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Zafiris J Daskalakis - One of the best experts on this subject based on the ideXlab platform.

  • Characterizing Cortical Oscillatory Responses in Major Depressive Disorder Before and After Convulsive Therapy: A TMS-EEG Study.
    Journal of affective disorders, 2021
    Co-Authors: Aron T Hill, Itay Hadas, Reza Zomorrodi, Daphne Voineskos, Paul B Fitzgerald, Daniel M Blumberger, Zafiris J Daskalakis
    Abstract:

    Combined transcranial magnetic stimulation and electroencephalography (TMS-EEG) is emerging as a powerful technique for interrogating neural circuit dysfunction in psychiatric disorders. Here, we utilized time-frequency analyses to characterize differences in neural oscillatory dynamics between subjects with major depressive disorder (MDD) and healthy controls (HC). We further examined changes in TMS-related oscillatory power following Convulsive Therapy. Oscillatory power was examined following TMS over the dorsolateral prefrontal and motor cortices (DLPFC and M1) in 38 MDD subjects, and 22 HCs. We further investigated how these responses changed in the MDD group following an acute course of Convulsive Therapy (either magnetic seizure Therapy [MST, n = 24] or electroConvulsive Therapy [ECT, n = 14]). Prior to treatment, MDD subjects exhibited increased oscillatory power within delta, theta, and alpha frequency bands with TMS-EEG over the DLPFC, but showed no differences to HCs with stimulation over M1. Following MST, DLPFC stimulation revealed attenuated baseline-normalized power in the delta and theta bands, with reductions in the delta, theta, and alpha power following ECT. TMS over M1 revealed reduced delta and theta power following ECT, with no changes observed following MST. An association was also observed between the treatment- induced change in alpha power and depression severity score. Limitations include the modest sample size, open-label MST and ECT treatment designs, and lack of a placebo condition. These results provide evidence of alterations in TMS-related oscillatory activity in MDD, and further suggest modulation of oscillatory power following ECT and MST. Copyright © 2021 Elsevier B.V. All rights reserved.

  • characterizing cortical oscillatory responses in major depressive disorder before and after Convulsive Therapy a tms eeg study
    Journal of Affective Disorders, 2021
    Co-Authors: Aron T Hill, Itay Hadas, Reza Zomorrodi, Daphne Voineskos, Paul B Fitzgerald, Daniel M Blumberger, Zafiris J Daskalakis
    Abstract:

    Abstract Background : Combined transcranial magnetic stimulation and electroencephalography (TMS-EEG) is emerging as a powerful technique for interrogating neural circuit dysfunction in psychiatric disorders. Here, we utilized time-frequency analyses to characterize differences in neural oscillatory dynamics between subjects with major depressive disorder (MDD) and healthy controls (HC). We further examined changes in TMS-related oscillatory power following Convulsive Therapy. Methods : Oscillatory power was examined following TMS over the dorsolateral prefrontal and motor cortices (DLPFC and M1) in 38 MDD subjects, and 22 HCs. We further investigated how these responses changed in the MDD group following an acute course of Convulsive Therapy (either magnetic seizure Therapy [MST, n = 24] or electroConvulsive Therapy [ECT, n = 14]). Results : Prior to treatment, MDD subjects exhibited increased oscillatory power within delta, theta, and alpha frequency bands with TMS-EEG over the DLPFC, but showed no differences to HCs with stimulation over M1. Following MST, DLPFC stimulation revealed attenuated baseline-normalized power in the delta and theta bands, with reductions in the delta, theta, and alpha power following ECT. TMS over M1 revealed reduced delta and theta power following ECT, with no changes observed following MST. An association was also observed between the treatment- induced change in alpha power and depression severity score. Limitations : Limitations include the modest sample size, open-label MST and ECT treatment designs, and lack of a placebo condition. Conclusions : These results provide evidence of alterations in TMS-related oscillatory activity in MDD, and further suggest modulation of oscillatory power following ECT and MST.

Aron T Hill - One of the best experts on this subject based on the ideXlab platform.

