The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Shangtzen Chang - One of the best experts on this subject based on the ideXlab platform.
-
insecticidal activities of leaf essential oils from cinnamomum osmophloeum against three mosquito species
Bioresource Technology, 2009Co-Authors: Sensung Cheng, Weijune Chen, Juyun Liu, Chingi Huang, Yenray Hsui, Shangtzen ChangAbstract:Abstract The larvicidal activities of leaf essential oils and their constituents from six chemotypes of indigenous cinnamon (Cinnamomum osmophloeum Kaneh.) trees were evaluated against three mosquito species. Results of larvicidal tests demonstrated that the leaf essential oils of cinnamaldehyde type and cinnamaldehyde/cinnamyl acetate type had an excellent inhibitory effect against Aedes albopictus larvae, and their LC50 values in 24 h were 40.8 μg/ml (LC90 = 81.7 μg/ml) and 46.5 μg/ml (LC90 = 83.3 μg/ml), respectively. Results of the 24-h mosquito larvicidal assays also showed that the effective constituents in leaf essential oils were trans-cinnamaldehyde and benzaldehyde and that the LC50 values of these constituents against A. albopictus larvae were below 50 μg/ml. In addition, cinnamaldehyde type leaf essential oil and trans-cinnamaldehyde have also exhibited great larvicidal performance against Culex quinquefasciatus and Armigeres subalbatus larvae. Comparisons of mosquito larvicidal activity of trans-cinnamaldehyde congeners revealed that α-methyl cinnamaldehyde, benzaldehyde, and trans-cinnamaldehyde exhibited strong mosquito larvicidal activity.
-
terminating red imported fire ants using cinnamomum osmophloeum leaf essential oil
Bioresource Technology, 2008Co-Authors: Sensung Cheng, Juyun Liu, Yenray Hsui, Chunya Lin, Shangtzen ChangAbstract:Eleven compounds from indigenous cinnamon (Cinnamomum osmophloeum) leaf essential oil were identified by GC-MS and the dominant constituent was trans-cinnamaldehyde (79.85%). The toxicity of leaf essential oil and trans-cinnamaldehyde were then determined to study their effectiveness in controlling the red imported fire ant, Solenopsis invicta Buren. The results of the toxicity tests indicated that both the indigenous cinnamon leaf essential oil and trans-cinnamaldehyde had an excellent inhibitory effect in controlling the red imported fire ant. The LT(50) values for both 2% leaf essential oil and 2% trans-cinnamaldehyde after open exposure were 105.0min and 32.2min; after close exposure were 18.5min and 21.2min, respectively.
-
cinnamaldehyde inhibits pro inflammatory cytokines secretion from monocytes macrophages through suppression of intracellular signaling
Food and Chemical Toxicology, 2008Co-Authors: Louis Kuoping Chao, Sensung Cheng, Kuofeng Hua, Hsienyeh Hsu, Ifan Lin, C Y Chen, Shuitein Chen, Shangtzen ChangAbstract:We investigated the in vitro anti-inflammatory effects of Cinnamaldehyde, a cytokine production inhibitor isolated from an essential oil produced from the leaves of Cinnamomum osmophloeum Kaneh, and its mechanism of action. Although Cinnamaldehyde has been reported to have contact sensitizing properties at high concentration (mM), we found that low concentration of Cinnamaldehyde (muM) inhibited the secretion of interleukin-1beta and tumor necrosis factor alpha within lipopolysaccharide (LPS) or lipoteichoic acid (LTA) stimulated murine J774A.1 macrophages. Cinnamaldehyde also suppressed the production of these cytokines from LPS stimulated human blood monocytes derived primary macrophages and human THP-1 monocytes. Furthermore, Cinnamaldehyde also inhibited the production of prointerleukin-1beta within LPS or LTA stimulated human THP-1 monocytes. Reactive oxygen species release from LPS stimulated J774A.1 macrophages was reduced by Cinnamaldehyde. The phosphorylation of extracellular signal-regulated kinase 1/2 and c-Jun N-terminal kinase 1/2 induced by LPS was also inhibited by Cinnamaldehyde; however, Cinnamaldehyde neither antagonize the binding of LPS to the cells nor alter the cell surface expression of toll-like receptor 4 and CD14. In addition, we also noted that Cinnamaldehyde appeared to elicit no cytotoxic effect upon J774A.1 macrophages under our experimental conditions, although Cinnamaldehyde reduced J774A.1 macrophages proliferation as analysed by MTT assay. Our current results have demonstrated the anti-oxidation and anti-inflammatory properties of Cinnamaldehyde that could provide the possibility for Cinnamaldehyde's future pharmaceutical application in the realm of immuno-modulation.
