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Yu-peng Bai - One of the best experts on this subject based on the ideXlab platform.

  • Effect of scopolamine on the acute severe Chlorphenamidine poisoning patients
    Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational di, 2012
    Co-Authors: Yu-peng Bai
    Abstract:

    Objective To investigate effectiveness of scopolamine on the acute severe Chlorphenamidine poisoning patients.Methods 72 cases of acute severe Chlorphenamidine poisoning patients were divided into Ⅰ and Ⅱ groups by the principle of a 1:1 sampling according to the order of admission.The Ⅰ group (36 cases) were treated with traditional multimodality therapy,including gastrolavage,catharsis,using reductant-oxidant (methylthioninium chloride and vitamin C),and symptomatic treatment.The Ⅱ group were treated with traditional multimodality therapy and scopolamine at the same times.Blood methemoglobin were measured at 0,third,seventh,twelfth,twenty-fourth hour,serum troponin Ⅰ (CTnI) and creatine kinase isoenzyme (CK-MB)levels at third,seventh,twenty-fourth,forty-eighth hour,hepatic and renal functions at third,twenty-fourth,forty-eighth hour,and electrocardiogram (ECG) were evaluated every 4 hours in 3 days after hospitalization on all patients.The two groups of patients were compared the efficacy and change detection of targets,Results 31 patients (86.11％ ) recovered and 5 patients (13.89％ ) died in Ⅰ group.All 36 cases recovered in Ⅱ group.The recovery rate of Ⅱ group was distinctively higher than that in Ⅰ group (P＜0.05) and the difference was statistically significant (P＜0.05).The average recovery time and the length of hospital stay in Ⅱ group were sharply shorter than those in Ⅰ group (P＜0.01) and the difference was statistically significant (P＜0.05).Serum CTnⅠ levels between seventh hour and forty-eighth hour,serum CK-MB levels between third hour and forty-eighth hour and methemoglobin concentration at third,seventh,twelfth,twenty-fourth hour were apparently lower in Ⅱ group,and the difference was statistically significant (P＜0.05).The abnormal rates of hepatic and renal functions in Ⅱ group were distinctively lower than those in Ⅰ group and the difference was statistically significant (P＜0.05).The abnormal rates of ECG in the second and third day in Ⅱ group were respectively 38.89％ and 11.11％,and were lower than those in Ⅰ group (64.71％ 、38.71％ ).The difference was statistically significant (P＜0.05).Conclusion Scopolamine has the excellent treatment effect on acute severe Chlorphenamidine poisoning patients and protec their hearts,livers,and kidneys.It complements the deficiency of reductant-oxidants,and combination of the two drugs can form the synergy effect. Key words: Chlorphenamidine;  Poisoning;  Scopolamine;  Treatment out come

  • Effect of scopolamine on the acute severe Chlorphenamidine poisoning patients
    Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational di, 2012
    Co-Authors: Yu-peng Bai
    Abstract:

    To investigate effectiveness of scopolamine on the acute severe Chlorphenamidine poisoning patients. 72 cases of acute severe Chlorphenamidine poisoning patients were divided into I and II groups by the principle of a 1:1 sampling according to the order of admission. The I group (36 cases) were treated with traditional multimodality therapy, including gastrolavage, catharsis, using reductant-oxidant (methylthioninium chloride and vitamin C), and symptomatic treatment. The II group were treated with traditional multimodality therapy and scopolamine at the same times. Blood methemoglobin were measured at 0, third, seventh, twelfth, twenty-fourth hour, serum troponin I (CTnI) and creatine kinase isoenzyme (CK-MB) levels at third, seventh, twenty-fourth, forty-eighth hour, hepatic and renal functions at third, twenty-fourth, forty-eighth hour, and electrocardiogram (ECG) were evaluated every 4 hours in 3 days after hospitalization on all patients. The two groups of patients were compared the efficacy and change detection of targets. 31 patients (86.11%) recovered and 5 patients (13.89%) died in I group. All 36 cases recovered in II group. The recovery rate of II group was distinctively higher than that in I group (P < 0.05) and the difference was statistically significant (P < 0.05). The average recovery time and the length of hospital stay in II group were sharply shorter than those in I group (P < 0.01) and the difference was statistically significant (P < 0.05). Serum CTnI levels between seventh hour and forty-eighth hour, serum CK-MB levels between third hour and forty-eighth hour and methemoglobin concentration at third, seventh, twelfth, twenty-fourth hour were apparently lower in II group, and the difference was statistically significant (P < 0.05). The abnormal rates of hepatic and renal functions in II group were distinctively lower than those in I group and the difference was statistically significant (P < 0.05). The abnormal rates of ECG in the second and third day in II group were respectively 38.89% and 11.11%, and were lower than those in I group (64.71%, 38.71%). The difference was statistically significant (P < 0.05). Scopolamine has the excellent treatment effect on acute severe Chlorphenamidine poisoning patients and protec their hearts, livers, and kidneys. It complements the deficiency of reductant-oxidants, and combination of the two drugs can form the synergy effect.

