The Experts below are selected from a list of 315 Experts worldwide ranked by ideXlab platform
Ingvar Bosaeus - One of the best experts on this subject based on the ideXlab platform.
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Rapeseed oil, olive oil, plant sterols, and Cholesterol Metabolism: an ileostomy study
European Journal of Clinical Nutrition, 2005Co-Authors: Lars Ellegård, H Andersson, Ingvar BosaeusAbstract:Objective: To study whether olive oil and rapeseed oil have different effects on Cholesterol Metabolism. Design: Short-term experimental study, with controlled diets. Setting: Outpatients at a metabolic-ward kitchen. Subjects: A total of nine volunteers with conventional ileostomies. Interventions: Two 3-day diet periods; controlled diet including 75 g of rapeseed oil or olive oil. Main outcome measures: Cholesterol absorption, ileal excretion of Cholesterol, and bile acids. Serum levels of Cholesterol and bile acid metabolites. Differences between diets evaluated with Wilcoxon's signed rank sum test. Results: Rapeseed oil diet contained 326 mg more plant sterols than the olive oil diet. Rapeseed oil tended to decrease Cholesterol absorption by 11% ( P =0.050), and increased excretion of Cholesterol, bile acids, and their sum as sterols by 9% ( P =0.021), 32% ( P =0.038), and 51% ( P =0.011) compared to olive oil. A serum marker for bile acid synthesis (7 α -hydroxy-4-cholesten-3-one) increased by 28% ( P =0.038) within 10 h of consumption, and serum Cholesterol levels decreased by 7% ( P =0.024), whereas a serum marker for Cholesterol synthesis (lathosterol) as well as serum levels of plant sterols remained unchanged. Conclusions: Rapeseed oil and olive oil have different effects on Cholesterol Metabolism. Rapeseed oil, tends to decrease Cholesterol absorption, increases excretion of Cholesterol and bile acids, increases serum marker of bile acid synthesis, and decreases serum levels of Cholesterol compared to olive oil. This could in part be explained by different concentrations of natural plant sterols. Sponsorship: Supported by the Göteborg Medical Society, the Swedish Medical Society, the Swedish Board for Agricultural Research (SJFR) grant 50.0444/98 and by University of Göteborg.
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Rapeseed oil, olive oil, plant sterols, and Cholesterol Metabolism: an ileostomy study.
European Journal of Clinical Nutrition, 2005Co-Authors: Lars Ellegård, H Andersson, Ingvar BosaeusAbstract:To study whether olive oil and rapeseed oil have different effects on Cholesterol Metabolism. Short-term experimental study, with controlled diets. Outpatients at a metabolic-ward kitchen. A total of nine volunteers with conventional ileostomies. Two 3-day diet periods; controlled diet including 75 g of rapeseed oil or olive oil. Cholesterol absorption, ileal excretion of Cholesterol, and bile acids. Serum levels of Cholesterol and bile acid metabolites. Differences between diets evaluated with Wilcoxon's signed rank sum test. Rapeseed oil diet contained 326 mg more plant sterols than the olive oil diet. Rapeseed oil tended to decrease Cholesterol absorption by 11% (P=0.050), and increased excretion of Cholesterol, bile acids, and their sum as sterols by 9% (P=0.021), 32% (P=0.038), and 51% (P=0.011) compared to olive oil. A serum marker for bile acid synthesis (7α-hydroxy-4-cholesten-3-one) increased by 28% (P=0.038) within 10 h of consumption, and serum Cholesterol levels decreased by 7% (P=0.024), whereas a serum marker for Cholesterol synthesis (lathosterol) as well as serum levels of plant sterols remained unchanged. Rapeseed oil and olive oil have different effects on Cholesterol Metabolism. Rapeseed oil, tends to decrease Cholesterol absorption, increases excretion of Cholesterol and bile acids, increases serum marker of bile acid synthesis, and decreases serum levels of Cholesterol compared to olive oil. This could in part be explained by different concentrations of natural plant sterols. Supported by the Goteborg Medical Society, the Swedish Medical Society, the Swedish Board for Agricultural Research (SJFR) grant 50.0444/98 and by University of Goteborg.
Peter J H Jones - One of the best experts on this subject based on the ideXlab platform.
