The Experts below are selected from a list of 24876 Experts worldwide ranked by ideXlab platform
Jianrong Wang - One of the best experts on this subject based on the ideXlab platform.
-
pH-Switchable vitamin B9 gels for stoichiometry-Controlled spherical Co-Crystallization.
Chemical communications (Cambridge England), 2016Co-Authors: Jianrong Wang, Junjie Bao, Xiaowu Fan, Wenjuan Dai, Xuefeng MeiAbstract:Vitamin B9 gels were found to be pH-switchable by adding triethylamine or acetic acid. Such recyclable gels can be used as novel Co-Crystallization media, resulting in four stoichiometric vitamin C Co-crystals. Under highly supersaturated Conditions, uniform microspheres of (VC)·(NA) with different particle sizes were obtained through a spherical Crystallization process.
-
drug drug Co Crystallization presents a new opportunity for the development of stable vitamins
Chemical Communications, 2016Co-Authors: Jianrong Wang, Wenjuan Dai, Xuefeng MeiAbstract:Drug–drug Co-Crystallization Could realize Combination drugs at a molecular level. Two polymorphic Co-crystals between VD2 and VD3 were successfully designed and synthesized. These enantiotropic polymorphs exhibit significantly different physiCochemical stabilities.
-
Drug–drug Co-Crystallization presents a new opportunity for the development of stable vitamins
Chemical communications (Cambridge England), 2016Co-Authors: Jianrong Wang, Wenjuan Dai, Yu Qihui, Xuefeng MeiAbstract:Drug–drug Co-Crystallization Could realize Combination drugs at a molecular level. Two polymorphic Co-crystals between VD2 and VD3 were successfully designed and synthesized. These enantiotropic polymorphs exhibit significantly different physiCochemical stabilities.
-
Improving the dissolution and bioavailability of 6-mercaptopurine via Co-Crystallization with isoniCotinamide.
Bioorganic & medicinal chemistry letters, 2015Co-Authors: Jianrong Wang, Chun Zhou, Yunfei Lin, Chen Chen, Guoyu Pan, Xuefeng MeiAbstract:6-Mercaptopurine (6-MP) is a clinically important antitumor drug. The Commercially available form was provided as monohydrate and belongs to BCS class II category. Co-Crystallization screening by reaction Crystallization method (RCM) and monitored by powder X-ray diffraction led to the disCovery of a new Co-crystal formed between 6-MP and isoniCotinamide (Co-crystal 1). Co-crystal 1 was thoroughly characterized by X-ray diffraction, FT-IR and Raman spectrosCopy, and thermal analysis. Noticeably, the in vitro and in vivo studies revealed that Co-crystal 1 possesses improved dissolution rate and superior bioavailability on animal model.
-
stabilizing vitamin d3 by Conformationally selective Co Crystallization
Chemical Communications, 2014Co-Authors: Jianrong Wang, Chun Zhou, Xueping YuAbstract:A four-membered square-shaped H-bonding structure was successfully designed to synthesize vitamin D3 Co-crystals. The Co-Crystallization process was found to be Conformationally selective to result in topochemically stable materials.
Miriam Martino - One of the best experts on this subject based on the ideXlab platform.
-
Co-Crystallization of zinc sulfate with sucrose: A promissory strategy to render zinc solid dosage forms more palatable
Journal of Food Engineering, 2016Co-Authors: Alex López-córdoba, Miriam Martino, Loreana Gallo, Verónica Bucalá, Alba S. NavarroAbstract:Abstract The objective of this work was to develop solid dosage forms to improve zinc nutrition in high-risk populations. Powders Containing zinc (17 mg/g) were obtained through Co-Crystallization in sucrose matrix with high encapsulation efficiency (98%). Co-crystallized powders showed water activity (0.6) and moisture Content (2.0%) values characteristic of good stability. Moreover, these products showed an infrared spectrum similar to that of sucrose, indicating that no chemical interactions took place between the matrix Components. Co-crystallized powders showed excellent Compactibility leading to suitably hard Compacts at a low Compression force (4.9 kN). Besides, tablets were obtained with optimal values of hardness (4.8 kg f ) and low disintegration times (
-
Yerba mate antioxidant powders obtained by Co-Crystallization: Stability during storage
Journal of Food Engineering, 2014Co-Authors: Alex López-córdoba, Lorena Deladino, Leidy Agudelo-mesa, Miriam MartinoAbstract:Abstract The interest on yerba mate has increased in the last years due to its high Content of bioactive Compounds related to health benefits. Antioxidant aqueous extracts of yerba mate were entrapped into a sucrose matrix by Co-Crystallization. The products were characterized in terms of their morphology, entrapment yield, loading capacity, water activity, moisture Content, antioxidant activity, thermal behavior, solubility and hygrosCopicity. It was found that the Co-Crystallization process led to high entrapment yield and maintained the antioxidant activity of the yerba mate extract towards DPPH radical. Also, the Co-crystallized powders showed values of water activity, moisture Content, hygrosCopicity and flowability indicative of high stability and good handling properties. The total polyphenols Content of the Co-crystallized products remained almost Constant along storage at 75% RH and 20 °C, however, fluctuations in their DPPH radical scavenging activity were observed.
