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Wayne K Goodman - One of the best experts on this subject based on the ideXlab platform.
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family accommodation in pediatric obsessive Compulsive Disorder
Journal of Clinical Child and Adolescent Psychology, 2007Co-Authors: Eric A Storch, Tanya K Murphy, Wayne K Goodman, Gary R Geffken, Lisa J Merlo, Marni L Jacob, Michael J Larson, Melanie Fernandez, Kristen GrabillAbstract:Despite the importance of the family in the treatment of pediatric obsessive-Compulsive Disorder (OCD), relatively little empirical attention has been directed to family accommodation of symptoms. This study examined the relations among family accommodation, OCD symptom severity, functional impairment, and internalizing and externalizing behavior problems in a sample of 57 clinic-referred youth 7 to 17 years old (M = 12.99 +/- 2.54) with OCD. Family accommodation was a frequent event across families. Family accommodation was positively related to symptom severity, parent-rated functional impairment (but not child-rated impairment), and externalizing and internalizing behavior problems. Family accommodation mediated the relation between symptom severity and parent-rated functional impairment.
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three year outcomes in deep brain stimulation for highly resistant obsessive Compulsive Disorder
Neuropsychopharmacology, 2006Co-Authors: Benjamin D Greenberg, Wayne K Goodman, Donald A Malone, Gerhard Friehs, Ali R Rezai, Cynthia S Kubu, Paul Malloy, Stephen Salloway, Michael S Okun, Steven A. RasmussenAbstract:Three-Year Outcomes in Deep Brain Stimulation for Highly Resistant Obsessive–Compulsive Disorder
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b lymphocyte antigen d8 17 a peripheral marker for childhood onset obsessive Compulsive Disorder and tourette s syndrome
American Journal of Psychiatry, 1997Co-Authors: Tanya K Murphy, Wayne K Goodman, Marilyn W Fudge, Ralph C Williams, Elia M Ayoub, Mayank Dalal, Mark H Lewis, John B ZabriskieAbstract:Objective: It has been hypothesized that Sydenham’s chorea, a major manifestation of rheumatic fever, may provide a medical model for obsessive-Compulsive Disorder and associated conditions, such as Tourette’s syndrome. Monoclonal antibody D8/17 identifies a B lymphocyte antigen with expanded expression in nearly all patients with rheumatic fever and is thought to be a trait marker for susceptibility to this complication of group A streptococcal infection. The authors investigated whether D8/17 expression is greater than normal in some forms of obsessive-Compulsive Disorder and Tourette’s syndrome. Method: By immunofluorescence techniques, 31 patients with childhood-onset obsessive-Compulsive Disorder and/or Tourette’s syndrome or chronic tic Disorder and 21 healthy comparison subjects were evaluated for percentage of D8/17positive B cells. None had rheumatic fever or Sydenham’s chorea. Levels of antineuronal antibodies and streptococcal antibodies were also determined. Results: The average percentage of B cells expressing the D8/17 antigen was significantly higher in the patients (mean=22%, SD=5%) than in the comparison subjects (mean=9%, SD=2%). When classified categorically, all patients but only one comparison subject were D8/17 positive. No difference between groups in the presence of antineuronal antibodies or high streptococcal titers was found. Conclusions: Patients with childhood-onset obsessive-Compulsive Disorder or Tourette’s syndrome had significantly greater B cell D8/17 expression than comparison subjects despite the absence of documented Sydenham’s chorea or rheumatic fever. These findings suggest that D8/17 may serve as a marker for susceptibility among some forms of childhood-onset obsessive-Compulsive Disorder and Tourette’s syndrome, as well as rheumatic fever or Sydenham’s chorea. (Am J Psychiatry 1997; 154:402‐407)
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a case controlled study of repetitive thoughts and behavior in adults with autistic Disorder and obsessive Compulsive Disorder