  • Characterizing Cortical Oscillatory Responses in Major Depressive Disorder Before and After Convulsive Therapy: A TMS-EEG Study.
    Journal of affective disorders, 2021
    Co-Authors: Aron T Hill, Itay Hadas, Reza Zomorrodi, Daphne Voineskos, Paul B Fitzgerald, Daniel M Blumberger, Zafiris J Daskalakis
    Abstract:

    Combined transcranial magnetic stimulation and electroencephalography (TMS-EEG) is emerging as a powerful technique for interrogating neural circuit dysfunction in psychiatric disorders. Here, we utilized time-frequency analyses to characterize differences in neural oscillatory dynamics between subjects with major depressive disorder (MDD) and healthy controls (HC). We further examined changes in TMS-related oscillatory power following Convulsive Therapy. Oscillatory power was examined following TMS over the dorsolateral prefrontal and motor cortices (DLPFC and M1) in 38 MDD subjects, and 22 HCs. We further investigated how these responses changed in the MDD group following an acute course of Convulsive Therapy (either magnetic seizure Therapy [MST, n = 24] or electroConvulsive Therapy [ECT, n = 14]). Prior to treatment, MDD subjects exhibited increased oscillatory power within delta, theta, and alpha frequency bands with TMS-EEG over the DLPFC, but showed no differences to HCs with stimulation over M1. Following MST, DLPFC stimulation revealed attenuated baseline-normalized power in the delta and theta bands, with reductions in the delta, theta, and alpha power following ECT. TMS over M1 revealed reduced delta and theta power following ECT, with no changes observed following MST. An association was also observed between the treatment- induced change in alpha power and depression severity score. Limitations include the modest sample size, open-label MST and ECT treatment designs, and lack of a placebo condition. These results provide evidence of alterations in TMS-related oscillatory activity in MDD, and further suggest modulation of oscillatory power following ECT and MST. Copyright © 2021 Elsevier B.V. All rights reserved.

  • characterizing cortical oscillatory responses in major depressive disorder before and after Convulsive Therapy a tms eeg study
    Journal of Affective Disorders, 2021
    Co-Authors: Aron T Hill, Itay Hadas, Reza Zomorrodi, Daphne Voineskos, Paul B Fitzgerald, Daniel M Blumberger, Zafiris J Daskalakis
    Abstract:

    Abstract Background : Combined transcranial magnetic stimulation and electroencephalography (TMS-EEG) is emerging as a powerful technique for interrogating neural circuit dysfunction in psychiatric disorders. Here, we utilized time-frequency analyses to characterize differences in neural oscillatory dynamics between subjects with major depressive disorder (MDD) and healthy controls (HC). We further examined changes in TMS-related oscillatory power following Convulsive Therapy. Methods : Oscillatory power was examined following TMS over the dorsolateral prefrontal and motor cortices (DLPFC and M1) in 38 MDD subjects, and 22 HCs. We further investigated how these responses changed in the MDD group following an acute course of Convulsive Therapy (either magnetic seizure Therapy [MST, n = 24] or electroConvulsive Therapy [ECT, n = 14]). Results : Prior to treatment, MDD subjects exhibited increased oscillatory power within delta, theta, and alpha frequency bands with TMS-EEG over the DLPFC, but showed no differences to HCs with stimulation over M1. Following MST, DLPFC stimulation revealed attenuated baseline-normalized power in the delta and theta bands, with reductions in the delta, theta, and alpha power following ECT. TMS over M1 revealed reduced delta and theta power following ECT, with no changes observed following MST. An association was also observed between the treatment- induced change in alpha power and depression severity score. Limitations : Limitations include the modest sample size, open-label MST and ECT treatment designs, and lack of a placebo condition. Conclusions : These results provide evidence of alterations in TMS-related oscillatory activity in MDD, and further suggest modulation of oscillatory power following ECT and MST.

Daniel M Blumberger - One of the best experts on this subject based on the ideXlab platform.

  • Characterizing Cortical Oscillatory Responses in Major Depressive Disorder Before and After Convulsive Therapy: A TMS-EEG Study.
    Journal of affective disorders, 2021
    Co-Authors: Aron T Hill, Itay Hadas, Reza Zomorrodi, Daphne Voineskos, Paul B Fitzgerald, Daniel M Blumberger, Zafiris J Daskalakis
    Abstract:

