The Experts below are selected from a list of 279 Experts worldwide ranked by ideXlab platform
Christopher M Elvin - One of the best experts on this subject based on the ideXlab platform.
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a highly elastic and adhesive gelatin tissue sealant for gastrointestinal surgery and Colon Anastomosis
Journal of Gastrointestinal Surgery, 2012Co-Authors: Tony Vuocolo, Roger Haddad, Glenn A Edwards, Russell E Lyons, N Liyou, Jerome A Werkmeister, John Alan Maurice Ramshaw, Christopher M ElvinAbstract:Background We describe the development of a highly elastic and adhesive surgical tissue sealant, based on photochemically crosslinked gelatin, for sealing sutured incisions in the gastrointestinal (GI) tract in a rabbit surgical model and in a canine Colon Anastomosis study.
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A Highly Elastic and Adhesive Gelatin Tissue Sealant for Gastrointestinal Surgery and Colon Anastomosis
Journal of Gastrointestinal Surgery, 2012Co-Authors: Tony Vuocolo, Roger Haddad, Glenn A Edwards, Russell E Lyons, N Liyou, Jerome A Werkmeister, John Alan Maurice Ramshaw, Christopher M ElvinAbstract:Background We describe the development of a highly elastic and adhesive surgical tissue sealant, based on photochemically crosslinked gelatin, for sealing sutured incisions in the gastrointestinal (GI) tract in a rabbit surgical model and in a canine Colon Anastomosis study. Methods The study included in vitro assessment of mechanical parameters of the tissue sealant and in vivo analysis of burst strength and histology at 24 h, 3 days and 7 days post surgery, in a rabbit model, to assess progress of wound healing at the suture sites. Utility of this sealant to repair and seal a lower Colonic resection and Anastomosis procedure in a canine model was also investigated. Results We show that a photopolymerised gelatin tissue sealant provides effective sealing of GI incisions and facilitates wound healing with no evidence of inflammation up to 28 days post-surgery. Blending of derivatised gelatin with underivatised gelatin allowed tuning of elasticity and elastic modulus of the photopolymerised sealant to suit surgical applications. High tissue adhesive strength was maintained at all blend ratios and exceeded 100 kPa. Conclusions This highly elastic and adhesive photopolymerised gelatin tissue sealant offers a number of advantages over currently available sealants suitable for GI surgical procedures.
Rudolf Rucman - One of the best experts on this subject based on the ideXlab platform.
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Stable gastric pentadecapeptide BPC 157 for colitis and multiple sclerosis: Healing of cysteamine-colitis and Colon-Colon- Anastomosis
The FASEB Journal, 2013Co-Authors: Predrag Sikiric, Robert Klicek, Danijela Kolenc, Jelena Šuran, Domagoj Drmic, Luka Brcic, Gorana Aralica, Sven Seiwerth, Rudolf RucmanAbstract:BPC 157 is interesting as an original anti-ulcer peptide (GEPPPGKPADDAGLV, M.W. 1419) stable in human gastric juice more than 24 hours, successful in trials for inflammatory bowel disease, phase II, wound treatment, no toxicity or side effects reported, LD1 not achieved, effective alone without carrier. The dehiscence of Colonic Anastomosis is associated with high mortality and morbidity rates. As a result, the problem of healing after a Colon resection requires a suitable solution, especially in inflammatory bowel disease with compromised healing. As a possible solution we suggest the use of BPC 157 which may also be effective for treating inflammatory bowel disease complications. After cysteamine (400 mg/kg ir) Colon-Colon Anastomosis was created in rats. The sacrifice was at day 3, 5, 7, and 14. BPC 157 (10μg/kg, 10 ng/kg) was applied ip once daily or in drinking water (0.16 μg/ml/12ml/day) till the sacrifice. Controls poor presentation did not heal cysteamine colitis and Colon-Colon Anastomosis ; BPC 157 simultaneously induced healing of both, the Anastomosis and the ulcerative colitis. Thereby, this evidence advocates BPC 157 in inflammatory bowel disease. Interestingly, accordingly with application of agents used in ulcerative colitis (i.e., natalizumab), the most recent evidence suggests its use also in multiple sclerosis therapy.
Talib Juma - One of the best experts on this subject based on the ideXlab platform.
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Exteriorized Colon Anastomosis for unprepared bowel: an alternative to routine colostomy.
