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James J Hudziak - One of the best experts on this subject based on the ideXlab platform.

  • right anterior cingulate cortical thickness and bilateral striatal volume correlate with Child Behavior Checklist aggressive Behavior scores in healthy Children
    Biological Psychiatry, 2011
    Co-Authors: Simon Ducharme, James J Hudziak, Kelly N Botteron, Hooman Ganjavi, Claude Lepage, Louis D Collins, Matthew D Albaugh, Alan C Evans, Sherif Karama
    Abstract:

    Background The anterior cingulate cortex (ACC), orbitofrontal cortex (OFC), and basal ganglia have been implicated in pathological aggression. This study aimed at identifying neuroanatomical correlates of impulsive aggression in healthy Children. Methods Data from 193 representative 6- to 18-year-old healthy Children were obtained from the National Institutes of Health Magnetic Resonance Imaging Study of Normal Brain Development after a blinded quality control. Cortical thickness and subcortical volumes were obtained with automated software. Aggression levels were measured with the Aggressive Behavior scale (AGG) of the Child Behavior Checklist. AGG scores were regressed against cortical thickness and basal ganglia volumes using first- and second-order linear models while controlling for age, gender, scanner site, and total brain volume. Gender by AGG interactions were analyzed. Results There were positive associations between bilateral striatal volumes and AGG scores (right: r = .238, p = .001; left: r = .188, p = .01). A significant association was found with right ACC and subgenual ACC cortical thickness in a second-order linear model ( p Conclusions This study shows the existence of relationships between impulsive aggression in healthy Children and the structure of the striatum and right ACC. It also suggests the existence of gender-specific patterns of association in OFC/ACC gray matter. These results may guide research on oppositional-defiant and conduct disorders.

  • assessment of dysregulated Children using the Child Behavior Checklist a receiver operating characteristic curve analysis
    Psychological Assessment, 2010
    Co-Authors: Robert R Althoff, David C Rettew, Lynsay Ayer, James J Hudziak
    Abstract:

    Disorders of self-regulatory Behavior are common reasons for referral to Child and adolescent clinicians. Here, the authors sought to compare 2 methods of empirically based assessment of Children with problems in self-regulatory Behavior. Using parental reports on 2,028 Children (53% boys) from a U.S. national probability sample of the Child Behavior Checklist (CBCL; T. M. Achenbach & L. A. Rescorla, 2001), the receiver operating characteristic curve analysis was applied to compare scores on the Posttraumatic Stress Problems Scale (PTSP) of the CBCL with the CBCL Dysregulation Profile (DP), identified using latent class analysis of the Attention Problems, Aggressive Behavior, and Anxious/Depressed scales of the CBCL. The CBCL-PTSP score demonstrated an area under the curve of between .88 and .91 for predicting membership in the CBCL-DP profile for boys and for girls. These findings suggest that the CBCL-PTSP, which others have shown does not uniquely identify Children who have been traumatized, does identify the same profile of Behavior as the CBCL-DP. Therefore, the authors recommend renaming the CBCL-PTSP the Dysregulation Short Scale and provide some guidelines for the use of the CBCL-DP scale and the CBCL-PTSP in clinical practice. (PsycINFO Database Record (c) 2010 APA, all rights reserved). Language: en

  • assessment of dysregulated Children using the Child Behavior Checklist a receiver operating characteristic curve analysis
    Psychological Assessment, 2010
    Co-Authors: Robert R Althoff, David C Rettew, Lynsay Ayer, James J Hudziak
    Abstract:

    Disorders of self-regulatory Behavior are common reasons for referral to Child and adolescent clinicians. Here, the authors sought to compare 2 methods of empirically based assessment of Children with problems in self-regulatory Behavior. Using parental reports on 2,028 Children (53% boys) from a U.S. national probability sample of the Child Behavior Checklist (CBCL; T. M. Achenbach & L. A. Rescorla, 2001), the receiver operating characteristic curve analysis was applied to compare scores on the Posttraumatic Stress Problems Scale (PTSP) of the CBCL with the CBCL Dysregulation Profile (DP), identified using latent class analysis of the Attention Problems, Aggressive Behavior, and Anxious/Depressed scales of the CBCL. The CBCL-PTSP score demonstrated an area under the curve of between .88 and .91 for predicting membership in the CBCL-DP profile for boys and for girls. These findings suggest that the CBCL-PTSP, which others have shown does not uniquely identify Children who have been traumatized, does identify the same profile of Behavior as the CBCL-DP. Therefore, the authors recommend renaming the CBCL-PTSP the Dysregulation Short Scale and provide some guidelines for the use of the CBCL-DP scale and the CBCL-PTSP in clinical practice.

