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Lisa F Berkman - One of the best experts on this subject based on the ideXlab platform.
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social disengagement and incident Cognitive Decline in community dwelling elderly persons
Annals of Internal Medicine, 1999Co-Authors: Shari S Bassuk, Thomas A Glass, Lisa F BerkmanAbstract:Social engagement, defined as the maintenance of many social connections and a high level of participation in social activities, has been thought to prevent Cognitive Decline in elderly persons. In...
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social disengagement and incident Cognitive Decline in community dwelling elderly persons
Annals of Internal Medicine, 1999Co-Authors: Shari S Bassuk, Thomas A Glass, Lisa F BerkmanAbstract:BACKGROUND: Social engagement, which is defined as the maintenance of many social connections and a high level of participation in social activities, has been thought to prevent Cognitive Decline in elderly persons. However, few longitudinal studies of this relation have been done. OBJECTIVE: To determine the relation between social disengagement and incident Cognitive Decline in community-dwelling elderly persons. DESIGN: Cohort study. SETTING: New Haven, Connecticut. PARTICIPANTS: 2812 noninstitutionalized elderly persons (65 years of age or older) who were interviewed in their homes in 1982, 1985, 1988, and 1994. MEASUREMENTS: A global social disengagement scale was constructed from the following indicators: presence of a spouse, monthly visual contact with three or more relatives or friends, yearly nonvisual contact with 10 or more relatives or friends, attendance at religious services, group membership, and regular social activities. Cognitive function was assessed with the Short Portable Mental Status Questionnaire. Response to the questionnaire was scored as high, medium, or low. Cognitive Decline was defined as a transition to a lower category. RESULTS: Compared with persons who had five or six social ties, those who had no social ties were at increased risk for incident Cognitive Decline after adjustment for age, initial Cognitive performance, sex, ethnicity, education, income, housing type, physical disability, cardiovascular profile, sensory impairment, symptoms of depression, smoking, alcohol use, and level of physical activity. The 3-year odds ratio was 2.24 (95% CI, 1.40 to 3.58; P < 0.001), the 6-year odds ratio was 1.91 (CI, 1.14 to 3.18; P = 0.01), and the 12-year odds ratio was 2.37 (CI, 1.07 to 4.88; P = 0.03). CONCLUSION: Social disengagement is a risk factor for Cognitive impairment among elderly persons.
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depressive symptomatology and incident Cognitive Decline in an elderly community sample
Archives of General Psychiatry, 1998Co-Authors: Shari S Bassuk, Lisa F Berkman, David WypijAbstract:Background It is not known whether depression is a cause or consequence of progressive Cognitive Decline. We assessed the relationship between depressive symptoms and subsequent Cognitive Decline in the community-dwelling elderly population. Methods Data were from a population-based cohort study that enrolled 2812 noninstitutionalized elderly residents of New Haven, Conn, and followed them with in-home visits in 1982, 1985, 1988, and 1994. Cognitive function was assessed with the Short Portable Mental Status Questionnaire (SPMSQ). Response to the SPMSQ was scored as high, medium, and low, and Cognitive Decline was defined as a transition to a lower category. Depressive symptoms were measured with the Center for Epidemiological Studies Depression Scale. Results An elevated level of depressive symptoms was associated with an increased risk of incident Cognitive Decline among medium SPMSQ performers (3-year odds ratio [OR], 1.72; 95% confidence interval [CI], 1.04-2.82, P =.03; 6-year OR, 2.40; 95% CI, 1.33-4.34; P =.004; 12-year OR, 1.65; 95% CI, 0.62-4.38; P =.31) but not among high performers (3-year OR, 0.93; 95% CI, 0.62-1.39; P =.71; 6-year OR, 1.03; 95% CI, 0.67-1.58; P =.90; 12-year OR, 1.26; 95% CI, 0.59-2.71; P =.55), after adjustment for age, sex, race, education, income, housing type, functional disability, cardiovascular profile, and alcohol use. Conclusions Depressive symptoms, particularly dysphoric mood, presage future Cognitive losses among elderly persons with moderate Cognitive impairments. However, the data do not provide support for the hypothesis that depressive symptoms are associated with the onset or rate of Cognitive Decline among Cognitively intact elderly persons.
David A. Bennett - One of the best experts on this subject based on the ideXlab platform.
