The Experts below are selected from a list of 297 Experts worldwide ranked by ideXlab platform
Israel Kolvin - One of the best experts on this subject based on the ideXlab platform.
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The peer relations of disruptive children with reference to Hyperactivity and conduct disorder
European child & adolescent psychiatry, 2000Co-Authors: Paul Mcardle, G. O'brien, A. Macmillan, Israel KolvinAbstract:Literature reviews indicate that children with disruptive behaviour disorders have peer relationship problems, but little information is available concerning the differential effects of Hyperactivity and conduct disorder on peer relationships. Using a database from North of England research, this paper uses standard frequency analysis complemented by multivariate analyses to explore the independent effects of pervasive Hyperactivity and conduct disorder on the sociometry of peer relations among 7- to 8- and 11- to 12-year-olds. The findings suggest that (a) social isolation in 7–8-year-olds shows no significant association with Hyperactivity. However there is a significant association with conduct disorder in 11–12-year-olds. (b) Rejection is not significantly associated with Hyperactivity alone nor with conduct disorder alone in 7–8-year-olds. However, it is associated with a combination of Hyperactivity and conduct disorder. In 11–12-year-olds rejection is associated with conduct disorder alone and with conduct disorder and Hyperactivity in combination. It is also associated with low cognitive ability alone and in combination with conduct disorder. Overall, these findings provide some limited evidence of adverse sociometric responses to both Hyperactivity and below average cognitive ability. However, in the at-risk samples analysed here, conduct disorder emerges as the most powerful independent predictor of isolation and rejection, and this is especially so among older children.
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Is there a comorbid relationship between Hyperactivity and emotional psychopathology?
European Child & Adolescent Psychiatry, 1997Co-Authors: Paul Mcardle, G. O'brien, Israel KolvinAbstract:Some of the early literature implied that emotional disorders were almost incompatible with Hyperactivity in childhood. The paper addresses this issue using a large epidemiological data base — of two cohorts of 7− & 8-year-old and 11− & 12-year-old children from the North of England. There are two themes, first, the paper reports on the prevalence of emotional symptoms and disorder among hyperactive children. Second, it explores co-occurrence of Hyperactivity and emotional psychopathology according to whether the Hyperactivity is situational or pervasive and according to the age of the child. Hyperactivity proved to have an association with emotional symptoms and disorder at both ages but the links with disorder were most prominent among the older children. Among our high risk or maladjusted samples the strongest links were with home-based situational Hyperactivity. However, among the general population cohort, emotional disorder proved to be a function of pervasiveness of Hyperactivity and older age.
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Hyperactivity: Prevalence and Relationship with Conduct Disorder
Journal of child psychology and psychiatry and allied disciplines, 1995Co-Authors: Paul Mcardle, Gregory O'brien, Israel KolvinAbstract:— This paper reports the prevalence of situational and pervasive Hyperactivity using different definitions of ‘caseness’, and explores the relationship between situational and pervasive Hyperactivity and conduct disorder, using a large data base from the North of England. The prevalence of Hyperactivity, and its relationship with conduct disorder, varied according to whether Hyperactivity was pervasive or situational, according to the age of the child and to the definition of Hyperactivity ‘caseness’. Among younger children only, school based situational and pervasive Hyperactivity had comparable comorbidity with other available evidence of psychiatric disorder and Hyperactivity was virtually a prerequisite for conduct disorder. Among older children, pervasive Hyperactivity had greater comorbidity with other psychiatric disorder than situational Hyperactivity and, furthermore, displayed the strongest links with conduct disorder.
Paul Mcardle - One of the best experts on this subject based on the ideXlab platform.
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The peer relations of disruptive children with reference to Hyperactivity and conduct disorder
European child & adolescent psychiatry, 2000Co-Authors: Paul Mcardle, G. O'brien, A. Macmillan, Israel KolvinAbstract:Literature reviews indicate that children with disruptive behaviour disorders have peer relationship problems, but little information is available concerning the differential effects of Hyperactivity and conduct disorder on peer relationships. Using a database from North of England research, this paper uses standard frequency analysis complemented by multivariate analyses to explore the independent effects of pervasive Hyperactivity and conduct disorder on the sociometry of peer relations among 7- to 8- and 11- to 12-year-olds. The findings suggest that (a) social isolation in 7–8-year-olds shows no significant association with Hyperactivity. However there is a significant association with conduct disorder in 11–12-year-olds. (b) Rejection is not significantly associated with Hyperactivity alone nor with conduct disorder alone in 7–8-year-olds. However, it is associated with a combination of Hyperactivity and conduct disorder. In 11–12-year-olds rejection is associated with conduct disorder alone and with conduct disorder and Hyperactivity in combination. It is also associated with low cognitive ability alone and in combination with conduct disorder. Overall, these findings provide some limited evidence of adverse sociometric responses to both Hyperactivity and below average cognitive ability. However, in the at-risk samples analysed here, conduct disorder emerges as the most powerful independent predictor of isolation and rejection, and this is especially so among older children.