-
chemical polymorphism and antifungal activity of essential oils from leaves of different provenances of indigenous cinnamon cinnamomum osmophloeum
Bioresource Technology, 2006Co-Authors: Sensung Cheng, Juyun Liu, Yenray Hsui, Shangtzen ChangAbstract:The essential oils isolated from nine geographical provenances of indigenous cinnamon (Cinnamomum osmophloeum Kaneh.) leaves were examined by GC-MS and their chemical constituents were compared. According to GC-MS and cluster analyses the leaf essential oils of the nine provenances and their relative contents were classified into six chemotypes-cinnamaldehyde type, cinnamaldehyde/cinnamyl acetate type, cinnamyl acetate type, linalool type, camphor type and mixed type. In addition, the antifungal activities of leaf essential oils and their constituents from six chemotypes of indigenous cinnamon were investigated in this study. Results from the antifungal tests demonstrated that the leaf essential oils of cinnamaldehyde type and cinnamaldehyde/cinnamyl acetate type had an excellent inhibitory effect against white-rot fungi, Trametes versicolor and Lenzites betulina and brown-rot fungus Laetiporus sulphureus. The antifungal indices of leaf essential oils from these two chemotypes at the level of 200 micro/ml against T. versicolor, L. betulina and L. sulphureus were all 100%. Among them, the IC(50) (50% of inhibitory concentrations) value of the essential oil of cinnamaldehyde type leaf against L. sulphureus was 52-59microg/ml. Cinnamaldehyde possessed the strongest antifungal activities in comparison with other constituents of the essential oils from cinnamaldehyde type leaf, at the level of 100microg/ml its antifungal indices against T. versicolor, L. betulina and L. sulphureus were 100%. The IC50 values of cinnamaldehyde against T. versicolor, L. betulina and L. sulphureus were 73, 74 and 73microg/ml, respectively.
-
antifungal property of the essential oils and their constituents from cinnamomum osmophloeum leaf against tree pathogenic fungi
Journal of the Science of Food and Agriculture, 2005Co-Authors: Hanchung Lee, Sensung Cheng, Shangtzen ChangAbstract:This study compares the chemical constituents of leaf essential oils from various geographical provenances of Cinnamomum osmophloeum and investigates their antifungal activities against six tree pathogenic fungi. According to GC-MS and cluster analyses, the leaf essential oils obtained from different geographical provenances and their relative contents were classified into six chemotypes: cinnamaldehyde type, cinnamaldehyde–cinnamyl acetate type, cinnamyl acetate type, linalool type, camphor type, and mixed type. Results from the antifungal tests show that the leaf essential oils of cinnamaldehyde type and cinnamaldehyde–cinnamyl acetate type have excellent inhibitory effect against Rhizoctonia solani, Collectotrichum gloeosporioides, Ganoderma australe and Fusarium solani. Furthermore, among the fourteen constituents of C osmophloeum leaf essential oils, Z-cinnamaldehyde, eugenol, geraniol and citral display the best antifungal properties. Comparisons of the antifungal properties of Z-cinnamaldehyde congeners reveal that Z-cinnamaldehyde exhibits the best antifungal property of this group. Copyright © 2005 Society of Chemical Industry
Sensung Cheng - One of the best experts on this subject based on the ideXlab platform.
