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Shinya Kusachi - One of the best experts on this subject based on the ideXlab platform.

  • triple energy high count rate x ray Computed Tomography Scanner using a cooled cadmium telluride detector
    Radiation Detectors in Medicine Industry and National Security XIX, 2018
    Co-Authors: Hodaka Moriyama, Eiichi Sato, Satoshi Yamaguchi, Osahiko Hagiwara, Hiroshi Matsukiyo, Manabu Watanabe, Sohei Yoshida, Yuichi Sato, Toshiyuki Enomoto, Shinya Kusachi
    Abstract:

    To obtain three kinds of tomograms at three different X-ray energy ranges simultaneously, we have constructed a triple-energy (TE) X-ray photon counter with a cooled cadmium telluride (CdTe) detector and three sets of comparators and microcomputers. X-ray photons are detected using the CdTe detector, and the event pulses produced using amplifiers are sent to three comparators simultaneously to regulate three threshold energies of 15, 33 and 50 keV. Using this counter, the energy ranges are 15-33, 33-50 and 50-100 keV; the maximum energy corresponds to the tube voltage. We performed TE Computed Tomography (TE-CT) at a tube voltage of 100 kV. Using four lead pinholes, three tomograms were obtained simultaneously. Iodine-K-edge CT was carried out utilizing an energy range of 33-50 keV. At a tube voltage of 100 kV and a current of 0.11 mA, the count rate was 21 kilocounts per second (kcps).

  • triple energy high count rate x ray Computed Tomography Scanner using a cadmium telluride detector
    Health technology, 2018
    Co-Authors: Eiichi Sato, Satoshi Yamaguchi, Osahiko Hagiwara, Hiroshi Matsukiyo, Manabu Watanabe, Sohei Yoshida, Yuichi Sato, Toshiyuki Enomoto, Tsukuru Sato, Shinya Kusachi
    Abstract:

    To obtain three kinds of tomograms at three different X-ray energy ranges simultaneously, we have constructed a triple-energy (TE) X-ray photon counter with a cadmium telluride (CdTe) detector and three sets of comparators and microcomputers (MCs). X-ray photons are detected using the CdTe detector, and the event pulses produced using amplifiers are sent to three comparators simultaneously to regulate three threshold energies of 15, 33, and 50 keV. Using this counter, the energy ranges are 15–33, 33–50 and 50–100 keV; the maximum energy corresponds to the tube voltage. We performed TE Computed Tomography (TE-CT) at a tube voltage of 100 kV. Using a 0.5-mm-diam lead pinhole, three tomograms were obtained simultaneously. K-edge CT using iodine and gadolinium media was carried out utilizing two energy ranges of 33–50 and 50–100 keV, respectively. At a tube voltage of 100 kV and a current of 130 μA, the count rate was 33 kilocounts per second (kcps), and the minimum count rates after penetrating objects in TE-CT were regulated to approximately 2 kcps by the tube current.

  • Investigation of a near-infrared-ray Computed Tomography Scanner
    Radiation Detectors: Systems and Applications XVII, 2016
    Co-Authors: Eiichi Sato, Yasuyuki Oda, Yuichi Satoi, Satoshi Yamaguchi, Tomotaka Ishii, Osahiko Hagiwara, Hiroshi Matsukiyo, Manabu Watanabe, Shinya Kusachi
    Abstract:

    In the near-infrared-ray Computed Tomography (NIR-CT) Scanner, NIR rays are produced from a light-emitting diode (LED) and detected using an NIR phototransistor (PT). The wavelengths of the LED peak intensity and the PT high sensitivity in the data table are both 940 nm. The photocurrents flowing through the PTR are converted into voltages using an emitter-follower circuit, and the output voltages are sent to a personal computer through an analog-digital converter. The NIR projection curves for Tomography are obtained by repeated linear scans and rotations of the object, and the scanning is conducted in both directions of its movement.

Eiichi Sato - One of the best experts on this subject based on the ideXlab platform.

