death caused by H2O2. Treatment with 50 μM H2O2for 6 h caused significant increase in cellular stress accompanied by cell death in RAW 264.7 macrophages. Pretreatment with Chamomile at 10-20 μg/mL for 16 h followed by H2O2treatment protected the macrophages against cell death. Chamomile exposure significantly increased the expression of antioxidant enzymes viz. heme oxygenase-1 (HO-1), peroxiredoxin-1 (Prx-1), and thioredoxin-1 (Trx-1) in a dose-dependent manner, compared with their respective controls. Chamomile increased nuclear translocation of Nrf2 with increased phosphorylated Nrf2 levels, and binding to the antioxidant response element in the nucleus. Significance: These molecular findings for the first time provide insights into the mechanisms underlying the induction of phase 2 enzymes through the Keap1-Nrf2 signaling pathway by Chamomile, and provide evidence that Chamomile possesses antioxidant and cytoprotective properties. © 2012 Elsevier Inc.
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Chamomile an anti inflammatory agent inhibits inducible nitric oxide synthase expression by blocking rela p65 activity
International Journal of Molecular Medicine, 2010Co-Authors: Natarajan Bhaskaran, Janmejai K. Srivastava, Sanjeev Shukla, Sanjay GuptaAbstract:Chamomile has long been used in traditional medicine for the treatment of inflammation-related disorders. In this study we investigated the inhibitory effects of Chamomile on nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression, and explored its potential anti-inflammatory mechanisms using RAW 264.7 macrophages. Chamomile treatment inhibited LPS-induced NO production and significantly blocked IL-1β, IL-6 and TNFα-induced NO levels in RAW 264.7 macrophages. Chamomile caused reduction in LPS-induced iNOS mRNA and protein expression. In RAW 264.7 macrophages, LPS-induced DNA binding activity of RelA/p65 was significantly inhibited by Chamomile, an effect that was mediated through the inhibition of IKKβ, the upstream kinase regulating NF-κB/Rel activity, and degradation of inhibitory factor-κB. These results demonstrate that Chamomile inhibits NO production and iNOS gene expression by inhibiting RelA/p65 activation and supports the utilization of Chamomile as an effective anti-inflammatory agent.
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Chamomile: A herbal medicine of the past with a bright future (review)
Molecular Medicine Reports, 2010Co-Authors: Janmejai K. Srivastava, Eswar Shankar, Sanjay GuptaAbstract:Chamomile is one of the most ancient medicinal herbs known to mankind. It is a member of Asteraceae/Compositae family and represented by two common varieties viz. German Chamomile (Chamomilla recutita) and Roman Chamomile (Chamaemelum nobile). The dried flowers of Chamomile contain many terpenoids and flavonoids contributing to its medicinal properties. Chamomile preparations are commonly used for many human ailments such as hay fever, inflammation, muscle spasms, menstrual disorders, insomnia, ulcers, wounds, gastrointestinal disorders, rheumatic pain, and hemorrhoids. Essential oils of Chamomile are used extensively in cosmetics and aromatherapy. Many different preparations of Chamomile have been developed, the most popular of which is in the form of herbal tea consumed more than one million cups per day. In this review we describe the use of Chamomile in traditional medicine with regard to evaluating its curative and preventive properties, highlight recent findings for its development as a therapeutic agent promoting human health.
Jeffrey B. Blumberg - One of the best experts on this subject based on the ideXlab platform.
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a review of the bioactivity and potential health benefits of Chamomile tea matricaria recutita l
Phytotherapy Research, 2006Co-Authors: Diane L. Mckay, Jeffrey B. BlumbergAbstract:Chamomile (Matricaria recutita L., Chamomilla recutita L., Matricaria chamomilla) is one of the most popular single ingredient herbal teas, or tisanes. Chamomile tea, brewed from dried flower heads, has been used traditionally for medicinal purposes. Evidence-based information regarding the bioactivity of this herb is presented. The main constituents of the flowers include several phenolic compounds, primarily the flavonoids apigenin, quercetin, patuletin, luteolin and their glucosides. The principal components of the essential oil extracted from the flowers are the terpenoids α-bisabolol and its oxides and azulenes, including chamazulene. Chamomile has moderate antioxidant and antimicrobial activities, and significant antiplatelet activity in vitro. Animal model studies indicate potent antiinflammatory action, some antimutagenic and cholesterol-lowering activities, as well as antispasmotic and anxiolytic effects. However, human studies are limited, and clinical trials examining the purported sedative properties of Chamomile tea are absent. Adverse reactions to Chamomile, consumed as a tisane or applied topically, have been reported among those with allergies to other plants in the daisy family, i.e. Asteraceae or Compositae. Copyright © 2006 John Wiley & Sons, Ltd.