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Cognitive Decline is associated with risk aversion and temporal discounting in older adults without dementia
PLOS ONE, 2015Co-Authors: Bryan D James, Patricia A. Boyle, Lei Yu, David A. BennettAbstract:Risk aversion and temporal discounting are preferences that are strongly linked to sub-optimal financial and health decision making ability. Prior studies have shown they differ by age and Cognitive ability, but it remains unclear whether differences are due to age-related Cognitive Decline or lower Cognitive abilities over the life span. We tested the hypothesis that Cognitive Decline is associated with higher risk aversion and temporal discounting in 455 older persons without dementia from the Memory and Aging Project, a longitudinal cohort study of aging in Chicago. All underwent repeated annual Cognitive evaluations using a detailed battery including 19 tests. Risk aversion was measured using standard behavioral economics questions: participants were asked to choose between a certain monetary payment versus a gamble in which they could gain more or nothing; potential gamble gains varied across questions. Temporal discounting: participants were asked to choose between an immediate, smaller payment and a delayed, larger one; two sets of questions addressed small and large stakes based on payment amount. Regression analyses were used to examine whether prior rate of Cognitive Decline predicted level of risk aversion and temporal discounting, controlling for age, sex, and education. Over an average of 5.5 (SD=2.9) years, cognition Declined at an average of 0.016 units per year (SD=0.03). More rapid Cognitive Decline predicted higher levels of risk aversion (p=0.002) and temporal discounting (small stakes: p=0.01, high stakes: p=0.006). Further, associations between Cognitive Decline and risk aversion (p=0.015) and large stakes temporal discounting (p=0.026) persisted in analyses restricted to persons without any Cognitive impairment (i.e., no dementia or mild Cognitive impairment); the association of Cognitive Decline and small stakes temporal discounting was no longer statistically significant (p=0.078). These findings are consistent with the hypothesis that subtle age-related changes in cognition can detrimentally affect individual preferences that are critical for maintaining health and well being.
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tdp 43 pathology Cognitive Decline and dementia in old age
JAMA Neurology, 2013Co-Authors: Robert S Wilson, David A. Bennett, Patricia A. Boyle, John Q Trojanowski, Eryun Chen, Julie A SchneiderAbstract:Importance Cognitive Decline is a leading cause of disability and death in old age but its neurobiological bases are not well understood. Objective To test the hypothesis that transactive response DNA-binding protein 43 (TDP-43) is related to late-life Cognitive Decline. Design, Setting, and Participants Longitudinal clinical-pathologic cohort study involving more than 40 Catholic groups across the United States. A total of 130 older Catholic nuns, priests, and monks underwent annual clinical evaluations, including detailed Cognitive testing, for a mean of 10.1 years prior to death. On neuropathologic examination, we collected semiquantitative measures of TDP-43 pathology, density of neuronal neurofibrillary tangles, area occupied by amyloid-beta plaques, and the presence of alpha-synuclein Lewy bodies from multiple brain regions. Gross and microscopic cerebral infarcts and hippocampal sclerosis were also identified. Main Outcomes and Measures Annual rate of change in a previously established composite measure of global cognition during a mean of 10.1 years of annual observation before death. Results Transactive response DNA-binding protein 43 pathology, ranging from sparse to severe, was identified in 46% of participants and was associated with amyloid plaques, tangles, and hippocampal sclerosis but not neocortical Lewy bodies or cerebral infarcts. After controlling for amyloid plaques, tangles, and hippocampal sclerosis, TDP-43 pathology was associated with more rapid Cognitive Decline and accounted for nearly as much of the variability in rates of global Cognitive Decline as did tangles. Transactive response DNA-binding protein 43 pathology had a distinct Cognitive profile that differed from other neuropathologic processes (related to Decline in episodic and working memory but not in other Cognitive domains), and it was elevated in those who developed dementia but not in those with mild Cognitive impairment. Conclusion and Relevance The results suggest that TDP-43 is an important brain pathology underlying Cognitive Decline and dementia in old age.
