The Experts below are selected from a list of 204 Experts worldwide ranked by ideXlab platform

Li Ming Dong - One of the best experts on this subject based on the ideXlab platform.

  • clinical features associated with lesions other than pituitary adenoma in patients with an optic Chiasmal Syndrome
    American Journal of Ophthalmology, 2004
    Co-Authors: Luis J. Mejico, Neil R Miller, Li Ming Dong
    Abstract:

    Abstract Purpose Pituitary adenomas are the most common cause of an optic Chiasmal Syndrome, and treatment of these lesions is considerably different from the treatment of most of the other lesions in this region. Although the diagnosis of a pituitary adenoma is usually inferred from the results of neuroimaging, lesions other than pituitary adenomas can have an appearance that suggests an adenoma. The objective of our study was to determine whether there are clinical findings that suggest a lesion producing a Chiasmal Syndrome is something other than a pituitary adenoma. Design Retrospective, case-controlled, analysis of medical record data. Methods The records of the Neuro-Ophthalmology Unit of the Wilmer Eye Institute were searched for patients with a Chiasmal Syndrome who had been evaluated before treatment and for whom pathologic or laboratory confirmation of the etiology was available. Presenting clinical features of these patients were recorded, and analyses with both a single variable and multiple variables were performed to determine whether there were any features that could identify with a high degree of probability the etiology of the lesion producing the Syndrome. Results The search revealed 149 patients who met the inclusion criteria, including 90 patients with pituitary adenomas and 59 patients with other lesions. Variables that were highly suggestive of an etiology other than pituitary adenoma included symptomatic visual loss, younger age, unilateral optic disk pallor, a relative afferent pupillary defect, and an absolute or a complete visual field defect or one was greater inferiorly than superiorly. Conclusion Although no single clinical feature can be used to determine the specific nature of a lesion that produces an optic Chiasmal Syndrome, certain features are highly suggestive of an etiology other than pituitary adenoma. When these features are present, the likelihood that a suprasellar lesion is a pituitary adenoma is much lower, regardless of the appearance on neuroimaging.

  • Clinical features associated with lesions other than pituitary adenoma in patients with an optic Chiasmal Syndrome
    American journal of ophthalmology, 2004
    Co-Authors: Luis J. Mejico, Neil R Miller, Li Ming Dong
    Abstract:

    Pituitary adenomas are the most common cause of an optic Chiasmal Syndrome, and treatment of these lesions is considerably different from the treatment of most of the other lesions in this region. Although the diagnosis of a pituitary adenoma is usually inferred from the results of neuroimaging, lesions other than pituitary adenomas can have an appearance that suggests an adenoma. The objective of our study was to determine whether there are clinical findings that suggest a lesion producing a Chiasmal Syndrome is something other than a pituitary adenoma. Retrospective, case-controlled, analysis of medical record data. The records of the Neuro-Ophthalmology Unit of the Wilmer Eye Institute were searched for patients with a Chiasmal Syndrome who had been evaluated before treatment and for whom pathologic or laboratory confirmation of the etiology was available. Presenting clinical features of these patients were recorded, and analyses with both a single variable and multiple variables were performed to determine whether there were any features that could identify with a high degree of probability the etiology of the lesion producing the Syndrome. The search revealed 149 patients who met the inclusion criteria, including 90 patients with pituitary adenomas and 59 patients with other lesions. Variables that were highly suggestive of an etiology other than pituitary adenoma included symptomatic visual loss, younger age, unilateral optic disk pallor, a relative afferent pupillary defect, and an absolute or a complete visual field defect or one was greater inferiorly than superiorly. Although no single clinical feature can be used to determine the specific nature of a lesion that produces an optic Chiasmal Syndrome, certain features are highly suggestive of an etiology other than pituitary adenoma. When these features are present, the likelihood that a suprasellar lesion is a pituitary adenoma is much lower, regardless of the appearance on neuroimaging.