American Journal of Psychiatry, 1995Co-Authors: Christopher J Mcdougle, Wayne K Goodman, Donald J. Cohen, Laura E Kresch, Susan T Naylor, Fred R Volkmar, Lawrence H PriceAbstract:Objective: The purpose of this study was to investigate the types of repetitive thoughts and behavior demonstrated by adults with autistic Disorder and compare them with those of age- and sex-matched adults with obsessive-Compulsive Disorder. Method: Fifty consecutive patients admitted to the Yale Adult Pervasive Developmental Disorders (Autism) Clinic with a primary diagnosis ofautistic Disorder (DSM-III-R and DSM-IV) completed the symptom checklist of the Yale-Brown Obsessive Compulsive Scale. Types of current obsessions and compulsions were evaluated. The comparison group consisted of 50 age- and sexmatched adults with obsessive-Compulsive Disorder (without tics) (DSM-III-R and DSM-IV). Results: Direct discriminant function analysis showed that the patients with autistic Disorder could be distinguished from those with obsessive-Compulsive Disorder on the basis of the types of current repetitive thoughts and behavior that they demonstrated. Compared to the obsessive-Compulsive group, the autistic patients were significantly less likely to experience thoughts with aggressive, contamination, sexual, religious, symmetry, and somatic content. Repetitive ordering; hoarding; telling or asking (trend); touching, tapping, or rubbing; and self-damaging or self-mutilating behavior occurred significantly more frequently in the autistic patients, whereas cleaning, checking, and counting behavior was less common in the autistic group than in the patients with obsessive-Compulsive Disorder. In addition, a specific subset of seven obsessive-Compulsive variables from the Yale-Brown Obsessive Compulsive Scale symptom checklist was identified that reliably predicted membership in the autistic group. Conclusions: These results suggest that the repetitive thoughts and behavior characteristic of autism differ significantly from the obsessive-Compulsive symptoms displayed by patients with obsessive-Compulsive Disorder. Future studies are warranted to assess the treatment response and neurobiological underpinnings ofrepetitive thoughts and behavior in patients with autism and obsessive-Compulsive Disorder.
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limited therapeutic effect of addition of buspirone in fluvoxamine refractory obsessive Compulsive Disorder
American Journal of Psychiatry, 1993Co-Authors: Christopher J Mcdougle, Wayne K Goodman, James F. Leckman, George R Heninger, L C Barr, Jacob C Holzer, Elinore F Mccancekatz, Lawrence H PriceAbstract:The authors found that buspirone added to the treatment of 33 patients with obsessive-Compulsive Disorder who were refractory to the serotonin reuptake inhibitor fluvoxamine was no better than placebo in reducing obsessive-Compulsive, depressive, or anxiety symptoms. This finding suggests that addition of buspirone to ongoing fluvoxamine therapy is not an effective treatment strategy for most patients with obsessive-Compulsive Disorder.
Michael A Jenike - One of the best experts on this subject based on the ideXlab platform.
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lower posterior cingulate cortex glutathione levels in obsessive Compulsive Disorder
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2016Co-Authors: Michael A Jenike, Brian P Brennan, Eric J Jensen, Christine Perriello, Harrison G Pope, James I HudsonAbstract:Background Several lines of evidence support the hypothesis that lower cerebral levels of glutathione (GSH), associated with increased oxidative stress, may contribute to obsessive-Compulsive Disorder (OCD). However, no studies to date have investigated brain GSH levels in individuals with OCD.
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open label study of duloxetine for the treatment of obsessive Compulsive Disorder
The International Journal of Neuropsychopharmacology, 2015Co-Authors: Darin D Dougherty, Michael A Jenike, Andrew K Corse, Tina Chou, Amanda Duffy, Amanda R Arulpragasam, Thilo Deckersbach, Nancy J KeuthenAbstract:Background: This study sought to investigate the efficacy of duloxetine for the treatment of obsessive-Compulsive Disorder (DSM-IV). Methods: Twenty individuals were enrolled in a 17-week, open-label trial of duloxetine at Massachusetts General Hospital. Data were collected between March 2007 and September 2012. Study measures assessing obsessive-Compulsive Disorder symptoms, quality of life, depression, and anxiety were administered at baseline and weeks 1, 5, 9, 13, and 17. The primary outcome measures were the Yale-Brown Obsessive Compulsive Scale and Clinical Global Improvement scale. Results: For the 12 study completers, pre- and posttreatment analyses revealed significant improvements (P < .05) on clinicianand self-rated measures of obsessive-Compulsive Disorder symptoms and quality of life. Among the 12 completers, more than one-half (n = 7) satisfied full medication response criteria. Intention-to-treat analyses (n = 20) showed similar improvements (P < .05) on primary and secondary study outcome measures. Conclusion: The results of this study suggest that duloxetine may provide a significant reduction in symptoms for patients with obsessive-Compulsive Disorder. ClinicalTrials.gov NCT00464698; http://clinicaltrials.gov/ct2/show/NCT00464698?term=NCT00464698&rank=1.