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guar gum and similar soluble fibers in the regulation of Cholesterol Metabolism current understandings and future research priorities
Vascular Health and Risk Management, 2008Co-Authors: Todd C Rideout, Peter J H Jones, Scott V Harding, Ming Z FanAbstract:The hypoCholesterolemic effects associated with soluble fiber consumption are clear from animal model and human clinical investigations. Moreover, the modulation of whole-body Cholesterol Metabolism in response to dietary fiber consumption, including intestinal Cholesterol absorption and fecal sterol and bile acid loss, has been the subject of many published reports. However, our understanding of how dietary fibers regulate molecular events at the gene/protein level and alter cellular Cholesterol Metabolism is limited. The modern emphasis on molecular nutrition and rapid progress in ‘high-dimensional’ biological techniques will permit further explorations of the role of genetic polymorphisms in determining the variable interindividual responses to soluble fibers. Furthermore, with traditional molecular biology tools and the application of ‘omic’ technology, specific insight into how fibers modulate the expression of genes and proteins that regulate intestinal Cholesterol absorption and alter hepatic sterol balance will be gained. Detailed knowledge of the molecular mechanisms by which soluble fibers reduce plasma Cholesterol concentrations is paramount to developing novel fiber-based “cocktails” that target specific metabolic pathways to gain maximal Cholesterol reductions.
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single nucleotide polymorphisms in abcg5 and abcg8 are associated with changes in Cholesterol Metabolism during weight loss
Journal of Lipid Research, 2007Co-Authors: Sylvia Santosa, Isabelle Demonty, Alice H Lichtenstein, Jose M Ordovas, Peter J H JonesAbstract:: The purpose of this study was to examine whether changes in Cholesterol Metabolism after weight loss were affected by single nucleotide polymorphisms (SNPs) in ABCG5 and ABCG8 genes. Thirty-five hyperCholesterolemic women lost 11.7 +/- 2.5 kg (P < 0.001). Cholesterol kinetics were assessed using stable isotope techniques. TaqMan PCR was used to detect SNPs in ABCG5/G8. Homozygous Q604E variants in ABCG5 had larger (P < 0.05) reductions in Cholesterol absorption and greater increases (P < 0.05) in synthesis in contrast to heterozygous and homozygous wild-type carriers. Heterozygous C54Y carriers had smaller declines (P = 0.047) in synthesis compared with homozygous variant individuals. The presence of at least one Y54 variant was associated with higher (P = 0.042) post-weight-loss synthesis compared with carriers of the C54 genotype. The direction of the results is consistent with cross-sectional studies on the effects of Q604E and C54Y polymorphisms on plasma Cholesterol. SNPs in ABCG5/G8 were found to be associated with the response of Cholesterol Metabolism to weight loss. The evidence for associations between SNPs in ABCG5/G8 and various parameters of Cholesterol Metabolism indicates the potential effectiveness of establishing genetic screening tools to determine optimal lipid-lowering treatment routes for individuals during weight reduction.
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Single nucleotide polymorphisms in ABCG5 and ABCG8 are associated with changes in Cholesterol Metabolism during weight loss
Journal of lipid research, 2007Co-Authors: Sylvia Santosa, Isabelle Demonty, Alice H Lichtenstein, Jose M Ordovas, Peter J H JonesAbstract:The purpose of this study was to examine whether changes in Cholesterol Metabolism after weight loss were affected by single nucleotide polymorphisms (SNPs) in ABCG5 and ABCG8 genes. Thirty-five hyperCholesterolemic women lost 11.7 ± 2.5 kg (P < 0.001). Cholesterol kinetics were assessed using stable isotope techniques. TaqMan PCR was used to detect SNPs in ABCG5/G8. Homozygous Q604E variants in ABCG5 had larger (P < 0.05) reductions in Cholesterol absorption and greater increases (P < 0.05) in synthesis in contrast to heterozygous and homozygous wild-type carriers. Heterozygous C54Y carriers had smaller declines (P = 0.047) in synthesis compared with homozygous variant individuals. The presence of at least one Y54 variant was associated with higher (P = 0.042) post-weight-loss synthesis compared with carriers of the C54 genotype. The direction of the results is consistent with cross-sectional studies on the effects of Q604E and C54Y polymorphisms on plasma Cholesterol.jlr SNPs in ABCG5/G8 were found to be associated with the response of Cholesterol Metabolism to weight loss. The evidence for associations between SNPs in ABCG5/G8 and various parameters of Cholesterol Metabolism indicates the potential effectiveness of establishing genetic screening tools to determine optimal lipid-lowering treatment routes for individuals during weight reduction.