    Combined transcranial magnetic stimulation and electroencephalography (TMS-EEG) is emerging as a powerful technique for interrogating neural circuit dysfunction in psychiatric disorders. Here, we utilized time-frequency analyses to characterize differences in neural oscillatory dynamics between subjects with major depressive disorder (MDD) and healthy controls (HC). We further examined changes in TMS-related oscillatory power following Convulsive Therapy. Oscillatory power was examined following TMS over the dorsolateral prefrontal and motor cortices (DLPFC and M1) in 38 MDD subjects, and 22 HCs. We further investigated how these responses changed in the MDD group following an acute course of Convulsive Therapy (either magnetic seizure Therapy [MST, n = 24] or electroConvulsive Therapy [ECT, n = 14]). Prior to treatment, MDD subjects exhibited increased oscillatory power within delta, theta, and alpha frequency bands with TMS-EEG over the DLPFC, but showed no differences to HCs with stimulation over M1. Following MST, DLPFC stimulation revealed attenuated baseline-normalized power in the delta and theta bands, with reductions in the delta, theta, and alpha power following ECT. TMS over M1 revealed reduced delta and theta power following ECT, with no changes observed following MST. An association was also observed between the treatment- induced change in alpha power and depression severity score. Limitations include the modest sample size, open-label MST and ECT treatment designs, and lack of a placebo condition. These results provide evidence of alterations in TMS-related oscillatory activity in MDD, and further suggest modulation of oscillatory power following ECT and MST. Copyright © 2021 Elsevier B.V. All rights reserved.

  • characterizing cortical oscillatory responses in major depressive disorder before and after Convulsive Therapy a tms eeg study
    Journal of Affective Disorders, 2021
    Co-Authors: Aron T Hill, Itay Hadas, Reza Zomorrodi, Daphne Voineskos, Paul B Fitzgerald, Daniel M Blumberger, Zafiris J Daskalakis
    Abstract:

    Abstract Background : Combined transcranial magnetic stimulation and electroencephalography (TMS-EEG) is emerging as a powerful technique for interrogating neural circuit dysfunction in psychiatric disorders. Here, we utilized time-frequency analyses to characterize differences in neural oscillatory dynamics between subjects with major depressive disorder (MDD) and healthy controls (HC). We further examined changes in TMS-related oscillatory power following Convulsive Therapy. Methods : Oscillatory power was examined following TMS over the dorsolateral prefrontal and motor cortices (DLPFC and M1) in 38 MDD subjects, and 22 HCs. We further investigated how these responses changed in the MDD group following an acute course of Convulsive Therapy (either magnetic seizure Therapy [MST, n = 24] or electroConvulsive Therapy [ECT, n = 14]). Results : Prior to treatment, MDD subjects exhibited increased oscillatory power within delta, theta, and alpha frequency bands with TMS-EEG over the DLPFC, but showed no differences to HCs with stimulation over M1. Following MST, DLPFC stimulation revealed attenuated baseline-normalized power in the delta and theta bands, with reductions in the delta, theta, and alpha power following ECT. TMS over M1 revealed reduced delta and theta power following ECT, with no changes observed following MST. An association was also observed between the treatment- induced change in alpha power and depression severity score. Limitations : Limitations include the modest sample size, open-label MST and ECT treatment designs, and lack of a placebo condition. Conclusions : These results provide evidence of alterations in TMS-related oscillatory activity in MDD, and further suggest modulation of oscillatory power following ECT and MST.

Daphne Voineskos - One of the best experts on this subject based on the ideXlab platform.

  • Characterizing Cortical Oscillatory Responses in Major Depressive Disorder Before and After Convulsive Therapy: A TMS-EEG Study.
    Journal of affective disorders, 2021
    Co-Authors: Aron T Hill, Itay Hadas, Reza Zomorrodi, Daphne Voineskos, Paul B Fitzgerald, Daniel M Blumberger, Zafiris J Daskalakis
    Abstract:

    Combined transcranial magnetic stimulation and electroencephalography (TMS-EEG) is emerging as a powerful technique for interrogating neural circuit dysfunction in psychiatric disorders. Here, we utilized time-frequency analyses to characterize differences in neural oscillatory dynamics between subjects with major depressive disorder (MDD) and healthy controls (HC). We further examined changes in TMS-related oscillatory power following Convulsive Therapy. Oscillatory power was examined following TMS over the dorsolateral prefrontal and motor cortices (DLPFC and M1) in 38 MDD subjects, and 22 HCs. We further investigated how these responses changed in the MDD group following an acute course of Convulsive Therapy (either magnetic seizure Therapy [MST, n = 24] or electroConvulsive Therapy [ECT, n = 14]). Prior to treatment, MDD subjects exhibited increased oscillatory power within delta, theta, and alpha frequency bands with TMS-EEG over the DLPFC, but showed no differences to HCs with stimulation over M1. Following MST, DLPFC stimulation revealed attenuated baseline-normalized power in the delta and theta bands, with reductions in the delta, theta, and alpha power following ECT. TMS over M1 revealed reduced delta and theta power following ECT, with no changes observed following MST. An association was also observed between the treatment- induced change in alpha power and depression severity score. Limitations include the modest sample size, open-label MST and ECT treatment designs, and lack of a placebo condition. These results provide evidence of alterations in TMS-related oscillatory activity in MDD, and further suggest modulation of oscillatory power following ECT and MST. Copyright © 2021 Elsevier B.V. All rights reserved.