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late onset obsessive Compulsive Disorder a case series
Journal of Neuropsychiatry and Clinical Neurosciences, 2000Co-Authors: Anthony P Weiss, Michael A JenikeAbstract:Obsessive-Compulsive Disorder (OCD) is a common and potentially disabling illness with onset usually in the second or third decade of life. Onset after age 50 is relatively rare and may be more likely to have an organic etiology. Out of an OCD patient population of over 1,000, the authors found 5 cases in which symptoms of OCD first developed late in life. Four of the 5 patients had intracerebral lesions in the frontal lobes and caudate nuclei, findings consistent with current theories about the pathogenesis of “idiopathic” OCD.
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the relationship between semantic organization and memory in obsessive Compulsive Disorder
Psychotherapy and Psychosomatics, 2000Co-Authors: Thilo Deckersbach, Cary R Savage, Lee Baer, Michael W Otto, Michael A JenikeAbstract:Background: A variety of evidence suggests that frontostriatal dysfunction is involved in obsessive-Compulsive Disorder (OCD). This evidence includes both neuroimaging findings and
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probing striatal function in obsessive Compulsive Disorder a pet study of implicit sequence learning
Journal of Neuropsychiatry and Clinical Neurosciences, 1997Co-Authors: Scott L Rauch, Adair Kendrick, Cary R Savage, Darin D Dougherty, Nathaniel M Alpert, Tim Curran, Halle D Brown, Peter A Manzo, A J Fischman, Michael A JenikeAbstract:Positron emission tomography was employed to contrast the brain activation pattern in patients with obsessive-Compulsive Disorder (OCD) to that of matched control subjects while they performed an implicit learning task. Although patients and control subjects evidenced comparable learning, imaging data from control subjects indicated bilateral inferior striatal activation, whereas OCD patients did not activate right or left inferior striatum and instead showed bilateral medial temporal activation. The findings further implicate corticostriatal dysfunction in obsessive-Compulsive Disorder. Furthermore, when OCD patients are confronted with stimuli that call for recruitment of corticostriatal systems, they instead appear to access brain regions normally associated with explicit (conscious) information processing.
Benjamin D Greenberg - One of the best experts on this subject based on the ideXlab platform.
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immune related comorbidities in childhood onset obsessive Compulsive Disorder lifetime prevalence in the obsessive Compulsive Disorder collaborative genetics association study
Journal of Child and Adolescent Psychopharmacology, 2019Co-Authors: Clara Westwellroper, Daniel A Geller, Kyle Williams, Jack Samuels, Joseph O Bienvenu, Bernadette Cullen, Fernando S Goes, Marco A Grados, Benjamin D Greenberg, James A KnowlesAbstract:Abstract Objective: To evaluate the lifetime prevalence of infectious, inflammatory, and autoimmune Disorders in a multisite study of probands with childhood-onset obsessive Compulsive Disorder (OC...