Lars Ellegård - One of the best experts on this subject based on the ideXlab platform.
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Rapeseed oil, olive oil, plant sterols, and Cholesterol Metabolism: an ileostomy study
European Journal of Clinical Nutrition, 2005Co-Authors: Lars Ellegård, H Andersson, Ingvar BosaeusAbstract:Objective: To study whether olive oil and rapeseed oil have different effects on Cholesterol Metabolism. Design: Short-term experimental study, with controlled diets. Setting: Outpatients at a metabolic-ward kitchen. Subjects: A total of nine volunteers with conventional ileostomies. Interventions: Two 3-day diet periods; controlled diet including 75 g of rapeseed oil or olive oil. Main outcome measures: Cholesterol absorption, ileal excretion of Cholesterol, and bile acids. Serum levels of Cholesterol and bile acid metabolites. Differences between diets evaluated with Wilcoxon's signed rank sum test. Results: Rapeseed oil diet contained 326 mg more plant sterols than the olive oil diet. Rapeseed oil tended to decrease Cholesterol absorption by 11% ( P =0.050), and increased excretion of Cholesterol, bile acids, and their sum as sterols by 9% ( P =0.021), 32% ( P =0.038), and 51% ( P =0.011) compared to olive oil. A serum marker for bile acid synthesis (7 α -hydroxy-4-cholesten-3-one) increased by 28% ( P =0.038) within 10 h of consumption, and serum Cholesterol levels decreased by 7% ( P =0.024), whereas a serum marker for Cholesterol synthesis (lathosterol) as well as serum levels of plant sterols remained unchanged. Conclusions: Rapeseed oil and olive oil have different effects on Cholesterol Metabolism. Rapeseed oil, tends to decrease Cholesterol absorption, increases excretion of Cholesterol and bile acids, increases serum marker of bile acid synthesis, and decreases serum levels of Cholesterol compared to olive oil. This could in part be explained by different concentrations of natural plant sterols. Sponsorship: Supported by the Göteborg Medical Society, the Swedish Medical Society, the Swedish Board for Agricultural Research (SJFR) grant 50.0444/98 and by University of Göteborg.
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Rapeseed oil, olive oil, plant sterols, and Cholesterol Metabolism: an ileostomy study.
European Journal of Clinical Nutrition, 2005Co-Authors: Lars Ellegård, H Andersson, Ingvar BosaeusAbstract:To study whether olive oil and rapeseed oil have different effects on Cholesterol Metabolism. Short-term experimental study, with controlled diets. Outpatients at a metabolic-ward kitchen. A total of nine volunteers with conventional ileostomies. Two 3-day diet periods; controlled diet including 75 g of rapeseed oil or olive oil. Cholesterol absorption, ileal excretion of Cholesterol, and bile acids. Serum levels of Cholesterol and bile acid metabolites. Differences between diets evaluated with Wilcoxon's signed rank sum test. Rapeseed oil diet contained 326 mg more plant sterols than the olive oil diet. Rapeseed oil tended to decrease Cholesterol absorption by 11% (P=0.050), and increased excretion of Cholesterol, bile acids, and their sum as sterols by 9% (P=0.021), 32% (P=0.038), and 51% (P=0.011) compared to olive oil. A serum marker for bile acid synthesis (7α-hydroxy-4-cholesten-3-one) increased by 28% (P=0.038) within 10 h of consumption, and serum Cholesterol levels decreased by 7% (P=0.024), whereas a serum marker for Cholesterol synthesis (lathosterol) as well as serum levels of plant sterols remained unchanged. Rapeseed oil and olive oil have different effects on Cholesterol Metabolism. Rapeseed oil, tends to decrease Cholesterol absorption, increases excretion of Cholesterol and bile acids, increases serum marker of bile acid synthesis, and decreases serum levels of Cholesterol compared to olive oil. This could in part be explained by different concentrations of natural plant sterols. Supported by the Goteborg Medical Society, the Swedish Medical Society, the Swedish Board for Agricultural Research (SJFR) grant 50.0444/98 and by University of Goteborg.