  • triple energy high count rate x ray Computed Tomography Scanner using a cooled cadmium telluride detector
    Radiation Detectors in Medicine Industry and National Security XIX, 2018
    Co-Authors: Hodaka Moriyama, Eiichi Sato, Satoshi Yamaguchi, Osahiko Hagiwara, Hiroshi Matsukiyo, Manabu Watanabe, Sohei Yoshida, Yuichi Sato, Toshiyuki Enomoto, Shinya Kusachi
    Abstract:

    To obtain three kinds of tomograms at three different X-ray energy ranges simultaneously, we have constructed a triple-energy (TE) X-ray photon counter with a cooled cadmium telluride (CdTe) detector and three sets of comparators and microcomputers. X-ray photons are detected using the CdTe detector, and the event pulses produced using amplifiers are sent to three comparators simultaneously to regulate three threshold energies of 15, 33 and 50 keV. Using this counter, the energy ranges are 15-33, 33-50 and 50-100 keV; the maximum energy corresponds to the tube voltage. We performed TE Computed Tomography (TE-CT) at a tube voltage of 100 kV. Using four lead pinholes, three tomograms were obtained simultaneously. Iodine-K-edge CT was carried out utilizing an energy range of 33-50 keV. At a tube voltage of 100 kV and a current of 0.11 mA, the count rate was 21 kilocounts per second (kcps).

  • 850 nm peak high sensitivity near infrared ray Computed Tomography Scanner in the living body window
    Health technology, 2018
    Co-Authors: Yuichi Sato, Eiichi Sato, Yasuyuki Oda, Osahiko Hagiwara, Hiroshi Matsukiyo, Sohei Yoshida, Tsukuru Sato, Akiko Takaoka, Hodaka Moriyama, Toshiyuki Enomoto
    Abstract:

    In the near-infrared-ray Computed Tomography (NIR-CT) Scanner, NIR photons are produced from a light-emitting diode (LED) and detected using a visible-ray (VR) phototransistor (PT) and an infrared filter. The LED-peak wavelength is 850 nm in the living-body (LB) window range, and the penetrating NIR photons are detected using the VR PT thorough an infrared filter and a 1.5-mm-diam 15-mm-length graphite collimator. The photocurrents flowing through the PT are converted into voltages using an emitter-follower circuit, and the output voltages are sent to a personal computer through an analog-digital converter. The NIR projection curves for Tomography are obtained by repeated translations and rotations of the object. The 850-nm-peak NIR photons penetrated LBs, and the NIR-CT was performed with changes in the relative sensitivities of 1 and 21.

  • triple energy high count rate x ray Computed Tomography Scanner using a cadmium telluride detector
    Health technology, 2018
    Co-Authors: Eiichi Sato, Satoshi Yamaguchi, Osahiko Hagiwara, Hiroshi Matsukiyo, Manabu Watanabe, Sohei Yoshida, Yuichi Sato, Toshiyuki Enomoto, Tsukuru Sato, Shinya Kusachi
    Abstract:

    To obtain three kinds of tomograms at three different X-ray energy ranges simultaneously, we have constructed a triple-energy (TE) X-ray photon counter with a cadmium telluride (CdTe) detector and three sets of comparators and microcomputers (MCs). X-ray photons are detected using the CdTe detector, and the event pulses produced using amplifiers are sent to three comparators simultaneously to regulate three threshold energies of 15, 33, and 50 keV. Using this counter, the energy ranges are 15–33, 33–50 and 50–100 keV; the maximum energy corresponds to the tube voltage. We performed TE Computed Tomography (TE-CT) at a tube voltage of 100 kV. Using a 0.5-mm-diam lead pinhole, three tomograms were obtained simultaneously. K-edge CT using iodine and gadolinium media was carried out utilizing two energy ranges of 33–50 and 50–100 keV, respectively. At a tube voltage of 100 kV and a current of 130 μA, the count rate was 33 kilocounts per second (kcps), and the minimum count rates after penetrating objects in TE-CT were regulated to approximately 2 kcps by the tube current.