W Pilecki - One of the best experts on this subject based on the ideXlab platform.

  • abnormalities of optical coherence tomography and visual evoked potentials in patients with Chiasmal compression Syndrome
    Acta Ophthalmologica, 2011
    Co-Authors: M Wasik, W Pilecki
    Abstract:

    Purpose To report abnormalities of retinal nerve fiber layer (RNFL) thickness measured by optical coherence tomography (OCT) and visual evoked potentials (VEP) in patients with compressive Chiasmal tumors confirmed on MRI examination. Methods 22 eyes of 12 patients with parasellar tumors causing Chiasmal compression Syndrome were included to the study and compared to 59 eyes of 30 healthy patients. Exclusion criteria were any other ophthalmic or general condition that can affect both VEP and OCT measurements. All patients underwent MRI of the head to confirm the diagnosis, retinal nerve fiber thickness measurements with OCT and visual evoked potentials examination. Results Average RNFL thickness in patients with Chiasmal compression (OD=96,06 ± 14,2µm, OS=92,4 ± 10,2µm) was significantly lower (p=0.016 and p=0.005) than in normal eyes (OD=104,7 ± 10µm, OS=104,5 ± 15µm respectively). It was noticed also reduced RNFL thickness in nasal quadrants. Visual evoked potentials showed mean P100 latency prolongation in examined patients (OD=112 ± 8,7ms and OS=108,4 ± 7,4ms), which was statistically significant (p<0.001 and p=0.001 respectively) in comparison to control group (103,1± 4,5ms and 102,5 ± 4,2ms respectively). Conclusion In patients with compressive Chiasmal Syndrome both RNFL thickness measurements with OCT and visual evoked potentials were significantly changed. These methods provide useful information in the diagnosis of Chiasmal lesions.

Avninder Sandhu - One of the best experts on this subject based on the ideXlab platform.

  • traumatic Chiasmal Syndrome a series of 19 patients
    Clinical and Experimental Ophthalmology, 2002
    Co-Authors: Ahmed Hassan, John L. Crompton, Avninder Sandhu
    Abstract:

    Purpose: To present a clinical series of 19 patients with traumatic Chiasmal Syndrome. Methods: A retrospective study was performed. This included all patients with traumatic Chiasmal Syndrome seen in the neuro-ophthalmology clinic at the Royal Adelaide Hospital between January 1970 and January 2000. Results: Of the 19 study patients, most were young males involved in motor accidents. Two-thirds had skull fractures. Three-quarters of patients had a final visual acuity of 6/12 or better in at least one eye. Ten patients had a complete optic nerve palsy. The incidence of diabetes insipidus in this study was 37%. The incidence of cranial nerve lesions, hypopituitarism, carotid cavernous fistula, and other deficits were documented. Magnetic resonance imaging and surgical findings were consistent with known mechanisms of Chiasmal injury. Conclusions: Trauma is a rare cause of Chiasmal Syndrome. Patients with bitemporal field defects should be questioned about prior head injury. In the acute setting, magnetic resonance imaging is the most useful investigation. The treating practitioner should anticipate and treat associated endocrine, ocular motility, and other disorders. Mechanisms of damage to the optic chiasm after trauma include direct tearing, contusion haemorrhage and contusion necrosis. These mechanisms should not be considered mutually exclusive. Unilateral temporal hemianopia with a fellow blind eye is not necessarily the result of Chiasmal disruption.

