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Padmaja Shivanand - One of the best experts on this subject based on the ideXlab platform.

  • release of Chlorpheniramine Maleate from fatty acid ester matrix disks prepared by melt extrusion
    Journal of Pharmacy and Pharmacology, 2011
    Co-Authors: W Prapaitrakul, Omar L Sprockel, Padmaja Shivanand
    Abstract:

    Chlorpheniramine Maleate was incorporated into disks consisting of glyceryl fatty acid esters, polyethylene glycol fatty acid esters or a combination of the two. A melt-extrusion process was used to prepare the matrix disks containing the drug. The release of the drug into distilled water, pH 1.2 buffer, and pH 7.5 buffer showed the expected square root of time dependence. An increase in the fatty acid ester hydrophilic-lipophilic balance (HLB) from 1 to 14 resulted in a 10-fold increase in the drug release rate from 0.25 +/- 0.01 to 25.84 +/- 1.29 mg cm-2 h-1/2. The maximum release rate was seen from the fatty acid ester with a melting point of 44 degrees C. The pH of the dissolution medium had a small impact on the rate of drug release, but the rate of agitation had no significant influence on the rate of drug release. By blending a fatty acid ester of a high melting point (64 degrees C) and a low HLB value of 2 with esters of lower melting points (33 to 50 degrees C) or higher HLB values (10 to 14), it was possible to modify the release from 10.0 +/- 0.70 to 21.5 +/- 0.57 mg cm-2 h-1/2.

  • release of Chlorpheniramine Maleate from fatty acid ester matrix disks prepared by melt extrusion
    Journal of Pharmacy and Pharmacology, 1991
    Co-Authors: W Prapaitrakul, Omar L Sprockel, Padmaja Shivanand
    Abstract:

    — Chlorpheniramine Maleate was incorporated into disks consisting of glyceryl fatty acid esters, polyethylene glycol fatty acid esters or a combination of the two. A melt-extrusion process was used to prepare the matrix disks containing the drug. The release of the drug into distilled water, pH 1·2 buffer, and pH 7·5 buffer showed the expected square root of time dependence. An increase in the fatty acid ester hydrophilic-lipophilic balance (HLB) from 1 to 14 resulted in a 10-fold increase in the drug release rate from 0·25 ± 0·01 to 25·84 ± 1·29 mg cm−2 h−½ The maximum release rate was seen from the fatty acid ester with a melting point of 44°C. The pH of the dissolution medium had a small impact on the rate of drug release, but the rate of agitation had no significant influence on the rate of drug release. By blending a fatty acid ester of a high melting point (64°C) and a low HLB value of 2 with esters of lower melting points (33 to 50°C) or higher HLB values (10 to 14), it was possible to modify the release from 10·0 ± 0·70 to 21·5 ± 0·57 mg cm−2 h−½

W Prapaitrakul - One of the best experts on this subject based on the ideXlab platform.

  • release of Chlorpheniramine Maleate from fatty acid ester matrix disks prepared by melt extrusion
    Journal of Pharmacy and Pharmacology, 2011
    Co-Authors: W Prapaitrakul, Omar L Sprockel, Padmaja Shivanand
    Abstract:

    Chlorpheniramine Maleate was incorporated into disks consisting of glyceryl fatty acid esters, polyethylene glycol fatty acid esters or a combination of the two. A melt-extrusion process was used to prepare the matrix disks containing the drug. The release of the drug into distilled water, pH 1.2 buffer, and pH 7.5 buffer showed the expected square root of time dependence. An increase in the fatty acid ester hydrophilic-lipophilic balance (HLB) from 1 to 14 resulted in a 10-fold increase in the drug release rate from 0.25 +/- 0.01 to 25.84 +/- 1.29 mg cm-2 h-1/2. The maximum release rate was seen from the fatty acid ester with a melting point of 44 degrees C. The pH of the dissolution medium had a small impact on the rate of drug release, but the rate of agitation had no significant influence on the rate of drug release. By blending a fatty acid ester of a high melting point (64 degrees C) and a low HLB value of 2 with esters of lower melting points (33 to 50 degrees C) or higher HLB values (10 to 14), it was possible to modify the release from 10.0 +/- 0.70 to 21.5 +/- 0.57 mg cm-2 h-1/2.