  • latent class analysis of the Child Behavior Checklist obsessive compulsive scale
    Comprehensive Psychiatry, 2009
    Co-Authors: Robert R Althoff, James J Hudziak, David C Rettew, Dorret I Boomsma
    Abstract:

    The Obsessive-Compulsive Scale (OCS) of the Child Behavior Checklist (CBCL) predicts obsessive-compulsive disorder and is highly heritable. Latent class analysis (LCA) of the OCS was used to identify profiles within this 8-item scale and to examine heritability of those profiles. The LCAwas performed on maternal CBCL reports of their 6- to 18-year–old Children from 2 US nationally representative samples from 1989 (n = 2475, 50% male) and 1999 (n = 2029, 53% male) and from Dutch twins in the Netherlands Twin Registry at ages 7 (n = 10 194, 49.3% male), 10 (n = 6448, 48.1% male), and 12 (n = 3674, 48.6% male) years. The heritability of the resultant classes was estimated using odds ratios of twin membership across classes. A 4-class solution fitted all samples best. The resulting classes were a “No or Few Symptoms” class, a “Worries and Has to Be Perfect” class, a “Thought Problems” class, and an “OCS” class. Within-class odds ratios were higher than across-class odds ratios and were higher for monozygotic than dizygotic twins. We conclude that LCA identifies an OCS class and that class is highly heritable using across-twin comparisons.

  • Child Behavior Checklist juvenile bipolar disorder cbcl jbd and cbcl posttraumatic stress problems cbcl ptsp scales are measures of a single dysregulatory syndrome
    Journal of Child Psychology and Psychiatry, 2009
    Co-Authors: Lynsay Ayer, Masha Y Ivanova, Robert R Althoff, David C Rettew, Ellen Waxler, Julie Sulman, James J Hudziak
    Abstract:

    Background: The Child Behavior Checklist Juvenile Bipolar Disorder (CBCL-JBD) profile and Posttraumatic Stress Problems (CBCL-PTSP) scale have been used to assess juvenile bipolar disorder (JBD) and posttraumatic stress disorder (PTSD), respectively. However, their validity is questionable according to previous research. Both measures are associated with severe psychopathology often encompassing multiple DSM-IV diagnoses. Further, Children who score highly on one of these scales often have elevated scores on the other, independent of PTSD or JBD diagnoses. We hypothesized that the two scales may be indicators of a single syndrome related to dysregulated mood, attention, and Behavior. We aimed to describe and identify the overlap between the CBCL-JBD profile and CBCL-PTSP scales. Method: Two thousand and twenty-nine (2029) Children from a nationally representative sample (1073 boys, 956 girls; mean age = 11.98; age range = 6‐18) were rated on emotional and Behavior problems by their parents using the CBCL. Comparative model testing via structural equation modeling was conducted to determine whether the CBCL-JBD profile and CBCL-PTSP scale are best described as measuring separate versus unitary constructs. Associations with suicidality and competency scores were also examined. Results: The CBCL-JBD and CBCL-PTSP demonstrated a high degree of overlap ( r= .89) at the latent variable level. The bestfitting, most parsimonious model was one in which the CBCL-JBD and CBCL-PTSP items identified a single latent construct, which was associated with higher parental endorsement of Child suicidal Behavior, and lower functioning. Conclusions: The CBCL-JBD profile and CBCL-PTSP scale overlap to a remarkable degree, and may be best described as measures of a single syndrome. This syndrome appears to be related to severe psychopathology, but may not conformtotraditional DSM-IVclassification. Theseresultscontribute totheongoingdebate aboutthe utility of the CBCL-JBD and CBCL-PTSP profiles, and offer promising methods of empirically based measurement of disordered self-regulation in youth. Keywords: Assessment, Child Behavior Checklist, bipolar disorder, posttraumatic stress disorder. Abbreviations: CBCL: Child Behavior Checklist; JBD: juvenile bipolar disorder; PTSP: posttraumatic stress problems.

Stephen V Faraone - One of the best experts on this subject based on the ideXlab platform.

  • can the Child Behavior Checklist cbcl help characterize the types of psychopathologic conditions driving Child psychiatry referrals
    Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, 2020
    Co-Authors: Joseph Biederman, Janet Wozniak, Yvonne K Woodworth, Mai Uchida, Maura Disalvo, Carrie Vaudreuil, Allison Green, Stephen V Faraone
    Abstract:

    Background Little is known about the scope of problems driving referrals to Child and adolescent psychiatry services. Identifying the full range of mental disorders affecting a particular Child can help triage the Child to a clinician with the appropriate level of expertise. The Child Behavior Checklist (CBCL) is an easy-to-use assessment tool that may provide invaluable information regarding the severity of the presenting complaints and also aid in the referral process. Objective To assess the utility of the CBCL to gain insights into the type of clinical problems driving referrals of youth to an outpatient pediatric psychiatry clinic. Method The sample consisted of 418 newly referred youth 4-18 years of age of both sexes. Parents completed the CBCL assessing psychopathology and competence. Rates of patients with elevated T-scores on each scale were calculated for the whole group and stratified by sex and age (≤12 versus >12). Results The CBCL identified high rates of psychopathology affecting referred youth. It also provided information on the type of suspected disorders affecting a particular Child as well as their severity, critical information to guide likely differing clinical needs and therapeutic approaches. It also helped identify a high number of youth affected with multiple psychopathological conditions, likely to require a high level of clinical attention. Overall, males were significantly more impaired than females but there were no major differences between Children and adolescents. Conclusions The CBCL can aid in the identification of individual and comorbid mental disorders affecting youth seeking mental health services by providing specific information about the presence and the severity of specific suspected disorder. These findings have implications for prioritizing scarce resources in Child mental health and for improved consideration of the complexity of clinical presentations to pediatric psychiatry programs of any type.