-
insecticidal activities of leaf essential oils from cinnamomum osmophloeum against three mosquito species
Bioresource Technology, 2009Co-Authors: Sensung Cheng, Weijune Chen, Juyun Liu, Chingi Huang, Yenray Hsui, Shangtzen ChangAbstract:Abstract The larvicidal activities of leaf essential oils and their constituents from six chemotypes of indigenous cinnamon (Cinnamomum osmophloeum Kaneh.) trees were evaluated against three mosquito species. Results of larvicidal tests demonstrated that the leaf essential oils of cinnamaldehyde type and cinnamaldehyde/cinnamyl acetate type had an excellent inhibitory effect against Aedes albopictus larvae, and their LC50 values in 24 h were 40.8 μg/ml (LC90 = 81.7 μg/ml) and 46.5 μg/ml (LC90 = 83.3 μg/ml), respectively. Results of the 24-h mosquito larvicidal assays also showed that the effective constituents in leaf essential oils were trans-cinnamaldehyde and benzaldehyde and that the LC50 values of these constituents against A. albopictus larvae were below 50 μg/ml. In addition, cinnamaldehyde type leaf essential oil and trans-cinnamaldehyde have also exhibited great larvicidal performance against Culex quinquefasciatus and Armigeres subalbatus larvae. Comparisons of mosquito larvicidal activity of trans-cinnamaldehyde congeners revealed that α-methyl cinnamaldehyde, benzaldehyde, and trans-cinnamaldehyde exhibited strong mosquito larvicidal activity.
-
terminating red imported fire ants using cinnamomum osmophloeum leaf essential oil
Bioresource Technology, 2008Co-Authors: Sensung Cheng, Juyun Liu, Yenray Hsui, Chunya Lin, Shangtzen ChangAbstract:Eleven compounds from indigenous cinnamon (Cinnamomum osmophloeum) leaf essential oil were identified by GC-MS and the dominant constituent was trans-cinnamaldehyde (79.85%). The toxicity of leaf essential oil and trans-cinnamaldehyde were then determined to study their effectiveness in controlling the red imported fire ant, Solenopsis invicta Buren. The results of the toxicity tests indicated that both the indigenous cinnamon leaf essential oil and trans-cinnamaldehyde had an excellent inhibitory effect in controlling the red imported fire ant. The LT(50) values for both 2% leaf essential oil and 2% trans-cinnamaldehyde after open exposure were 105.0min and 32.2min; after close exposure were 18.5min and 21.2min, respectively.
-
cinnamaldehyde inhibits pro inflammatory cytokines secretion from monocytes macrophages through suppression of intracellular signaling
Food and Chemical Toxicology, 2008Co-Authors: Louis Kuoping Chao, Sensung Cheng, Kuofeng Hua, Hsienyeh Hsu, Ifan Lin, C Y Chen, Shuitein Chen, Shangtzen ChangAbstract:We investigated the in vitro anti-inflammatory effects of Cinnamaldehyde, a cytokine production inhibitor isolated from an essential oil produced from the leaves of Cinnamomum osmophloeum Kaneh, and its mechanism of action. Although Cinnamaldehyde has been reported to have contact sensitizing properties at high concentration (mM), we found that low concentration of Cinnamaldehyde (muM) inhibited the secretion of interleukin-1beta and tumor necrosis factor alpha within lipopolysaccharide (LPS) or lipoteichoic acid (LTA) stimulated murine J774A.1 macrophages. Cinnamaldehyde also suppressed the production of these cytokines from LPS stimulated human blood monocytes derived primary macrophages and human THP-1 monocytes. Furthermore, Cinnamaldehyde also inhibited the production of prointerleukin-1beta within LPS or LTA stimulated human THP-1 monocytes. Reactive oxygen species release from LPS stimulated J774A.1 macrophages was reduced by Cinnamaldehyde. The phosphorylation of extracellular signal-regulated kinase 1/2 and c-Jun N-terminal kinase 1/2 induced by LPS was also inhibited by Cinnamaldehyde; however, Cinnamaldehyde neither antagonize the binding of LPS to the cells nor alter the cell surface expression of toll-like receptor 4 and CD14. In addition, we also noted that Cinnamaldehyde appeared to elicit no cytotoxic effect upon J774A.1 macrophages under our experimental conditions, although Cinnamaldehyde reduced J774A.1 macrophages proliferation as analysed by MTT assay. Our current results have demonstrated the anti-oxidation and anti-inflammatory properties of Cinnamaldehyde that could provide the possibility for Cinnamaldehyde's future pharmaceutical application in the realm of immuno-modulation.