  • characterizing cortical oscillatory responses in major depressive disorder before and after Convulsive Therapy a tms eeg study
    Journal of Affective Disorders, 2021
    Co-Authors: Aron T Hill, Itay Hadas, Reza Zomorrodi, Daphne Voineskos, Paul B Fitzgerald, Daniel M Blumberger, Zafiris J Daskalakis
    Abstract:

    Abstract Background : Combined transcranial magnetic stimulation and electroencephalography (TMS-EEG) is emerging as a powerful technique for interrogating neural circuit dysfunction in psychiatric disorders. Here, we utilized time-frequency analyses to characterize differences in neural oscillatory dynamics between subjects with major depressive disorder (MDD) and healthy controls (HC). We further examined changes in TMS-related oscillatory power following Convulsive Therapy. Methods : Oscillatory power was examined following TMS over the dorsolateral prefrontal and motor cortices (DLPFC and M1) in 38 MDD subjects, and 22 HCs. We further investigated how these responses changed in the MDD group following an acute course of Convulsive Therapy (either magnetic seizure Therapy [MST, n = 24] or electroConvulsive Therapy [ECT, n = 14]). Results : Prior to treatment, MDD subjects exhibited increased oscillatory power within delta, theta, and alpha frequency bands with TMS-EEG over the DLPFC, but showed no differences to HCs with stimulation over M1. Following MST, DLPFC stimulation revealed attenuated baseline-normalized power in the delta and theta bands, with reductions in the delta, theta, and alpha power following ECT. TMS over M1 revealed reduced delta and theta power following ECT, with no changes observed following MST. An association was also observed between the treatment- induced change in alpha power and depression severity score. Limitations : Limitations include the modest sample size, open-label MST and ECT treatment designs, and lack of a placebo condition. Conclusions : These results provide evidence of alterations in TMS-related oscillatory activity in MDD, and further suggest modulation of oscillatory power following ECT and MST.

Con Stough - One of the best experts on this subject based on the ideXlab platform.

  • The effects of electro-Convulsive Therapy on the speed of information processing in major depression.
    Journal of affective disorders, 2007
    Co-Authors: George Tsourtos, Jo Spong, Con Stough
    Abstract:

    This study investigates whether cognitive impairment is evident in inpatients diagnosed with Major Depression (MD) following electro-Convulsive Therapy (ECT), and if so, whether it is independent from depressive symptomatology. Speed of information processing was measured using the inspection time (IT) task. IT was compared between twelve inpatients diagnosed with MD receiving ECT and twelve age-, gender-, verbal IQ-, and depression and anxiety severity matched control inpatients diagnosed with MD not receiving ECT, over four testing sessions (prior to ECT, following one ECT session, following the completion of an ECT block, and 4 to 6 weeks after the ECT block (follow-up)). The mean IT score for the inpatients diagnosed with MD who received ECT slowed significantly from the first ECT to immediately after the ECT block, and was significantly faster at follow-up. The mean IT score of the inpatients diagnosed with MD not receiving ECT gradually but significantly became faster over the entire equivalent time period. Small sample sizes. ECT temporarily slows information processing speed in MD patients, independent of depression symptomatology.

  • The effects of electro-Convulsive Therapy on the speed of information processing in major depression.
    Journal of Affective Disorders, 2007
    Co-Authors: George Tsourtos, Jo Spong, Con Stough
    Abstract:

    Abstract Background This study investigates whether cognitive impairment is evident in inpatients diagnosed with Major Depression (MD) following electro-Convulsive Therapy (ECT), and if so, whether it is independent from depressive symptomatology. Methods Speed of information processing was measured using the inspection time (IT) task. IT was compared between twelve inpatients diagnosed with MD receiving ECT and twelve age-, gender-, verbal IQ-, and depression and anxiety severity matched control inpatients diagnosed with MD not receiving ECT, over four testing sessions (prior to ECT, following one ECT session, following the completion of an ECT block, and 4 to 6 weeks after the ECT block (follow-up)). Results The mean IT score for the inpatients diagnosed with MD who received ECT slowed significantly from the first ECT to immediately after the ECT block, and was significantly faster at follow-up. The mean IT score of the inpatients diagnosed with MD not receiving ECT gradually but significantly became faster over the entire equivalent time period. Limitations Small sample sizes. Conclusions ECT temporarily slows information processing speed in MD patients, independent of depression symptomatology.