  • high correspondence between Child Behavior Checklist rule breaking Behavior scale with conduct disorder in males and females
    Child Psychiatry & Human Development, 2020
    Co-Authors: Amy M Yule, Stephen V Faraone, Janet Wozniak, Timothy E. Wilens, Yvonne K Woodworth, Maura Disalvo, Rachael M Lyons, Joseph Biederman
    Abstract:

    This study investigated the diagnostic utility of the Child Behavior Checklist (CBCL) Rule-Breaking Behavior scale to identify Children of both sexes with conduct disorder (CD). Participants were derived from four independent datasets of Children with and without attention deficit hyperactivity disorder and bipolar-I disorder of both sexes. Participants had structured diagnostic interviews with raters blinded to subject ascertainment status. Receiver operating characteristic (ROC) curves were used to examine the scale’s ability to identify Children with and without CD. The sample consisted of 674 participants (mean age of 11.7 ± 3.3 years, 57% male, 94% Caucasian). The interaction to test if CBCL Rule-Breaking Behavior scores identified males and females with CD differently was not significant, thus we performed ROC analysis in the combined group. The ROC analysis of the scale yielded an area under the curve of 0.9. A score of ≥ 60 on the scale correctly classified 82% of participants with CD with 85% sensitivity, 81% specificity, 48% positive predictive value, 96% negative predictive value. The CBCL Rule-Breaking Behavior scale was an efficient tool to identify Children with CD.

  • further evidence of the diagnostic utility of the Child Behavior Checklist for identifying pediatric bipolar i disorder
    Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, 2019
    Co-Authors: Amy M Yule, Stephen V Faraone, Janet Wozniak, Timothy E. Wilens, Maura Fitzgerald, Yvonne K Woodworth, Alexa Pulli, Mai Uchida, Joseph Biederman
    Abstract:

    Background Pediatric bipolar (BP) disorder is a prevalent and highly morbid disorder. While structured diagnostic interviews have been developed to aide in the diagnosis of pediatric BP disorder, these tools are lengthy, costly, and not widely available. One possible diagnostic aid is the Child Behavior Checklist (CBCL). Objective To assess the diagnostic utility of the Child Behavior Checklist (CBCL)-Bipolar (BP) profile to identify Children with a diagnosis of BP-I disorder. Method Subjects were derived from four independent datasets of Children and adolescents with and without attention deficit hyperactivity disorder (ADHD) and BP-I. Subjects were recruited from pediatric and psychiatric clinics and the community. All subjects had structured clinical interviews with raters blinded to subject ascertainment status. We used an empirically-derived profile from the CBCL consisting of an aggregate t-score from the Attention, Anxiety/Depression, and Aggression subscales (CBCL-BP profile) to operationalize the presence or absence of bipolar symptoms. Receiver operating characteristic (ROC) curves were used to examine the ability of the CBCL-BP profile to identify Children with and without a structured interview diagnosis of BP-I disorder. Results The sample consisted of 661 subjects (mean age: 11.7 ± 3.3 years, 57% male, and 94% Caucasian). Twenty percent of participants (N=130) met structured interview criteria for a full diagnosis of BP-I disorder. The ROC analysis of the CBCL-BP profile yielded an area under the curve of 0.91. A t-score of ≥195 on the CBCL-BP profile correctly classified 86% of subjects with BP-I disorder with 80% sensitivity, 87% specificity, 61% positive predictive value, 95% negative predictive value. Conclusion The CBCL-BP profile efficiently discriminated pediatric subjects with and without a structured interview diagnosis of BP-I disorder. Findings suggest that the CBCL-BP profile may be an efficient tool to help identify Children who are very likely to suffer from BP-I disorder.

  • further evidence that severe scores in the aggression anxiety depression attention subscales of Child Behavior Checklist severe dysregulation profile can screen for bipolar disorder symptomatology a conditional probability analysis
    Journal of Affective Disorders, 2014
    Co-Authors: Mai Uchida, Stephen V Faraone, Janet Wozniak, Yvonne K Woodworth, Thomas J Spencer, Marykate Martelon, Tara Kenworthy, Joseph Biederman
    Abstract:

    Abstract Background Previous work shows that Children with high scores (2SD, combined score≥210) on the Attention Problems, Aggressive Behavior, and Anxious-Depressed (A-A-A) subscales of the Child Behavior Checklist (CBCL) are more likely than other Children to meet criteria for bipolar (BP)-I disorder. However, the utility of this profile as a screening tool has remained unclear. Methods We compared 140 patients with pediatric BP-I disorder, 83 with attention deficit hyperactivity disorder (ADHD), and 114 control subjects. We defined the CBCL-Severe Dysregulation profile as an aggregate cutoff score of≥210 on the A-A-A scales. Patients were assessed with structured diagnostic interviews and functional measures. Results Patients with BP-I disorder were significantly more likely than both control subjects (Odds Ratio [OR]: 173.2; 95% Confidence Interval [CI], 21.2 to 1413.8; P P Limitations Non-clinician raters administered structured diagnostic interviews, and the sample was referred and largely Caucasian. Conclusions The CBCL-Severe Dysregulation profile can be useful as a screen for BP-I disorder in Children in clinical practice.