  • effects of treatment with redox agent blood transfusion and scopolamine on 200 patients with severe Chlorphenamidine poisoning
    Chinese Journal of Industrial Hygiene and Occupational Diseases, 2003
    Co-Authors: Bao-xian Yang, Ben-wu Liu, Chang-feng Duan, Yu-peng Bai
    Abstract:

    OBJECTIVE To verify the effects of treatment with blood transfusion and scopolamine on severe Chlorphenamidine poisoning (SCP). METHODS 400 patients with severe oral Chlorphenamidine poisoning were randomly divided into two groups. 200 patients (Group I) were treated with the traditional combined therapy including gastrolavage, purgation and taking redox agent (methylene blue and vitamin C) while the other 200 patients (Group II) in addition to the above mentioned therapy, received blood transfusion and scopolamine injection. RESULTS The cure rate of Group II was 99.5% and significantly higher than that of Group I (91.0%, P < 0.01). The average time of improving in health in Group II [(8.71 +/- 1.49) h] was obviously shorter than those in Group I [(10.65 +/- 1.72) h, P < 0.01]. Blood methemoglobin concentrations in Group II at 3, 7, 12, 24 h after admission [(43.58 +/- 2.69), (34.21 +/- 2.30), (20.60 +/- 4.03), (13.50 +/- 1.65) g/L respectively] were obviously lower than those in Group I [(54.42 +/- 12.79), (42.17 +/- 22.34), (30.66 +/- 17.67), (19.01 +/- 0.61) g/L respectively, P < 0.01]. CONCLUSION Blood transfusion and scopolamine had distinctive therapeutic effect on SCP to makeup the deficiency of redox agent. Combination of three therapies may potentiate the detoxication for Chlorphenamidine.

  • Effects of treatment with redox agent, blood transfusion and scopolamine on 200 patients with severe Chlorphenamidine poisoning
    Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational di, 2003
    Co-Authors: Bao-xian Yang, Ben-wu Liu, Chang-feng Duan, Yu-peng Bai
    Abstract:

    To verify the effects of treatment with blood transfusion and scopolamine on severe Chlorphenamidine poisoning (SCP). 400 patients with severe oral Chlorphenamidine poisoning were randomly divided into two groups. 200 patients (Group I) were treated with the traditional combined therapy including gastrolavage, purgation and taking redox agent (methylene blue and vitamin C) while the other 200 patients (Group II) in addition to the above mentioned therapy, received blood transfusion and scopolamine injection. The cure rate of Group II was 99.5% and significantly higher than that of Group I (91.0%, P < 0.01). The average time of improving in health in Group II [(8.71 +/- 1.49) h] was obviously shorter than those in Group I [(10.65 +/- 1.72) h, P < 0.01]. Blood methemoglobin concentrations in Group II at 3, 7, 12, 24 h after admission [(43.58 +/- 2.69), (34.21 +/- 2.30), (20.60 +/- 4.03), (13.50 +/- 1.65) g/L respectively] were obviously lower than those in Group I [(54.42 +/- 12.79), (42.17 +/- 22.34), (30.66 +/- 17.67), (19.01 +/- 0.61) g/L respectively, P < 0.01]. Blood transfusion and scopolamine had distinctive therapeutic effect on SCP to makeup the deficiency of redox agent. Combination of three therapies may potentiate the detoxication for Chlorphenamidine.

Bao-xian Yang - One of the best experts on this subject based on the ideXlab platform.

  • effects of treatment with redox agent blood transfusion and scopolamine on 200 patients with severe Chlorphenamidine poisoning
    Chinese Journal of Industrial Hygiene and Occupational Diseases, 2003
    Co-Authors: Bao-xian Yang, Ben-wu Liu, Chang-feng Duan, Yu-peng Bai
    Abstract:

