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Toru Nakazawa - One of the best experts on this subject based on the ideXlab platform.
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the optic nerve head vasoreactive response to systemic hyperoxia and Visual Field Defect progression in open angle glaucoma a pilot study
Acta Ophthalmologica, 2020Co-Authors: Naoki Kiyota, Hiroshi Kunikata, Kazuko Omodaka, Yukihiro Shiga, Masayuki Yasuda, Naoko Aizawa, Satoru Tsuda, Kyongsun Pak, Toru NakazawaAbstract:PURPOSE To investigate the effect of optic nerve head (ONH) tissue vasoreactivity on glaucoma Visual Field Defect progression. METHODS This prospective, longitudinal study comprised 28 eyes of 16 patients with open-angle glaucoma. Baseline data were obtained from oxygen inhalation testing, including laser speckle flowgraphy measurements of tissue-area mean blur rate (MT), which represents ONH tissue blood flow, and the mean percentage change in MT (MT-change). Follow-up data were collected for at least 2 years, including at least 5 reliable Visual Field tests. The average total deviation (TD) was calculated in each sector of the Garway-Heath map; in this study, superior, central and inferior TD corresponded to inferior, temporal and superior MT or MT-change, respectively. MT and MT-change in three sectors per eye were included as explanatory variables in a multivariable linear mixed-effects model, with TD slope set as the response variable. RESULTS At baseline, lower MT and higher diastolic blood pressure were associated with lower MT-change (p < 0.05). Additionally, MT-change significantly contributed to TD slope in the corresponding sectors (β = 0.41, p = 0.01). CONCLUSIONS Weaker ONH tissue vasoreactivity to systemic hyperoxia, assessed with laser speckle flowgraphy, was associated with lower baseline ONH tissue blood flow, higher diastolic blood pressure and rapid Visual Field Defect progression. Laser speckle flowgraphy variables during oxygen provocation testing may represent potentially useful predictive biomarkers of glaucoma progression.
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sectoral differences in the association of optic nerve head blood flow and glaucomatous Visual Field Defect severity and progression
Investigative Ophthalmology & Visual Science, 2019Co-Authors: Naoki Kiyota, Hiroshi Kunikata, Kazuko Omodaka, Yukihiro Shiga, Masayuki Yasuda, Naoko Aizawa, Satoru Tsuda, Toru NakazawaAbstract:Purpose To investigate sectoral differences in the relationship between optic nerve head tissue blood flow, anatomically corresponding Visual Field Defect severity, and future progression. Methods This retrospective longitudinal medical chart review comprised 508 eyes of 319 open-angle glaucoma patients (mean deviation: -9.2 ± 7.0 dB), followed for an average of 4.7 ± 1.1 years; an average 11.7 ± 3.7 Visual Field tests were performed. Average total deviation (TD) was calculated in the superior, central, and inferior sectors of the Humphrey 24-2 program. The optic nerve head was divided to obtain inferior, temporal, and superior tissue-area mean blur rate (MT), derived from laser speckle flowgraphy. At baseline, the correlation between MT and TD was compared in anatomically corresponding sectors. We performed a multivariate analysis to determine the contribution of baseline MT to corresponding TD slope and to determine background factors influencing superior to temporal MT. We used a linear-mixed effect model for the statistical analysis. Results At baseline, the highest β coefficients were found between MT-superior and TD-inferior, MT-temporal and TD-central, and between MT-inferior and TD-superior, in that order (β = 0.38, β = 0.27, β = 0.26, respectively). MT-superior and MT-temporal independently contributed to corresponding TD slope (P < 0.05). Male sex, high body mass index, and the prevalence of sleep apnea syndrome were contributing factors to lower superior to temporal MT (P < 0.05). Conclusions Review of medical history, measurements of systemic variables, and laser speckle flowgraphy parameters might help clinicians to predict Visual Field Defect severity and progression.