-
chemical polymorphism and antifungal activity of essential oils from leaves of different provenances of indigenous cinnamon cinnamomum osmophloeum
Bioresource Technology, 2006Co-Authors: Sensung Cheng, Juyun Liu, Yenray Hsui, Shangtzen ChangAbstract:The essential oils isolated from nine geographical provenances of indigenous cinnamon (Cinnamomum osmophloeum Kaneh.) leaves were examined by GC-MS and their chemical constituents were compared. According to GC-MS and cluster analyses the leaf essential oils of the nine provenances and their relative contents were classified into six chemotypes-cinnamaldehyde type, cinnamaldehyde/cinnamyl acetate type, cinnamyl acetate type, linalool type, camphor type and mixed type. In addition, the antifungal activities of leaf essential oils and their constituents from six chemotypes of indigenous cinnamon were investigated in this study. Results from the antifungal tests demonstrated that the leaf essential oils of cinnamaldehyde type and cinnamaldehyde/cinnamyl acetate type had an excellent inhibitory effect against white-rot fungi, Trametes versicolor and Lenzites betulina and brown-rot fungus Laetiporus sulphureus. The antifungal indices of leaf essential oils from these two chemotypes at the level of 200 micro/ml against T. versicolor, L. betulina and L. sulphureus were all 100%. Among them, the IC(50) (50% of inhibitory concentrations) value of the essential oil of cinnamaldehyde type leaf against L. sulphureus was 52-59microg/ml. Cinnamaldehyde possessed the strongest antifungal activities in comparison with other constituents of the essential oils from cinnamaldehyde type leaf, at the level of 100microg/ml its antifungal indices against T. versicolor, L. betulina and L. sulphureus were 100%. The IC50 values of cinnamaldehyde against T. versicolor, L. betulina and L. sulphureus were 73, 74 and 73microg/ml, respectively.
-
antifungal property of the essential oils and their constituents from cinnamomum osmophloeum leaf against tree pathogenic fungi
Journal of the Science of Food and Agriculture, 2005Co-Authors: Hanchung Lee, Sensung Cheng, Shangtzen ChangAbstract:This study compares the chemical constituents of leaf essential oils from various geographical provenances of Cinnamomum osmophloeum and investigates their antifungal activities against six tree pathogenic fungi. According to GC-MS and cluster analyses, the leaf essential oils obtained from different geographical provenances and their relative contents were classified into six chemotypes: cinnamaldehyde type, cinnamaldehyde–cinnamyl acetate type, cinnamyl acetate type, linalool type, camphor type, and mixed type. Results from the antifungal tests show that the leaf essential oils of cinnamaldehyde type and cinnamaldehyde–cinnamyl acetate type have excellent inhibitory effect against Rhizoctonia solani, Collectotrichum gloeosporioides, Ganoderma australe and Fusarium solani. Furthermore, among the fourteen constituents of C osmophloeum leaf essential oils, Z-cinnamaldehyde, eugenol, geraniol and citral display the best antifungal properties. Comparisons of the antifungal properties of Z-cinnamaldehyde congeners reveal that Z-cinnamaldehyde exhibits the best antifungal property of this group. Copyright © 2005 Society of Chemical Industry
Byoung-mog Kwon - One of the best experts on this subject based on the ideXlab platform.