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much of late life Cognitive Decline is not due to common neurodegenerative pathologies
Annals of Neurology, 2013Co-Authors: Patricia A. Boyle, Julie A Schneider, Robert S Wilson, Alasdair M Barr, William G Honer, David A. BennettAbstract:Objective The pathologic indices of Alzheimer disease, cerebrovascular disease, and Lewy body disease accumulate in the brains of older persons with and without dementia, but the extent to which they account for late life Cognitive Decline remains unknown. We tested the hypothesis that these pathologic indices account for the majority of late life Cognitive Decline. Methods A total of 856 deceased participants from 2 longitudinal clinical–pathologic studies, Rush Memory and Aging Project and Religious Orders Study, completed a mean of 7.5 annual evaluations, including 17 Cognitive tests. Neuropathologic examinations provided quantitative measures of global Alzheimer pathology, amyloid load, tangle density, macroscopic infarcts, microinfarcts, and neocortical Lewy bodies. Random coefficient models were used to examine the linear relation of pathologic indices with global Cognitive Decline. In subsequent analyses, random change point models were used to examine the relation of the pathologic indices with the onset of terminal Decline and rates of preterminal and terminal Decline (ie, nonlinear Decline). Results Cognition Declined a mean of about 0.11U per year (estimate = −0.109, standard error [SE] = 0.004, p < 0.001), with significant individual differences in rates of Decline; the variance estimate for the individual slopes was 0.013 (SE = 0.112, p < 0.001). In separate analyses, global Alzheimer pathology, amyloid, tangles, macroscopic infarcts, and neocortical Lewy bodies were associated with faster rates of Decline and explained 22%, 6%, 34%, 2%, and 8% of the variation in Decline, respectively. When analyzed simultaneously, the pathologic indices accounted for a total of 41% of the variation in Decline, and the majority remained unexplained. Furthermore, in random change point models examining the influence of the pathologic indices on the onset of terminal Decline and the preterminal and terminal components of the Cognitive trajectory, the common pathologic indices accounted for less than a third of the variation in the onset of terminal Decline and rates of preterminal and terminal Decline. Interpretation The pathologic indices of the common causes of dementia are important determinants of Cognitive Decline in old age and account for a large proportion of the variation in late life Cognitive Decline. Surprisingly, however, much of the variation in Cognitive Decline remains unexplained, suggesting that other important determinants of Cognitive Decline remain to be identified. Identification of the mechanisms that contribute to the large unexplained proportion of Cognitive Decline is urgently needed to prevent late life Cognitive Decline. Ann Neurol 2013;74:478–489
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late life social activity and Cognitive Decline in old age
Journal of The International Neuropsychological Society, 2011Co-Authors: Bryan D James, Robert S Wilson, Lisa L Barnes, David A. BennettAbstract:We examined the association of social activity with Cognitive Decline in 1138 persons without dementia at baseline with a mean age of 79.6 (SD = 7.5) who were followed for up to 12 years (mean = 5.2; SD = 2.8). Using mixed models adjusted for age, sex, education, race, social network size, depression, chronic conditions, disability, neuroticism, extraversion, Cognitive activity, and physical activity, more social activity was associated with less Cognitive Decline during average follow-up of 5.2 years (SD = 2.7). A one point increase in social activity score (range = 1-4.2; mean = 2.6; SD = 0.6) was associated with a 47% decrease in the rate of Decline in global Cognitive function (p < .001). The rate of global Cognitive Decline was reduced by an average of 70% in persons who were frequently socially active (score = 3.33, 90th percentile) compared to persons who were infrequently socially active (score = 1.83, 10th percentile). This association was similar across five domains of Cognitive function. Sensitivity analyses revealed that individuals with the lowest levels of cognition or with mild Cognitive impairment at baseline did not drive this relationship. These results confirm that more socially active older adults experience less Cognitive Decline in old age.
