The Experts below are selected from a list of 312 Experts worldwide ranked by ideXlab platform
Siegfried Bauer - One of the best experts on this subject based on the ideXlab platform.
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cost efficient open source desktop size radial stretching system with force sensor
IEEE Access, 2015Co-Authors: Stefan E Schausberger, Rainer Kaltseis, Michael Drack, Umut D Cakmak, Zoltan Major, Siegfried BauerAbstract:The rapid and efficient development of soft active materials requires readily available, compact testing equipment. We propose a desktop-sized, cost-efficient, and open source radial stretching system as an alternative to commercially available biaxial and uniaxial stretching devices. It allows for doubling the diameter of an elastomer membrane while measuring the applied force. Our development enables significant cost reduction ( $ €) and increase the availability of equibiaxial deformation measurements for scientific material analysis. Construction plans, source code, and electronic Circuit Diagrams are freely available under a creative commons license.
Kurt W. Kohn - One of the best experts on this subject based on the ideXlab platform.
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depicting combinatorial complexity with the molecular interaction map notation
Molecular Systems Biology, 2006Co-Authors: Kurt W. Kohn, Mirit I. Aladjem, John N. Weinstein, Yves PommierAbstract:To help us understand how bioregulatory networks operate, we need a standard notation for Diagrams analogous to electronic Circuit Diagrams. Such Diagrams must surmount the difficulties posed by complex patterns of protein modifications and multiprotein complexes. To meet that challenge, we have designed the molecular interaction map (MIM) notation (http://discover.nci.nih.gov/mim/). Here we show the advantages of the MIM notation for three important types of Diagrams: (1) explicit Diagrams that define specific pathway models for computer simulation; (2) heuristic maps that organize the available information about molecular interactions and encompass the possible processes or pathways; and (3) Diagrams of combinatorially complex models. We focus on signaling from the epidermal growth factor receptor family (EGFR, ErbB), a network that reflects the major challenges of representing in a compact manner the combinatorial complexity of multimolecular complexes. By comparing MIMs with other Diagrams of this network that have recently been published, we show the utility of the MIM notation. These comparisons may help cell and systems biologists adopt a graphical language that is unambiguous and generally understood.
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Circuit Diagrams for biological networks
Molecular Systems Biology, 2006Co-Authors: Kurt W. Kohn, Mirit I. AladjemAbstract:Mol Syst Biol. 2: 2006.0002 Metabolic maps have long been a staple of biochemistry students, providing clear and concise charts depicting the flow of metabolites and energy in cells. However, depicting the molecular networks involved in signaling pathways that regulate cell function have proven challenging, due to the enormous amount of information that needs to be conveyed for each participant in the network and the cross‐connections between pathways. This challenge must nevertheless be addressed in order to understand the underlying design of such networks, and to utilize the findings of modern biology most effectively to combat diseases, such as cancers, that arise from defects in cell regulation. Another difficulty is that bioregulatory networks are replete with interconnections and loops that make intuition about network function unreliable; therefore, computer simulations may be needed. In a recent issue of Nature Biotechnology , Kitano et al (2005) describe a notation for biological network Diagrams, ‘process Diagrams’, the formalism of which allows a straightforward conversion of human‐readable Diagrams into machine‐readable documents. Hiroaki Kitano and his Symbiotic Systems Project have in recent years focused their attention on bioregulatory networks, how they convey functionality and robustness on biological organisms and how they can be diagrammed and simulated. Kitano (2004) recently reviewed the fascinating field of biological robustness, and insightfully discussed the features that convey robustness to a network. Aiming for a deep understanding …
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molecular interaction maps of bioregulatory networks a general rubric for systems biology
Molecular Biology of the Cell, 2005Co-Authors: Kurt W. Kohn, Mirit I. Aladjem, John N. Weinstein, Yves PommierAbstract:A standard for bioregulatory network Diagrams is urgently needed in the same way that Circuit Diagrams are needed in electronics. Several graphical notations have been proposed, but none has become standard. We have prepared many detailed bioregulatory network Diagrams using the molecular interaction map (MIM) notation, and we now feel confident that it is suitable as a standard. Here, we describe the MIM notation formally and discuss its merits relative to alternative proposals. We show by simple examples how to denote all of the molecular interactions commonly found in bioregulatory networks. There are two forms of MIM Diagrams. "Heuristic" MIMs present the repertoire of interactions possible for molecules that are colocalized in time and place. "Explicit" MIMs define particular models (derived from heuristic MIMs) for computer simulation. We show also how pathways or processes can be highlighted on a canonical heuristic MIM. Drawing a MIM diagram, adhering to the rules of notation, imposes a logical discipline that sharpens one's understanding of the structure and function of a network.
Susanna M Bachle - One of the best experts on this subject based on the ideXlab platform.
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adeno associated virus technologies and methods for targeted neuronal manipulation
Frontiers in Neuroanatomy, 2019Co-Authors: Leila Haery, Benjamin E Deverman, Katherine Matho, Ali Cetin, Kenton Woodard, Constance L Cepko, Karen I Guerin, Meghan A Rego, Ina Ersing, Susanna M BachleAbstract:Cell-type-specific expression of molecular tools and sensors is critical to construct Circuit Diagrams and to investigate the activity and function of neurons within the nervous system. Strategies for targeted manipulation include combinations of classical genetic tools such as Cre/loxP and Flp/FRT, use of cis-regulatory elements, targeted knock-in transgenic mice, and gene delivery by AAV and other viral vectors. The combination of these complex technologies with the goal of precise neuronal targeting is a challenge in the lab. This report will discuss the theoretical and practical aspects of combining current technologies and establish best practices for achieving targeted manipulation of specific cell types. Novel applications and tools, as well as areas for development, will be envisioned and discussed.
Alexande S Shadri - One of the best experts on this subject based on the ideXlab platform.
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instrument current transducers with rogowski coils in protective relaying applications
International Journal of Electrical Power & Energy Systems, 2015Co-Authors: Denis Solovev, Alexande S ShadriAbstract:Abstract The purpose of this work is informing the scientific community and vendors of a certain type of instrument transducers for protection and control applications in industrial electric installations. Such transducers can increase the accuracy and decrease the size of the measuring system for all service conditions at any industrial facilities. The work contains Circuit Diagrams of negative sequence current transducers offered by the author and obtaining primary currents from Rogowski coils. The statistical data based on the field tests of the discussed equipment is also presented in the paper. The algorithm for calculation of parameter values for negative sequence current transducers is discussed. The paper may be of interest for investigators and engineers engaged in research, design and commissioning of protection and control equipment, current instrument and measurement devices used in industrial applications, and also for undergraduate and postgraduate students in electrical engineering.
Stefan E Schausberger - One of the best experts on this subject based on the ideXlab platform.
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cost efficient open source desktop size radial stretching system with force sensor
IEEE Access, 2015Co-Authors: Stefan E Schausberger, Rainer Kaltseis, Michael Drack, Umut D Cakmak, Zoltan Major, Siegfried BauerAbstract:The rapid and efficient development of soft active materials requires readily available, compact testing equipment. We propose a desktop-sized, cost-efficient, and open source radial stretching system as an alternative to commercially available biaxial and uniaxial stretching devices. It allows for doubling the diameter of an elastomer membrane while measuring the applied force. Our development enables significant cost reduction ( $ €) and increase the availability of equibiaxial deformation measurements for scientific material analysis. Construction plans, source code, and electronic Circuit Diagrams are freely available under a creative commons license.