  • severity of the aggression anxiety depression attention Child Behavior Checklist profile discriminates between different levels of deficits in emotional regulation in youth with attention deficit hyperactivity disorder
    Journal of Developmental and Behavioral Pediatrics, 2012
    Co-Authors: Joseph Biederman, Stephen V Faraone, Carter R. Petty, Helen Day, Rachel L Goldin, Thomas J Spencer, Craig B H Surman, Janet Wozniak
    Abstract:

    OBJECTIVE:: We examined whether severity scores (1 SD vs 2 SDs) of a unique profile of the Child Behavior Checklist (CBCL) consisting of the Anxiety/Depression, Aggression, and Attention (AAA) scales would help differentiate levels of deficits in Children with attention-deficit hyperactivity disorder (ADHD). STUDY DESIGN:: Subjects were 197 Children with ADHD and 224 without ADHD. We defined deficient emotional self-regulation (DESR) as an aggregate cutoff score of >180 but Language: en

Joseph Biederman - One of the best experts on this subject based on the ideXlab platform.

  • can the Child Behavior Checklist cbcl help characterize the types of psychopathologic conditions driving Child psychiatry referrals
    Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, 2020
    Co-Authors: Joseph Biederman, Janet Wozniak, Yvonne K Woodworth, Mai Uchida, Maura Disalvo, Carrie Vaudreuil, Allison Green, Stephen V Faraone
    Abstract:

    Background Little is known about the scope of problems driving referrals to Child and adolescent psychiatry services. Identifying the full range of mental disorders affecting a particular Child can help triage the Child to a clinician with the appropriate level of expertise. The Child Behavior Checklist (CBCL) is an easy-to-use assessment tool that may provide invaluable information regarding the severity of the presenting complaints and also aid in the referral process. Objective To assess the utility of the CBCL to gain insights into the type of clinical problems driving referrals of youth to an outpatient pediatric psychiatry clinic. Method The sample consisted of 418 newly referred youth 4-18 years of age of both sexes. Parents completed the CBCL assessing psychopathology and competence. Rates of patients with elevated T-scores on each scale were calculated for the whole group and stratified by sex and age (≤12 versus >12). Results The CBCL identified high rates of psychopathology affecting referred youth. It also provided information on the type of suspected disorders affecting a particular Child as well as their severity, critical information to guide likely differing clinical needs and therapeutic approaches. It also helped identify a high number of youth affected with multiple psychopathological conditions, likely to require a high level of clinical attention. Overall, males were significantly more impaired than females but there were no major differences between Children and adolescents. Conclusions The CBCL can aid in the identification of individual and comorbid mental disorders affecting youth seeking mental health services by providing specific information about the presence and the severity of specific suspected disorder. These findings have implications for prioritizing scarce resources in Child mental health and for improved consideration of the complexity of clinical presentations to pediatric psychiatry programs of any type.

  • high correspondence between Child Behavior Checklist rule breaking Behavior scale with conduct disorder in males and females
    Child Psychiatry & Human Development, 2020
    Co-Authors: Amy M Yule, Stephen V Faraone, Janet Wozniak, Timothy E. Wilens, Yvonne K Woodworth, Maura Disalvo, Rachael M Lyons, Joseph Biederman
    Abstract:

    This study investigated the diagnostic utility of the Child Behavior Checklist (CBCL) Rule-Breaking Behavior scale to identify Children of both sexes with conduct disorder (CD). Participants were derived from four independent datasets of Children with and without attention deficit hyperactivity disorder and bipolar-I disorder of both sexes. Participants had structured diagnostic interviews with raters blinded to subject ascertainment status. Receiver operating characteristic (ROC) curves were used to examine the scale’s ability to identify Children with and without CD. The sample consisted of 674 participants (mean age of 11.7 ± 3.3 years, 57% male, 94% Caucasian). The interaction to test if CBCL Rule-Breaking Behavior scores identified males and females with CD differently was not significant, thus we performed ROC analysis in the combined group. The ROC analysis of the scale yielded an area under the curve of 0.9. A score of ≥ 60 on the scale correctly classified 82% of participants with CD with 85% sensitivity, 81% specificity, 48% positive predictive value, 96% negative predictive value. The CBCL Rule-Breaking Behavior scale was an efficient tool to identify Children with CD.

  • further evidence of the diagnostic utility of the Child Behavior Checklist for identifying pediatric bipolar i disorder
    Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, 2019
    Co-Authors: Amy M Yule, Stephen V Faraone, Janet Wozniak, Timothy E. Wilens, Maura Fitzgerald, Yvonne K Woodworth, Alexa Pulli, Mai Uchida, Joseph Biederman
    Abstract:

    Background Pediatric bipolar (BP) disorder is a prevalent and highly morbid disorder. While structured diagnostic interviews have been developed to aide in the diagnosis of pediatric BP disorder, these tools are lengthy, costly, and not widely available. One possible diagnostic aid is the Child Behavior Checklist (CBCL). Objective To assess the diagnostic utility of the Child Behavior Checklist (CBCL)-Bipolar (BP) profile to identify Children with a diagnosis of BP-I disorder. Method Subjects were derived from four independent datasets of Children and adolescents with and without attention deficit hyperactivity disorder (ADHD) and BP-I. Subjects were recruited from pediatric and psychiatric clinics and the community. All subjects had structured clinical interviews with raters blinded to subject ascertainment status. We used an empirically-derived profile from the CBCL consisting of an aggregate t-score from the Attention, Anxiety/Depression, and Aggression subscales (CBCL-BP profile) to operationalize the presence or absence of bipolar symptoms. Receiver operating characteristic (ROC) curves were used to examine the ability of the CBCL-BP profile to identify Children with and without a structured interview diagnosis of BP-I disorder. Results The sample consisted of 661 subjects (mean age: 11.7 ± 3.3 years, 57% male, and 94% Caucasian). Twenty percent of participants (N=130) met structured interview criteria for a full diagnosis of BP-I disorder. The ROC analysis of the CBCL-BP profile yielded an area under the curve of 0.91. A t-score of ≥195 on the CBCL-BP profile correctly classified 86% of subjects with BP-I disorder with 80% sensitivity, 87% specificity, 61% positive predictive value, 95% negative predictive value. Conclusion The CBCL-BP profile efficiently discriminated pediatric subjects with and without a structured interview diagnosis of BP-I disorder. Findings suggest that the CBCL-BP profile may be an efficient tool to help identify Children who are very likely to suffer from BP-I disorder.