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Cognitive Decline in the elderly: an analysis of population heterogeneity
Age and Ageing, 2011Co-Authors: Kathleen M. Hayden, Bruce R Reed, Jennifer J. Manly, Douglas Tommet, Robert H. Pietrzak, Gordon J. Chelune, Frances M. Yang, Andrew J. Revell, David A. Bennett, Richard N. JonesAbstract:Background: studies of Cognitive ageing at the group level suggest that age is associated with Cognitive Decline; however, there may be individual differences such that not all older adults will experience Cognitive Decline. Objective: to evaluate patterns of Cognitive Decline in a cohort of older adults initially free of dementia. Design, setting and subjects: elderly Catholic clergy members participating in the Religious Orders Study were followed for up to 15 years. Cognitive performance was assessed annually. Methods: performance on a composite global measure of cognition was analysed using random effects models for baseline performance and change over time. A profile mixture component was used to identify subgroups with different Cognitive trajectories over the study period. Results: from a sample of 1,049 participants (mean age 75 years), three subgroups were identified based on the distribution of baseline performance and change over time. The majority (65%) of participants belonged to a slow Decline class that did not experience substantial Cognitive Decline over the observation period [−0.04 baseline total sample standard deviation (SD) units/year]. About 27% experienced moderate Decline (−0.19 SD/year), and 8% belonged to a class experiencing rapid Decline (−0.57 SD/year). A subsample analysis revealed that when substantial Cognitive Decline does occur, the magnitude and rate of Decline is correlated with neuropathological processes. Conclusions: in this sample, the most common pattern of Cognitive Decline is extremely slow, perceptible on a time scale measured by decades, not years. While in need of cross validation, these findings suggest that Cognitive changes associated with ageing may be minimal and emphasise the importance of understanding the full range of age-related pathologies that may diminish brain function.
Shari S Bassuk - One of the best experts on this subject based on the ideXlab platform.
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social disengagement and incident Cognitive Decline in community dwelling elderly persons
Annals of Internal Medicine, 1999Co-Authors: Shari S Bassuk, Thomas A Glass, Lisa F BerkmanAbstract:Social engagement, defined as the maintenance of many social connections and a high level of participation in social activities, has been thought to prevent Cognitive Decline in elderly persons. In...
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social disengagement and incident Cognitive Decline in community dwelling elderly persons
Annals of Internal Medicine, 1999Co-Authors: Shari S Bassuk, Thomas A Glass, Lisa F BerkmanAbstract:BACKGROUND: Social engagement, which is defined as the maintenance of many social connections and a high level of participation in social activities, has been thought to prevent Cognitive Decline in elderly persons. However, few longitudinal studies of this relation have been done. OBJECTIVE: To determine the relation between social disengagement and incident Cognitive Decline in community-dwelling elderly persons. DESIGN: Cohort study. SETTING: New Haven, Connecticut. PARTICIPANTS: 2812 noninstitutionalized elderly persons (65 years of age or older) who were interviewed in their homes in 1982, 1985, 1988, and 1994. MEASUREMENTS: A global social disengagement scale was constructed from the following indicators: presence of a spouse, monthly visual contact with three or more relatives or friends, yearly nonvisual contact with 10 or more relatives or friends, attendance at religious services, group membership, and regular social activities. Cognitive function was assessed with the Short Portable Mental Status Questionnaire. Response to the questionnaire was scored as high, medium, or low. Cognitive Decline was defined as a transition to a lower category. RESULTS: Compared with persons who had five or six social ties, those who had no social ties were at increased risk for incident Cognitive Decline after adjustment for age, initial Cognitive performance, sex, ethnicity, education, income, housing type, physical disability, cardiovascular profile, sensory impairment, symptoms of depression, smoking, alcohol use, and level of physical activity. The 3-year odds ratio was 2.24 (95% CI, 1.40 to 3.58; P < 0.001), the 6-year odds ratio was 1.91 (CI, 1.14 to 3.18; P = 0.01), and the 12-year odds ratio was 2.37 (CI, 1.07 to 4.88; P = 0.03). CONCLUSION: Social disengagement is a risk factor for Cognitive impairment among elderly persons.