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the relationship between increased oxidative stress and Visual Field Defect progression in glaucoma patients with sleep apnoea syndrome
Acta Ophthalmologica, 2018Co-Authors: Erika Yamada, Noriko Himori, Hiroshi Kunikata, Kazuko Omodaka, Hiromasa Ogawa, Masakazu Ichinose, Toru NakazawaAbstract:Purpose Sleep apnoea syndrome (SAS) is often associated with glaucoma, and intermittent hypoxia, present in SAS, can contribute to glaucoma pathogenesis. However, the relationships between SAS, high systemic oxidative stress and the speed of glaucoma progression are unclear. Thus, we investigated these relationships in glaucoma patients with and without SAS. Methods Peripheral blood samples were collected from 166 eyes of 166 Japanese patients: 42 controls, 109 open-angle glaucoma (OAG) patients without SAS and 15 OAG patients with SAS. Prognostic factors for Visual Field Defect progression were determined with logistic regression. Diacron reactive oxygen metabolites (dROM) and biological antioxidant potential (BAP) were measured with a free radical analyser. Clinical parameters were also recorded. Intergroup comparisons used the Mann-Whitney U test. Results Multiple regression analysis showed that SAS was a statistically significant contributing factor to fast Visual Field Defect progression, defined as mean deviation (MD) slope ≤-2.0 dB/Y (SAS: odds ratio (OR) = 14.48; p = 0.002). The non-SAS and SAS groups had similar age, sex, intraocular pressure (IOP), axial length and antiglaucoma drug use. The SAS group had a significantly higher dROM level (p = 0.001), BAP level (p = 0.038) and steeper MD slope (p = 0.001) than the non-SAS group. Conclusion Glaucoma patients with SAS have higher dROM, as well as steeper MD slope, than patients without SAS, suggesting that SAS may induce systemic oxidative stress and promote glaucomatous Visual Field Defect progression.
Lee M Jampol - One of the best experts on this subject based on the ideXlab platform.
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medical mystery Visual Field Defect the answer
The New England Journal of Medicine, 2006Co-Authors: Jr Jeevan R Mathura, Lee M JampolAbstract:To the Editor: The medical mystery in the October 12 issue1 involved a 31-year-old woman who presented with a sudden onset of an inferonasal Visual-Field deficit in the left eye. Two days earlier, ...
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medical mystery Visual Field Defect
The New England Journal of Medicine, 2006Co-Authors: Jr Jeevan R Mathura, Lee M JampolAbstract:This 31-year-old woman presented with a Visual-Field deficit in the left eye and a systolic ejection murmur. What is the diagnosis?
John C Welch - One of the best experts on this subject based on the ideXlab platform.
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dehydration injury as a possible cause of Visual Field Defect after pars plana vitrectomy for macular hole
American Journal of Ophthalmology, 1997Co-Authors: John C WelchAbstract:Purpose To present the hypothesis that a Visual Field Defect after pars plana vitrectomy for macular hole may be caused by dehydration injury to the nerve fiber layer during the fluid-air exchange. Methods In a consecutive nonrandomized series of 45 operations on 35 eyes of 34 patients with full-thickness macular hole, the surgical method was changed with postoperative Visual Field testing performed. Result The incidence and location of the postoperative Visual Field Defect was affected only by changing the location of the infusion cannula. Conclusion Dehydration injury of the nerve fiber layer during the fluid-air exchange should be considered as a possible cause of Visual Field Defect after pars plana vitrectomy for macular hole.
Kenya Yuki - One of the best experts on this subject based on the ideXlab platform.
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glaucomatous Visual Field Defect severity and the prevalence of motor vehicle collisions in japanese a hospital clinic based cross sectional study
Journal of Ophthalmology, 2015Co-Authors: Takeshi Ono, Kenya Yuki, Sachiko Tanabe, Keisuke Kouyama, Kazumi Fukagawa, Miki Uchino, Masaru Shimoyama, Takayuki Abe, Ryo Asaoka, Yoko OzawaAbstract:Purpose. This study examined the association between the severity of Visual Field Defects and the prevalence of motor vehicle collisions (MVCs) in subjects with primary open-angle glaucoma (POAG). Methods. This is a cross-sectional study. Japanese patients who have had driver's licence between 40 and 85 years of age were screened for eligibility. Participants answered a questionnaire about MVCs experienced during the previous 5 years. Subjects with POAG were classified as having mild, moderate, or severe Visual Field Defect. We evaluated associations between the severity of POAG and the prevalence of MVCs by logistic regression models. Results. The prevalence of MVCs was significantly associated with the severity of POAG categorized by worse eye MD (control: 30/187 = 16.0%; mild POAG: 17/92 = 18.5%; moderate POAG: 14/60 = 23.3%; severe POAG: 14/47 = 29.8%; P = 0.025, Cochran-Armitage trend test). Compared to the control group, the adjusted OR for MVC prevalence in subjects with mild, moderate, or severe POAG in the worse eye was 1.07 (95% CI: 0.55 to 2.10), 1.44 (95% CI: 0.68 to 3.08), and 2.28 (95% CI: 1.07 to 4.88). Conclusions. There is a significant association between the severity of glaucoma in the worse eye MD and the prevalence of MVCs.