  • further evidence that severe scores in the aggression anxiety depression attention subscales of Child Behavior Checklist severe dysregulation profile can screen for bipolar disorder symptomatology a conditional probability analysis
    Journal of Affective Disorders, 2014
    Co-Authors: Mai Uchida, Stephen V Faraone, Janet Wozniak, Yvonne K Woodworth, Thomas J Spencer, Marykate Martelon, Tara Kenworthy, Joseph Biederman
    Abstract:

    Abstract Background Previous work shows that Children with high scores (2SD, combined score≥210) on the Attention Problems, Aggressive Behavior, and Anxious-Depressed (A-A-A) subscales of the Child Behavior Checklist (CBCL) are more likely than other Children to meet criteria for bipolar (BP)-I disorder. However, the utility of this profile as a screening tool has remained unclear. Methods We compared 140 patients with pediatric BP-I disorder, 83 with attention deficit hyperactivity disorder (ADHD), and 114 control subjects. We defined the CBCL-Severe Dysregulation profile as an aggregate cutoff score of≥210 on the A-A-A scales. Patients were assessed with structured diagnostic interviews and functional measures. Results Patients with BP-I disorder were significantly more likely than both control subjects (Odds Ratio [OR]: 173.2; 95% Confidence Interval [CI], 21.2 to 1413.8; P P Limitations Non-clinician raters administered structured diagnostic interviews, and the sample was referred and largely Caucasian. Conclusions The CBCL-Severe Dysregulation profile can be useful as a screen for BP-I disorder in Children in clinical practice.

  • severity of the aggression anxiety depression attention Child Behavior Checklist profile discriminates between different levels of deficits in emotional regulation in youth with attention deficit hyperactivity disorder
    Journal of Developmental and Behavioral Pediatrics, 2012
    Co-Authors: Joseph Biederman, Stephen V Faraone, Carter R. Petty, Helen Day, Rachel L Goldin, Thomas J Spencer, Craig B H Surman, Janet Wozniak
    Abstract:

    OBJECTIVE:: We examined whether severity scores (1 SD vs 2 SDs) of a unique profile of the Child Behavior Checklist (CBCL) consisting of the Anxiety/Depression, Aggression, and Attention (AAA) scales would help differentiate levels of deficits in Children with attention-deficit hyperactivity disorder (ADHD). STUDY DESIGN:: Subjects were 197 Children with ADHD and 224 without ADHD. We defined deficient emotional self-regulation (DESR) as an aggregate cutoff score of >180 but Language: en

Robert R Althoff - One of the best experts on this subject based on the ideXlab platform.

  • assessment of dysregulated Children using the Child Behavior Checklist a receiver operating characteristic curve analysis
    Psychological Assessment, 2010
    Co-Authors: Robert R Althoff, David C Rettew, Lynsay Ayer, James J Hudziak
    Abstract:

    Disorders of self-regulatory Behavior are common reasons for referral to Child and adolescent clinicians. Here, the authors sought to compare 2 methods of empirically based assessment of Children with problems in self-regulatory Behavior. Using parental reports on 2,028 Children (53% boys) from a U.S. national probability sample of the Child Behavior Checklist (CBCL; T. M. Achenbach & L. A. Rescorla, 2001), the receiver operating characteristic curve analysis was applied to compare scores on the Posttraumatic Stress Problems Scale (PTSP) of the CBCL with the CBCL Dysregulation Profile (DP), identified using latent class analysis of the Attention Problems, Aggressive Behavior, and Anxious/Depressed scales of the CBCL. The CBCL-PTSP score demonstrated an area under the curve of between .88 and .91 for predicting membership in the CBCL-DP profile for boys and for girls. These findings suggest that the CBCL-PTSP, which others have shown does not uniquely identify Children who have been traumatized, does identify the same profile of Behavior as the CBCL-DP. Therefore, the authors recommend renaming the CBCL-PTSP the Dysregulation Short Scale and provide some guidelines for the use of the CBCL-DP scale and the CBCL-PTSP in clinical practice. (PsycINFO Database Record (c) 2010 APA, all rights reserved). Language: en

  • assessment of dysregulated Children using the Child Behavior Checklist a receiver operating characteristic curve analysis
    Psychological Assessment, 2010
    Co-Authors: Robert R Althoff, David C Rettew, Lynsay Ayer, James J Hudziak
    Abstract:

    Disorders of self-regulatory Behavior are common reasons for referral to Child and adolescent clinicians. Here, the authors sought to compare 2 methods of empirically based assessment of Children with problems in self-regulatory Behavior. Using parental reports on 2,028 Children (53% boys) from a U.S. national probability sample of the Child Behavior Checklist (CBCL; T. M. Achenbach & L. A. Rescorla, 2001), the receiver operating characteristic curve analysis was applied to compare scores on the Posttraumatic Stress Problems Scale (PTSP) of the CBCL with the CBCL Dysregulation Profile (DP), identified using latent class analysis of the Attention Problems, Aggressive Behavior, and Anxious/Depressed scales of the CBCL. The CBCL-PTSP score demonstrated an area under the curve of between .88 and .91 for predicting membership in the CBCL-DP profile for boys and for girls. These findings suggest that the CBCL-PTSP, which others have shown does not uniquely identify Children who have been traumatized, does identify the same profile of Behavior as the CBCL-DP. Therefore, the authors recommend renaming the CBCL-PTSP the Dysregulation Short Scale and provide some guidelines for the use of the CBCL-DP scale and the CBCL-PTSP in clinical practice.

  • latent class analysis of the Child Behavior Checklist obsessive compulsive scale
    Comprehensive Psychiatry, 2009
    Co-Authors: Robert R Althoff, James J Hudziak, David C Rettew, Dorret I Boomsma
    Abstract:

    The Obsessive-Compulsive Scale (OCS) of the Child Behavior Checklist (CBCL) predicts obsessive-compulsive disorder and is highly heritable. Latent class analysis (LCA) of the OCS was used to identify profiles within this 8-item scale and to examine heritability of those profiles. The LCAwas performed on maternal CBCL reports of their 6- to 18-year–old Children from 2 US nationally representative samples from 1989 (n = 2475, 50% male) and 1999 (n = 2029, 53% male) and from Dutch twins in the Netherlands Twin Registry at ages 7 (n = 10 194, 49.3% male), 10 (n = 6448, 48.1% male), and 12 (n = 3674, 48.6% male) years. The heritability of the resultant classes was estimated using odds ratios of twin membership across classes. A 4-class solution fitted all samples best. The resulting classes were a “No or Few Symptoms” class, a “Worries and Has to Be Perfect” class, a “Thought Problems” class, and an “OCS” class. Within-class odds ratios were higher than across-class odds ratios and were higher for monozygotic than dizygotic twins. We conclude that LCA identifies an OCS class and that class is highly heritable using across-twin comparisons.

  • Child Behavior Checklist juvenile bipolar disorder cbcl jbd and cbcl posttraumatic stress problems cbcl ptsp scales are measures of a single dysregulatory syndrome
    Journal of Child Psychology and Psychiatry, 2009
    Co-Authors: Lynsay Ayer, Masha Y Ivanova, Robert R Althoff, David C Rettew, Ellen Waxler, Julie Sulman, James J Hudziak
    Abstract:

    Background: The Child Behavior Checklist Juvenile Bipolar Disorder (CBCL-JBD) profile and Posttraumatic Stress Problems (CBCL-PTSP) scale have been used to assess juvenile bipolar disorder (JBD) and posttraumatic stress disorder (PTSD), respectively. However, their validity is questionable according to previous research. Both measures are associated with severe psychopathology often encompassing multiple DSM-IV diagnoses. Further, Children who score highly on one of these scales often have elevated scores on the other, independent of PTSD or JBD diagnoses. We hypothesized that the two scales may be indicators of a single syndrome related to dysregulated mood, attention, and Behavior. We aimed to describe and identify the overlap between the CBCL-JBD profile and CBCL-PTSP scales. Method: Two thousand and twenty-nine (2029) Children from a nationally representative sample (1073 boys, 956 girls; mean age = 11.98; age range = 6‐18) were rated on emotional and Behavior problems by their parents using the CBCL. Comparative model testing via structural equation modeling was conducted to determine whether the CBCL-JBD profile and CBCL-PTSP scale are best described as measuring separate versus unitary constructs. Associations with suicidality and competency scores were also examined. Results: The CBCL-JBD and CBCL-PTSP demonstrated a high degree of overlap ( r= .89) at the latent variable level. The bestfitting, most parsimonious model was one in which the CBCL-JBD and CBCL-PTSP items identified a single latent construct, which was associated with higher parental endorsement of Child suicidal Behavior, and lower functioning. Conclusions: The CBCL-JBD profile and CBCL-PTSP scale overlap to a remarkable degree, and may be best described as measures of a single syndrome. This syndrome appears to be related to severe psychopathology, but may not conformtotraditional DSM-IVclassification. Theseresultscontribute totheongoingdebate aboutthe utility of the CBCL-JBD and CBCL-PTSP profiles, and offer promising methods of empirically based measurement of disordered self-regulation in youth. Keywords: Assessment, Child Behavior Checklist, bipolar disorder, posttraumatic stress disorder. Abbreviations: CBCL: Child Behavior Checklist; JBD: juvenile bipolar disorder; PTSP: posttraumatic stress problems.