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depressive symptomatology and incident Cognitive Decline in an elderly community sample
Archives of General Psychiatry, 1998Co-Authors: Shari S Bassuk, Lisa F Berkman, David WypijAbstract:Background It is not known whether depression is a cause or consequence of progressive Cognitive Decline. We assessed the relationship between depressive symptoms and subsequent Cognitive Decline in the community-dwelling elderly population. Methods Data were from a population-based cohort study that enrolled 2812 noninstitutionalized elderly residents of New Haven, Conn, and followed them with in-home visits in 1982, 1985, 1988, and 1994. Cognitive function was assessed with the Short Portable Mental Status Questionnaire (SPMSQ). Response to the SPMSQ was scored as high, medium, and low, and Cognitive Decline was defined as a transition to a lower category. Depressive symptoms were measured with the Center for Epidemiological Studies Depression Scale. Results An elevated level of depressive symptoms was associated with an increased risk of incident Cognitive Decline among medium SPMSQ performers (3-year odds ratio [OR], 1.72; 95% confidence interval [CI], 1.04-2.82, P =.03; 6-year OR, 2.40; 95% CI, 1.33-4.34; P =.004; 12-year OR, 1.65; 95% CI, 0.62-4.38; P =.31) but not among high performers (3-year OR, 0.93; 95% CI, 0.62-1.39; P =.71; 6-year OR, 1.03; 95% CI, 0.67-1.58; P =.90; 12-year OR, 1.26; 95% CI, 0.59-2.71; P =.55), after adjustment for age, sex, race, education, income, housing type, functional disability, cardiovascular profile, and alcohol use. Conclusions Depressive symptoms, particularly dysphoric mood, presage future Cognitive losses among elderly persons with moderate Cognitive impairments. However, the data do not provide support for the hypothesis that depressive symptoms are associated with the onset or rate of Cognitive Decline among Cognitively intact elderly persons.
John Q Trojanowski - One of the best experts on this subject based on the ideXlab platform.
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apoe thought disorder and spare ad predict Cognitive Decline in established parkinson s disease
Movement Disorders, 2018Co-Authors: Thomas F Tropea, Sharon X Xie, Vivianna M Van Deerlin, Jacqueline Rick, Lana M Chahine, Nabila Dahodwala, Jimit Doshi, Christos Davatzikos, Leslie M Shaw, John Q TrojanowskiAbstract:BACKGROUND People with PD are at high risk of developing Cognitive impairment and dementia. Cross-sectional studies have identified candidate biomarkers associated with Cognitive Decline. However, longitudinal studies on this topic are rarer, and few have investigated the use of biomarker panels encompassing multiple modalities. The objective of this study was to find baseline predictors of Cognitive Decline in longitudinally followed, nondemented Parkinson's disease patients. METHODS We performed a prospective cohort study of 100 PD patients with a median disease duration of 6.4 years. All participants were nondemented at baseline. We examined 16 baseline biomarkers from clinical, genetic, biochemical, and MRI-based imaging modalities for their association with longitudinal Cognitive Decline for up to 8 years. We investigated biomarkers individually, as well as in a multivariate linear mixed-effects model encompassing multimodal biomarkers, with change in the Mattis Dementia Rating Scale-2 over time as the primary outcome. Annual consensus process-derived Cognitive diagnosis was used for Cox proportional hazards modeling of risk for Cognitive Decline. RESULTS In multivariate analysis, the presence of the APOE E4 allele, thought disorder, and an Alzheimer's disease pattern of brain atrophy (spatial pattern of abnormality for recognition of early Alzheimer's disease index) best predicted Cognitive Decline, with APOE E4 genotype exerting the greatest effect. The presence of the APOE E4 allele was associated with a 3.5 times higher risk of worsening Cognitive diagnosis over time (HR, 3.53; 95% CI, 1.52-8.24; P < 0.05). The APOE genotype effect was not specific to any Mattis Dementia Rating Scale-2 domain. CONCLUSIONS Our results confirm the importance of Alzheimer's disease biomarkers as risk factors for Cognitive Decline in established Parkinson's disease. © 2017 International Parkinson and Movement Disorder Society.
