The Experts below are selected from a list of 66 Experts worldwide ranked by ideXlab platform

Bailey, Jeffrey A. - One of the best experts on this subject based on the ideXlab platform.

  • A liquid Calcium+vitamin D3 supplement is effective prophylaxis against hypocalcemic toxicity during apheresis platelet donation
    'Wiley', 2017
    Co-Authors: Weinstein Robert, Haynes Stefanie, Zhao Yong, Hickson Elda, Linden Jeanne, St. Pierre Patricia, Ducharme Paula, Sulmasy Paula, Graves Molly, Bailey, Jeffrey A.
    Abstract:

    Hypocalcemic toxicity, because of return of Citrate anion to the donor, is the major toxicity of apheresis platelet donation. Oral Calcium carbonate, given prophylactically at the start of donation, has shown limited ability to alleviate this toxicity. We examined whether repeated prophylactic doses of Calcium carbonate, or of a liquid preparation containing Calcium Citrate, Calcium phosphate, and vitamin D3 , would be more effective at preventing symptoms of hypocalcemic toxicity. Symptoms were reported by 48% of donors who received no prophylaxis and 60% of donors who received 1000 mg of oral Calcium carbonate at the start of, and every 20 minutes during, donation (P = 0.711). Only 19.2% of donors who received the liquid preparation (1000 mg Calcium, 1000 IU vitamin D3 ) reported symptoms (P = 0.040 versus no prophylaxis, P = 0.039 versus Calcium carbonate). This difference was not because of gender, weight, age, or blood volume of the donor. Neither Calcium preparation prevented a measurable fall in plasma ionized Calcium during donation. We conclude that liquid Calcium Citrate/Calcium phosphate/vitamin D3 provides effective prophylaxis against hypocalcemic toxicity during platelet donation, however it does not prevent a fall in plasma ionized Calcium

Jeffrey A Bailey - One of the best experts on this subject based on the ideXlab platform.

  • a liquid Calcium vitamin d3 supplement is effective prophylaxis against hypocalcemic toxicity during apheresis platelet donation
    Journal of Clinical Apheresis, 2018
    Co-Authors: Robert Weinstein, Stefanie Haynes, Yong Zhao, Elda Hickson, Jeanne Linden, Patricia St Pierre, Paula Ducharme, Paula Sulmasy, Molly Graves, Jeffrey A Bailey
    Abstract:

    Hypocalcemic toxicity, because of return of Citrate anion to the donor, is the major toxicity of apheresis platelet donation. Oral Calcium carbonate, given prophylactically at the start of donation, has shown limited ability to alleviate this toxicity. We examined whether repeated prophylactic doses of Calcium carbonate, or of a liquid preparation containing Calcium Citrate, Calcium phosphate, and vitamin D3, would be more effective at preventing symptoms of hypocalcemic toxicity. Symptoms were reported by 48% of donors who received no prophylaxis and 60% of donors who received 1000 mg of oral Calcium carbonate at the start of, and every 20 minutes during, donation (P = 0.711). Only 19.2% of donors who received the liquid preparation (1000 mg Calcium, 1000 IU vitamin D3) reported symptoms (P = 0.040 versus no prophylaxis, P = 0.039 versus Calcium carbonate). This difference was not because of gender, weight, age, or blood volume of the donor. Neither Calcium preparation prevented a measurable fall in plasma ionized Calcium during donation. We conclude that liquid Calcium Citrate/Calcium phosphate/vitamin D3 provides effective prophylaxis against hypocalcemic toxicity during platelet donation, however it does not prevent a fall in plasma ionized Calcium.

Claudio Ronco - One of the best experts on this subject based on the ideXlab platform.

  • regional Citrate Calcium anticoagulation during polymyxin b hemoperfusion a case series
    International Journal of Artificial Organs, 2018
    Co-Authors: Francesco Forfori, Etrusca Brogi, Anna Sidoti, Martina Giraudini, Gianpaola Monti, Nadia Zarrillo, Vincenzo Cantaluppi, Claudio Ronco
    Abstract:

    INTRODUCTION: So far, only heparin-based anticoagulation has been proposed during polymyxin-B hemoperfusion. However, postsurgical septic patients can be at high risk of bleeding due to either surgical complications or septic coagulation derangement. Consequently, heparin should not represent in some cases the anticoagulation regimen of choice in this type of patients. METHODS AND RESULTS: We present a case series of four postsurgical septic patients treated with polymyxin-B hemoperfusion using regional Citrate anticoagulation. All the treatments were performed without complications. During each treatment, there were no episodes of filter clotting, no bleeding, and no metabolic complications for any of the patients. CONCLUSION: To our knowledge, this is the second published report on the use of Citrate anticoagulation during polymyxin-B hemoperfusion. Our case series continued to show that regional Citrate anticoagulation regimen is feasible and safe during polymyxin-B hemoperfusion treatment in postsurgical septic patients.