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the association between Visual Field Defect severity and fear of falling in primary open angle glaucoma
Investigative Ophthalmology & Visual Science, 2013Co-Authors: Kenya Yuki, Yoko Ozawa, Sachiko Tanabe, Keisuke Kouyama, Kazumi Fukagawa, Miki Uchino, Masaru Shimoyama, Naoki Ozeki, Daisuke Shiba, Takayuki AbeAbstract:[Purpose] To determine if glaucomatous Visual Field Defect severity is associated with fear of falling. [Methods] This is a cross-sectional study. A total of 387 consecutive subjects with primary open-angle glaucoma (POAG) were enrolled in this study along with 293 ocular disease-free control subjects, who were screened at the same institutions. We defined mild POAG as mean deviation (MD) of -6 dB or better, moderate POAG as MD of -6 to -12 dB, and severe POAG as MD of -12 dB or worse in the better eye. All participants were requested to answer a questionnaire on fear of falling. Associations between POAG severity and the prevalence of fear of falling were evaluated with the Cochran-Armitage trend test. Multivariable factors including age-adjusted odds ratios (ORs) for the prevalence of fear of falling and 95% confidence intervals (CIs) were evaluated with logistic regression models. [Results] The prevalence of fear of falling was 35/293 (11.9%) in the control group, 38/313 (12.1%) in the mild POAG group, 12/48 (25.0%) in the moderate POAG group, and 6/26 (23.1%) in the severe POAG group, and the trend was statistically significant (P=0.028 Cochran-Armitage trend test). The adjusted ORs for prevalence in the mild, moderate, and severe POAG groups compared with that in the control group were 1.44 (95% CI: 0.83 to 2.51), 2.33 (95% CI: 1.00 to 5.44) and 4.06 (95% CI: 1.39 to 11.90), respectively. [Conclusions] Among patients with POAG, the severity of Visual Field Defects is associated with fear of falling. Language: en
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low diastolic blood pressure is associated with the progression of normal tension glaucoma
Ophthalmologica, 2012Co-Authors: Yoshihiko Okumura, Kenya Yuki, Kazuo TsubotaAbstract:Aims: The objective of this study was to investigate the association between blood pressure (BP) and Visual Field Defect progression in normal-tension glaucoma (N
Kazuko Omodaka - One of the best experts on this subject based on the ideXlab platform.
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the optic nerve head vasoreactive response to systemic hyperoxia and Visual Field Defect progression in open angle glaucoma a pilot study
Acta Ophthalmologica, 2020Co-Authors: Naoki Kiyota, Hiroshi Kunikata, Kazuko Omodaka, Yukihiro Shiga, Masayuki Yasuda, Naoko Aizawa, Satoru Tsuda, Kyongsun Pak, Toru NakazawaAbstract:PURPOSE To investigate the effect of optic nerve head (ONH) tissue vasoreactivity on glaucoma Visual Field Defect progression. METHODS This prospective, longitudinal study comprised 28 eyes of 16 patients with open-angle glaucoma. Baseline data were obtained from oxygen inhalation testing, including laser speckle flowgraphy measurements of tissue-area mean blur rate (MT), which represents ONH tissue blood flow, and the mean percentage change in MT (MT-change). Follow-up data were collected for at least 2 years, including at least 5 reliable Visual Field tests. The average total deviation (TD) was calculated in each sector of the Garway-Heath map; in this study, superior, central and inferior TD corresponded to inferior, temporal and superior MT or MT-change, respectively. MT and MT-change in three sectors per eye were included as explanatory variables in a multivariable linear mixed-effects model, with TD slope set as the response variable. RESULTS At baseline, lower MT and higher diastolic blood pressure were associated with lower MT-change (p < 0.05). Additionally, MT-change significantly contributed to TD slope in the corresponding sectors (β = 0.41, p = 0.01). CONCLUSIONS Weaker ONH tissue vasoreactivity to systemic hyperoxia, assessed with laser speckle flowgraphy, was associated with lower baseline ONH tissue blood flow, higher diastolic blood pressure and rapid Visual Field Defect progression. Laser speckle flowgraphy variables during oxygen provocation testing may represent potentially useful predictive biomarkers of glaucoma progression.