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A review of the bioactivity and potential health benefits of Chamomile tea (Matricaria recutita L.)
Phytotherapy Research, 2006Co-Authors: Diane L. Mckay, Jeffrey B. BlumbergAbstract:Chamomile (Matricaria recutita L., Chamomilla recutita L., Matricaria chamomilla) is one of the most popular single ingredient herbal teas, or tisanes. Chamomile tea, brewed from dried flower heads, has been used traditionally for medicinal purposes. Evidence-based information regarding the bioactivity of this herb is presented. The main constituents of the flowers include several phenolic compounds, primarily the flavonoids apigenin, quercetin, patuletin, luteolin and their glucosides. The principal components of the essential oil extracted from the flowers are the terpenoids alpha-bisabolol and its oxides and azulenes, including chamazulene. Chamomile has moderate antioxidant and antimicrobial activities, and significant antiplatelet activity in vitro. Animal model studies indicate potent antiinflammatory action, some antimutagenic and cholesterol-lowering activities, as well as antispasmotic and anxiolytic effects. However, human studies are limited, and clinical trials examining the purported sedative properties of Chamomile tea are absent. Adverse reactions to Chamomile, consumed as a tisane or applied topically, have been reported among those with allergies to other plants in the daisy family, i.e. Asteraceae or Compositae.
Lucie Nováková - One of the best experts on this subject based on the ideXlab platform.
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development and application of uhplc ms ms method for the determination of phenolic compounds in Chamomile flowers and Chamomile tea extracts
Talanta, 2010Co-Authors: Lucie Nováková, Anna Vildová, Joana Patricia Mateus, Tiago Gonçalves, Petr SolichAbstract:UHPLC-MS/MS method using BEH C18 analytical column was developed for the separation and quantitation of 12 phenolic compounds of Chamomile (Matricaria recutita L.). The separation was accomplished using gradient elution with mobile phase consisting of methanol and formic acid 0.1%. ESI in both positive and negative ion mode was optimized with the aim to reach high sensitivity and selectivity for quantitation using SRM experiment. ESI in negative ion mode was found to be more convenient for quantitative analysis of all phenolics except of chlorogenic acid and kaempherol, which demonstrated better results of linearity, accuracy and precision in ESI positive ion mode. The results of method validation confirmed, that developed UHPLC-MS/MS method was convenient and reliable for the determination of phenolic compounds in Chamomile extracts with linearity >0.9982, accuracy within 76.7-126.7% and precision within 2.2-12.7% at three spiked concentration levels. Method sensitivity expressed as LOQ was typically 5-20 nmol/l. Extracts of Chamomile flowers and Chamomile tea were subjected to UHPLC-MS/MS analysis. The most abundant phenolic compounds in both Chamomile flowers and Chamomile tea extracts were chlorogenic acid, umbelliferone, apigenin and apigenin-7-glucoside. In Chamomile tea extracts there was greater abundance of flavonoid glycosides such as rutin or quercitrin, while the aglycone apigenin and its glycoside were present in lower amount.
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Development and application of UHPLC–MS/MS method for the determination of phenolic compounds in Chamomile flowers and Chamomile tea extracts
Talanta, 2010Co-Authors: Lucie Nováková, Anna Vildová, Joana Patricia Mateus, Tiago Gonçalves, Petr SolichAbstract:UHPLC-MS/MS method using BEH C18 analytical column was developed for the separation and quantitation of 12 phenolic compounds of Chamomile (Matricaria recutita L.). The separation was accomplished using gradient elution with mobile phase consisting of methanol and formic acid 0.1%. ESI in both positive and negative ion mode was optimized with the aim to reach high sensitivity and selectivity for quantitation using SRM experiment. ESI in negative ion mode was found to be more convenient for quantitative analysis of all phenolics except of chlorogenic acid and kaempherol, which demonstrated better results of linearity, accuracy and precision in ESI positive ion mode. The results of method validation confirmed, that developed UHPLC-MS/MS method was convenient and reliable for the determination of phenolic compounds in Chamomile extracts with linearity >0.9982, accuracy within 76.7-126.7% and precision within 2.2-12.7% at three spiked concentration levels. Method sensitivity expressed as LOQ was typically 5-20 nmol/l. Extracts of Chamomile flowers and Chamomile tea were subjected to UHPLC-MS/MS analysis. The most abundant phenolic compounds in both Chamomile flowers and Chamomile tea extracts were chlorogenic acid, umbelliferone, apigenin and apigenin-7-glucoside. In Chamomile tea extracts there was greater abundance of flavonoid glycosides such as rutin or quercitrin, while the aglycone apigenin and its glycoside were present in lower amount.