  • Investigation of a high-sensitivity near-infrared-ray Computed Tomography Scanner
    Radiation Detectors in Medicine Industry and National Security XVIII, 2017
    Co-Authors: Eiichi Sato, Yasuyuki Oda, Satoshi Yamaguchi, Tomotaka Ishii, Osahiko Hagiwara, Hiroshi Matsukiyo, Sohei Yoshida, Yuichi Sato, Toshiyuki Enomoto, Manabu Watanabe
    Abstract:

    In the near-infrared-ray Computed Tomography (NIR-CT) Scanner, NIR rays are produced from a light-emitting diode (LED) and detected using a phototransistor (PT) and an infrared filter. The LED-peak wavelength is 850 nm, and 850- nm-peak NIRs are detected using the filtrated PD. The photocurrents flowing through the PT are converted into voltages using an emitter-follower circuit, and the output voltages are sent to a personal computer through an analog-digital converter. The NIR projection curves for Tomography are obtained by repeated translations and rotations of the object, and the translating is conducted in both directions of its movement. The 850-nm NIRs easily penetrated living bodies, and the NIR-CT was performed with changes in the sensitivity at relative sensitivities of 1 and 21.

  • Investigation of a near-infrared-ray Computed Tomography Scanner
    Radiation Detectors: Systems and Applications XVII, 2016
    Co-Authors: Eiichi Sato, Yasuyuki Oda, Yuichi Satoi, Satoshi Yamaguchi, Tomotaka Ishii, Osahiko Hagiwara, Hiroshi Matsukiyo, Manabu Watanabe, Shinya Kusachi
    Abstract:

    In the near-infrared-ray Computed Tomography (NIR-CT) Scanner, NIR rays are produced from a light-emitting diode (LED) and detected using an NIR phototransistor (PT). The wavelengths of the LED peak intensity and the PT high sensitivity in the data table are both 940 nm. The photocurrents flowing through the PTR are converted into voltages using an emitter-follower circuit, and the output voltages are sent to a personal computer through an analog-digital converter. The NIR projection curves for Tomography are obtained by repeated linear scans and rotations of the object, and the scanning is conducted in both directions of its movement.

Kazuro Miyahara - One of the best experts on this subject based on the ideXlab platform.

  • Measurements of body surface area and volume in male Japanese White rabbits using a Computed Tomography Scanner: comparison with male New Zealand White rabbits.
    Experimental animals, 2019
    Co-Authors: Tadashi Itoh, Mifumi Kawabe, Takahiko Nagase, Masafumi Miyoshi, Katsumi Endo, Kazuro Miyahara
    Abstract:

    The body surface area (BSA) of animals has generally been estimated by multiplying the k value by the measured body weight (BW) raised to the power of 2/3 (Meeh's formula). In mathematical terms, the assumption that the density and body shape of animals are essentially constant means that the BSA is proportional to BW2/3. In this study, we measured the BSA and volume of 50 male Japanese White rabbits (JW) at 10 to 54 weeks of age using a Computed Tomography Scanner, then calculated the k value, density, and sphericity. The variations in these parameters were then analyzed in relation to growth. The obtained results indicated that the k value was negatively correlated to BW, and that this negative correlation was mainly due to the variation in density. Based on the regression analysis, we propose the following linear regression equation for calculating the k value in male JW at 10-54 weeks of age: the k value = 14.602 - 0.959 × BW [kg]. The calculated values ranged from 10.9 to 12.7 (working BW range: 1.98 to 3.81 kg). The k value of male New Zealand White rabbits (NZW) determined in our previous study and that of male JW in the present study were compared. It was revealed that the k value of male JW was larger than that of male NZW. We concluded that different breeds of rabbits express different k values.

