The Experts below are selected from a list of 258 Experts worldwide ranked by ideXlab platform
Robert M Olson - One of the best experts on this subject based on the ideXlab platform.
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serum prostate specific antigen and digital rectal examination for early detection of prostate cancer in a national community based Program
Urology, 1996Co-Authors: David E Crawford, Edward P Deantoni, Ruth Etzioni, Virginia C Schaefer, Robert M OlsonAbstract:Abstract Objectives This study analyzed methods of prostate cancer early detection in community settings throughout the United States against standards and findings of earlier studies conducted at academic medical centers. Methods The study was conducted at 148 clinical centers during Prostate Cancer Awareness Week in September 1993 and continued through June 1994. A total of 31,953 eligible subjects were tested by both digital rectal examination (DRE) and prostate-specific antigen (PSA). PSA was tested with the Abbott IMx PSA assay and reported by Roche Biomedical, Inc. Results The study confirmed that elevated PSA levels (greater than 4.0 ng/mL) aid in the detection of organconfined prostate cancer when used in conjunction with the DRE. Reflecting more conservative biopsy decision-making practices, study results nonetheless are comparable to earlier reports. Among 1307 subjects who underwent biopsy, 322 cancers were detected. The cancer detection rate was 3.6% for PSA, 3.0% for DRE, and 4.7% if either test result was positive. The positive predictive value (PPV) for elevated PSA levels (greater than 4.0 ng/mL) was 31.6%, significantly better ( P Conclusions Community practice throughout the United States demonstrates that PSA and DRE are consistently effective and efficient in the early detection of prostate cancer.
Samantha M. Kimball - One of the best experts on this subject based on the ideXlab platform.
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The Association between Serum 25(OH)D Status and Blood Pressure in Participants of a Community-Based Program Taking Vitamin D Supplements
Nutrients, 2017Co-Authors: Naghmeh Mirhosseini, Hassanali Vatanparast, Samantha M. KimballAbstract:Background: Vitamin D deficiency is a risk factor for hypertension. Methods: We assessed 8155 participants in a Community-Based Program to investigate the association between serum 25-hydroxyvitamin D (25(OH)D) status and blood pressure (BP) and the influence of vitamin D supplementation on hypertension. Participants were provided vitamin D supplements to reach a target serum 25(OH)D > 100 nmol/L. A nested case-control study was conducted to examine the effect of achieving physiological vitamin D status in those who were hypertensive and not taking BP-lowering medication, and hypertensive participants that initiated BP-lowering medication after Program entry. Results: At baseline, 592 participants (7.3%) were hypertensive; of those, 71% were no longer hypertensive at follow-up (12 ± 3 months later). There was a significant negative association between BP and serum 25(OH)D level (systolic BP: coefficient = −0.07, p < 0.001; diastolic BP: coefficient = −0.1, p < 0.001). Reduced mean systolic (−18 vs. −14 mmHg) and diastolic (−12 vs. −12 mmHg) BP, pulse pressure (−5 vs. −1 mmHg) and mean arterial pressure (−14 vs. −13 mmHg) were not significantly different between hypertensive participants who did and did not take BP-lowering medication. Conclusion: Improved serum 25(OH)D concentrations in hypertensive individuals who were vitamin D insufficient were associated with improved control of systolic and diastolic BP.
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evaluation of vitamin d3 intakes up to 15 000 international units day and serum 25 hydroxyvitamin d concentrations up to 300 nmol l on calcium metabolism in a community setting
Dermato-endocrinology, 2017Co-Authors: Samantha M. Kimball, Naghmeh Mirhosseini, Michael F HolickAbstract:ABSTRACTSupplementation by the general public with vitamin D at doses above the Tolerable Upper Level of Intake (UL) is becoming quite common. The objective of the current analysis was to characterize the effect of vitamin D supplementation at doses up to 15,000 IU/d in a Community-Based Program on vitamin D status, calcium homeostasis as well as on kidney, liver and immune function. We evaluated data collected for 3,882 participants in a community Program for whom there were blood measurements at Program entry and at follow-up within 6–18 months between 2013 and 2015. Participants were supplemented with a wide range of vitamin D doses (1,000 – 15,000 IU/d) aimed at achieving serum 25-hydroxyvitamin D [25(OH)D] levels of at least 100 nmol/L. Serum 25(OH)D concentrations up to 300 nmol/L were achieved without perturbation of calcium homeostasis or incidence of toxicity. Hypercalcemia and hypercalciuria were not related to an increase in 25(OH)D concentrations nor vitamin D dose. To achieve serum 25(OH)D le...
Michael F Holick - One of the best experts on this subject based on the ideXlab platform.