Xuefeng Mei - One of the best experts on this subject based on the ideXlab platform.
-
pH-Switchable vitamin B9 gels for stoichiometry-Controlled spherical Co-Crystallization.
Chemical communications (Cambridge England), 2016Co-Authors: Jianrong Wang, Junjie Bao, Xiaowu Fan, Wenjuan Dai, Xuefeng MeiAbstract:Vitamin B9 gels were found to be pH-switchable by adding triethylamine or acetic acid. Such recyclable gels can be used as novel Co-Crystallization media, resulting in four stoichiometric vitamin C Co-crystals. Under highly supersaturated Conditions, uniform microspheres of (VC)·(NA) with different particle sizes were obtained through a spherical Crystallization process.
-
drug drug Co Crystallization presents a new opportunity for the development of stable vitamins
Chemical Communications, 2016Co-Authors: Jianrong Wang, Wenjuan Dai, Xuefeng MeiAbstract:Drug–drug Co-Crystallization Could realize Combination drugs at a molecular level. Two polymorphic Co-crystals between VD2 and VD3 were successfully designed and synthesized. These enantiotropic polymorphs exhibit significantly different physiCochemical stabilities.
-
Drug–drug Co-Crystallization presents a new opportunity for the development of stable vitamins
Chemical communications (Cambridge England), 2016Co-Authors: Jianrong Wang, Wenjuan Dai, Yu Qihui, Xuefeng MeiAbstract:Drug–drug Co-Crystallization Could realize Combination drugs at a molecular level. Two polymorphic Co-crystals between VD2 and VD3 were successfully designed and synthesized. These enantiotropic polymorphs exhibit significantly different physiCochemical stabilities.
-
a new polymorph of 1 hydroxy 2 naphthoic acid obtained during failed Co Crystallization experiments
Acta Crystallographica Section B Structural Crystallography and Crystal Chemistry, 2015Co-Authors: Qi Zhang, Xuefeng MeiAbstract:Pharmaceutical salt-forming acid 1-hydroxy-2-naphthoic acid (HNA) is widely used in pharmaceutical Co-crystal preparation. In this work, we report a new polymorph of HNA obtained during attempted Co-Crystallization experiments. The reported form and the new form were fully characterized and their thermodynamic relationship was also established to be monotropic with the new form being the more stable form.
-
Improving the dissolution and bioavailability of 6-mercaptopurine via Co-Crystallization with isoniCotinamide.
Bioorganic & medicinal chemistry letters, 2015Co-Authors: Jianrong Wang, Chun Zhou, Yunfei Lin, Chen Chen, Guoyu Pan, Xuefeng MeiAbstract:6-Mercaptopurine (6-MP) is a clinically important antitumor drug. The Commercially available form was provided as monohydrate and belongs to BCS class II category. Co-Crystallization screening by reaction Crystallization method (RCM) and monitored by powder X-ray diffraction led to the disCovery of a new Co-crystal formed between 6-MP and isoniCotinamide (Co-crystal 1). Co-crystal 1 was thoroughly characterized by X-ray diffraction, FT-IR and Raman spectrosCopy, and thermal analysis. Noticeably, the in vitro and in vivo studies revealed that Co-crystal 1 possesses improved dissolution rate and superior bioavailability on animal model.
Alex López-córdoba - One of the best experts on this subject based on the ideXlab platform.