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three year outcomes in deep brain stimulation for highly resistant obsessive Compulsive Disorder
Neuropsychopharmacology, 2006Co-Authors: Benjamin D Greenberg, Wayne K Goodman, Donald A Malone, Gerhard Friehs, Ali R Rezai, Cynthia S Kubu, Paul Malloy, Stephen Salloway, Michael S Okun, Steven A. RasmussenAbstract:Three-Year Outcomes in Deep Brain Stimulation for Highly Resistant Obsessive–Compulsive Disorder
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altered cortical excitability in obsessive Compulsive Disorder
Neurology, 2000Co-Authors: Benjamin D Greenberg, Dennis L Murphy, Ulf Ziemann, Gabriela Coralocatelli, A Harmon, J C Keel, Eric M WassermannAbstract:Objective: To assess cortical inhibitory and excitatory mechanisms in obsessive–Compulsive Disorder (OCD). Background: Transcranial magnetic stimulation (TMS) studies have found decreased neuronal inhibition and a reduced cortical silent period in the primary motor area in Tourette’s syndrome, focal dystonia, and other Disorders believed to involve dysfunction of subcortical structures, including the basal ganglia. Dysfunction of the basal ganglia and linked regions also has been implicated in OCD, which has significant clinical and familial overlap with tic Disorders. Methods: We applied the TMS techniques previously used in Tourette’s syndrome to a group of 16 OCD patients (seven unmedicated) and 11 age-matched healthy volunteers extensively screened for psychopathology. Measures of motor cortex excitability included resting and active motor threshold, cortical silent period duration, and intracortical inhibition and facilitation using a paired-pulse TMS technique with a subthreshold conditioning stimulus. Results: Similar to recent findings in Tourette’s syndrome and focal dystonia, this study reports significantly decreased intracortical inhibition (ICI) relative to the volunteers at interstimulus intervals from 2 to 5 msec. We also found decreased active and resting motor evoked potential threshold in the OCD patients, another indication of increased cortical excitability. Neither abnormality appeared medication related. The decreases in ICI and motor threshold were greatest in OCD patients with comorbid tics, but remained significant in patients without tics. Conclusions: The data suggest abnormal cortical excitability in obsessive–Compulsive Disorder. These findings are congruent with the hypothesis that Tourette’s syndrome and obsessive–Compulsive Disorder (OCD) are analogous Disorders with overlapping dysfunction in corticobasal circuits. Patients with tic-related OCD may have more abnormal motor cortex excitability than OCD patients without tics.
Lawrence H Price - One of the best experts on this subject based on the ideXlab platform.
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a case controlled study of repetitive thoughts and behavior in adults with autistic Disorder and obsessive Compulsive Disorder
American Journal of Psychiatry, 1995Co-Authors: Christopher J Mcdougle, Wayne K Goodman, Donald J. Cohen, Laura E Kresch, Susan T Naylor, Fred R Volkmar, Lawrence H PriceAbstract:Objective: The purpose of this study was to investigate the types of repetitive thoughts and behavior demonstrated by adults with autistic Disorder and compare them with those of age- and sex-matched adults with obsessive-Compulsive Disorder. Method: Fifty consecutive patients admitted to the Yale Adult Pervasive Developmental Disorders (Autism) Clinic with a primary diagnosis ofautistic Disorder (DSM-III-R and DSM-IV) completed the symptom checklist of the Yale-Brown Obsessive Compulsive Scale. Types of current obsessions and compulsions were evaluated. The comparison group consisted of 50 age- and sexmatched adults with obsessive-Compulsive Disorder (without tics) (DSM-III-R and DSM-IV). Results: Direct discriminant function analysis showed that the patients with autistic Disorder could be distinguished from those with obsessive-Compulsive Disorder on the basis of the types of current repetitive thoughts and behavior that they demonstrated. Compared to the obsessive-Compulsive group, the autistic patients were significantly less likely to experience thoughts with aggressive, contamination, sexual, religious, symmetry, and somatic content. Repetitive ordering; hoarding; telling or asking (trend); touching, tapping, or rubbing; and self-damaging or self-mutilating behavior occurred significantly more frequently in the autistic patients, whereas cleaning, checking, and counting behavior was less common in the autistic group than in the patients with obsessive-Compulsive Disorder. In addition, a specific subset of seven obsessive-Compulsive variables from the Yale-Brown Obsessive Compulsive Scale symptom checklist was identified that reliably predicted membership in the autistic group. Conclusions: These results suggest that the repetitive thoughts and behavior characteristic of autism differ significantly from the obsessive-Compulsive symptoms displayed by patients with obsessive-Compulsive Disorder. Future studies are warranted to assess the treatment response and neurobiological underpinnings ofrepetitive thoughts and behavior in patients with autism and obsessive-Compulsive Disorder.