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Is there a comorbid relationship between Hyperactivity and emotional psychopathology?
European Child & Adolescent Psychiatry, 1997Co-Authors: Paul Mcardle, G. O'brien, Israel KolvinAbstract:Some of the early literature implied that emotional disorders were almost incompatible with Hyperactivity in childhood. The paper addresses this issue using a large epidemiological data base — of two cohorts of 7− & 8-year-old and 11− & 12-year-old children from the North of England. There are two themes, first, the paper reports on the prevalence of emotional symptoms and disorder among hyperactive children. Second, it explores co-occurrence of Hyperactivity and emotional psychopathology according to whether the Hyperactivity is situational or pervasive and according to the age of the child. Hyperactivity proved to have an association with emotional symptoms and disorder at both ages but the links with disorder were most prominent among the older children. Among our high risk or maladjusted samples the strongest links were with home-based situational Hyperactivity. However, among the general population cohort, emotional disorder proved to be a function of pervasiveness of Hyperactivity and older age.
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Hyperactivity: Prevalence and Relationship with Conduct Disorder
Journal of child psychology and psychiatry and allied disciplines, 1995Co-Authors: Paul Mcardle, Gregory O'brien, Israel KolvinAbstract:— This paper reports the prevalence of situational and pervasive Hyperactivity using different definitions of ‘caseness’, and explores the relationship between situational and pervasive Hyperactivity and conduct disorder, using a large data base from the North of England. The prevalence of Hyperactivity, and its relationship with conduct disorder, varied according to whether Hyperactivity was pervasive or situational, according to the age of the child and to the definition of Hyperactivity ‘caseness’. Among younger children only, school based situational and pervasive Hyperactivity had comparable comorbidity with other available evidence of psychiatric disorder and Hyperactivity was virtually a prerequisite for conduct disorder. Among older children, pervasive Hyperactivity had greater comorbidity with other psychiatric disorder than situational Hyperactivity and, furthermore, displayed the strongest links with conduct disorder.
Myung Koo Lee - One of the best experts on this subject based on the ideXlab platform.
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inhibition of thip on morphine induced Hyperactivity reverse tolerance and postsynaptic dopamine receptor supersensitivity
Archives of Pharmacal Research, 2002Co-Authors: Inseup Yoon, Imchul Shin, Jintae Hong, Myung Koo LeeAbstract:This study was performed to investigate the effect of tetrahydroisoxazolopyridine (THIP), a GABAA agonist, on the morphine-induced Hyperactivity, reverse tolerance and postsynaptic dopamine receptor supersensitivity in mice. A single administration of morphine induced Hyperactivity in mice. However, the morphine-induced Hyperactivity was inhibited dose-dependently by the administration of THIP (0.2, 0.4 and 0.8 mg/kg, i.p.). In contrast, daily administration of morphine resulted in a reverse tolerance to the Hyperactivity caused by morphine (10 mg/kg, s.c.). THIP inhibited the development of reverse tolerance in the mice that had received the repeated same morphine (10 mg/kg, s.c.) doses. The postsynaptic dopamine receptor super-sensitivity, which was evidenced by the enhanced ambulatory activity after the administration of apomorphine (2 mg/kg, s.c.), also developed in the reverse tolerant mice. THIP also inhibited the development of the postsynaptic dopamine receptor supersensitivity induced by the chronic morphine administration. These results suggest that the Hyperactivity, reverse tolerance and postsynaptic dopamine receptor supersensitivity induced by morphine can be inhibited activating the GABAA receptors.
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inhibition of baclofen on morphine induced Hyperactivity reverse tolerance and postsynaptic dopamine receptor supersensitivity
Pharmacological Research, 2001Co-Authors: Sanghee Woo, Hackseang Kim, Jaesuk Yun, Myung Koo Lee, Yeonhee Seong, Choongon JangAbstract:This study was performed to investigate the effect of tetrahydroisoxazolopyridine (THIP), a GABAA agonist, on the morphine-induced Hyperactivity, reverse tolerance and postsynaptic dopamine receptor supersensitivity in mice. A single administration of morphine induced Hyperactivity in mice. However, the morphine-induced Hyperactivity was inhibited dose-dependently by the administration of THIP (0.2, 0.4 and 0.8 mg/kg, i.p.). In contrast, daily administration of morphine resulted in a reverse tolerance to the Hyperactivity caused by morphine (10 mg/kg, s.c). THIP inhibited the development of reverse tolerance in the mice that had received the repeated same morphine (10 mg/kg, s.c.) doses. The postsynaptic dopamine receptor supersensitivity, which was evidenced by the enhanced ambulatory activity after the administration of apomorphine (2 mg/kg, s.c), also developed in the reverse tolerant mice. THIP also inhibited the development of the postsynaptic dopamine receptor supersensitivity induced by the chronic morphine administration. These results suggest that the Hyperactivity, reverse tolerance and postsynaptic dopamine receptor supersensitivity induced by morphine can be inhibited activating the GABAA receptors.