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tdp 43 pathology Cognitive Decline and dementia in old age
JAMA Neurology, 2013Co-Authors: Robert S Wilson, David A. Bennett, Patricia A. Boyle, John Q Trojanowski, Eryun Chen, Julie A SchneiderAbstract:Importance Cognitive Decline is a leading cause of disability and death in old age but its neurobiological bases are not well understood. Objective To test the hypothesis that transactive response DNA-binding protein 43 (TDP-43) is related to late-life Cognitive Decline. Design, Setting, and Participants Longitudinal clinical-pathologic cohort study involving more than 40 Catholic groups across the United States. A total of 130 older Catholic nuns, priests, and monks underwent annual clinical evaluations, including detailed Cognitive testing, for a mean of 10.1 years prior to death. On neuropathologic examination, we collected semiquantitative measures of TDP-43 pathology, density of neuronal neurofibrillary tangles, area occupied by amyloid-beta plaques, and the presence of alpha-synuclein Lewy bodies from multiple brain regions. Gross and microscopic cerebral infarcts and hippocampal sclerosis were also identified. Main Outcomes and Measures Annual rate of change in a previously established composite measure of global cognition during a mean of 10.1 years of annual observation before death. Results Transactive response DNA-binding protein 43 pathology, ranging from sparse to severe, was identified in 46% of participants and was associated with amyloid plaques, tangles, and hippocampal sclerosis but not neocortical Lewy bodies or cerebral infarcts. After controlling for amyloid plaques, tangles, and hippocampal sclerosis, TDP-43 pathology was associated with more rapid Cognitive Decline and accounted for nearly as much of the variability in rates of global Cognitive Decline as did tangles. Transactive response DNA-binding protein 43 pathology had a distinct Cognitive profile that differed from other neuropathologic processes (related to Decline in episodic and working memory but not in other Cognitive domains), and it was elevated in those who developed dementia but not in those with mild Cognitive impairment. Conclusion and Relevance The results suggest that TDP-43 is an important brain pathology underlying Cognitive Decline and dementia in old age.
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csf amyloid β 1 42 predicts Cognitive Decline in parkinson disease
Neurology, 2010Co-Authors: A Siderowf, John Q Trojanowski, Sharon X Xie, Howard I Hurtig, Dan Weintraub, John E Duda, Alice Chenplotkin, L M Shaw, Vivianna M Van Deerlin, C ClarkAbstract:Objective: Cognitive Decline associated with Parkinson disease (PD) is common and highly disabling. Biomarkers that help identify patients at risk for Cognitive Decline would be useful additions to the clinical management of the disease. Methods: A total of 45 patients with PD were enrolled in this prospective cohort study and had at least 1 yearly longitudinal follow-up evaluation. CSF was collected at baseline and cognition was assessed at baseline and follow-up visits using the Mattis Dementia Rating Scale (DRS-2). CSF was tested for amyloid β 1-42 (Aβ 1-42 ), p-tau 181p , and total tau levels using the Luminex xMAP platform. Mixed linear models were used to test for associations between baseline CSF biomarker levels and change in cognition over time. Results: Lower baseline CSF Aβ 1-42 was associated with more rapid Cognitive Decline. Subjects with CSF Aβ 1-42 levels ≤192 pg/mL Declined an average of 5.85 (95% confidence interval 2.11–9.58, p = 0.002) points per year more rapidly on the DRS-2 than subjects above that cutoff, after adjustment for age, disease duration, and baseline Cognitive status. CSF total tau and p-tau 181p levels were not significantly associated with Cognitive Decline. Conclusions: Reduced CSF Aβ 1-42 was an independent predictor of Cognitive Decline in patients with PD. This observation is consistent with previous research showing that Alzheimer disease pathology contributes to Cognitive impairment in PD. This biomarker may provide clinically useful prognostic information, particularly if combined with other risk factors for Cognitive impairment in PD.
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csf amyloid beta 1 42 predicts Cognitive Decline in parkinson disease
Neurology, 2010Co-Authors: A Siderowf, John Q Trojanowski, Sharon X Xie, Howard I Hurtig, Dan Weintraub, John E Duda, Alice Chenplotkin, L M Shaw, Vivianna M Van Deerlin, Christopher M ClarkAbstract:Objective: Cognitive Decline associated with Parkinson disease (PD) is common and highly disabling. Biomarkers that help identify patients at risk for Cognitive Decline would be useful additions to the clinical management of the disease. Methods: A total of 45 patients with PD were enrolled in this prospective cohort study and had at least 1 yearly longitudinal follow-up evaluation. CSF was collected at baseline and cognition was assessed at baseline and follow-up visits using the Mattis Dementia Rating Scale (DRS-2). CSF was tested for amyloid β 1-42 (Aβ 1-42 ), p-tau 181p , and total tau levels using the Luminex xMAP platform. Mixed linear models were used to test for associations between baseline CSF biomarker levels and change in cognition over time. Results: Lower baseline CSF Aβ 1-42 was associated with more rapid Cognitive Decline. Subjects with CSF Aβ 1-42 levels ≤192 pg/mL Declined an average of 5.85 (95% confidence interval 2.11–9.58, p = 0.002) points per year more rapidly on the DRS-2 than subjects above that cutoff, after adjustment for age, disease duration, and baseline Cognitive status. CSF total tau and p-tau 181p levels were not significantly associated with Cognitive Decline. Conclusions: Reduced CSF Aβ 1-42 was an independent predictor of Cognitive Decline in patients with PD. This observation is consistent with previous research showing that Alzheimer disease pathology contributes to Cognitive impairment in PD. This biomarker may provide clinically useful prognostic information, particularly if combined with other risk factors for Cognitive impairment in PD.