-
Cinnamaldehydes in cancer chemotherapy
Phytotherapy Research, 2016Co-Authors: Suhyung Hong, Ismail Ahmed Ismail, Sungmin Kang, Dong Cho Han, Byoung-mog KwonAbstract:Cinnamaldehyde and cinnamaldehyde-derived compounds are candidates for the development of anticancer drugs that have received extensive research attention. In this review, we summarize recent findings detailing the positive and negative aspects of cinnamaldehyde and its derivatives as potential anticancer drug candidates. Furthermore, we describe the in vivo pharmacokinetics and metabolism of Cinnamaldehydes. The oxidative and antioxidative properties of Cinnamaldehydes, which contribute to their potential in chemotherapy, have also been discussed. Moreover, the mechanism(s) by which Cinnamaldehydes induce apoptosis in cancer cells have been explored. In addition, evidence of the regulatory effects of Cinnamaldehydes on cancer cell invasion and metastasis has been described. Finally, the application of Cinnamaldehydes in treating various types of cancer, including breast, prostate, and colon cancers, has been discussed in detail. The effects of Cinnamaldehydes on leukemia, hepatocellular carcinoma, and oral cancer have been summarized briefly. Copyright © 2016 John Wiley & Sons, Ltd.
-
delayed occurrence of h ras12v induced hepatocellular carcinoma with long term treatment with Cinnamaldehydes
European Journal of Pharmacology, 2006Co-Authors: Eun Yi Moon, Mi Ran Lee, Ai Guo Wang, Jun Hee Lee, Hyoung Chin Kim, Hwan Mook Kim, Jinman Kim, Byoung-mog KwonAbstract:Abstract Cinnamaldehyde from the bark of Cinnamomum cassia has been reported to have antitumor activity mediated by the inhibition of farnesyl transferase. We assessed in vivo the chemo-preventive effect of Cinnamaldehydes on H- ras 12V-induced hepatocellular carcinoma formation. A mouse model of hepatocellular carcinoma was established by using the transgene of mutated H- ras 12V under the regulation of albumin enhancer/promoter. When treated with cinnamaldehyde for 10 weeks, hepatic tumor development was delayed with 2′-benzoyloxycinnamaldehyde (BCA) compared with control hepatocellular carcinoma formation. The effect of 2′-hydroxycinnamaldehyde (HCA) was comparable. The number of lesions and the size of each lesion were significantly reduced by BCA. Cell proliferation in the lesion was detected by incorporation of 5-bromo-2′-deoxyuridine (BrdU). BCA increased the number of splenocytes, concanavalin A-stimulated splenocyte proliferation and the infiltration of lymphocytes into liver. Data suggest that the delayed hepatic tumor development observed with BCA could be mediated by a long-term immunostimulating effect on T cells.
-
synthesis and in vitro cytotoxicity of Cinnamaldehydes to human solid tumor cells
Archives of Pharmacal Research, 1998Co-Authors: Byoung-mog Kwon, Seungho Lee, Sang Un Choi, Sung Hee Park, Chong Ock Lee, Young Kwon Cho, Nack Do Sung, Song Hae BokAbstract:Cinnamaldehydes and related compounds were synthesized from various cinnamic acids based on the 2′-hydroxycinnamaldehyde isolated from the bark ofCinnamomum cassia Blume. The cytotoxicity to human solid tumor cells such as A549, SK-OV-3, SK-MEL-2, XF498 and HCT15 were measured. Cinnamic acid, cinnamates and cinnamyl alcohols did not show any cytotoxicity against the human tumor cells. Cinnamaldehydes and realted compounds were resistant to A549 cell line up to 15 μg/ml. In contrast, HCT15 and SK-MEL-2 cells were much sensitive to these cinnamaldehyde analogues which showed ED50 values 0.63-8.1 μg/ml. Cytotoxicity of the saturated aldehydes was much weak compared to their unsaturated aldehydes. From these studies, it was found that the key functional group of the cinnamaldehyde-related compounds in the antitumor activity is the propenal group.
-
Cinnamaldehyde inhibits lymphocyte proliferation and modulates T-cell differentiation.