  • Measurements of body surface area and volume in laboratory rabbits (New Zealand White rabbits) using a Computed Tomography Scanner.
    Experimental animals, 2018
    Co-Authors: Tadashi Itoh, Mifumi Kawabe, Takahiko Nagase, Masafumi Miyoshi, Tsuneo Koike, Kazuro Miyahara
    Abstract:

    The body surface area (BSA) of an organism is one of the important parameters for evaluating physiological functions. In drug development, normalization by BSA is an appropriate method for extrapolating doses between species. The BSA of animals has generally been estimated by multiplying the k value by 2/3 of the power of the body weight (BW) (Meeh's formula). In mathematics, if it is assumed that the density and body shape of the animals are essentially constant, the BSA is proportional to BW2/3. In this study, we measured the BSA and volume (V) of 72 laboratory rabbits (48 males and 24 females of New Zealand White rabbits [NZW]), using a Computed Tomography Scanner. After BSA and V determination, the k value, density, and sphericity were calculated. We analyzed variations in the k value, density, and body shape of laboratory rabbits. The mean k value of the 72 NZW was 11.0. We advocate using Meeh's formula, as follows, for estimating BSA of laboratory rabbits (NZW): 100 × BSA [m2] = 11.0 × BW [kg]2/3.

  • body surface area measurement in juvenile miniature pigs using a Computed Tomography Scanner
    Experimental Animals, 2017
    Co-Authors: Tadashi Itoh, Mifumi Kawabe, Takahiko Nagase, Hisami Matsushita, Masami Kato, Masafumi Miyoshi, Kazuro Miyahara
    Abstract:

    The use of miniature pigs in non-clinical studies for medical drugs or devices has gradually been increasing in recent years. It is anticipated that the use of juvenile miniature pigs in laboratory practice will also increase. Therefore, it is important to investigate various parameters of juvenile miniature pigs. The body surface area (BSA) of an organism is one of the important parameters for evaluating physiological functions. In drug development, normalization by BSA is an appropriate method for extrapolating doses between species. The BSA of animals has generally been estimated by multiplying the k value by 2/3 of the power of the body weight (BW) (Meeh’s formula). To our knowledge, the BSA of juvenile miniature pigs has not as yet been reported. In this study, we measured the BSA of 13 miniature pigs less than 1 month old, using a Computed Tomography Scanner and 3-dimensional analysis software. The measurement results showed the BSAs of these 13 juvenile miniature pigs to be in the range of 386 to 1,672 cm2(working BW range: 278 to 3,200 g). After BSA determination, the k values were calculated from the BSA and the BW. The mean calculated k value was 8.58. We advocate using Meeh’s formula, as follows, for estimating the BSA of juvenile miniature pigs less than 1 month old (before weaning): BSA (cm2)=8.58 × BW (g)2/3.

  • body surface area measurement in laboratory miniature pigs using a Computed Tomography Scanner
    Journal of Toxicological Sciences, 2016
    Co-Authors: Tadashi Itoh, Mifumi Kawabe, Takahiko Nagase, Masafumi Miyoshi, Katsumi Endo, Kazuro Miyahara
    Abstract:

    The body surface area (BSA) of an organism is an important parameter for evaluating physiological functions. In drug development, normalization by BSA is an appropriate method for extrapolating doses between species. The BSA of animals has generally been estimated by multiplying a constant by the power of the body weight (BW). Recently, the use of miniature pigs in non-clinical studies for medical drugs or devices has gradually been increasing. However, verification of their BSA is not as yet sufficient. In this study, we measured the BSAs of 40 laboratory miniature pigs (11 males and 9 females of Gottingen minipig and 14 males and 6 females of Nippon Institute for Biological Science [NIBS] miniature pig) by analyzing Computed Tomography (CT) images, since measurements using a CT Scanner were expected to more precisely determine BSA than classical measuring techniques. The measurement results showed the BSAs of the 20 Gottingen minipigs to range from 0.4358 to 0.8356 m(2) (the working BW range: 12.7-37.0 kg) and 20 NIBS miniature pigs to range from 0.2906 to 0.8675 m(2) (the working BW range: 7.9-41.5 kg). Since accuracy and reproducibility were confirmed by measuring the surface area of an acrylic cuboid, we concluded the measurement method employed in this study to be very reliable. We propose the following estimating formula for BSA of laboratory miniature pigs: 100 × BSA [m(2)] = 7.98 × BW [kg](2/3).

Andrew D. Austin - One of the best experts on this subject based on the ideXlab platform.