    OBJECTIVE To verify the effects of treatment with blood transfusion and scopolamine on severe Chlorphenamidine poisoning (SCP). METHODS 400 patients with severe oral Chlorphenamidine poisoning were randomly divided into two groups. 200 patients (Group I) were treated with the traditional combined therapy including gastrolavage, purgation and taking redox agent (methylene blue and vitamin C) while the other 200 patients (Group II) in addition to the above mentioned therapy, received blood transfusion and scopolamine injection. RESULTS The cure rate of Group II was 99.5% and significantly higher than that of Group I (91.0%, P < 0.01). The average time of improving in health in Group II [(8.71 +/- 1.49) h] was obviously shorter than those in Group I [(10.65 +/- 1.72) h, P < 0.01]. Blood methemoglobin concentrations in Group II at 3, 7, 12, 24 h after admission [(43.58 +/- 2.69), (34.21 +/- 2.30), (20.60 +/- 4.03), (13.50 +/- 1.65) g/L respectively] were obviously lower than those in Group I [(54.42 +/- 12.79), (42.17 +/- 22.34), (30.66 +/- 17.67), (19.01 +/- 0.61) g/L respectively, P < 0.01]. CONCLUSION Blood transfusion and scopolamine had distinctive therapeutic effect on SCP to makeup the deficiency of redox agent. Combination of three therapies may potentiate the detoxication for Chlorphenamidine.

  • Effects of treatment with redox agent, blood transfusion and scopolamine on 200 patients with severe Chlorphenamidine poisoning
    Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational di, 2003
    Co-Authors: Bao-xian Yang, Ben-wu Liu, Chang-feng Duan, Yu-peng Bai
    Abstract:

    To verify the effects of treatment with blood transfusion and scopolamine on severe Chlorphenamidine poisoning (SCP). 400 patients with severe oral Chlorphenamidine poisoning were randomly divided into two groups. 200 patients (Group I) were treated with the traditional combined therapy including gastrolavage, purgation and taking redox agent (methylene blue and vitamin C) while the other 200 patients (Group II) in addition to the above mentioned therapy, received blood transfusion and scopolamine injection. The cure rate of Group II was 99.5% and significantly higher than that of Group I (91.0%, P < 0.01). The average time of improving in health in Group II [(8.71 +/- 1.49) h] was obviously shorter than those in Group I [(10.65 +/- 1.72) h, P < 0.01]. Blood methemoglobin concentrations in Group II at 3, 7, 12, 24 h after admission [(43.58 +/- 2.69), (34.21 +/- 2.30), (20.60 +/- 4.03), (13.50 +/- 1.65) g/L respectively] were obviously lower than those in Group I [(54.42 +/- 12.79), (42.17 +/- 22.34), (30.66 +/- 17.67), (19.01 +/- 0.61) g/L respectively, P < 0.01]. Blood transfusion and scopolamine had distinctive therapeutic effect on SCP to makeup the deficiency of redox agent. Combination of three therapies may potentiate the detoxication for Chlorphenamidine.

Ben-wu Liu - One of the best experts on this subject based on the ideXlab platform.

  • effects of treatment with redox agent blood transfusion and scopolamine on 200 patients with severe Chlorphenamidine poisoning
    Chinese Journal of Industrial Hygiene and Occupational Diseases, 2003
    Co-Authors: Bao-xian Yang, Ben-wu Liu, Chang-feng Duan, Yu-peng Bai
    Abstract:

    OBJECTIVE To verify the effects of treatment with blood transfusion and scopolamine on severe Chlorphenamidine poisoning (SCP). METHODS 400 patients with severe oral Chlorphenamidine poisoning were randomly divided into two groups. 200 patients (Group I) were treated with the traditional combined therapy including gastrolavage, purgation and taking redox agent (methylene blue and vitamin C) while the other 200 patients (Group II) in addition to the above mentioned therapy, received blood transfusion and scopolamine injection. RESULTS The cure rate of Group II was 99.5% and significantly higher than that of Group I (91.0%, P < 0.01). The average time of improving in health in Group II [(8.71 +/- 1.49) h] was obviously shorter than those in Group I [(10.65 +/- 1.72) h, P < 0.01]. Blood methemoglobin concentrations in Group II at 3, 7, 12, 24 h after admission [(43.58 +/- 2.69), (34.21 +/- 2.30), (20.60 +/- 4.03), (13.50 +/- 1.65) g/L respectively] were obviously lower than those in Group I [(54.42 +/- 12.79), (42.17 +/- 22.34), (30.66 +/- 17.67), (19.01 +/- 0.61) g/L respectively, P < 0.01]. CONCLUSION Blood transfusion and scopolamine had distinctive therapeutic effect on SCP to makeup the deficiency of redox agent. Combination of three therapies may potentiate the detoxication for Chlorphenamidine.

