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Khalid Yunis - One of the best experts on this subject based on the ideXlab platform.
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The effect of Consanguinity on neonatal outcomes and health.
Human Heredity, 2014Co-Authors: Hussein A. Abbas, Khalid YunisAbstract:Consanguineous marriages constitute a significant fraction of marriages worldwide and confer a major public health concern on newborns. In addition to the risk of acquiring a recessive genetic disease, the offspring of consanguineous parents are plausibly at an increased risk of preterm birth, decreased anthropometric measurements, congenital defects and mortality. How Consanguinity confers such an increased risk is still largely unknown. In this review, we discuss the effect of Consanguinity on selected gestational outcomes by delineating the different studies that have led to such findings. We also investigate the different conclusions that have emerged regarding the effect of Consanguinity on gestational outcomes.
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Consanguinity and reproductive wastage in the Palestinian Territories.
Paediatric and Perinatal Epidemiology, 2009Co-Authors: Shireen Assaf, Marwan Khawaja, Jocelyn Dejong, Ziad Mahfoud, Khalid YunisAbstract:Many studies have found that Consanguinity poses a threat to child mortality and health and can also pose a threat to offspring survival before birth. However there are conflicting findings with some studies having found no increased risk on offspring survival associated with Consanguinity. Data from a population-based survey conducted in 2004 in the Palestinian Territories was used to assess the risk of Consanguinity on offspring survival. The analysis was conducted on 4418 women aged 15-49 who were asked whether or not they had experienced a stillbirth or a spontaneous abortion. These two outcomes were combined together for the analysis of reproductive wastage. Multivariable negative binomial regression was conducted to calculate the incidence risk ratios (IRR) for each region in the Palestinian Territories separately. The strongest risk factors for reproductive wastage after controlling for other variables were found to be Consanguinity age and parity with age presenting the highest IRRs. Standard of living locality type education level womens employment and past intrauterine device use were not found to be significant risk factors for reproductive wastage. In the West Bank only first cousin level of Consanguinity was found to be significant and hamola level (or from same family clan) lost its significance after adjusting for other variables. In the Gaza Strip both the first cousin and hamola levels of Consanguinity were significant and presented almost equal IRRs of 1.3. In conclusion Consanguinity was found to be a significant risk factor for reproductive wastage.
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effect of Consanguinity on birth weight for gestational age in a developing country
American Journal of Epidemiology, 2007Co-Authors: Ghina R Mumtaz, Marwan Khawaja, Hala Tamim, Mona Kanaan, Mustafa Khogali, Gerard Wakim, Khalid YunisAbstract:: Consanguinity, the marriage between relatives, has been associated with adverse child health outcomes because it increases homozygosity of recessive alleles. The objective of this study was to assess the effect of Consanguinity on the birth weight of newborns in Greater Beirut, Lebanon. Cross-sectional data were collected on 10,289 consecutive liveborn singleton newborns admitted to eight hospitals belonging to the National Collaborative Perinatal Neonatal Network during the years 2000 and 2001. Birth weight was modeled by use of the fetal growth ratio, defined as the ratio of the observed birth weight to the median birth weight for gestational age. A mixed-effect multiple linear regression model was used to predict the net effect of first- and second-cousin marriage on the birth weight for gestational age, accounting for within-hospital clustering of data. After controlling for medical and sociodemographic covariates, the authors found a statistically significant negative association between Consanguinity and birth weight at each gestational age. No significant difference was observed in the decrease in birth weight between the first- and second-cousin marriages. Overall, Consanguinity was associated with a decrease in birth weight for gestational age by 1.8% (beta = -0.018, 95% confidence interval: -0.027, -0.008). The largest effects on fetal growth were seen with lower parity and smoking during pregnancy.
Marwan Khawaja - One of the best experts on this subject based on the ideXlab platform.
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Consanguinity and reproductive wastage in the Palestinian Territories.
Paediatric and Perinatal Epidemiology, 2009Co-Authors: Shireen Assaf, Marwan Khawaja, Jocelyn Dejong, Ziad Mahfoud, Khalid YunisAbstract:Many studies have found that Consanguinity poses a threat to child mortality and health and can also pose a threat to offspring survival before birth. However there are conflicting findings with some studies having found no increased risk on offspring survival associated with Consanguinity. Data from a population-based survey conducted in 2004 in the Palestinian Territories was used to assess the risk of Consanguinity on offspring survival. The analysis was conducted on 4418 women aged 15-49 who were asked whether or not they had experienced a stillbirth or a spontaneous abortion. These two outcomes were combined together for the analysis of reproductive wastage. Multivariable negative binomial regression was conducted to calculate the incidence risk ratios (IRR) for each region in the Palestinian Territories separately. The strongest risk factors for reproductive wastage after controlling for other variables were found to be Consanguinity age and parity with age presenting the highest IRRs. Standard of living locality type education level womens employment and past intrauterine device use were not found to be significant risk factors for reproductive wastage. In the West Bank only first cousin level of Consanguinity was found to be significant and hamola level (or from same family clan) lost its significance after adjusting for other variables. In the Gaza Strip both the first cousin and hamola levels of Consanguinity were significant and presented almost equal IRRs of 1.3. In conclusion Consanguinity was found to be a significant risk factor for reproductive wastage.