  • novel use of a micro Computed Tomography Scanner to trace larvae of wood boring insects
    Australian Journal of Entomology, 2011
    Co-Authors: John T Jennings, Andrew D. Austin
    Abstract:

    Tracing the tunnels of wood boring larvae in wood or other plant material is generally a difficult and destructive process. Here we present a novel non-destructive method using an in vivo micro-CT Scanner to obtain tomograms of small tunnels. The tunnels were formed by larval xiphydriid woodwasps in the branches of the Tasmanian tree Anodopetalum biglandulosum (Cunoniaceae) and show that, as the larvae develop, the tunnels become progressively larger until pupation occurs just below the surface of the bark. The adult then chews its way through the remaining wood and bark before emerging. This non-destructive method is discussed more broadly in regard to its application for tracing the tunnels of wood boring insects, for detecting insects in grain and other plant material for quarantine purposes, and for tracking the tunnelling behaviour and development of live insects in wood.

  • Novel use of a micro‐Computed Tomography Scanner to trace larvae of wood boring insects
    Australian Journal of Entomology, 2010
    Co-Authors: John T Jennings, Andrew D. Austin
    Abstract:

    Tracing the tunnels of wood boring larvae in wood or other plant material is generally a difficult and destructive process. Here we present a novel non-destructive method using an in vivo micro-CT Scanner to obtain tomograms of small tunnels. The tunnels were formed by larval xiphydriid woodwasps in the branches of the Tasmanian tree Anodopetalum biglandulosum (Cunoniaceae) and show that, as the larvae develop, the tunnels become progressively larger until pupation occurs just below the surface of the bark. The adult then chews its way through the remaining wood and bark before emerging. This non-destructive method is discussed more broadly in regard to its application for tracing the tunnels of wood boring insects, for detecting insects in grain and other plant material for quarantine purposes, and for tracking the tunnelling behaviour and development of live insects in wood.

Hiroshi Matsukiyo - One of the best experts on this subject based on the ideXlab platform.

  • triple energy high count rate x ray Computed Tomography Scanner using a cooled cadmium telluride detector
    Radiation Detectors in Medicine Industry and National Security XIX, 2018
    Co-Authors: Hodaka Moriyama, Eiichi Sato, Satoshi Yamaguchi, Osahiko Hagiwara, Hiroshi Matsukiyo, Manabu Watanabe, Sohei Yoshida, Yuichi Sato, Toshiyuki Enomoto, Shinya Kusachi
    Abstract:

    To obtain three kinds of tomograms at three different X-ray energy ranges simultaneously, we have constructed a triple-energy (TE) X-ray photon counter with a cooled cadmium telluride (CdTe) detector and three sets of comparators and microcomputers. X-ray photons are detected using the CdTe detector, and the event pulses produced using amplifiers are sent to three comparators simultaneously to regulate three threshold energies of 15, 33 and 50 keV. Using this counter, the energy ranges are 15-33, 33-50 and 50-100 keV; the maximum energy corresponds to the tube voltage. We performed TE Computed Tomography (TE-CT) at a tube voltage of 100 kV. Using four lead pinholes, three tomograms were obtained simultaneously. Iodine-K-edge CT was carried out utilizing an energy range of 33-50 keV. At a tube voltage of 100 kV and a current of 0.11 mA, the count rate was 21 kilocounts per second (kcps).

  • 850 nm peak high sensitivity near infrared ray Computed Tomography Scanner in the living body window
    Health technology, 2018
    Co-Authors: Yuichi Sato, Eiichi Sato, Yasuyuki Oda, Osahiko Hagiwara, Hiroshi Matsukiyo, Sohei Yoshida, Tsukuru Sato, Akiko Takaoka, Hodaka Moriyama, Toshiyuki Enomoto
    Abstract:

    In the near-infrared-ray Computed Tomography (NIR-CT) Scanner, NIR photons are produced from a light-emitting diode (LED) and detected using a visible-ray (VR) phototransistor (PT) and an infrared filter. The LED-peak wavelength is 850 nm in the living-body (LB) window range, and the penetrating NIR photons are detected using the VR PT thorough an infrared filter and a 1.5-mm-diam 15-mm-length graphite collimator. The photocurrents flowing through the PT are converted into voltages using an emitter-follower circuit, and the output voltages are sent to a personal computer through an analog-digital converter. The NIR projection curves for Tomography are obtained by repeated translations and rotations of the object. The 850-nm-peak NIR photons penetrated LBs, and the NIR-CT was performed with changes in the relative sensitivities of 1 and 21.