  • Effects of treatment with redox agent, blood transfusion and scopolamine on 200 patients with severe Chlorphenamidine poisoning
    Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational di, 2003
    Co-Authors: Bao-xian Yang, Ben-wu Liu, Chang-feng Duan, Yu-peng Bai
    Abstract:

    To verify the effects of treatment with blood transfusion and scopolamine on severe Chlorphenamidine poisoning (SCP). 400 patients with severe oral Chlorphenamidine poisoning were randomly divided into two groups. 200 patients (Group I) were treated with the traditional combined therapy including gastrolavage, purgation and taking redox agent (methylene blue and vitamin C) while the other 200 patients (Group II) in addition to the above mentioned therapy, received blood transfusion and scopolamine injection. The cure rate of Group II was 99.5% and significantly higher than that of Group I (91.0%, P < 0.01). The average time of improving in health in Group II [(8.71 +/- 1.49) h] was obviously shorter than those in Group I [(10.65 +/- 1.72) h, P < 0.01]. Blood methemoglobin concentrations in Group II at 3, 7, 12, 24 h after admission [(43.58 +/- 2.69), (34.21 +/- 2.30), (20.60 +/- 4.03), (13.50 +/- 1.65) g/L respectively] were obviously lower than those in Group I [(54.42 +/- 12.79), (42.17 +/- 22.34), (30.66 +/- 17.67), (19.01 +/- 0.61) g/L respectively, P < 0.01]. Blood transfusion and scopolamine had distinctive therapeutic effect on SCP to makeup the deficiency of redox agent. Combination of three therapies may potentiate the detoxication for Chlorphenamidine.

Chang-feng Duan - One of the best experts on this subject based on the ideXlab platform.

  • effects of treatment with redox agent blood transfusion and scopolamine on 200 patients with severe Chlorphenamidine poisoning
    Chinese Journal of Industrial Hygiene and Occupational Diseases, 2003
    Co-Authors: Bao-xian Yang, Ben-wu Liu, Chang-feng Duan, Yu-peng Bai
    Abstract:

    OBJECTIVE To verify the effects of treatment with blood transfusion and scopolamine on severe Chlorphenamidine poisoning (SCP). METHODS 400 patients with severe oral Chlorphenamidine poisoning were randomly divided into two groups. 200 patients (Group I) were treated with the traditional combined therapy including gastrolavage, purgation and taking redox agent (methylene blue and vitamin C) while the other 200 patients (Group II) in addition to the above mentioned therapy, received blood transfusion and scopolamine injection. RESULTS The cure rate of Group II was 99.5% and significantly higher than that of Group I (91.0%, P < 0.01). The average time of improving in health in Group II [(8.71 +/- 1.49) h] was obviously shorter than those in Group I [(10.65 +/- 1.72) h, P < 0.01]. Blood methemoglobin concentrations in Group II at 3, 7, 12, 24 h after admission [(43.58 +/- 2.69), (34.21 +/- 2.30), (20.60 +/- 4.03), (13.50 +/- 1.65) g/L respectively] were obviously lower than those in Group I [(54.42 +/- 12.79), (42.17 +/- 22.34), (30.66 +/- 17.67), (19.01 +/- 0.61) g/L respectively, P < 0.01]. CONCLUSION Blood transfusion and scopolamine had distinctive therapeutic effect on SCP to makeup the deficiency of redox agent. Combination of three therapies may potentiate the detoxication for Chlorphenamidine.

  • Effects of treatment with redox agent, blood transfusion and scopolamine on 200 patients with severe Chlorphenamidine poisoning
    Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational di, 2003
    Co-Authors: Bao-xian Yang, Ben-wu Liu, Chang-feng Duan, Yu-peng Bai
    Abstract:

    To verify the effects of treatment with blood transfusion and scopolamine on severe Chlorphenamidine poisoning (SCP). 400 patients with severe oral Chlorphenamidine poisoning were randomly divided into two groups. 200 patients (Group I) were treated with the traditional combined therapy including gastrolavage, purgation and taking redox agent (methylene blue and vitamin C) while the other 200 patients (Group II) in addition to the above mentioned therapy, received blood transfusion and scopolamine injection. The cure rate of Group II was 99.5% and significantly higher than that of Group I (91.0%, P < 0.01). The average time of improving in health in Group II [(8.71 +/- 1.49) h] was obviously shorter than those in Group I [(10.65 +/- 1.72) h, P < 0.01]. Blood methemoglobin concentrations in Group II at 3, 7, 12, 24 h after admission [(43.58 +/- 2.69), (34.21 +/- 2.30), (20.60 +/- 4.03), (13.50 +/- 1.65) g/L respectively] were obviously lower than those in Group I [(54.42 +/- 12.79), (42.17 +/- 22.34), (30.66 +/- 17.67), (19.01 +/- 0.61) g/L respectively, P < 0.01]. Blood transfusion and scopolamine had distinctive therapeutic effect on SCP to makeup the deficiency of redox agent. Combination of three therapies may potentiate the detoxication for Chlorphenamidine.

J. Moscowitz - One of the best experts on this subject based on the ideXlab platform.