World journal of gastroenterology, 2007Co-Authors: Sami Asfar, H. Al-sayer, Talib JumaAbstract:AIM: To see the possibility of avoiding routine colostomy in patients presenting with unprepared bowel. METHODS: The cohort is composed of 103 patients, of these, 86 patients presented as emergencies (self-inflected and iatrogenic Colon injuries, stab wounds and blast injury of the Colon, volvulus sigmoid, obstructing left Colon cancer, and strangulated ventral hernia). Another 17 patients were managed electively for other Colon pathologies. During laparotomy, the involved segment was resected and the two ends of the Colon were brought out via a separate colostomy wound. One layer of interrupted 3/0 silk was used for Colon Anastomosis. The exteriorized segment was immediately covered with a colostomy bag. Between the 5th and 7th postoperative day, the Colon was easily dropped into the peritoneal cavity. The defect in the abdominal wall was closed with interrupted nonabsorbable suture. The skin was left open for secondary closure. RESULTS: The mean hospital stay (± SD) was 11.5 ± 2.6 d (8-20 d). The exteriorized Colon was successfully dropped back into the peritoneal cavity in all patients except two. One developed a leak from oesophago-jejunostomy and from the exteriorized Colon. She subsequently died of sepsis and multiple organ failure (MOF). In a second patient the Colon proximal to the exteriorized Anastomosis prolapsed and developed severe serositis, an elective ileo-colic Anastomosis (to the left Colon) was successfully performed. CONCLUSION: Exteriorized Colon Anastomosis is simple, avoids the inconvenience of colostomy and can be an alternative to routine colostomy. It is suitable where colostomy is socially unacceptable or the facilities and care is not available.
Ignaz Schneider - One of the best experts on this subject based on the ideXlab platform.
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Laparoscopic-assisted Colon Anastomosis using the Valtrac ring: an animal study.
Diseases of the colon and rectum, 1999Co-Authors: Karlheinz Thaler, Frank Schoenleben, H. Scheidbach, Ferdinand Dr Koeckerling, Werner Hohenberger, Ignaz SchneiderAbstract:PURPOSE: For deep Colon anastomoses in laparoscopic surgery, the mainstay is the circular stapler. Theoretically, however, such anastomoses can also be constructed with the aid of the Valtrac® ring. The aim of the present study was to investigate the feasibility of this approach. METHODS: In this approved animal study nine pigs weighing 15 to 20 kg were operated on under general anesthesia. After intracorporeal preparation, the Colon was divided at the level of the entry to the pelvis. To fix the proximal half of the Valtrac® ring, the proximal limb of the Colon was exteriorizedvia a minilaparotomy. After replacing this part of the Colon—now bearing the Valtrac® ring—in the abdominal cavity and reestablishment of pneumoperitoneum, the ring was fixed to the applicator inserted transanally into the abdominal cavity. After placement of the distal half of the ring in the rectal limb and extracorporeal knotting of the pursestring suture previously placed with the aid of the laparoscopic pursestring clamp, the two halves of the Valtrac® ring were reliably closed with the help of the applicator. RESULTS: Eight of nine animals survived. One animal died on the fourth postoperative day as a result of an anastomotic insufficiency. At follow-up examination in the fifth postoperative week, none of the surviving eight animals showed any signs of prior anastomotic insufficiency. CONCLUSION: This animal study has shown that using the newly developed applicator system, the Valtrac® ring can be just as readily employed as the circular stapler for creation of a Colonic Anastomosis below the level of the promontorium.
Tony Vuocolo - One of the best experts on this subject based on the ideXlab platform.
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a highly elastic and adhesive gelatin tissue sealant for gastrointestinal surgery and Colon Anastomosis
Journal of Gastrointestinal Surgery, 2012Co-Authors: Tony Vuocolo, Roger Haddad, Glenn A Edwards, Russell E Lyons, N Liyou, Jerome A Werkmeister, John Alan Maurice Ramshaw, Christopher M ElvinAbstract:Background We describe the development of a highly elastic and adhesive surgical tissue sealant, based on photochemically crosslinked gelatin, for sealing sutured incisions in the gastrointestinal (GI) tract in a rabbit surgical model and in a canine Colon Anastomosis study.
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A Highly Elastic and Adhesive Gelatin Tissue Sealant for Gastrointestinal Surgery and Colon Anastomosis
Journal of Gastrointestinal Surgery, 2012Co-Authors: Tony Vuocolo, Roger Haddad, Glenn A Edwards, Russell E Lyons, N Liyou, Jerome A Werkmeister, John Alan Maurice Ramshaw, Christopher M ElvinAbstract:Background We describe the development of a highly elastic and adhesive surgical tissue sealant, based on photochemically crosslinked gelatin, for sealing sutured incisions in the gastrointestinal (GI) tract in a rabbit surgical model and in a canine Colon Anastomosis study. Methods The study included in vitro assessment of mechanical parameters of the tissue sealant and in vivo analysis of burst strength and histology at 24 h, 3 days and 7 days post surgery, in a rabbit model, to assess progress of wound healing at the suture sites. Utility of this sealant to repair and seal a lower Colonic resection and Anastomosis procedure in a canine model was also investigated. Results We show that a photopolymerised gelatin tissue sealant provides effective sealing of GI incisions and facilitates wound healing with no evidence of inflammation up to 28 days post-surgery. Blending of derivatised gelatin with underivatised gelatin allowed tuning of elasticity and elastic modulus of the photopolymerised sealant to suit surgical applications. High tissue adhesive strength was maintained at all blend ratios and exceeded 100 kPa. Conclusions This highly elastic and adhesive photopolymerised gelatin tissue sealant offers a number of advantages over currently available sealants suitable for GI surgical procedures.