  • triple energy high count rate x ray Computed Tomography Scanner using a cadmium telluride detector
    Health technology, 2018
    Co-Authors: Eiichi Sato, Satoshi Yamaguchi, Osahiko Hagiwara, Hiroshi Matsukiyo, Manabu Watanabe, Sohei Yoshida, Yuichi Sato, Toshiyuki Enomoto, Tsukuru Sato, Shinya Kusachi
    Abstract:

    To obtain three kinds of tomograms at three different X-ray energy ranges simultaneously, we have constructed a triple-energy (TE) X-ray photon counter with a cadmium telluride (CdTe) detector and three sets of comparators and microcomputers (MCs). X-ray photons are detected using the CdTe detector, and the event pulses produced using amplifiers are sent to three comparators simultaneously to regulate three threshold energies of 15, 33, and 50 keV. Using this counter, the energy ranges are 15–33, 33–50 and 50–100 keV; the maximum energy corresponds to the tube voltage. We performed TE Computed Tomography (TE-CT) at a tube voltage of 100 kV. Using a 0.5-mm-diam lead pinhole, three tomograms were obtained simultaneously. K-edge CT using iodine and gadolinium media was carried out utilizing two energy ranges of 33–50 and 50–100 keV, respectively. At a tube voltage of 100 kV and a current of 130 μA, the count rate was 33 kilocounts per second (kcps), and the minimum count rates after penetrating objects in TE-CT were regulated to approximately 2 kcps by the tube current.

  • Investigation of a high-sensitivity near-infrared-ray Computed Tomography Scanner
    Radiation Detectors in Medicine Industry and National Security XVIII, 2017
    Co-Authors: Eiichi Sato, Yasuyuki Oda, Satoshi Yamaguchi, Tomotaka Ishii, Osahiko Hagiwara, Hiroshi Matsukiyo, Sohei Yoshida, Yuichi Sato, Toshiyuki Enomoto, Manabu Watanabe
    Abstract:

    In the near-infrared-ray Computed Tomography (NIR-CT) Scanner, NIR rays are produced from a light-emitting diode (LED) and detected using a phototransistor (PT) and an infrared filter. The LED-peak wavelength is 850 nm, and 850- nm-peak NIRs are detected using the filtrated PD. The photocurrents flowing through the PT are converted into voltages using an emitter-follower circuit, and the output voltages are sent to a personal computer through an analog-digital converter. The NIR projection curves for Tomography are obtained by repeated translations and rotations of the object, and the translating is conducted in both directions of its movement. The 850-nm NIRs easily penetrated living bodies, and the NIR-CT was performed with changes in the sensitivity at relative sensitivities of 1 and 21.

  • Investigation of a near-infrared-ray Computed Tomography Scanner
    Radiation Detectors: Systems and Applications XVII, 2016
    Co-Authors: Eiichi Sato, Yasuyuki Oda, Yuichi Satoi, Satoshi Yamaguchi, Tomotaka Ishii, Osahiko Hagiwara, Hiroshi Matsukiyo, Manabu Watanabe, Shinya Kusachi
    Abstract:

    In the near-infrared-ray Computed Tomography (NIR-CT) Scanner, NIR rays are produced from a light-emitting diode (LED) and detected using an NIR phototransistor (PT). The wavelengths of the LED peak intensity and the PT high sensitivity in the data table are both 940 nm. The photocurrents flowing through the PTR are converted into voltages using an emitter-follower circuit, and the output voltages are sent to a personal computer through an analog-digital converter. The NIR projection curves for Tomography are obtained by repeated linear scans and rotations of the object, and the scanning is conducted in both directions of its movement.