Konrad H Stopsack - One of the best experts on this subject based on the ideXlab platform.
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Cholesterol Metabolism and prostate cancer lethality
Cancer Research, 2016Co-Authors: Konrad H Stopsack, Travis Gerke, Jennifer A Sinnott, Kathryn L Penney, Svitlana Tyekucheva, Howard D SessoAbstract:Cholesterol Metabolism has been implicated in prostate cancer pathogenesis. Here, we assessed the association of intratumoral mRNA expression of Cholesterol synthesis enzymes, transporters, and regulators in tumor specimen at diagnosis and lethal prostate cancer, defined as mortality or metastases from prostate cancer in contrast to nonlethal disease without evidence of metastases after at least 8 years of follow-up. We analyzed the prospective prostate cancer cohorts within the Health Professionals Follow-up Study (n = 249) and the Physicians' Health Study (n = 153) as well as expectantly managed patients in the Swedish Watchful Waiting Study (n = 338). The expression of squalene monooxygenase (SQLE) was associated with lethal cancer in all three cohorts. Men with high SQLE expression (>1 standard deviation above the mean) were 8.3 times (95% confidence interval, 3.5 to 19.7) more likely to have lethal cancer despite therapy compared with men with the mean level of SQLE expression. Absolute SQLE expression was associated with lethal cancer independently from Gleason grade and stage, as was a SQLE expression ratio in tumor versus surrounding benign prostate tissue. Higher SQLE expression was tightly associated with increased histologic markers of angiogenesis. Collectively, this study establishes the prognostic value of intratumoral Cholesterol synthesis as measured via SQLE, its second rate-limiting enzyme. SQLE expression at cancer diagnosis is prognostic for lethal prostate cancer both after curative-intent prostatectomy and in a watchful waiting setting, possibly by facilitating micrometastatic disease. Cancer Res; 76(16); 4785-90. ©2016 AACR.
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abstract 60 pten expression Cholesterol Metabolism and lethal prostate cancer
Cancer Research, 2016Co-Authors: Konrad H Stopsack, Travis Gerke, Lorelei A Mucci, Jennifer R RiderAbstract:BACKGROUND: We previously showed that mRNA expression of squalene monooxygenase (SQLE), part of the Cholesterol synthesis pathway, is associated with lethal prostate cancer. In-vitro studies suggest that loss of PTEN expression and resulting PI3K pathway activation drive Cholesterol ester accumulation in aggressive prostate cancers through sterol regulatory element-binding protein (SREBP) and acyl coenzyme A-Cholesterol acyltransferase (ACAT1) activity. In two prospective cohorts, we studied whether lower PTEN expression is associated with Cholesterol Metabolism and how this relates to lethal prostate cancer. METHODS: We analyzed men with prostate cancer from the prospective prostatectomy Health Professionals Follow-up Study and Physicians’ Health Study. 105 men had lethal cancer and 284 men non-lethal disease without metastases at 8 years of follow-up. Whole-transcriptome mRNA expression profiling data was available from diagnostic prostate tumor specimens. Linear regression models were used to assess continuous and categorical associations, and Pearson correlation coefficients were calculated. Logistic regression was used to obtain odds ratios (ORs) and 95% confidence intervals (CIs) of lethal prostate cancer. RESULTS: Both lower PTEN and higher SQLE expression were associated with higher Gleason grade (p trend 0.05). Adjusting for PTEN mildly attenuated the association of SQLE with lethal cancer (OR, 2.07; 95% CI, 1.57 to 2.73), as did additional adjustment for age, Gleason grade, and stage (SQLE: OR, 1.75; 95% CI, 1.29 to 2.40). In the lowest quartile of PTEN expression, SQLE was less strongly associated with lethal cancer (OR 1.74; 95% CI, 1.20 to 2.52) compared to the upper three quartiles (OR 2.47; 95% CI, 1.69 to 3.60; p interaction = 0.2). CONCLUSION: Low PTEN mRNA expression and high SQLE are features of aggressive prostate cancers. However, at the time of prostatectomy, SREBF1/2 expression and resulting ACAT1 expression do not appear to be major characteristics of prostate cancers with lethal outcomes. Citation Format: Konrad H. Stopsack, Travis A. Gerke, Lorelei A. Mucci, Jennifer R. Rider. PTEN expression, Cholesterol Metabolism, and lethal prostate cancer. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 60.
