The Experts below are selected from a list of 261 Experts worldwide ranked by ideXlab platform

R. M. Lawrence - One of the best experts on this subject based on the ideXlab platform.

  • Organic Syntheses - Lipase‐catalyzed kinetic resolution of alcohols via Chloroacetate esters: (−)‐(1R,2S)‐trans‐2‐phenylcyclohexanol and (+)‐(1S,2R)‐trans‐2‐Phenylcyclohexanol
    Organic Syntheses, 2003
    Co-Authors: A. Schwartz, P. Madan, J. K. Whitesell, R. M. Lawrence
    Abstract:

    Lipase-catalyzed kinetic resolution of alcohols via Chloroacetate esters: (−)-(1R,2S)-trans-2-phenylcyclohexanol and (+)-(1S,2R)-trans-2-phenylcyclohexanol intermediate: 100 g (0.567 mol) of racemic trans-2-phenylcyclohexanol intermediate: racemic trans-2-phenylcyclohexyl Chloroacetate product: (−)-(1R,2S)-trans-2-phenylcyclohexanol byproduct: (−)-(1S,2R)-trans-2-phenylcyclohexyl Chloroacetate byproduct: (−)-(1R,2S)-trans-2-phenylcyclohexanol product: (+)-(1S,2R)-trans-2-phenylcyclohexanol Keywords: acylation; enzymatic reactions; esterification, of substituted monobasic acids; hydrolysis, esters and lactones; ring opening reactions; assay methods, of enantiomeric purity of alcohols by NMR analysis of mosher esters; benzene; chloroacetyl chloride, lachrymator; dimethylaniline, poison; pH controller

  • lipase catalyzed kinetic resolution of alcohols via Chloroacetate esters 1r 2s trans 2 phenylcyclohexanol and 1s 2r trans 2 phenylcyclohexanol
    Organic Syntheses, 2003
    Co-Authors: A. Schwartz, P. Madan, J. K. Whitesell, R. M. Lawrence
    Abstract:

    Lipase-catalyzed kinetic resolution of alcohols via Chloroacetate esters: (−)-(1R,2S)-trans-2-phenylcyclohexanol and (+)-(1S,2R)-trans-2-phenylcyclohexanol intermediate: 100 g (0.567 mol) of racemic trans-2-phenylcyclohexanol intermediate: racemic trans-2-phenylcyclohexyl Chloroacetate product: (−)-(1R,2S)-trans-2-phenylcyclohexanol byproduct: (−)-(1S,2R)-trans-2-phenylcyclohexyl Chloroacetate byproduct: (−)-(1R,2S)-trans-2-phenylcyclohexanol product: (+)-(1S,2R)-trans-2-phenylcyclohexanol Keywords: acylation; enzymatic reactions; esterification, of substituted monobasic acids; hydrolysis, esters and lactones; ring opening reactions; assay methods, of enantiomeric purity of alcohols by NMR analysis of mosher esters; benzene; chloroacetyl chloride, lachrymator; dimethylaniline, poison; pH controller

A. Schwartz - One of the best experts on this subject based on the ideXlab platform.

  • Organic Syntheses - Lipase‐catalyzed kinetic resolution of alcohols via Chloroacetate esters: (−)‐(1R,2S)‐trans‐2‐phenylcyclohexanol and (+)‐(1S,2R)‐trans‐2‐Phenylcyclohexanol
    Organic Syntheses, 2003
    Co-Authors: A. Schwartz, P. Madan, J. K. Whitesell, R. M. Lawrence
    Abstract:

    Lipase-catalyzed kinetic resolution of alcohols via Chloroacetate esters: (−)-(1R,2S)-trans-2-phenylcyclohexanol and (+)-(1S,2R)-trans-2-phenylcyclohexanol intermediate: 100 g (0.567 mol) of racemic trans-2-phenylcyclohexanol intermediate: racemic trans-2-phenylcyclohexyl Chloroacetate product: (−)-(1R,2S)-trans-2-phenylcyclohexanol byproduct: (−)-(1S,2R)-trans-2-phenylcyclohexyl Chloroacetate byproduct: (−)-(1R,2S)-trans-2-phenylcyclohexanol product: (+)-(1S,2R)-trans-2-phenylcyclohexanol Keywords: acylation; enzymatic reactions; esterification, of substituted monobasic acids; hydrolysis, esters and lactones; ring opening reactions; assay methods, of enantiomeric purity of alcohols by NMR analysis of mosher esters; benzene; chloroacetyl chloride, lachrymator; dimethylaniline, poison; pH controller

  • lipase catalyzed kinetic resolution of alcohols via Chloroacetate esters 1r 2s trans 2 phenylcyclohexanol and 1s 2r trans 2 phenylcyclohexanol
    Organic Syntheses, 2003
    Co-Authors: A. Schwartz, P. Madan, J. K. Whitesell, R. M. Lawrence
    Abstract:

    Lipase-catalyzed kinetic resolution of alcohols via Chloroacetate esters: (−)-(1R,2S)-trans-2-phenylcyclohexanol and (+)-(1S,2R)-trans-2-phenylcyclohexanol intermediate: 100 g (0.567 mol) of racemic trans-2-phenylcyclohexanol intermediate: racemic trans-2-phenylcyclohexyl Chloroacetate product: (−)-(1R,2S)-trans-2-phenylcyclohexanol byproduct: (−)-(1S,2R)-trans-2-phenylcyclohexyl Chloroacetate byproduct: (−)-(1R,2S)-trans-2-phenylcyclohexanol product: (+)-(1S,2R)-trans-2-phenylcyclohexanol Keywords: acylation; enzymatic reactions; esterification, of substituted monobasic acids; hydrolysis, esters and lactones; ring opening reactions; assay methods, of enantiomeric purity of alcohols by NMR analysis of mosher esters; benzene; chloroacetyl chloride, lachrymator; dimethylaniline, poison; pH controller

Jianming Liu - One of the best experts on this subject based on the ideXlab platform.

  • Chloroacetate promotes and participates in the oxidative annulation of pyridines isoquinoline by using oxygen as the oxidant
    Chemistry-an Asian Journal, 2016
    Co-Authors: Yuanyuan Yue, Yangyang Sun, Shufang Zhao, Xuyang Yan, Yaru Shi, Kelei Zhuo, Jianming Liu
    Abstract:

    The aerobic oxidative annulation of chalcones, pyridines/isoquinoline and ethyl Chloroacetate to indolizines was achieved by cascade reaction. Various functional groups on chalcones were tolerated. And different pyridines derivatives could also be suitable substrates. Ethyl Chloroacetate is an essential component in participating of the oxidative annulation process. Overall, this protocol is very practical and efficient by using molecular oxygen as oxidant with high selectivity for the annulation product.

  • Chloroacetate Promotes and Participates in the Oxidative Annulation of Pyridines/Isoquinoline by Using Oxygen as the Oxidant.
    Chemistry an Asian journal, 2016
    Co-Authors: Yuanyuan Yue, Yangyang Sun, Shufang Zhao, Xuyang Yan, Yaru Shi, Kelei Zhuo, Jianming Liu
    Abstract:

    The aerobic oxidative annulation of chalcones, pyridines/isoquinoline and ethyl Chloroacetate to indolizines was achieved by cascade reaction. Various functional groups on chalcones were tolerated. And different pyridines derivatives could also be suitable substrates. Ethyl Chloroacetate is an essential component in participating of the oxidative annulation process. Overall, this protocol is very practical and efficient by using molecular oxygen as oxidant with high selectivity for the annulation product.

  • Chloroacetate promoted selective oxidation of heterobenzylic methylenes under copper catalysis
    Angewandte Chemie, 2015
    Co-Authors: Kelei Zhuo, Jianming Liu, Xin Zhang, Chao Liu, Ren Liu, Heng Zhang, Aiwen Lei
    Abstract:

    The efficient selective oxidation and functionalization of CH bonds with molecular oxygen and a copper catalyst to prepare the corresponding ketones was achieved with ethyl Chloroacetate as a promoter. In this transformation, various substituted N-heterocyclic compounds were well tolerated. Preliminary mechanistic investigations indicated that organic radical species were involved in the overall process. The N-heterocyclic compounds and ethyl Chloroacetate work synergistically to activate CH bonds in the methylene group, which results in the easy generation of free radical intermediates, thus leading to the corresponding ketones in good yields.

  • Chloroacetate‐Promoted Selective Oxidation of Heterobenzylic Methylenes under Copper Catalysis
    Angewandte Chemie (International ed. in English), 2014
    Co-Authors: Jianming Liu, Kelei Zhuo, Xin Zhang, Chao Liu, Ren Liu, Heng Zhang, Aiwen Lei
    Abstract:

    The efficient selective oxidation and functionalization of CH bonds with molecular oxygen and a copper catalyst to prepare the corresponding ketones was achieved with ethyl Chloroacetate as a promoter. In this transformation, various substituted N-heterocyclic compounds were well tolerated. Preliminary mechanistic investigations indicated that organic radical species were involved in the overall process. The N-heterocyclic compounds and ethyl Chloroacetate work synergistically to activate CH bonds in the methylene group, which results in the easy generation of free radical intermediates, thus leading to the corresponding ketones in good yields.

P. Madan - One of the best experts on this subject based on the ideXlab platform.

  • Organic Syntheses - Lipase‐catalyzed kinetic resolution of alcohols via Chloroacetate esters: (−)‐(1R,2S)‐trans‐2‐phenylcyclohexanol and (+)‐(1S,2R)‐trans‐2‐Phenylcyclohexanol
    Organic Syntheses, 2003
    Co-Authors: A. Schwartz, P. Madan, J. K. Whitesell, R. M. Lawrence
    Abstract:

    Lipase-catalyzed kinetic resolution of alcohols via Chloroacetate esters: (−)-(1R,2S)-trans-2-phenylcyclohexanol and (+)-(1S,2R)-trans-2-phenylcyclohexanol intermediate: 100 g (0.567 mol) of racemic trans-2-phenylcyclohexanol intermediate: racemic trans-2-phenylcyclohexyl Chloroacetate product: (−)-(1R,2S)-trans-2-phenylcyclohexanol byproduct: (−)-(1S,2R)-trans-2-phenylcyclohexyl Chloroacetate byproduct: (−)-(1R,2S)-trans-2-phenylcyclohexanol product: (+)-(1S,2R)-trans-2-phenylcyclohexanol Keywords: acylation; enzymatic reactions; esterification, of substituted monobasic acids; hydrolysis, esters and lactones; ring opening reactions; assay methods, of enantiomeric purity of alcohols by NMR analysis of mosher esters; benzene; chloroacetyl chloride, lachrymator; dimethylaniline, poison; pH controller

  • lipase catalyzed kinetic resolution of alcohols via Chloroacetate esters 1r 2s trans 2 phenylcyclohexanol and 1s 2r trans 2 phenylcyclohexanol
    Organic Syntheses, 2003
    Co-Authors: A. Schwartz, P. Madan, J. K. Whitesell, R. M. Lawrence
    Abstract:

    Lipase-catalyzed kinetic resolution of alcohols via Chloroacetate esters: (−)-(1R,2S)-trans-2-phenylcyclohexanol and (+)-(1S,2R)-trans-2-phenylcyclohexanol intermediate: 100 g (0.567 mol) of racemic trans-2-phenylcyclohexanol intermediate: racemic trans-2-phenylcyclohexyl Chloroacetate product: (−)-(1R,2S)-trans-2-phenylcyclohexanol byproduct: (−)-(1S,2R)-trans-2-phenylcyclohexyl Chloroacetate byproduct: (−)-(1R,2S)-trans-2-phenylcyclohexanol product: (+)-(1S,2R)-trans-2-phenylcyclohexanol Keywords: acylation; enzymatic reactions; esterification, of substituted monobasic acids; hydrolysis, esters and lactones; ring opening reactions; assay methods, of enantiomeric purity of alcohols by NMR analysis of mosher esters; benzene; chloroacetyl chloride, lachrymator; dimethylaniline, poison; pH controller

J. K. Whitesell - One of the best experts on this subject based on the ideXlab platform.

  • Organic Syntheses - Lipase‐catalyzed kinetic resolution of alcohols via Chloroacetate esters: (−)‐(1R,2S)‐trans‐2‐phenylcyclohexanol and (+)‐(1S,2R)‐trans‐2‐Phenylcyclohexanol
    Organic Syntheses, 2003
    Co-Authors: A. Schwartz, P. Madan, J. K. Whitesell, R. M. Lawrence
    Abstract:

    Lipase-catalyzed kinetic resolution of alcohols via Chloroacetate esters: (−)-(1R,2S)-trans-2-phenylcyclohexanol and (+)-(1S,2R)-trans-2-phenylcyclohexanol intermediate: 100 g (0.567 mol) of racemic trans-2-phenylcyclohexanol intermediate: racemic trans-2-phenylcyclohexyl Chloroacetate product: (−)-(1R,2S)-trans-2-phenylcyclohexanol byproduct: (−)-(1S,2R)-trans-2-phenylcyclohexyl Chloroacetate byproduct: (−)-(1R,2S)-trans-2-phenylcyclohexanol product: (+)-(1S,2R)-trans-2-phenylcyclohexanol Keywords: acylation; enzymatic reactions; esterification, of substituted monobasic acids; hydrolysis, esters and lactones; ring opening reactions; assay methods, of enantiomeric purity of alcohols by NMR analysis of mosher esters; benzene; chloroacetyl chloride, lachrymator; dimethylaniline, poison; pH controller

  • lipase catalyzed kinetic resolution of alcohols via Chloroacetate esters 1r 2s trans 2 phenylcyclohexanol and 1s 2r trans 2 phenylcyclohexanol
    Organic Syntheses, 2003
    Co-Authors: A. Schwartz, P. Madan, J. K. Whitesell, R. M. Lawrence
    Abstract:

    Lipase-catalyzed kinetic resolution of alcohols via Chloroacetate esters: (−)-(1R,2S)-trans-2-phenylcyclohexanol and (+)-(1S,2R)-trans-2-phenylcyclohexanol intermediate: 100 g (0.567 mol) of racemic trans-2-phenylcyclohexanol intermediate: racemic trans-2-phenylcyclohexyl Chloroacetate product: (−)-(1R,2S)-trans-2-phenylcyclohexanol byproduct: (−)-(1S,2R)-trans-2-phenylcyclohexyl Chloroacetate byproduct: (−)-(1R,2S)-trans-2-phenylcyclohexanol product: (+)-(1S,2R)-trans-2-phenylcyclohexanol Keywords: acylation; enzymatic reactions; esterification, of substituted monobasic acids; hydrolysis, esters and lactones; ring opening reactions; assay methods, of enantiomeric purity of alcohols by NMR analysis of mosher esters; benzene; chloroacetyl chloride, lachrymator; dimethylaniline, poison; pH controller