International journal of immunopharmacology, 1998Co-Authors: Woo Suk Koh, Sun Young Yoon, Byoung-mog Kwon, T C Jeong, K S Nam, Mi Young HanAbstract:Two kinds of cinnamaldehyde derivative, 2'-hydroxycinnamaldehyde (HCA) and 2'-benzoxy-cinnamaldehyde (BCA), were studied for their immunomodulatory effects. These compounds were screened as anticancer drug candidates from stem bark of Cinnamomum cassia for their inhibitory effect on farnesyl protein transferase activity. Ras activation, which is accompanied with its farnesylation, has been known to be important in immune cell activation as well as in carcinogenesis. Treatment of these Cinnamaldehydes to mouse splenocyte cultures induced suppression of lymphoproliferation following both Con A and LPS stimulation in a dose-dependent manner. A dose of I microM of HCA and BCA inhibited the Con A-stimulated proliferation by 69% and 60%, and the LPS-induced proliferation by 29% and 21%, respectively. However, the proliferation induced by PMA plus ionomycin was affected by neither HCA nor BCA treatment. Decreased levels of antibody production by HCA or BCA treatment were observed in both SRBC-immunized mice and LPS-stimulated splenocyte cultures. The exposure of thymocytes to HCA or BCA for 48 h accelerated T-cell differentiation from CD4 and CD8 double positive cells to CD4 or CD8 single positive cells. The inhibitory effect of cinnamaldehyde on lymphoproliferation was specific to the early phase of cell activation, showing the strongest inhibition of Con A- or LPS-stimulated proliferation when added concomitantly with the mitogens. In addition, the treatment of HCA and BCA to splenocyte cultures attenuated the Con A-triggered progression of cell cycle at G1 phase with no inhibition of S to G2/M phase transition. Although cinnamaldehyde treatment had no effect on the IL-2 production by splenocyte cultures stimulated with Con A, it inhibited markedly and dose-dependently the expression of IL-2Ralpha and interferon-gamma. Taken together, the results in this study suggest both HCA and BCA inhibit the lymphoproliferation and induce a T-cell differentiation through the blockade of early steps in signaling pathway leading to cell growth.
-
Synthesis and In vitro cytotoxicity of Cinnamaldehydes to human solid tumor cells
Pharmaceutical Society of Korea, 1998Co-Authors: Byoung-mog Kwon, Seungho Lee, Sang Un Choi, Sung Hee Park, Chong Ock Lee, Young Kwon Cho, Nack Do Sung, Song Hae BokAbstract:Cinnamaldehydes and related compounds were synthesized from various cinnamic acids based on the 2′-hydroxycinnamaldehyde isolated from the bark of Cinnamomum cassia Blume. The cytotoxicity to human solid tumor cells such as A549, SK-OV-3, SK-MEL-2, XF498 and HCT15 were measured. Cinnamic acid, cinnamates and cinnamyl alcohols did not show any cytotoxicity against the human tumor cells. Cinnamaldehydes and realted compounds were resistant to A549 cell line up to 15 μg/ml. In contrast, HCT15 and SK-MEL-2 cells were much sensitive to these cinnamaldehyde analogues which showed ED50 values 0.63∼8.1 μg/ml. Cytotoxicity of the saturated aldehydes was much weak compared to their unsaturated aldehydes. From these studies, it was found that the key functional group of the cinnamaldehyde-related compounds in the antitumor activity is the propenal group.ope
Juyun Liu - One of the best experts on this subject based on the ideXlab platform.