  • regional Citrate Calcium anticoagulation during polymyxin b hemoperfusion a case series
    International Journal of Artificial Organs, 2018
    Co-Authors: Francesco Forfori, Etrusca Brogi, Anna Sidoti, Martina Giraudini, Gianpaola Monti, Nadia Zarrillo, Vincenzo Cantaluppi, Claudio Ronco
    Abstract:

    Introduction:So far, only heparin-based anticoagulation has been proposed during polymyxin-B hemoperfusion. However, postsurgical septic patients can be at high risk of bleeding due to either surgi...

Fernando Pizarro - One of the best experts on this subject based on the ideXlab platform.

  • Effect of various Calcium salts on non-heme iron bioavailability in fasted women of childbearing age.
    Journal of Trace Elements in Medicine and Biology, 2018
    Co-Authors: Valeria Candia, Israel Ríos-castillo, Frank Carrera-gil, Berta Vizcarra, Sotiris Chaniotakis, Manuel Olivares, Fernando Pizarro
    Abstract:

    Abstract Introduction Micronutrient deficiencies are one of the most important public health issues worldwide and iron (Fe) deficiency anemia is the most prevalent micronutrient deficiency. Iron deficiency often coexists with Calcium deficiency and iron and Calcium supplementation often overlap. This has led to investigations into the interaction between these two minerals, and whether Calcium may inhibit iron absorption in the gut. Objective To determine the effect of various Calcium salts on non-heme iron bioavailability in fasted women of childbearing age. Methods A randomized and single blinded trial was conducted on 27 women of childbearing age (35–45 years old) divided into 2 groups (n1 = 13 and n2 = 14, respectively). On four different days, after an overnight fast, they received 5 mg of Fe as FeSO4 (labeled with 55Fe or 59Fe) with 800 mg of elemental Calcium in the form of either Calcium chloride, Calcium gluconate, Calcium Citrate, Calcium carbonate, Calcium lactate, Calcium sulfate or Calcium phosphate. Calcium chloride was used as the control salt in both groups. Iron was labeled with the radioisotopes 59Fe or 55Fe, and the absorption of iron was measured by erythrocyte incorporation of radioactive Fe Results 800 mg of elemental Calcium as Calcium Citrate produced a significant decrease in non-heme iron bioavailability (repeated measures ANOVA, F = 3.79, p = 0.018). Conclusion Of the various Calcium salts tested, Calcium Citrate was the only salt that decreased non-heme iron bioavailability relative to the Calcium chloride control when taken on an empty stomach. These results suggest that inhibition of non-heme iron absorption in fasted individuals is dependent upon the Calcium salt in question and not solely dependent on the presence of Calcium.

Herma C Holscher - One of the best experts on this subject based on the ideXlab platform.

  • etiology of nephrocalcinosis in preterm neonates association of nutritional intake and urinary parameters
    Kidney International, 2000
    Co-Authors: Eveline A Schellfeith, Joana Kistvan E Holthe, Nikk Conneman, Paul H T Van Zwieten, Herma C Holscher
    Abstract:

    Etiology of nephrocalcinosis in preterm neonates: Association of nutritional intake and urinary parameters. Background Nephrocalcinosis (NC) in preterm neonates has been described frequently, and small-scale studies suggest an unfavorable effect on renal function. The etiologic factors have not yet been fully clarified. We performed a prospective observational study to identify factors that influence the development of NC. Methods The study population consisted of 215 preterm neonates with a gestational age Results NC was diagnosed by means of US in 33% at four weeks and in 41% at term. Patients with NC at four weeks had a significantly higher mean intake of Calcium ( P P P P P P P P P P = 0.005). Conclusions NC develops as a result of an imbalance between stone-inhibiting and stone-promoting factors. A high intake of Calcium, phosphorus, and ascorbic acid, a low urinary Citrate/Calcium ratio, a high urinary Calcium/creatinine ratio, immaturity, and medication to prevent or treat chronic lung disease with hypercalciuric side effects appear to contribute to the high incidence of NC in preterm neonates.