Jonna Kuntsi - One of the best experts on this subject based on the ideXlab platform.
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Hyperactive-Impulsive Symptom Scores and Oppositional Behaviours Reflect Alternate Manifestations of a Single Liability
Behavior Genetics, 2009Co-Authors: Alexis C. Wood, Philip Asherson, Frühling V. Rijsdijk, Jonna KuntsiAbstract:Attention deficit Hyperactivity disorder and oppositional behaviours frequently co-occur, We aimed to study the etiology of this overlap in a general population–based twin sample, assessing the symptom domains of Hyperactivity-impulsivity and inattentiveness separately for their overlap with oppositionality. We further aimed to investigate whether rater bias may contribute to the overlap in previous data which used one rater only . Using parent and teacher ratings on Hyperactivity-impulsivity, inattentiveness and oppositionality, and actigraph measurements of activity level, for 668 7–9-year-old twin pairs, oppositionality showed a higher overlap with Hyperactivity-impulsivity ( r = 0.95) than with inattentiveness ( r = 0.52) and all etiological influences on Hyperactivity-impulsivity were shared with those on oppositionality, indicated by a genetic correlation of 0.95 and a child-specific environmental correlation of 0.94. Actigraph data did not show an overlap with ratings of oppositionality. In middle childhood, symptoms of Hyperactivity-impulsivity and oppositional behaviour may represent the same underlying liability, whereas the inattentive domain is more distinct.
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Hyperactivity in Children: A Focus on Genetic Research and Psychological Theories
Clinical Child and Family Psychology Review, 2000Co-Authors: Jonna Kuntsi, Jim StevensonAbstract:Hyperactivity has attracted a large amount of research interest in recent years. Here we review developments in genetic research and in research testing psychological theories of the condition. Family, adoptee and twin studies indicate a strong role for genetic factors in the etiology of Hyperactivity. Evidence is emerging also from molecular genetic studies, implicating specific genes that may be involved. At the level of cognitive functioning, a divided, focused or sustained attention deficit does not seem to be a ‘core’ deficit in Hyperactivity. Although children with Hyperactivity often perform poorly on certain executive function tasks, there is disagreement about the interpretation of these findings. The association reported in some studies between a slow inhibitory process and Hyperactivity may reflect a generally slow, variable in speed and inaccurate pattern of responding. Hypotheses about psychological mechanisms such as state regulation or delay aversion provide alternative, and particularly encouraging, interpretations of the findings. We discuss the possible integration of the two lines of research—those of genetic research and research on psychological mechanisms.
Choongon Jang - One of the best experts on this subject based on the ideXlab platform.
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inhibition of baclofen on morphine induced Hyperactivity reverse tolerance and postsynaptic dopamine receptor supersensitivity
Pharmacological Research, 2001Co-Authors: Sanghee Woo, Hackseang Kim, Jaesuk Yun, Myung Koo Lee, Yeonhee Seong, Choongon JangAbstract:This study was performed to investigate the effect of tetrahydroisoxazolopyridine (THIP), a GABAA agonist, on the morphine-induced Hyperactivity, reverse tolerance and postsynaptic dopamine receptor supersensitivity in mice. A single administration of morphine induced Hyperactivity in mice. However, the morphine-induced Hyperactivity was inhibited dose-dependently by the administration of THIP (0.2, 0.4 and 0.8 mg/kg, i.p.). In contrast, daily administration of morphine resulted in a reverse tolerance to the Hyperactivity caused by morphine (10 mg/kg, s.c). THIP inhibited the development of reverse tolerance in the mice that had received the repeated same morphine (10 mg/kg, s.c.) doses. The postsynaptic dopamine receptor supersensitivity, which was evidenced by the enhanced ambulatory activity after the administration of apomorphine (2 mg/kg, s.c), also developed in the reverse tolerant mice. THIP also inhibited the development of the postsynaptic dopamine receptor supersensitivity induced by the chronic morphine administration. These results suggest that the Hyperactivity, reverse tolerance and postsynaptic dopamine receptor supersensitivity induced by morphine can be inhibited activating the GABAA receptors.
