The Experts below are selected from a list of 38349 Experts worldwide ranked by ideXlab platform
Sanjay Garg - One of the best experts on this subject based on the ideXlab platform.
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CHAPTER 10:Swelling-Controlled Drug Delivery Systems
Biomaterials Science Series, 2018Co-Authors: Thomas G. Barclay, Yunmei Song, Sanjay GargAbstract:Polymeric smart materials have a significant role in providing tuneable and sustained release of both hydrophilic and hydrophobic Drugs. This chapter is a review on the use of swelling Controlled Drug Delivery systems in the pharmaceutical industry, examining the evolution of swellable polymeric materials into effective Delivery systems for therapeutic agents. Within the sub-classes of swelling devices, swellable matrices and superdisintegrants, the discussion of swellable Controlled Drug Delivery devices and systems focus on their structures, properties, and swelling mechanisms. Major factors influencing the manner of Drug release will also be investigated, as will mathematical models used to predict Drug release characteristics. In the final section, the potential drawbacks of swellable Controlled Drug Delivery systems will be discussed.
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bioadhesive microspheres as a Controlled Drug Delivery system
International Journal of Pharmaceutics, 2003Co-Authors: Jaspreet Kaur Vasir, Kaustubh Tambwekar, Sanjay GargAbstract:Abstract The concept of Controlled Drug Delivery has been traditionally used to obtain specific release rates or spatial targeting of active ingredients. The phenomenon of bioadhesion, introduced by Park and Robinson [Park, K., Robinson, J.R., 1984. Bioadhesive polymers as platforms for oral Controlled Drug Delivery: method to study bioadhesion. Int. J. Pharm. 198, 107–127], has been studied extensively in the last decade and applied to improve the performance of these Drug Delivery systems. Recent advances in polymer science and Drug carrier technologies have promulgated the development of novel Drug carriers such as bioadhesive microspheres that have boosted the use of “bioadhesion” in Drug Delivery. This article presents the spectrum of potential applications of bioadhesive microspheres in Controlled Drug Delivery ranging from the small molecules, to peptides, and to the macromolecular Drugs such as proteins, oligonucleotides and even DNA. The development of mucus or cell-specific bioadhesive polymers and the concepts of cytoadhesion and bioinvasion provide unprecedented opportunities for targeting Drugs to specific cells or intracellular compartments. Developments in the techniques for in vitro and in vivo evaluation of bioadhesive microspheres have also been discussed.
David A. Puleo - One of the best experts on this subject based on the ideXlab platform.
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Advances in Controlled Drug Delivery for Treatment of Osteoporosis.
Current osteoporosis reports, 2016Co-Authors: Theodora A. Asafo-adjei, A J Chen, Amir Najarzadeh, David A. PuleoAbstract:Osteoporosis, which is characterized by resorption of bone exceeding formation, remains a significant human health concern, and the impact of this condition will only increase with the "graying" of the worldwide population. This review focuses on current and emerging approaches for delivering therapeutic agents to restore bone remodeling homeostasis. Well-known antiresorptive and anabolic agents, such as estrogen, estrogen analogs, bisphosphonates, calcitonin, and parathyroid hormone, along with newer modulators and antibodies, are primarily administered orally, intravenously, or subcutaneously. Although these treatments can be effective, continuing problems include patient noncompliance and adverse systemic or remote-site effects. Controlled Drug Delivery via polymeric, targeted, and active release systems extends Drug half-life by shielding against premature degradation and improves bioavailability while also providing prolonged, sustained, or intermittent release at therapeutic doses to more effectively treat osteoporosis and associated fracture risk.
Fuzhai Cui - One of the best experts on this subject based on the ideXlab platform.
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The application of nanomaterials in Controlled Drug Delivery for bone regeneration.
Journal of biomedical materials research. Part A, 2015Co-Authors: Shuo Shi, Wenbao Jiang, Tianxiao Zhao, Katerina E. Aifantis, Hui Wang, Lei Lin, Yubo Fan, Qingling Feng, Fuzhai CuiAbstract:Bone regeneration is a complicated process that involves a series of biological events, such as cellular recruitment, proliferation and differentiation, and so forth, which have been found to be significantly affected by Controlled Drug Delivery. Recently, a lot of research studies have been launched on the application of nanomaterials in Controlled Drug Delivery for bone regeneration. In this article, the latest research progress in this area regarding the use of bioceramics-based, polymer-based, metallic oxide-based and other types of nanomaterials in Controlled Drug Delivery for bone regeneration are reviewed and discussed, which indicates that the controlling Drug Delivery with nanomaterials should be a very promising treatment in orthopedics. Furthermore, some new challenges about the future research on the application of nanomaterials in Controlled Drug Delivery for bone regeneration are described in the conclusion and perspectives part.
Antonia Martínez-luévanos - One of the best experts on this subject based on the ideXlab platform.
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Porous aerogel and core/shell nanoparticles for Controlled Drug Delivery: A review.
Materials science & engineering. C Materials for biological applications, 2018Co-Authors: Tzipatly A. Esquivel-castro, M.c. Ibarra-alonso, Jorge Oliva, Antonia Martínez-luévanosAbstract:Abstract This review presents the methods and general strategies for the synthesis of porous aerogels and core/shell nanoparticles with efficient and Controlled Drug Delivery. Different mechanisms of Drug Delivery are also discussed, which are influenced by the porosity, surface area, pH and surface functionalization of the aerogel and core/shell nanoparticles. Various porous inorganic, organic, and hybrid systems were compared. In addition, the main physical and chemical characteristics of these porous nanoparticles which enhance the Drug loading on the porous nanoparticles were discussed.
Theodora A. Asafo-adjei - One of the best experts on this subject based on the ideXlab platform.
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Advances in Controlled Drug Delivery for Treatment of Osteoporosis.
Current osteoporosis reports, 2016Co-Authors: Theodora A. Asafo-adjei, A J Chen, Amir Najarzadeh, David A. PuleoAbstract:Osteoporosis, which is characterized by resorption of bone exceeding formation, remains a significant human health concern, and the impact of this condition will only increase with the "graying" of the worldwide population. This review focuses on current and emerging approaches for delivering therapeutic agents to restore bone remodeling homeostasis. Well-known antiresorptive and anabolic agents, such as estrogen, estrogen analogs, bisphosphonates, calcitonin, and parathyroid hormone, along with newer modulators and antibodies, are primarily administered orally, intravenously, or subcutaneously. Although these treatments can be effective, continuing problems include patient noncompliance and adverse systemic or remote-site effects. Controlled Drug Delivery via polymeric, targeted, and active release systems extends Drug half-life by shielding against premature degradation and improves bioavailability while also providing prolonged, sustained, or intermittent release at therapeutic doses to more effectively treat osteoporosis and associated fracture risk.