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Consanguinity TRENDS AND CORRELATES IN THE PALESTINIAN TERRITORIES
Journal of Biosocial Science, 2008Co-Authors: Shireen Assaf, Marwan KhawajaAbstract:. Secondary analysis of the trends and correlates of Consanguinity in the Palestinian Territories was conducted using data from two separate surveys in 1995 and 2004. The analysis was conducted on ever-married women aged 15-54 who were asked about their relation to their husband in both surveys. A total of 16,197 women in 1995 and 4971 women in 2004 were successfully interviewed. Consanguinity was found to be widely practised in the Palestinian Territories with rates of total Consanguinity reaching 45% of all marriages in 2004. Analysis was conducted with the data from the two surveys combined and this indicated that Consanguinity was significantly decreasing with time after controlling for other variables. Age of the women, their age at marriage, region and locality type they lived in and their standard of living were all found to be significant predictors of Consanguinity. The education level of the women was not found to be significant. After controlling for the survey year, women's labour force status was also found to be a non-significant predictor of Consanguinity. Although Consanguinity was found to be significantly decreasing slowly with time after controlling for other variables, the future trends of Consanguinity are not known due to the unstable political situation in the territories, which could have a direct effect on marriage patterns.
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effect of Consanguinity on birth weight for gestational age in a developing country
American Journal of Epidemiology, 2007Co-Authors: Ghina R Mumtaz, Marwan Khawaja, Hala Tamim, Mona Kanaan, Mustafa Khogali, Gerard Wakim, Khalid YunisAbstract:: Consanguinity, the marriage between relatives, has been associated with adverse child health outcomes because it increases homozygosity of recessive alleles. The objective of this study was to assess the effect of Consanguinity on the birth weight of newborns in Greater Beirut, Lebanon. Cross-sectional data were collected on 10,289 consecutive liveborn singleton newborns admitted to eight hospitals belonging to the National Collaborative Perinatal Neonatal Network during the years 2000 and 2001. Birth weight was modeled by use of the fetal growth ratio, defined as the ratio of the observed birth weight to the median birth weight for gestational age. A mixed-effect multiple linear regression model was used to predict the net effect of first- and second-cousin marriage on the birth weight for gestational age, accounting for within-hospital clustering of data. After controlling for medical and sociodemographic covariates, the authors found a statistically significant negative association between Consanguinity and birth weight at each gestational age. No significant difference was observed in the decrease in birth weight between the first- and second-cousin marriages. Overall, Consanguinity was associated with a decrease in birth weight for gestational age by 1.8% (beta = -0.018, 95% confidence interval: -0.027, -0.008). The largest effects on fetal growth were seen with lower parity and smoking during pregnancy.
Ana H Heller - One of the best experts on this subject based on the ideXlab platform.
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frequent detection of parental Consanguinity in children with developmental disorders by a combined cgh and snp microarray
Molecular Cytogenetics, 2013Co-Authors: Yao Shan Fan, Xiaomei Ouyang, Jinghong Peng, Stephanie Sacharow, Mustafa Tekin, Deborah Barbouth, Olaf Bodamer, Roman Yusupov, Christina Navarrete, Ana H HellerAbstract:Background Genomic microarrays have been used as the first-tier cytogenetic diagnostic test for patients with developmental delay/intellectual disability, autism spectrum disorders and/or multiple congenital anomalies. The use of SNP arrays has revealed regions of homozygosity in the genome which can lead to identification of uniparental disomy and parental Consanguinity in addition to copy number variations. Consanguinity is associated with an increased risk of birth defects and autosomal recessive disorders. However, the frequency of parental Consanguinity in children with developmental disabilities is unknown, and consanguineous couples may not be identified during doctor’s visit or genetic counseling without microarray.
Pascale Salameh - One of the best experts on this subject based on the ideXlab platform.