  • Traumatic Chiasmal Syndrome: a series of 19 patients
    Clinical & experimental ophthalmology, 2002
    Co-Authors: Ahmed Hassan, John L. Crompton, Avninder Sandhu
    Abstract:

    To present a clinical series of 19 patients with traumatic Chiasmal Syndrome. A retrospective study was performed. This included all patients with traumatic Chiasmal Syndrome seen in the neuro-ophthalmology clinic at the Royal Adelaide Hospital between January 1970 and January 2000. Of the 19 study patients, most were young males involved in motor accidents. Two-thirds had skull fractures. Three-quarters of patients had a final visual acuity of 6/12 or better in at least one eye. Ten patients had a complete optic nerve palsy. The incidence of diabetes insipidus in this study was 37%. The incidence of cranial nerve lesions, hypopituitarism, carotid cavernous fistula, and other deficits were documented. Magnetic resonance imaging and surgical findings were consistent with known mechanisms of Chiasmal injury. Trauma is a rare cause of Chiasmal Syndrome. Patients with bitemporal field defects should be questioned about prior head injury. In the acute setting, magnetic resonance imaging is the most useful investigation. The treating practitioner should anticipate and treat associated endocrine, ocular motility, and other disorders. Mechanisms of damage to the optic chiasm after trauma include direct tearing, contusion haemorrhage and contusion necrosis. These mechanisms should not be considered mutually exclusive. Unilateral temporal hemianopia with a fellow blind eye is not necessarily the result of Chiasmal disruption.

Luis J. Mejico - One of the best experts on this subject based on the ideXlab platform.

  • clinical features associated with lesions other than pituitary adenoma in patients with an optic Chiasmal Syndrome
    American Journal of Ophthalmology, 2004
    Co-Authors: Luis J. Mejico, Neil R Miller, Li Ming Dong
    Abstract:

    Abstract Purpose Pituitary adenomas are the most common cause of an optic Chiasmal Syndrome, and treatment of these lesions is considerably different from the treatment of most of the other lesions in this region. Although the diagnosis of a pituitary adenoma is usually inferred from the results of neuroimaging, lesions other than pituitary adenomas can have an appearance that suggests an adenoma. The objective of our study was to determine whether there are clinical findings that suggest a lesion producing a Chiasmal Syndrome is something other than a pituitary adenoma. Design Retrospective, case-controlled, analysis of medical record data. Methods The records of the Neuro-Ophthalmology Unit of the Wilmer Eye Institute were searched for patients with a Chiasmal Syndrome who had been evaluated before treatment and for whom pathologic or laboratory confirmation of the etiology was available. Presenting clinical features of these patients were recorded, and analyses with both a single variable and multiple variables were performed to determine whether there were any features that could identify with a high degree of probability the etiology of the lesion producing the Syndrome. Results The search revealed 149 patients who met the inclusion criteria, including 90 patients with pituitary adenomas and 59 patients with other lesions. Variables that were highly suggestive of an etiology other than pituitary adenoma included symptomatic visual loss, younger age, unilateral optic disk pallor, a relative afferent pupillary defect, and an absolute or a complete visual field defect or one was greater inferiorly than superiorly. Conclusion Although no single clinical feature can be used to determine the specific nature of a lesion that produces an optic Chiasmal Syndrome, certain features are highly suggestive of an etiology other than pituitary adenoma. When these features are present, the likelihood that a suprasellar lesion is a pituitary adenoma is much lower, regardless of the appearance on neuroimaging.

  • Clinical features associated with lesions other than pituitary adenoma in patients with an optic Chiasmal Syndrome
    American journal of ophthalmology, 2004
    Co-Authors: Luis J. Mejico, Neil R Miller, Li Ming Dong
    Abstract:

    Pituitary adenomas are the most common cause of an optic Chiasmal Syndrome, and treatment of these lesions is considerably different from the treatment of most of the other lesions in this region. Although the diagnosis of a pituitary adenoma is usually inferred from the results of neuroimaging, lesions other than pituitary adenomas can have an appearance that suggests an adenoma. The objective of our study was to determine whether there are clinical findings that suggest a lesion producing a Chiasmal Syndrome is something other than a pituitary adenoma. Retrospective, case-controlled, analysis of medical record data. The records of the Neuro-Ophthalmology Unit of the Wilmer Eye Institute were searched for patients with a Chiasmal Syndrome who had been evaluated before treatment and for whom pathologic or laboratory confirmation of the etiology was available. Presenting clinical features of these patients were recorded, and analyses with both a single variable and multiple variables were performed to determine whether there were any features that could identify with a high degree of probability the etiology of the lesion producing the Syndrome. The search revealed 149 patients who met the inclusion criteria, including 90 patients with pituitary adenomas and 59 patients with other lesions. Variables that were highly suggestive of an etiology other than pituitary adenoma included symptomatic visual loss, younger age, unilateral optic disk pallor, a relative afferent pupillary defect, and an absolute or a complete visual field defect or one was greater inferiorly than superiorly. Although no single clinical feature can be used to determine the specific nature of a lesion that produces an optic Chiasmal Syndrome, certain features are highly suggestive of an etiology other than pituitary adenoma. When these features are present, the likelihood that a suprasellar lesion is a pituitary adenoma is much lower, regardless of the appearance on neuroimaging.

Susumu Ishida - One of the best experts on this subject based on the ideXlab platform.

  • Sudden bilateral vision loss due to third ventricular cavernous angioma with intratumoral hemorrhage - case report
    BMC Ophthalmology, 2019
    Co-Authors: Kan Ishijima, Yasuhiro Shinmei, Mayo Nozaki, Shigeru Yamaguchi, Shinki Chin, Susumu Ishida
    Abstract:

    Background We report a rare case of sudden bilateral vision loss due to third ventricular cavernous angioma with intratumoral hemorrhage. Case presentation A 45-year-old woman presented decreased visual acuity in both eyes. Her best corrected visual acuity was 0.1 in the right eye and 0.15 in the left eye. Goldmann perimetry showed bilateral central scotomas and bitemporal visual field defects. MRI demonstrated a lesion with mixed hypo- and hyperintensity at the optic chiasm, which was thought to be an intratumoral hemorrhage. The patient underwent bifrontal craniotomy. The tumor was exposed via an anterior interhemispheric approach, and histological evaluation of the mass led to a diagnosis of cavernous angioma. Six months after the surgery, her best corrected visual acuity was 0.9 in the right eye and 0.9 in the left, with slight bitemporal visual field defects. Conclusion Third ventricular cavernous angioma is considered in the differential diagnosis of Chiasmal Syndrome. Contrast-enhanced MRI and FDG-PET might be useful for differential diagnosis of cavernous angioma from other Chiasmal tumors including glioblastoma .

  • Sudden bilateral vision loss due to third ventricular cavernous angioma with intratumoral hemorrhage - case report
    BMC ophthalmology, 2019
    Co-Authors: Kan Ishijima, Yasuhiro Shinmei, Mayo Nozaki, Shigeru Yamaguchi, Shinki Chin, Susumu Ishida
    Abstract:

    We report a rare case of sudden bilateral vision loss due to third ventricular cavernous angioma with intratumoral hemorrhage. A 45-year-old woman presented decreased visual acuity in both eyes. Her best corrected visual acuity was 0.1 in the right eye and 0.15 in the left eye. Goldmann perimetry showed bilateral central scotomas and bitemporal visual field defects. MRI demonstrated a lesion with mixed hypo- and hyperintensity at the optic chiasm, which was thought to be an intratumoral hemorrhage. The patient underwent bifrontal craniotomy. The tumor was exposed via an anterior interhemispheric approach, and histological evaluation of the mass led to a diagnosis of cavernous angioma. Six months after the surgery, her best corrected visual acuity was 0.9 in the right eye and 0.9 in the left, with slight bitemporal visual field defects. Third ventricular cavernous angioma is considered in the differential diagnosis of Chiasmal Syndrome. Contrast-enhanced MRI and FDG-PET might be useful for differential diagnosis of cavernous angioma from other Chiasmal tumors including glioblastoma.