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limited therapeutic effect of addition of buspirone in fluvoxamine refractory obsessive Compulsive Disorder
American Journal of Psychiatry, 1993Co-Authors: Christopher J Mcdougle, Wayne K Goodman, James F. Leckman, George R Heninger, L C Barr, Jacob C Holzer, Elinore F Mccancekatz, Lawrence H PriceAbstract:The authors found that buspirone added to the treatment of 33 patients with obsessive-Compulsive Disorder who were refractory to the serotonin reuptake inhibitor fluvoxamine was no better than placebo in reducing obsessive-Compulsive, depressive, or anxiety symptoms. This finding suggests that addition of buspirone to ongoing fluvoxamine therapy is not an effective treatment strategy for most patients with obsessive-Compulsive Disorder.
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the serotonin hypothesis of obsessive Compulsive Disorder implications of pharmacologic challenge studies
The Journal of Clinical Psychiatry, 1992Co-Authors: L C Barr, Wayne K Goodman, Lawrence H Price, Christopher J Mcdougle, Dennis S CharneyAbstract:Demonstration of the efficacy of serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitors such as clomipramine in the treatment of obsessive Compulsive Disorder has fueled interest in the neurobiological basis of this illness. Results of treatment studies, investigations of biolopical markers, and pharmacologic challenges are reviewed and implications for a 5-HT theory of obsessive Compulsive Disorder discussed. While the nature of the dysregulation in serotonin transmission that may attend obsessive Compulsive Disorder has yet to be fully elucidated
Daniel A Geller - One of the best experts on this subject based on the ideXlab platform.
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immune related comorbidities in childhood onset obsessive Compulsive Disorder lifetime prevalence in the obsessive Compulsive Disorder collaborative genetics association study
Journal of Child and Adolescent Psychopharmacology, 2019Co-Authors: Clara Westwellroper, Daniel A Geller, Kyle Williams, Jack Samuels, Joseph O Bienvenu, Bernadette Cullen, Fernando S Goes, Marco A Grados, Benjamin D Greenberg, James A KnowlesAbstract:Abstract Objective: To evaluate the lifetime prevalence of infectious, inflammatory, and autoimmune Disorders in a multisite study of probands with childhood-onset obsessive Compulsive Disorder (OC...
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immunoglobulin a dysgammaglobulinemia is associated with pediatric onset obsessive Compulsive Disorder
Journal of Child and Adolescent Psychopharmacology, 2019Co-Authors: Kyle Williams, Daniel A Geller, Leah Shorsergentile, Suraj Sarvode Mothi, Noah C Berman, Mark S Pasternack, Jolan E WalterAbstract:Abstract Background: Inflammation and immune dysregulation have been implicated in the pathogenesis of pediatric-onset obsessive-Compulsive Disorder (OCD) and tic Disorders such as Tourette syndrom...
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neurocognitive function in pediatric obsessive Compulsive Disorder
World Journal of Biological Psychiatry, 2018Co-Authors: Daniel A Geller, Lee Baer, Amitai Abramovitch, Andrew Mittelman, Abigail Stark, Kesley Ramsey, Allison Cooperman, Evelyn S StewartAbstract:Objectives: The small body of neuropsychological research in paediatric obsessive-Compulsive Disorder (OCD) yields inconsistent results. A recent meta-analysis found small effect sizes, concluding ...
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practice parameter for the assessment and treatment of children and adolescents with obsessive Compulsive Disorder
Journal of the American Academy of Child and Adolescent Psychiatry, 2012Co-Authors: Daniel A Geller, John S MarchAbstract:Research in etiology, neurobiology, genetics, clinical correlates, and evidence-based treatments in children and adolescents with obsessive-Compulsive Disorder indicate a need for the revision of the Practice Parameters for the Assessment and Treatment of Children and Adolescents with Obsessive-Compulsive Disorder first published a decade ago. The present article highlights the clinical assessment and reviews and summarizes the evidence base for treatment. Based on this evidence, specific recommendations are provided for assessment, cognitive behavioral therapy, pharmacotherapy, combined treatment, and other interventions.