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Christophe Baudouin - One of the best experts on this subject based on the ideXlab platform.

  • Th1- and Th2-related Chemokine and Chemokine Receptor expression on the ocular surface in endotoxin-induced uveitis.
    Molecular Vision, 2020
    Co-Authors: L. Trinh, Marianne Houssier, Françoise Brignole-baudouin, Hong Liang, Aude Pauly, Christophe Baudouin
    Abstract:

    To determine whether the ocular surface inflammation in uveitis mimics or counteracts intraocular inflammatory pathways by directly comparing T-helper (Th) lymphocytes Th1 and Th2 markers in conjunctival and ciliary body expression in endotoxin-induced uveitis (EIU). This study used the following inflammatory markers: Chemokine Receptor, CC Chemokine Receptor 4 (CCR4), and its ligand, macrophage-derived Chemokine (MDC), to evaluate Th2 participation; Chemokine Receptor, CCR5, to evaluate the Th1 system; and its ligand, regulated on activation normal T cell expressed and secreted (RANTES), to evaluate both Th1 and Th2 systems.

  • Th1- and Th2-related Chemokine and Chemokine Receptor expression on the ocular surface in endotoxin-induced uveitis.
    Molecular Vision, 2008
    Co-Authors: L. Trinh, Marianne Houssier, Françoise Brignole-baudouin, Arno Pauly, Hong Liang, Christophe Baudouin
    Abstract:

    Purpose To determine whether the ocular surface inflammation in uveitis mimics or counteracts intraocular inflammatory pathways by directly comparing T-helper (Th) lymphocytes Th1 and Th2 markers in conjunctival and ciliary body expression in endotoxin-induced uveitis (EIU). This study used the following inflammatory markers: Chemokine Receptor, CC Chemokine Receptor 4 (CCR4), and its ligand, macrophage-derived Chemokine (MDC), to evaluate Th2 participation; Chemokine Receptor, CCR5, to evaluate the Th1 system; and its ligand, regulated on activation normal T cell expressed and secreted (RANTES), to evaluate both Th1 and Th2 systems.

And Andrew T. Mcphail - One of the best experts on this subject based on the ideXlab platform.

  • Chemokine Receptor ccr 5 inhibitors produced by chaetomium globosum
    Journal of Natural Products, 2006
    Co-Authors: Shuwei Yang, Joseph Terracciano, Vincent P Gullo, Bahige M Baroudy, Tzeming Chan, Ronald Mierzwa, Mohindar S. Puar, Mahesh Patel, Nicole Wagner, And Andrew T. Mcphail
    Abstract:

    Two novel Chemokine Receptor CCR-5 inhibitors, Sch 210971 (1) and Sch 210972 (2), were isolated from the fungal fermentation broth of Chaetomium globosum by normal- and reversed-phase HPLC purifications. The structure determination of 1 and 2 was accomplished on the basis of UV, MS, and NMR spectral data analyses including COSY, NOESY, HMQC, and HMBC experiments. The structure and relative configuration of 2 were determined unequivocally by X-ray crystallographic analysis. The major component 2 demonstrated a potent inhibitory activity of IC50 = 79 nM in the CCR-5 Receptor in vitro binding assay.

L. Trinh - One of the best experts on this subject based on the ideXlab platform.

  • Th1- and Th2-related Chemokine and Chemokine Receptor expression on the ocular surface in endotoxin-induced uveitis.
    Molecular Vision, 2020
    Co-Authors: L. Trinh, Marianne Houssier, Françoise Brignole-baudouin, Hong Liang, Aude Pauly, Christophe Baudouin
    Abstract:

    To determine whether the ocular surface inflammation in uveitis mimics or counteracts intraocular inflammatory pathways by directly comparing T-helper (Th) lymphocytes Th1 and Th2 markers in conjunctival and ciliary body expression in endotoxin-induced uveitis (EIU). This study used the following inflammatory markers: Chemokine Receptor, CC Chemokine Receptor 4 (CCR4), and its ligand, macrophage-derived Chemokine (MDC), to evaluate Th2 participation; Chemokine Receptor, CCR5, to evaluate the Th1 system; and its ligand, regulated on activation normal T cell expressed and secreted (RANTES), to evaluate both Th1 and Th2 systems.

  • Th1- and Th2-related Chemokine and Chemokine Receptor expression on the ocular surface in endotoxin-induced uveitis.
    Molecular Vision, 2008
    Co-Authors: L. Trinh, Marianne Houssier, Françoise Brignole-baudouin, Arno Pauly, Hong Liang, Christophe Baudouin
    Abstract:

    Purpose To determine whether the ocular surface inflammation in uveitis mimics or counteracts intraocular inflammatory pathways by directly comparing T-helper (Th) lymphocytes Th1 and Th2 markers in conjunctival and ciliary body expression in endotoxin-induced uveitis (EIU). This study used the following inflammatory markers: Chemokine Receptor, CC Chemokine Receptor 4 (CCR4), and its ligand, macrophage-derived Chemokine (MDC), to evaluate Th2 participation; Chemokine Receptor, CCR5, to evaluate the Th1 system; and its ligand, regulated on activation normal T cell expressed and secreted (RANTES), to evaluate both Th1 and Th2 systems.

Shuwei Yang - One of the best experts on this subject based on the ideXlab platform.