  • release of Chlorpheniramine Maleate from fatty acid ester matrix disks prepared by melt extrusion
    Journal of Pharmacy and Pharmacology, 1991
    Co-Authors: W Prapaitrakul, Omar L Sprockel, Padmaja Shivanand
    Abstract:

    — Chlorpheniramine Maleate was incorporated into disks consisting of glyceryl fatty acid esters, polyethylene glycol fatty acid esters or a combination of the two. A melt-extrusion process was used to prepare the matrix disks containing the drug. The release of the drug into distilled water, pH 1·2 buffer, and pH 7·5 buffer showed the expected square root of time dependence. An increase in the fatty acid ester hydrophilic-lipophilic balance (HLB) from 1 to 14 resulted in a 10-fold increase in the drug release rate from 0·25 ± 0·01 to 25·84 ± 1·29 mg cm−2 h−½ The maximum release rate was seen from the fatty acid ester with a melting point of 44°C. The pH of the dissolution medium had a small impact on the rate of drug release, but the rate of agitation had no significant influence on the rate of drug release. By blending a fatty acid ester of a high melting point (64°C) and a low HLB value of 2 with esters of lower melting points (33 to 50°C) or higher HLB values (10 to 14), it was possible to modify the release from 10·0 ± 0·70 to 21·5 ± 0·57 mg cm−2 h−½

Omar L Sprockel - One of the best experts on this subject based on the ideXlab platform.

  • release of Chlorpheniramine Maleate from fatty acid ester matrix disks prepared by melt extrusion
    Journal of Pharmacy and Pharmacology, 2011
    Co-Authors: W Prapaitrakul, Omar L Sprockel, Padmaja Shivanand
    Abstract:

    Chlorpheniramine Maleate was incorporated into disks consisting of glyceryl fatty acid esters, polyethylene glycol fatty acid esters or a combination of the two. A melt-extrusion process was used to prepare the matrix disks containing the drug. The release of the drug into distilled water, pH 1.2 buffer, and pH 7.5 buffer showed the expected square root of time dependence. An increase in the fatty acid ester hydrophilic-lipophilic balance (HLB) from 1 to 14 resulted in a 10-fold increase in the drug release rate from 0.25 +/- 0.01 to 25.84 +/- 1.29 mg cm-2 h-1/2. The maximum release rate was seen from the fatty acid ester with a melting point of 44 degrees C. The pH of the dissolution medium had a small impact on the rate of drug release, but the rate of agitation had no significant influence on the rate of drug release. By blending a fatty acid ester of a high melting point (64 degrees C) and a low HLB value of 2 with esters of lower melting points (33 to 50 degrees C) or higher HLB values (10 to 14), it was possible to modify the release from 10.0 +/- 0.70 to 21.5 +/- 0.57 mg cm-2 h-1/2.

  • release of Chlorpheniramine Maleate from fatty acid ester matrix disks prepared by melt extrusion
    Journal of Pharmacy and Pharmacology, 1991
    Co-Authors: W Prapaitrakul, Omar L Sprockel, Padmaja Shivanand
    Abstract:

    — Chlorpheniramine Maleate was incorporated into disks consisting of glyceryl fatty acid esters, polyethylene glycol fatty acid esters or a combination of the two. A melt-extrusion process was used to prepare the matrix disks containing the drug. The release of the drug into distilled water, pH 1·2 buffer, and pH 7·5 buffer showed the expected square root of time dependence. An increase in the fatty acid ester hydrophilic-lipophilic balance (HLB) from 1 to 14 resulted in a 10-fold increase in the drug release rate from 0·25 ± 0·01 to 25·84 ± 1·29 mg cm−2 h−½ The maximum release rate was seen from the fatty acid ester with a melting point of 44°C. The pH of the dissolution medium had a small impact on the rate of drug release, but the rate of agitation had no significant influence on the rate of drug release. By blending a fatty acid ester of a high melting point (64°C) and a low HLB value of 2 with esters of lower melting points (33 to 50°C) or higher HLB values (10 to 14), it was possible to modify the release from 10·0 ± 0·70 to 21·5 ± 0·57 mg cm−2 h−½

Nora H Alshaalan - One of the best experts on this subject based on the ideXlab platform.