H Andersson - One of the best experts on this subject based on the ideXlab platform.
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Rapeseed oil, olive oil, plant sterols, and Cholesterol Metabolism: an ileostomy study
European Journal of Clinical Nutrition, 2005Co-Authors: Lars Ellegård, H Andersson, Ingvar BosaeusAbstract:Objective: To study whether olive oil and rapeseed oil have different effects on Cholesterol Metabolism. Design: Short-term experimental study, with controlled diets. Setting: Outpatients at a metabolic-ward kitchen. Subjects: A total of nine volunteers with conventional ileostomies. Interventions: Two 3-day diet periods; controlled diet including 75 g of rapeseed oil or olive oil. Main outcome measures: Cholesterol absorption, ileal excretion of Cholesterol, and bile acids. Serum levels of Cholesterol and bile acid metabolites. Differences between diets evaluated with Wilcoxon's signed rank sum test. Results: Rapeseed oil diet contained 326 mg more plant sterols than the olive oil diet. Rapeseed oil tended to decrease Cholesterol absorption by 11% ( P =0.050), and increased excretion of Cholesterol, bile acids, and their sum as sterols by 9% ( P =0.021), 32% ( P =0.038), and 51% ( P =0.011) compared to olive oil. A serum marker for bile acid synthesis (7 α -hydroxy-4-cholesten-3-one) increased by 28% ( P =0.038) within 10 h of consumption, and serum Cholesterol levels decreased by 7% ( P =0.024), whereas a serum marker for Cholesterol synthesis (lathosterol) as well as serum levels of plant sterols remained unchanged. Conclusions: Rapeseed oil and olive oil have different effects on Cholesterol Metabolism. Rapeseed oil, tends to decrease Cholesterol absorption, increases excretion of Cholesterol and bile acids, increases serum marker of bile acid synthesis, and decreases serum levels of Cholesterol compared to olive oil. This could in part be explained by different concentrations of natural plant sterols. Sponsorship: Supported by the Göteborg Medical Society, the Swedish Medical Society, the Swedish Board for Agricultural Research (SJFR) grant 50.0444/98 and by University of Göteborg.
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Rapeseed oil, olive oil, plant sterols, and Cholesterol Metabolism: an ileostomy study.
European Journal of Clinical Nutrition, 2005Co-Authors: Lars Ellegård, H Andersson, Ingvar BosaeusAbstract:To study whether olive oil and rapeseed oil have different effects on Cholesterol Metabolism. Short-term experimental study, with controlled diets. Outpatients at a metabolic-ward kitchen. A total of nine volunteers with conventional ileostomies. Two 3-day diet periods; controlled diet including 75 g of rapeseed oil or olive oil. Cholesterol absorption, ileal excretion of Cholesterol, and bile acids. Serum levels of Cholesterol and bile acid metabolites. Differences between diets evaluated with Wilcoxon's signed rank sum test. Rapeseed oil diet contained 326 mg more plant sterols than the olive oil diet. Rapeseed oil tended to decrease Cholesterol absorption by 11% (P=0.050), and increased excretion of Cholesterol, bile acids, and their sum as sterols by 9% (P=0.021), 32% (P=0.038), and 51% (P=0.011) compared to olive oil. A serum marker for bile acid synthesis (7α-hydroxy-4-cholesten-3-one) increased by 28% (P=0.038) within 10 h of consumption, and serum Cholesterol levels decreased by 7% (P=0.024), whereas a serum marker for Cholesterol synthesis (lathosterol) as well as serum levels of plant sterols remained unchanged. Rapeseed oil and olive oil have different effects on Cholesterol Metabolism. Rapeseed oil, tends to decrease Cholesterol absorption, increases excretion of Cholesterol and bile acids, increases serum marker of bile acid synthesis, and decreases serum levels of Cholesterol compared to olive oil. This could in part be explained by different concentrations of natural plant sterols. Supported by the Goteborg Medical Society, the Swedish Medical Society, the Swedish Board for Agricultural Research (SJFR) grant 50.0444/98 and by University of Goteborg.