  • latent class analysis shows strong heritability of the Child Behavior Checklist juvenile bipolar phenotype
    Biological Psychiatry, 2006
    Co-Authors: Robert R Althoff, Stephen V Faraone, David C Rettew, Dorret I Boomsma, James J Hudziak
    Abstract:

    BACKGROUND: The Child Behavior Checklist (CBCL) has been used to provide a quantitative description of Childhood bipolar disorder (BPAD). Many have reported that Children in the clinical range on the Attention Problems (AP), Aggressive Behavior (AGG), and Anxious-Depressed (A/D) syndromes simultaneously are more likely to meet the criteria for Childhood BPAD. The purpose of this study was to determine if Latent Class Analysis (LCA) could identify heritable phenotypes representing the CBCL-Juvenile Bipolar (CBCL-JBD) profile and whether this phenotype demonstrates increased frequency of suicidal endorsement. METHODS: The CBCL data were received by survey of mothers of twins in two large twin samples, the Netherlands Twin Registry. The setting for the study was the general community twin sample. Participants included 6246 10-year-old Dutch twins from the Netherlands Twin Registry. The main outcome measure consisted of the LCA on the items comprising the AP, AGG, and A/D subscales and means from the suicidal items #18 and #91 within classes. RESULTS: A 7 class model fit best for girls and an 8 class fit best for boys. The most common class for boys or girls was one with no symptoms. The CBCL-JBD phenotype was the least common--about 4%-5% of the boys and girls. This class was the only one that had significant elevations on the suicidal items of the CBCL. Gender differences were present across latent classes with girls showing no aggression without the CBCL-JBD phenotype and rarely showing attention problems in isolation. Evidence of high heritability of these latent classes was found with odds ratios. CONCLUSIONS: In a general population sample, LCA identifies a CBCL-JBD phenotype latent class that is associated with high rates of suicidality, is highly heritable, and speaks to the comorbidity between attention problems, aggressive Behavior, and anxious/depression in Children. Language: en

Dorret I Boomsma - One of the best experts on this subject based on the ideXlab platform.

  • latent class analysis of the Child Behavior Checklist obsessive compulsive scale
    Comprehensive Psychiatry, 2009
    Co-Authors: Robert R Althoff, James J Hudziak, David C Rettew, Dorret I Boomsma
    Abstract:

    The Obsessive-Compulsive Scale (OCS) of the Child Behavior Checklist (CBCL) predicts obsessive-compulsive disorder and is highly heritable. Latent class analysis (LCA) of the OCS was used to identify profiles within this 8-item scale and to examine heritability of those profiles. The LCAwas performed on maternal CBCL reports of their 6- to 18-year–old Children from 2 US nationally representative samples from 1989 (n = 2475, 50% male) and 1999 (n = 2029, 53% male) and from Dutch twins in the Netherlands Twin Registry at ages 7 (n = 10 194, 49.3% male), 10 (n = 6448, 48.1% male), and 12 (n = 3674, 48.6% male) years. The heritability of the resultant classes was estimated using odds ratios of twin membership across classes. A 4-class solution fitted all samples best. The resulting classes were a “No or Few Symptoms” class, a “Worries and Has to Be Perfect” class, a “Thought Problems” class, and an “OCS” class. Within-class odds ratios were higher than across-class odds ratios and were higher for monozygotic than dizygotic twins. We conclude that LCA identifies an OCS class and that class is highly heritable using across-twin comparisons.

  • latent class analysis shows strong heritability of the Child Behavior Checklist juvenile bipolar phenotype
    Biological Psychiatry, 2006
    Co-Authors: Robert R Althoff, Stephen V Faraone, David C Rettew, Dorret I Boomsma, James J Hudziak
    Abstract:

    BACKGROUND: The Child Behavior Checklist (CBCL) has been used to provide a quantitative description of Childhood bipolar disorder (BPAD). Many have reported that Children in the clinical range on the Attention Problems (AP), Aggressive Behavior (AGG), and Anxious-Depressed (A/D) syndromes simultaneously are more likely to meet the criteria for Childhood BPAD. The purpose of this study was to determine if Latent Class Analysis (LCA) could identify heritable phenotypes representing the CBCL-Juvenile Bipolar (CBCL-JBD) profile and whether this phenotype demonstrates increased frequency of suicidal endorsement. METHODS: The CBCL data were received by survey of mothers of twins in two large twin samples, the Netherlands Twin Registry. The setting for the study was the general community twin sample. Participants included 6246 10-year-old Dutch twins from the Netherlands Twin Registry. The main outcome measure consisted of the LCA on the items comprising the AP, AGG, and A/D subscales and means from the suicidal items #18 and #91 within classes. RESULTS: A 7 class model fit best for girls and an 8 class fit best for boys. The most common class for boys or girls was one with no symptoms. The CBCL-JBD phenotype was the least common--about 4%-5% of the boys and girls. This class was the only one that had significant elevations on the suicidal items of the CBCL. Gender differences were present across latent classes with girls showing no aggression without the CBCL-JBD phenotype and rarely showing attention problems in isolation. Evidence of high heritability of these latent classes was found with odds ratios. CONCLUSIONS: In a general population sample, LCA identifies a CBCL-JBD phenotype latent class that is associated with high rates of suicidality, is highly heritable, and speaks to the comorbidity between attention problems, aggressive Behavior, and anxious/depression in Children. Language: en

  • the obsessive compulsive scale of the Child Behavior Checklist predicts obsessive compulsive disorder a receiver operating characteristic curve analysis
    Journal of Child Psychology and Psychiatry, 2006
    Co-Authors: James J Hudziak, C E M Van Beijsterveldt, Robert R Althoff, Catherine Stanger, Elliot C Nelson, Dorret I Boomsma, Gregory L Hanna, Richard D Todd
    Abstract:

    Background: The purpose of this study was to determine a score on the Obsessive Compulsive Scale (OCS) from the Child Behavior Checklist (CBCL) to screen for obsessive compulsive disorder (OCD) in Children and to rigorously test the specificity and sensitivity of a single cutpoint. Methods: A receiver operating characteristic (ROC) curve analysis was applied to data from 61 patients with clinically determined OCD, 64 clinical controls and 73 general population controls to determine the best sum score on the CBCL-OCS to predict confirmed OCD in Children. Using the ROC-determined cutoff, this score was applied to a national sample of CBCL data from 2460 singleton Children ages 4‐18 and to 20,016 Children ages 7‐18 from three large general population twin samples to determine the estimated prevalence in the general population. Results: Using a CBCL-OCS score of 5 demonstrated an area under the curve (AUC) of .88 with high sensitivity (92%) and moderate specificity (67%) compared to clinical controls. Compared to the general population controls, the AUC was .96 with high sensitivity (92%) and specificity (89%). In the twin samples, the number of participants with CBCL-OCS scores above this cutpoint was 2.3‐7.1%. Conclusions: These findings suggest that the OCS of the CBCL may provide a highly effective way to screen for Childhood OCD, and that the prevalence of Childhood OCD may have been underestimated, thus prompting the need for further research into screening Children for this condition. Keywords: Obsessive compulsive disorder, Child Behavior Checklist, prevalence, Obsessive Compulsive Scale.

  • prevalence and genetic architecture of Child Behavior Checklist juvenile bipolar disorder
    Biological Psychiatry, 2005
    Co-Authors: James J Hudziak, Stephen V Faraone, Robert R Althoff, Eske M Derks, Dorret I Boomsma
    Abstract:

    Background No consensus has been reached yet on how best to characterize Children with juvenile bipolar disorder (JBD). Several groups have shown that Children on the attention problems (AP), aggressive Behavior (AGG), and anxious-depressed (AD) syndromes of the Child Behavior Checklist (CBCL) are likely to meet criteria for DSM-JBD. We aimed to use a large population-based twin sample to evaluate the prevalence and genetic architecture of the CBCL-JBD (deviant on AP, AGG, and AD) phenotype and compare these data to Children who are deviant on just the CBCL-AP syndrome. Methods Structural equation modeling (SEM) was applied to CBCL data from 5418, 3562, and 1971 Dutch twin pairs at ages 7, 10, and 12 years. Results The CBCL-JBD phenotype occurs in ∼1% of Children at each age. Among the Children who meet criteria for the CBCL-AP phenotype (∼ 5%), between 13 and 20% also meet criteria for CBCL-JBD. The best SEM for CBCL-JBD includes additive genetic, shared and unique environmental factors. The best SEM for CBCL-AP includes dominant and additive genetic and unique environmental factors. Conclusions These data suggest that CBCL-JBD is common, and even more common among Children who have severe attention problems. CBCL-JBD shows familial aggregation due to both genetic and shared environmental factors.

  • genetic and environmental contributions to the Child Behavior Checklist obsessive compulsive scale a cross cultural twin study
    Archives of General Psychiatry, 2004
    Co-Authors: James J Hudziak, C E M Van Beijsterveldt, Robert R Althoff, Catherine Stanger, David C Rettew, Elliot C Nelson, Richard D Todd, Meike Bartels, Dorret I Boomsma
    Abstract:

    Context We have reported elsewhere on the development of an 8-item Obsessive-Compulsive Scale (OCS) contained in the Child Behavior Checklist (CBCL) to identify Children who meet criteria for DSM-IV obsessive-compulsive disorder. Twin studies of obsessive-compulsive disorder have indicated a significant genetic component to its expression. Objective To determine the relative contributions of genetic and environmental influences on Childhood obsessive-compulsive Behavior using the CBCL OCS in twin samples. Design The CBCL data were received by survey of twins in the Netherlands Twin Registry (NTR) and the Missouri Twin Study (USA/MOTWIN). Setting General community twin samples. Participants Participants were 4246 twin pairs aged 7 years, 2841 aged 10 years, and 1562 aged 12 years (who also participated in the study at 7 and 10 years of age) from the NTR and 1461 mixed-age twin pairs (average age, approximately 9 years) from the USA/MOTWIN. Main Outcome Measures Model fitting to test for genetic and environmental influences, sex differences, and sibling interaction/rater contrast effects on the CBCL OCS. Results In each case, the best-fitting model was one that indicated significant additive genetic influences (range, 45%-58%; 95% confidence interval [CI], 45%-61%), and unique environmental influences (range, 42%-55%; 95% CI, 39%-55%), with shared environmental influences in the NTR sample aged 12 years (16%). Sex differences were seen in the mixed-age USA/MOTWIN model, but not in the NTR samples. No evidence of dominance, sibling interaction, or rater-contrast effects was seen. These data were relatively consistent across age and cultures. Conclusions The CBCL OCS is influenced by genetic factors (approximately 55%) and unique environmental factors (approximately 45%) in the younger sample, with common environmental influences only at 12 years of age. These effects do not vary with differences in sex or sibling interaction/rater contrast effects. Our data reveal higher genetic influences for obsessive-compulsive Behavior and do not demonstrate genetic differences across sex.