-
insecticidal activities of leaf essential oils from cinnamomum osmophloeum against three mosquito species
Bioresource Technology, 2009Co-Authors: Sensung Cheng, Weijune Chen, Juyun Liu, Chingi Huang, Yenray Hsui, Shangtzen ChangAbstract:Abstract The larvicidal activities of leaf essential oils and their constituents from six chemotypes of indigenous cinnamon (Cinnamomum osmophloeum Kaneh.) trees were evaluated against three mosquito species. Results of larvicidal tests demonstrated that the leaf essential oils of cinnamaldehyde type and cinnamaldehyde/cinnamyl acetate type had an excellent inhibitory effect against Aedes albopictus larvae, and their LC50 values in 24 h were 40.8 μg/ml (LC90 = 81.7 μg/ml) and 46.5 μg/ml (LC90 = 83.3 μg/ml), respectively. Results of the 24-h mosquito larvicidal assays also showed that the effective constituents in leaf essential oils were trans-cinnamaldehyde and benzaldehyde and that the LC50 values of these constituents against A. albopictus larvae were below 50 μg/ml. In addition, cinnamaldehyde type leaf essential oil and trans-cinnamaldehyde have also exhibited great larvicidal performance against Culex quinquefasciatus and Armigeres subalbatus larvae. Comparisons of mosquito larvicidal activity of trans-cinnamaldehyde congeners revealed that α-methyl cinnamaldehyde, benzaldehyde, and trans-cinnamaldehyde exhibited strong mosquito larvicidal activity.
-
terminating red imported fire ants using cinnamomum osmophloeum leaf essential oil
Bioresource Technology, 2008Co-Authors: Sensung Cheng, Juyun Liu, Yenray Hsui, Chunya Lin, Shangtzen ChangAbstract:Eleven compounds from indigenous cinnamon (Cinnamomum osmophloeum) leaf essential oil were identified by GC-MS and the dominant constituent was trans-cinnamaldehyde (79.85%). The toxicity of leaf essential oil and trans-cinnamaldehyde were then determined to study their effectiveness in controlling the red imported fire ant, Solenopsis invicta Buren. The results of the toxicity tests indicated that both the indigenous cinnamon leaf essential oil and trans-cinnamaldehyde had an excellent inhibitory effect in controlling the red imported fire ant. The LT(50) values for both 2% leaf essential oil and 2% trans-cinnamaldehyde after open exposure were 105.0min and 32.2min; after close exposure were 18.5min and 21.2min, respectively.
-
chemical polymorphism and antifungal activity of essential oils from leaves of different provenances of indigenous cinnamon cinnamomum osmophloeum
Bioresource Technology, 2006Co-Authors: Sensung Cheng, Juyun Liu, Yenray Hsui, Shangtzen ChangAbstract:The essential oils isolated from nine geographical provenances of indigenous cinnamon (Cinnamomum osmophloeum Kaneh.) leaves were examined by GC-MS and their chemical constituents were compared. According to GC-MS and cluster analyses the leaf essential oils of the nine provenances and their relative contents were classified into six chemotypes-cinnamaldehyde type, cinnamaldehyde/cinnamyl acetate type, cinnamyl acetate type, linalool type, camphor type and mixed type. In addition, the antifungal activities of leaf essential oils and their constituents from six chemotypes of indigenous cinnamon were investigated in this study. Results from the antifungal tests demonstrated that the leaf essential oils of cinnamaldehyde type and cinnamaldehyde/cinnamyl acetate type had an excellent inhibitory effect against white-rot fungi, Trametes versicolor and Lenzites betulina and brown-rot fungus Laetiporus sulphureus. The antifungal indices of leaf essential oils from these two chemotypes at the level of 200 micro/ml against T. versicolor, L. betulina and L. sulphureus were all 100%. Among them, the IC(50) (50% of inhibitory concentrations) value of the essential oil of cinnamaldehyde type leaf against L. sulphureus was 52-59microg/ml. Cinnamaldehyde possessed the strongest antifungal activities in comparison with other constituents of the essential oils from cinnamaldehyde type leaf, at the level of 100microg/ml its antifungal indices against T. versicolor, L. betulina and L. sulphureus were 100%. The IC50 values of cinnamaldehyde against T. versicolor, L. betulina and L. sulphureus were 73, 74 and 73microg/ml, respectively.
