The Experts below are selected from a list of 324 Experts worldwide ranked by ideXlab platform
Noah A Rosenberg - One of the best experts on this subject based on the ideXlab platform.
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the probability of topological Concordance of gene trees and species trees
Theoretical Population Biology, 2002Co-Authors: Noah A RosenbergAbstract:Abstract The Concordance of gene trees and species trees is reconsidered in detail, allowing for samples of arbitrary size to be taken from the species. A sense of Concordance for gene tree and species tree topologies is clarified, such that if the “collapsed gene tree” produced by a gene tree has the same topology as the species tree, the gene tree is said to be topologically concordant with the species tree. The term speciodendric is introduced to refer to genes whose trees are topologically concordant with species trees. For a given three-species topology, probabilities of each of the three possible collapsed gene tree topologies are given, as are probabilities of monophyletic Concordance and Concordance in the sense of N. Takahata (1989), Genetics 122, 957–966. Increasing the sample size is found to increase the probability of topological Concordance, but a limit exists on how much the topological Concordance probability can be increased. Suggested sample sizes beyond which this probability can be increased only minimally are given. The results are discussed in terms of implications for molecular studies of phylogenetics and speciation.
Lili Miles - One of the best experts on this subject based on the ideXlab platform.
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multimodality imaging in the surgical treatment of children with nonlesional epilepsy
Neurology, 2011Co-Authors: Katherine D Holland, Douglas F Rose, Leonid Rozhkov, Hisako Fujiwara, Anna W Byars, Todd M Arthur, Ton Degrauw, James L Leach, Michael J Gelfand, Lili MilesAbstract:Objectives: To evaluate the diagnostic value of individual noninvasive presurgical modalities and to study their role in surgical management of nonlesional pediatric epilepsy patients. Methods: We retrospectively studied 14 children (3–18 years) with nonlesional intractable focal epilepsy. Clinical characteristics, surgical outcome, localizing features on 3 presurgical diagnostic tests (subtraction peri-ictal SPECT coregistered to MRI [SISCOM], statistical parametric mapping [SPM] analysis of [18F] FDG-PET, magnetoencephalography [MEG]), and intracranial EEG (iEEG) were reviewed. The localization of each individual test was determined for lobar location by visual inspection. Concordance of localization between each test and iEEG was scored as follows: 2 = lobar Concordance; 1 = hemispheric Concordance; 0 = discordance or nonlocalization. Total Concordance score in each patient was measured by the summation of Concordance scores for all 3 tests. Results: Seven (50%) of 14 patients were seizure-free for at least 12 months after surgery. One (7%) had only rare seizures and 6 (43%) had persistent seizures. MEG (79%, 11/14) and SISCOM (79%, 11/14) showed greater lobar Concordance with iEEG than SPM-PET (13%, 3/14) (p Conclusions: Our data suggest that MEG and SISCOM are better tools for lobar localization than SPM analysis of FDG-PET in children with nonlesional epilepsy. A multimodality approach may improve surgical outcome as well as selection of surgical candidates in patients without MRI abnormalities.
Jouko Lonnqvist - One of the best experts on this subject based on the ideXlab platform.
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high Concordance of bipolar i disorder in a nationwide sample of twins
American Journal of Psychiatry, 2004Co-Authors: Tuula Kieseppa, Timo Partonen, Jari Haukka, Jaakko Kaprio, Jouko LonnqvistAbstract:OBJECTIVE: The few studies of bipolar I disorder in twins have consistently emphasized the genetic contribution to disease liability. The authors report what appears to be the first twin study of bipolar I disorder involving a population-based twin sample, in which the diagnoses were made by using structured, personal interviews. METHOD: All Finnish same-sex twins (N=19,124) born from 1940 to 1957 were screened for a diagnosis of bipolar I disorder as recorded in the National Hospital Discharge Register between 1969 and 1991 or self-reported in surveys of the Finnish Twin Cohort in 1975, 1981, and 1990. Thirty-eight pairs were thereby identified and invited to participate in the study; the participation rate was 68%. Lifetime diagnoses were made by using the Structured Clinical Interview for DSM-IV. The authors calculated probandwise and pairwise Concordances and correlations in liability and applied biometrical model fitting. RESULTS: The probandwise Concordance rates were 0.43 (95% CI=0.10 to 0.82) for ...
Stefan Friedl - One of the best experts on this subject based on the ideXlab platform.
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Link Concordance, boundary link Concordance and eta-invariants
Mathematical Proceedings of the Cambridge Philosophical Society, 2005Co-Authors: Stefan FriedlAbstract:We study eta-invariants of links and show that in many cases they form link Concordance invariants, in particular that many eta-invariants vanish for slice links. This result contains and generalizes previous invariants by Smolinsky and Cha–Ko. We give a formula for the eta-invariant for boundary links. In several interesting cases this allows us to show that a given link is not slice. We show that even more eta-invariants have to vanish for boundary slice links.
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Link Concordance, boundary link Concordance and eta invariants
arXiv: Geometric Topology, 2003Co-Authors: Stefan FriedlAbstract:We study the eta-invariants of links and show that in many cases they form link Concordance invariants, in particular that many eta-invariants vanish for slice links. This result contains and generalizes previous invariants by Smolinsky and Cha--Ko. We give a formula for the eta-invariant for boundary links. In several intersting cases this allows us to show that a given link is not slice. We show that even more eta-invariants have to vanish for boundary slice links. We give an example of a boundary link $L$ that is not boundary slice but where all the known link Concordance invariants computed so far are zero.
Nikolas Zolas - One of the best experts on this subject based on the ideXlab platform.
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getting patents and economic data to speak to each other an algorithmic links with probabilities approach for joint analyses of patenting and economic activity
Research Policy, 2014Co-Authors: Travis J Lybbert, Nikolas ZolasAbstract:International technological diffusion is a key determinant of cross-country differences in economic performance. While patents can be a useful proxy for innovation and technological change and diffusion, fully exploiting patent data for such economic analyses requires patents to be tied to measures of economic activity. In this paper, we describe and explore a new algorithmic approach to constructing Concordances between the International Patent Classification (IPC) system that organizes patents by technical features and industry classification systems that organize economic data, such as the Standard International Trade Classification (SITC) and the International Standard Industrial Classification (ISIC). This ‘Algorithmic Links with Probabilities’ (ALP) approach mines patent data using keywords extracted from industry descriptions and processes the resulting matches using a probabilistic framework. We compare the results of this ALP Concordance to existing technology Concordances. Based on these comparisons, we discuss advantages of this approach relative to conventional approaches. ALP Concordances provide a meso-level mapping to industries that complements existing macro- and firm-level mappings – and open new possibilities for empirical patent analysis.