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Consanguinity in lebanon prevalence distribution and determinants
Journal of Biosocial Science, 2009Co-Authors: B Barbour, Pascale SalamehAbstract:The union of individuals with a common ancestor may lead to serious health consequences in their offspring. Consanguinity is high in Middle Eastern communities; it was around 26% in 1988. The objective of this study was to determine the prevalence of Consanguinity in Beirut and other Lebanese regions, and its associated factors in different subgroups. The cross-sectional study was performed on a convenience sample of married women in Lebanon. The women were administered a standardized questionnaire in a face-to-face interview by independent enquirers. Among 1556 women, the overall prevalence of consanguineous marriages was 35.5%, and the Consanguinity coefficient was 0.020; 968 marriages (62.2%) were not consanguineous, 492 (31.6%) were first cousin, 61 (3.9%) were second cousin and 36 (2.3%) had lower degrees of Consanguinity. Beirut suburb dwelling, low education subgroups, women working in the home and non-Christian religion presented the highest rates of Consanguinity (p<0.05). Consanguinity is associated with couples' nulliparity and child chronic morbidity. Factors that could affect Consanguinity are having consanguineous parents, having a favourable opinion towards Consanguinity, choosing a spouse for religious reasons, particularly in Islam, woman having a low education, woman working in the home and women thinking that Consanguinity would not lead to serious diseases. Consanguinity is therefore still a prevailing problem in Lebanon. Specific health education, and genetic counselling in particular, are suggested to explain the consequences of Consanguinity to the general population and to help couples make informed choices.
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Consanguinity in Lebanon: prevalence, distribution and determinants.
Journal of Biosocial Science, 2009Co-Authors: B Barbour, Pascale SalamehAbstract:The union of individuals with a common ancestor may lead to serious health consequences in their offspring. Consanguinity is high in Middle Eastern communities; it was around 26% in 1988. The objective of this study was to determine the prevalence of Consanguinity in Beirut and other Lebanese regions, and its associated factors in different subgroups. The cross-sectional study was performed on a convenience sample of married women in Lebanon. The women were administered a standardized questionnaire in a face-to-face interview by independent enquirers. Among 1556 women, the overall prevalence of consanguineous marriages was 35.5%, and the Consanguinity coefficient was 0.020; 968 marriages (62.2%) were not consanguineous, 492 (31.6%) were first cousin, 61 (3.9%) were second cousin and 36 (2.3%) had lower degrees of Consanguinity. Beirut suburb dwelling, low education subgroups, women working in the home and non-Christian religion presented the highest rates of Consanguinity (p
Mordechai Shohat - One of the best experts on this subject based on the ideXlab platform.
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Consanguinity and common adult diseases in Israeli Arab communities.
American Journal of Medical Genetics, 1997Co-Authors: Lutfi Jaber, Tamar Shohat, Jerome I. Rotter, Mordechai ShohatAbstract:Consanguinity has a deleterious effect with regard to congenital malformation and rare autosomal recessive diseases; however, little information exists on its role in multifactorial common adult morbidity. We investigated the effects of Consanguinity on the prevalence of common diseases in adulthood, including diabetes mellitus, myocardial infarction, bronchial asthma, and duodenal ulcer. As part of a larger study investigating the inbreeding coefficient in the Israeli-Arab community, we distributed questionnaires to parents of 4,100 second-grade students in 158 randomly chosen schools. Among the 3,772 responders (92%), 34.8% of the students' fathers and 31% of their mothers were found to be born to consanguineous matings. There was no difference in the prevalence (males, females) between the offspring of consanguineous versus non-consanguineous matings for diabetes mellitus (Consanguinity: 4.3%, 1.5% vs. non-Consanguinity: 2.9%, 1.6%) myocardial infarction (2.7%, 0.03% vs. 2.3%, 0.03%), bronchial asthma (2.4%, 2.0% vs. 3.7%, 2.3%), or duodenal ulcer (7.0%, 3.0% vs. 7.8%, 2.9%), respectively. The study suggests that even in a population with a high rate of Consanguinity, there is no significant increase in the prevalence of these common adult diseases. Am. J. Med. Genet. 70:346–348, 1997. © 1997 Wiley-Liss, Inc.
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Demographic characteristics of the Israeli Arab community in connection with Consanguinity.
Israel journal of medical sciences, 1996Co-Authors: Jaber L, Mordechai ShohatAbstract:In a previous nationwide survey of the Israeli Arab community we showed that 44% of all marriages are consanguineous. Further analysis of the data from this previous survey was undertaken, and we defined six demographic characteristics that may be associated with Consanguinity or non-Consanguinity in the marriages. Of these, we found a significant correlation (P