-
chemical composition and mosquito larvicidal activity of essential oils from leaves of different cinnamomum osmophloeum provenances
Journal of Agricultural and Food Chemistry, 2004Co-Authors: Sensung Cheng, Weijune Chen, Juyun Liu, Kunhsien Tsai, Shangtzen ChangAbstract:Chemical compositions of leaf essential oils from eight provenances of indigenous cinnamon (Cinnamomum osmophloeum Kaneh.) were compared. According to GC-MS and cluster analyses, the leaf essential oils of the eight provenances and their relative contents were classified into five chemotypescinnamaldehyde type, linalool type, camphor type, cinnamaldehyde/cinnamyl acetate type, and mixed type. The larvicidal activities of leaf essential oils and their constituents from the five chemotypes of indigenous cinnamon trees were evaluated by mosquito larvicidal assay. Results of larvicidal tests demonstrated that the leaf essential oils of cinnamaldehyde type and cinnamaldehyde/cinnamyl acetate type had an excellent inhibitory effect against the fourth-instar larvae of Aedes aegypti. The LC50 values for cinnamaldehyde type and cinnamaldehyde/cinnamyl acetate type against A. aegypti larvae in 24 h were 36 ppm (LC90 = 79 ppm) and 44 ppm (LC90 = 85 ppm), respectively. Results of the 24-h mosquito larvicidal assays a...
Tom Coenye - One of the best experts on this subject based on the ideXlab platform.
-
cinnamaldehyde and cinnamaldehyde derivatives reduce virulence in vibrio spp by decreasing the dna binding activity of the quorum sensing response regulator luxr
BMC Microbiology, 2008Co-Authors: Gilles Brackman, Tom Defoirdt, Carol M Miyamoto, Peter Bossier, Serge Van Calenbergh, Hans Nelis, Tom CoenyeAbstract:Background To date, only few compounds targeting the AI-2 based quorum sensing (QS) system are known. In the present study, we screened cinnamaldehyde and substituted Cinnamaldehydes for their ability to interfere with AI-2 based QS. The mechanism of QS inhibition was elucidated by measuring the effect on bioluminescence in several Vibrio harveyi mutants. We also studied in vitro the ability of these compounds to interfere with biofilm formation, stress response and virulence of Vibrio spp. The compounds were also evaluated in an in vivo assay measuring the reduction of Vibrio harveyi virulence towards Artemia shrimp.
-
Cinnamaldehyde and cinnamaldehyde derivatives reduce virulence in Vibrio spp. by decreasing the DNA-binding activity of the quorum sensing response regulator LuxR
BMC Microbiology, 2008Co-Authors: Gilles Brackman, Tom Defoirdt, Peter Bossier, Serge Van Calenbergh, Hans Nelis, Carol Miyamoto, Tom CoenyeAbstract:Background To date, only few compounds targeting the AI-2 based quorum sensing (QS) system are known. In the present study, we screened cinnamaldehyde and substituted Cinnamaldehydes for their ability to interfere with AI-2 based QS. The mechanism of QS inhibition was elucidated by measuring the effect on bioluminescence in several Vibrio harveyi mutants. We also studied in vitro the ability of these compounds to interfere with biofilm formation, stress response and virulence of Vibrio spp. The compounds were also evaluated in an in vivo assay measuring the reduction of Vibrio harveyi virulence towards Artemia shrimp. Results Our results indicate that cinnamaldehyde and several substituted derivatives interfere with AI-2 based QS without inhibiting bacterial growth. The active compounds neither interfered with the bioluminescence system as such, nor with the production of AI-2. Study of the effect in various mutants suggested that the target protein is LuxR. Mobility shift assays revealed a decreased DNA-binding ability of LuxR. The compounds were further shown to (i) inhibit biofilm formation in several Vibrio spp., (ii) result in a reduced ability to survive starvation and antibiotic treatment, (iii) reduce pigment and protease production in Vibrio anguillarum and (iv) protect gnotobiotic Artemia shrimp against virulent Vibrio harveyi BB120. Conclusion Cinnamaldehyde and cinnamaldehyde derivatives interfere with AI-2 based QS in various Vibrio spp. by decreasing the DNA-binding ability of LuxR. The use of these compounds resulted in several marked phenotypic changes, including reduced virulence and increased susceptibility to stress. Since inhibitors of AI-2 based quorum sensing are rare, and considering the role of AI-2 in several processes these compounds may be useful leads towards antipathogenic drugs.