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sectoral differences in the association of optic nerve head blood flow and glaucomatous Visual Field Defect severity and progression
Investigative Ophthalmology & Visual Science, 2019Co-Authors: Naoki Kiyota, Hiroshi Kunikata, Kazuko Omodaka, Yukihiro Shiga, Masayuki Yasuda, Naoko Aizawa, Satoru Tsuda, Toru NakazawaAbstract:Purpose To investigate sectoral differences in the relationship between optic nerve head tissue blood flow, anatomically corresponding Visual Field Defect severity, and future progression. Methods This retrospective longitudinal medical chart review comprised 508 eyes of 319 open-angle glaucoma patients (mean deviation: -9.2 ± 7.0 dB), followed for an average of 4.7 ± 1.1 years; an average 11.7 ± 3.7 Visual Field tests were performed. Average total deviation (TD) was calculated in the superior, central, and inferior sectors of the Humphrey 24-2 program. The optic nerve head was divided to obtain inferior, temporal, and superior tissue-area mean blur rate (MT), derived from laser speckle flowgraphy. At baseline, the correlation between MT and TD was compared in anatomically corresponding sectors. We performed a multivariate analysis to determine the contribution of baseline MT to corresponding TD slope and to determine background factors influencing superior to temporal MT. We used a linear-mixed effect model for the statistical analysis. Results At baseline, the highest β coefficients were found between MT-superior and TD-inferior, MT-temporal and TD-central, and between MT-inferior and TD-superior, in that order (β = 0.38, β = 0.27, β = 0.26, respectively). MT-superior and MT-temporal independently contributed to corresponding TD slope (P < 0.05). Male sex, high body mass index, and the prevalence of sleep apnea syndrome were contributing factors to lower superior to temporal MT (P < 0.05). Conclusions Review of medical history, measurements of systemic variables, and laser speckle flowgraphy parameters might help clinicians to predict Visual Field Defect severity and progression.
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the relationship between increased oxidative stress and Visual Field Defect progression in glaucoma patients with sleep apnoea syndrome
Acta Ophthalmologica, 2018Co-Authors: Erika Yamada, Noriko Himori, Hiroshi Kunikata, Kazuko Omodaka, Hiromasa Ogawa, Masakazu Ichinose, Toru NakazawaAbstract:Purpose Sleep apnoea syndrome (SAS) is often associated with glaucoma, and intermittent hypoxia, present in SAS, can contribute to glaucoma pathogenesis. However, the relationships between SAS, high systemic oxidative stress and the speed of glaucoma progression are unclear. Thus, we investigated these relationships in glaucoma patients with and without SAS. Methods Peripheral blood samples were collected from 166 eyes of 166 Japanese patients: 42 controls, 109 open-angle glaucoma (OAG) patients without SAS and 15 OAG patients with SAS. Prognostic factors for Visual Field Defect progression were determined with logistic regression. Diacron reactive oxygen metabolites (dROM) and biological antioxidant potential (BAP) were measured with a free radical analyser. Clinical parameters were also recorded. Intergroup comparisons used the Mann-Whitney U test. Results Multiple regression analysis showed that SAS was a statistically significant contributing factor to fast Visual Field Defect progression, defined as mean deviation (MD) slope ≤-2.0 dB/Y (SAS: odds ratio (OR) = 14.48; p = 0.002). The non-SAS and SAS groups had similar age, sex, intraocular pressure (IOP), axial length and antiglaucoma drug use. The SAS group had a significantly higher dROM level (p = 0.001), BAP level (p = 0.038) and steeper MD slope (p = 0.001) than the non-SAS group. Conclusion Glaucoma patients with SAS have higher dROM, as well as steeper MD slope, than patients without SAS, suggesting that SAS may induce systemic oxidative stress and promote glaucomatous Visual Field Defect progression.