-
Co-Crystallization of zinc sulfate with sucrose: A promissory strategy to render zinc solid dosage forms more palatable
Journal of Food Engineering, 2016Co-Authors: Alex López-córdoba, Miriam Martino, Loreana Gallo, Verónica Bucalá, Alba S. NavarroAbstract:Abstract The objective of this work was to develop solid dosage forms to improve zinc nutrition in high-risk populations. Powders Containing zinc (17 mg/g) were obtained through Co-Crystallization in sucrose matrix with high encapsulation efficiency (98%). Co-crystallized powders showed water activity (0.6) and moisture Content (2.0%) values characteristic of good stability. Moreover, these products showed an infrared spectrum similar to that of sucrose, indicating that no chemical interactions took place between the matrix Components. Co-crystallized powders showed excellent Compactibility leading to suitably hard Compacts at a low Compression force (4.9 kN). Besides, tablets were obtained with optimal values of hardness (4.8 kg f ) and low disintegration times (
-
Yerba mate antioxidant powders obtained by Co-Crystallization: Stability during storage
Journal of Food Engineering, 2014Co-Authors: Alex López-córdoba, Lorena Deladino, Leidy Agudelo-mesa, Miriam MartinoAbstract:Abstract The interest on yerba mate has increased in the last years due to its high Content of bioactive Compounds related to health benefits. Antioxidant aqueous extracts of yerba mate were entrapped into a sucrose matrix by Co-Crystallization. The products were characterized in terms of their morphology, entrapment yield, loading capacity, water activity, moisture Content, antioxidant activity, thermal behavior, solubility and hygrosCopicity. It was found that the Co-Crystallization process led to high entrapment yield and maintained the antioxidant activity of the yerba mate extract towards DPPH radical. Also, the Co-crystallized powders showed values of water activity, moisture Content, hygrosCopicity and flowability indicative of high stability and good handling properties. The total polyphenols Content of the Co-crystallized products remained almost Constant along storage at 75% RH and 20 °C, however, fluctuations in their DPPH radical scavenging activity were observed.
Peter J. Myler - One of the best experts on this subject based on the ideXlab platform.
-
Ligand Co-Crystallization of aminoacyl-tRNA synthetases from infectious disease organisms.
Scientific Reports, 2017Co-Authors: Spencer O. Moen, Thomas E. Edwards, David M. Dranow, Matthew C. Clifton, Banumathi Sankaran, Wesley C. Van Voorhis, Amit Sharma, Colin Manoil, Bart L. Staker, Peter J. MylerAbstract:Aminoacyl-tRNA synthetases (aaRSs) charge tRNAs with their Cognate amino acid, an essential precursor step to loading of charged tRNAs onto the ribosome and addition of the amino acid to the growing polypeptide chain during protein synthesis. Because of this important biological function, aminoacyl-tRNA synthetases have been the focus of anti-infective drug development efforts and two aaRS inhibitors have been approved as drugs. Several researchers in the scientific Community requested aminoacyl-tRNA synthetases to be targeted in the Seattle Structural Genomics Center for Infectious Disease (SSGCID) structure determination pipeline. Here we investigate thirty-one aminoacyl-tRNA synthetases from infectious disease organisms by Co-Crystallization in the presence of their Cognate amino acid, ATP, and/or inhibitors. Crystal structures were determined for a CysRS from Borrelia burgdorferi bound to AMP, GluRS from Borrelia burgdorferi and Burkholderia thailandensis bound to glutamic acid, a TrpRS from the eukaryotic pathogen Encephalitozoon cuniculi bound to tryptophan, a HisRS from Burkholderia thailandensis bound to histidine, and a LysRS from Burkholderia thailandensis bound to lysine. Thus, the presence of ligands may promote aaRS Crystallization and structure determination. Comparison with homologous structures shows Conformational flexibility that appears to be a recurring theme with this enzyme class.
-
ligand Co Crystallization of aminoacyl trna synthetases from infectious disease organisms
Scientific Reports, 2017Co-Authors: Spencer O. Moen, Thomas E. Edwards, David M. Dranow, Matthew C. Clifton, Banumathi Sankaran, Amit Sharma, Colin Manoil, Bart L. Staker, Wesley C Van Voorhis, Peter J. MylerAbstract:Aminoacyl-tRNA synthetases (aaRSs) charge tRNAs with their Cognate amino acid, an essential precursor step to loading of charged tRNAs onto the ribosome and addition of the amino acid to the growing polypeptide chain during protein synthesis. Because of this important biological function, aminoacyl-tRNA synthetases have been the focus of anti-infective drug development efforts and two aaRS inhibitors have been approved as drugs. Several researchers in the scientific Community requested aminoacyl-tRNA synthetases to be targeted in the Seattle Structural Genomics Center for Infectious Disease (SSGCID) structure determination pipeline. Here we investigate thirty-one aminoacyl-tRNA synthetases from infectious disease organisms by Co-Crystallization in the presence of their Cognate amino acid, ATP, and/or inhibitors. Crystal structures were determined for a CysRS from Borrelia burgdorferi bound to AMP, GluRS from Borrelia burgdorferi and Burkholderia thailandensis bound to glutamic acid, a TrpRS from the eukaryotic pathogen Encephalitozoon cuniculi bound to tryptophan, a HisRS from Burkholderia thailandensis bound to histidine, and a LysRS from Burkholderia thailandensis bound to lysine. Thus, the presence of ligands may promote aaRS Crystallization and structure determination. Comparison with homologous structures shows Conformational flexibility that appears to be a recurring theme with this enzyme class.