A Siderowf - One of the best experts on this subject based on the ideXlab platform.
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csf amyloid β 1 42 predicts Cognitive Decline in parkinson disease
Neurology, 2010Co-Authors: A Siderowf, John Q Trojanowski, Sharon X Xie, Howard I Hurtig, Dan Weintraub, John E Duda, Alice Chenplotkin, L M Shaw, Vivianna M Van Deerlin, C ClarkAbstract:Objective: Cognitive Decline associated with Parkinson disease (PD) is common and highly disabling. Biomarkers that help identify patients at risk for Cognitive Decline would be useful additions to the clinical management of the disease. Methods: A total of 45 patients with PD were enrolled in this prospective cohort study and had at least 1 yearly longitudinal follow-up evaluation. CSF was collected at baseline and cognition was assessed at baseline and follow-up visits using the Mattis Dementia Rating Scale (DRS-2). CSF was tested for amyloid β 1-42 (Aβ 1-42 ), p-tau 181p , and total tau levels using the Luminex xMAP platform. Mixed linear models were used to test for associations between baseline CSF biomarker levels and change in cognition over time. Results: Lower baseline CSF Aβ 1-42 was associated with more rapid Cognitive Decline. Subjects with CSF Aβ 1-42 levels ≤192 pg/mL Declined an average of 5.85 (95% confidence interval 2.11–9.58, p = 0.002) points per year more rapidly on the DRS-2 than subjects above that cutoff, after adjustment for age, disease duration, and baseline Cognitive status. CSF total tau and p-tau 181p levels were not significantly associated with Cognitive Decline. Conclusions: Reduced CSF Aβ 1-42 was an independent predictor of Cognitive Decline in patients with PD. This observation is consistent with previous research showing that Alzheimer disease pathology contributes to Cognitive impairment in PD. This biomarker may provide clinically useful prognostic information, particularly if combined with other risk factors for Cognitive impairment in PD.
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csf amyloid beta 1 42 predicts Cognitive Decline in parkinson disease
Neurology, 2010Co-Authors: A Siderowf, John Q Trojanowski, Sharon X Xie, Howard I Hurtig, Dan Weintraub, John E Duda, Alice Chenplotkin, L M Shaw, Vivianna M Van Deerlin, Christopher M ClarkAbstract:Objective: Cognitive Decline associated with Parkinson disease (PD) is common and highly disabling. Biomarkers that help identify patients at risk for Cognitive Decline would be useful additions to the clinical management of the disease. Methods: A total of 45 patients with PD were enrolled in this prospective cohort study and had at least 1 yearly longitudinal follow-up evaluation. CSF was collected at baseline and cognition was assessed at baseline and follow-up visits using the Mattis Dementia Rating Scale (DRS-2). CSF was tested for amyloid β 1-42 (Aβ 1-42 ), p-tau 181p , and total tau levels using the Luminex xMAP platform. Mixed linear models were used to test for associations between baseline CSF biomarker levels and change in cognition over time. Results: Lower baseline CSF Aβ 1-42 was associated with more rapid Cognitive Decline. Subjects with CSF Aβ 1-42 levels ≤192 pg/mL Declined an average of 5.85 (95% confidence interval 2.11–9.58, p = 0.002) points per year more rapidly on the DRS-2 than subjects above that cutoff, after adjustment for age, disease duration, and baseline Cognitive status. CSF total tau and p-tau 181p levels were not significantly associated with Cognitive Decline. Conclusions: Reduced CSF Aβ 1-42 was an independent predictor of Cognitive Decline in patients with PD. This observation is consistent with previous research showing that Alzheimer disease pathology contributes to Cognitive impairment in PD. This biomarker may provide clinically useful prognostic information, particularly if combined with other risk factors for Cognitive impairment in PD.