  • Sch 213766, A Novel Chemokine Receptor CCR-5 Inhibitor from Chaetomium globosum
    The Journal of Antibiotics, 2007
    Co-Authors: Shuwei Yang, Joseph Terracciano, Bahige M Baroudy, Tzeming Chan, Ronald Mierzwa, Mohindar S. Puar, Mahesh Patel, Nicole Wagner, Vincent Gullo, Min Chu
    Abstract:

    A novel fungal secondary metabolite, Sch 213766 was isolated from the fungal fermentation broth of Chaetomium globosum as the Chemokine Receptor CCR-5 inhibitor and shown to be the methyl ester of the previously described tetramic acid Sch 210972 on the basis of UV, MS and NMR spectral data analyses. Sch213766 exhibited an IC_50 value of 8.6 μM in the CCR-5 Receptor in vitro binding assay.

  • Chemokine Receptor ccr 5 inhibitors produced by chaetomium globosum
    Journal of Natural Products, 2006
    Co-Authors: Shuwei Yang, Joseph Terracciano, Vincent P Gullo, Bahige M Baroudy, Tzeming Chan, Ronald Mierzwa, Mohindar S. Puar, Mahesh Patel, Nicole Wagner, And Andrew T. Mcphail
    Abstract:

    Two novel Chemokine Receptor CCR-5 inhibitors, Sch 210971 (1) and Sch 210972 (2), were isolated from the fungal fermentation broth of Chaetomium globosum by normal- and reversed-phase HPLC purifications. The structure determination of 1 and 2 was accomplished on the basis of UV, MS, and NMR spectral data analyses including COSY, NOESY, HMQC, and HMBC experiments. The structure and relative configuration of 2 were determined unequivocally by X-ray crystallographic analysis. The major component 2 demonstrated a potent inhibitory activity of IC50 = 79 nM in the CCR-5 Receptor in vitro binding assay.

Craig Gerard - One of the best experts on this subject based on the ideXlab platform.

  • CC Chemokine Receptor 1 enhances susceptibility to Leishmania major during early phase of infection.
    Immunology and Cell Biology, 2003
    Co-Authors: Miriam Rodriguez-sosa, Lucia E. Rosas, Luis I. Terrazas, Bao Lu, Craig Gerard, Abhay R. Satoskar
    Abstract:

    CC Chemokine Receptor 1 enhances susceptibility to Leishmania major during early phase of infection

  • requirement of the Chemokine Receptor cxcr3 for acute allograft rejection
    Journal of Experimental Medicine, 2000
    Co-Authors: Wayne W Hancock, Bao Lu, Vilmos Csizmadia, Kerrie L Faia, Jennifer A King, Stephen T Smiley, Mai Ling, Norma P Gerard, Craig Gerard
    Abstract:

    Chemokines provide signals for activation and recruitment of effector cells into sites of inflammation, acting via specific G protein–coupled Receptors. However, in vitro data demonstrating the presence of multiple ligands for a given Chemokine Receptor, and often multiple Receptors for a given Chemokine, have led to concerns of biologic redundancy. Here we show that acute cardiac allograft rejection is accompanied by progressive intragraft production of the Chemokines interferon (IFN)-γ–inducible protein of 10 kD (IP-10), monokine induced by IFN-γ (Mig), and IFN-inducible T cell α chemoattractant (I-TAC), and by infiltration of activated T cells bearing the corresponding Chemokine Receptor, CXCR3. We used three in vivo models to demonstrate a role for CXCR3 in the development of transplant rejection. First, CXCR3-deficient (CXCR3−/−) mice showed profound resistance to development of acute allograft rejection. Second, CXCR3−/− allograft recipients treated with a brief, subtherapeutic course of cyclosporin A maintained their allografts permanently and without evidence of chronic rejection. Third, CXCR+/+ mice treated with an anti-CXCR3 monoclonal antibody showed prolongation of allograft survival, even if begun after the onset of rejection. Taken in conjunction with our findings of CXCR3 expression in rejecting human cardiac allografts, we conclude that CXCR3 plays a key role in T cell activation, recruitment, and allograft destruction.

  • Cloning and chromosomal mapping of an orphan Chemokine Receptor: mouse RDC1
    Immunogenetics, 1998
    Co-Authors: Michael Heesen, Craig Gerard, Michael A. Berman, Alain Charest, David E. Housman, Martin E. Dorf
    Abstract:

    Degenerate RT-PCR was used to identify a new seven-transmembrane-spanning Receptor expressed in astrocytes. A Receptor, termed RDC1, displaying the characteristic structural features of a Chemokine Receptor was cloned. The predicted 362-amino-acid sequence displayed 92% and 91% similarity to the human and dog orphan Receptor RDC1, respectively. In addition, RDC1 shares 43% amino acid similarity to rabbit and mouse CXCR2. Transcripts of RDC1 were found in astrocytes, heart, kidney, the mesangial tumor line MES-13, spleen, and neutrophils by means of northern blot. Using linkage analysis of interspecies backcross mice, we localized to chromosome 1 the genes for mouse CXCR2, CXCR4, and RDC1. Mouse RDC1 is linked to and lies between the genes for the mouse CXC Chemokine Receptors CXCR2 and CXCR4. The combined data of chromosomal location and sequence similarity suggest that RDC1 is an orphan CXC Chemokine Receptor.