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evaluation of vitamin d3 intakes up to 15 000 international units day and serum 25 hydroxyvitamin d concentrations up to 300 nmol l on calcium metabolism in a community setting
Dermato-endocrinology, 2017Co-Authors: Samantha M. Kimball, Naghmeh Mirhosseini, Michael F HolickAbstract:ABSTRACTSupplementation by the general public with vitamin D at doses above the Tolerable Upper Level of Intake (UL) is becoming quite common. The objective of the current analysis was to characterize the effect of vitamin D supplementation at doses up to 15,000 IU/d in a Community-Based Program on vitamin D status, calcium homeostasis as well as on kidney, liver and immune function. We evaluated data collected for 3,882 participants in a community Program for whom there were blood measurements at Program entry and at follow-up within 6–18 months between 2013 and 2015. Participants were supplemented with a wide range of vitamin D doses (1,000 – 15,000 IU/d) aimed at achieving serum 25-hydroxyvitamin D [25(OH)D] levels of at least 100 nmol/L. Serum 25(OH)D concentrations up to 300 nmol/L were achieved without perturbation of calcium homeostasis or incidence of toxicity. Hypercalcemia and hypercalciuria were not related to an increase in 25(OH)D concentrations nor vitamin D dose. To achieve serum 25(OH)D le...
David E Crawford - One of the best experts on this subject based on the ideXlab platform.
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serum prostate specific antigen and digital rectal examination for early detection of prostate cancer in a national community based Program
Urology, 1996Co-Authors: David E Crawford, Edward P Deantoni, Ruth Etzioni, Virginia C Schaefer, Robert M OlsonAbstract:Abstract Objectives This study analyzed methods of prostate cancer early detection in community settings throughout the United States against standards and findings of earlier studies conducted at academic medical centers. Methods The study was conducted at 148 clinical centers during Prostate Cancer Awareness Week in September 1993 and continued through June 1994. A total of 31,953 eligible subjects were tested by both digital rectal examination (DRE) and prostate-specific antigen (PSA). PSA was tested with the Abbott IMx PSA assay and reported by Roche Biomedical, Inc. Results The study confirmed that elevated PSA levels (greater than 4.0 ng/mL) aid in the detection of organconfined prostate cancer when used in conjunction with the DRE. Reflecting more conservative biopsy decision-making practices, study results nonetheless are comparable to earlier reports. Among 1307 subjects who underwent biopsy, 322 cancers were detected. The cancer detection rate was 3.6% for PSA, 3.0% for DRE, and 4.7% if either test result was positive. The positive predictive value (PPV) for elevated PSA levels (greater than 4.0 ng/mL) was 31.6%, significantly better ( P Conclusions Community practice throughout the United States demonstrates that PSA and DRE are consistently effective and efficient in the early detection of prostate cancer.
Naghmeh Mirhosseini - One of the best experts on this subject based on the ideXlab platform.
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The Association between Serum 25(OH)D Status and Blood Pressure in Participants of a Community-Based Program Taking Vitamin D Supplements
Nutrients, 2017Co-Authors: Naghmeh Mirhosseini, Hassanali Vatanparast, Samantha M. KimballAbstract:Background: Vitamin D deficiency is a risk factor for hypertension. Methods: We assessed 8155 participants in a Community-Based Program to investigate the association between serum 25-hydroxyvitamin D (25(OH)D) status and blood pressure (BP) and the influence of vitamin D supplementation on hypertension. Participants were provided vitamin D supplements to reach a target serum 25(OH)D > 100 nmol/L. A nested case-control study was conducted to examine the effect of achieving physiological vitamin D status in those who were hypertensive and not taking BP-lowering medication, and hypertensive participants that initiated BP-lowering medication after Program entry. Results: At baseline, 592 participants (7.3%) were hypertensive; of those, 71% were no longer hypertensive at follow-up (12 ± 3 months later). There was a significant negative association between BP and serum 25(OH)D level (systolic BP: coefficient = −0.07, p < 0.001; diastolic BP: coefficient = −0.1, p < 0.001). Reduced mean systolic (−18 vs. −14 mmHg) and diastolic (−12 vs. −12 mmHg) BP, pulse pressure (−5 vs. −1 mmHg) and mean arterial pressure (−14 vs. −13 mmHg) were not significantly different between hypertensive participants who did and did not take BP-lowering medication. Conclusion: Improved serum 25(OH)D concentrations in hypertensive individuals who were vitamin D insufficient were associated with improved control of systolic and diastolic BP.
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evaluation of vitamin d3 intakes up to 15 000 international units day and serum 25 hydroxyvitamin d concentrations up to 300 nmol l on calcium metabolism in a community setting
Dermato-endocrinology, 2017Co-Authors: Samantha M. Kimball, Naghmeh Mirhosseini, Michael F HolickAbstract:ABSTRACTSupplementation by the general public with vitamin D at doses above the Tolerable Upper Level of Intake (UL) is becoming quite common. The objective of the current analysis was to characterize the effect of vitamin D supplementation at doses up to 15,000 IU/d in a Community-Based Program on vitamin D status, calcium homeostasis as well as on kidney, liver and immune function. We evaluated data collected for 3,882 participants in a community Program for whom there were blood measurements at Program entry and at follow-up within 6–18 months between 2013 and 2015. Participants were supplemented with a wide range of vitamin D doses (1,000 – 15,000 IU/d) aimed at achieving serum 25-hydroxyvitamin D [25(OH)D] levels of at least 100 nmol/L. Serum 25(OH)D concentrations up to 300 nmol/L were achieved without perturbation of calcium homeostasis or incidence of toxicity. Hypercalcemia and hypercalciuria were not related to an increase in 25(OH)D concentrations nor vitamin D dose. To achieve serum 25(OH)D le...