  • determination of phenylephrine hydrochloride and Chlorpheniramine Maleate in binary mixture using chemometric assisted spectrophotometric and high performance liquid chromatographic uv methods
    Journal of Saudi Chemical Society, 2010
    Co-Authors: Nora H Alshaalan
    Abstract:

    Abstract Four methods have been developed for the simultaneous determination of phenylephrine hydrochloride and Chlorpheniramine Maleate without previous separation. In the first method both drugs are determined using first derivative UV spectrophotometry, with zero-crossing measurement. The second method depends on first derivative of the ratios spectra. The third method describes the use of multivariate spectrophotometric calibration for the simultaneous determination of the analyzed binary mixture where the resolution is accomplished by using partial least squares (PLS) regression analysis. In the fourth method (HPLC), a reversed-phase column and a mobile phase of methanol:water:acetonitrile (80:12:8 v/v/v/) at 0.9 ml/min flow rate have been used to separate both drugs with a UV detection at 270 nm. All the proposed methods are extensively validated. They have the advantage to be economic and time saving. All the described methods can be readily utilized for analysis of pharmaceutical formulations. The results obtained using the proposed methods are statistically analyzed and compared with some reported methods.

Tuncel Ozden - One of the best experts on this subject based on the ideXlab platform.

  • simultaneous determination of paracetamol phenylephrine hydrochloride oxolamine citrate and Chlorpheniramine Maleate by hplc in pharmaceutical dosage forms
    Journal of Chemistry, 2011
    Co-Authors: Ozan Pirol, Murat Sukuroglu, Tuncel Ozden
    Abstract:

    A new high performance liquid chromatographic (HPLC) method was developed for the determination of paracetamol, phenylephrine hydrochloride, oxolamine citrate and Chlorpheniramine Maleate in combined pharmaceutical formulations and dosage forms. The separation was performed on an Agilent Zorbax SB-CN column with the mobile phase consisting of 0.02 M phosphate buffer (pH:4) and acetonitrile (85:15,v/v) in flow rate 1.5 mL at 22 °C. The overall retention time of the analytes was 3.5 min. The method was validated with respect to linearity, precision, accuracy and recovery. The relative standard deviation for 10 replicate measurements of paracetamol, phenylephrine HCl, oxolamine citrate and Chlorpheniramine Maleate were 0.12, 0.36 0.18 and 0.59%, respectively. Total recoveries of analytes were 99.99, 100.56, 100.20 and 99.60%, respectively. No chromatographic interference from the tablet excipients was found. The linearity of paracetamol, phenylephrine HCl, oxolamine citrate and Chlorpheniramine Maleate were in the range of 20-120 μg/mL, 0.4-2.4 μg/mL, 8-48 μg/mL and 0.16-0.96 μg/mL, respectively. This simple, fast, economical and precise high performance liquid chromatographic method can be adopted for routine quality control analysis.

  • simultaneous high performance liquid chromatographic determination of paracetamol phenylephrine hcl and Chlorpheniramine Maleate in pharmaceutical dosage forms
    Journal of Chromatographic Science, 2002
    Co-Authors: Hamide Senyuva, Tuncel Ozden
    Abstract:

    A rapid, precise, and specific high-performance liquid chromatographic method is described for the simultaneous determination of paracetamol, phenylephrine HCI, and Chlorpheniramine Maleate in combined pharmaceutical dosage forms. The method involves the use of a microBondapak CN RP analytical column (125 A, 10 microm, 3.9 x 150 mm) at 22 degrees C as the stationary phase with the mixture of acetonitrile and phosphate buffer (pH 6.22, 78:22) as the mobile phase. Derivatization of the drugs is not required. The method is applied to commercial pediatric cough-cold syrups, tablets, and capsules marketed in Turkey. The relative standard deviation for 10 replicate measurements of each drug in the medicaments is always less than 2%.

  • simultaneous high performance liquid chromatographic determination of paracetamol phenylephrine hcl and Chlorpheniramine Maleate in pharmaceutical dosage forms
    Journal of Chromatographic Science, 2002
    Co-Authors: Hamide Senyuva, Tuncel Ozden
    Abstract:

    A rapid, precise, and specific high-performance liquid chromatographic method is described for the simultaneous determination of paracetamol, phenylephrine HCI, and Chlorpheniramine Maleate in combined pharmaceutical dosage forms. The method involves the use of a μBondapak CN RP analytical column (125 A, 10 μm, 3.9 x 150 mm) at 22°C as the stationary phase with the mixture of acetonitrile and phosphate buffer (pH 6.22, 78:22) as the mobile phase. Derivatization of the drugs is not required. The method is applied to commercial pediatric cough-cold syrups, tablets, and capsules marketed in Turkey. The relative standard deviation for 10 replicate measurements of each drug in the medicaments is always less than 2%.