The Experts below are selected from a list of 219 Experts worldwide ranked by ideXlab platform

Kimito Kawahata - One of the best experts on this subject based on the ideXlab platform.

O N Manousos - One of the best experts on this subject based on the ideXlab platform.

  • autoimmune hemolytic anemia and positive Coombs Test associated with ulcerative colitis
    The American Journal of Gastroenterology, 1997
    Co-Authors: E Giannadaki, Spiros P Potamianos, Maria Roussomoustakaki, D Kyriakou, N Fragkiadakis, O N Manousos
    Abstract:

    Objectives: To estimate the frequency of autoimmune hemolytic anemia and Coombs positivity without overt hemolysis in ulcerative colitis, to determine possible subsets of patients with ulcerative colitis susceptible to this complication, and to assess the efficacy of the applied therapeutic modalities. Methods: Three hundred and two patients with ulcerative colitis treated at the University Hospital of Heraklion, Crete, over a 6-yr period were included. Within this group, a subgroup of 152 patients were studied prospectively for the presence of a positive direct Coombs Test. Results: Autoimmune hemolytic anemia was diagnosed in five of 302 patients with ulcerative colitis (1.7%). One more patient developed Coombs-positive hemolytic anemia, attributed to sulfasalazine. A positive Coombs Test without evidence of hemolysis was found in three of 152 patients (2%). The mean age of all Coombs-positive patients was 50.5 yr, and there was a definitive male preponderance (male: female, 2:1). Autoimmune hemolytic anemia occurred during active colitis in all cases. The mean time between the onset of colitis and the diagnosis of autoimmune hemolytic anemia was 17 months. Three of five patients with autoimmune hemolytic anemia (60%) and seven of nine of all Coombs-positive patients (77.7%) had total colitis. All patients with autoimmune hemolytic anemia were treated initially with large doses of corticosteroids. Three of five (60%) had good hematological responses. One patient responded to the addition of azathioprine, and one underwent splenectomy and proctocolectomy. Conclusions: In this study, the frequency with which autoimmune hemolytic anemia was associated with ulcerative colitis was higher than in previous reports. The complication occurred early in the course of colitis and was related to activity and extent of the disease. In contrast to others studies, we found a preponderance of males. Although corticosteroids and/or immunosuppressive therapy was successful in most of our cases, one patient required surgery.

Mirjana Nesin - One of the best experts on this subject based on the ideXlab platform.

  • Corrected end-tidal carbon monoxide closely correlates with the corrected reticulocyte count in Coombs' Test-positive term neonates.
    Pediatrics, 2020
    Co-Authors: Maria Cristina Javier, Alfred Krauss, Mirjana Nesin
    Abstract:

    To evaluate clinical usefulness of corrected end-tidal carbon monoxide (ETCOc) measurements in healthy, term, Coombs' Test-positive neonates and correlate it to the corrected reticulocyte count (RC). ETCOc and RC were determined (at 36 +/- 12 hours of age) in 50 Coombs' Test-positive neonates and compared with the ETCOc values of 50 Coombs' Test-negative neonates. Fifty percent of Coombs' Test-positive infants had RCs <5% (within a normal range for a healthy newborn) and ETCOc = 1.8 +/- 0.34 parts per million (ppm) and likely did not exhibit hemolysis. Among infants with elevated RCs, 72% had RCs between 5% and 8% and ETCOc = 2.77 +/- 0.68 ppm, and 28% had RCs >8% and ETCOc = 4.52 +/- 0.83 ppm. There was an almost linear correlation (r = 0.86) between the RC and the ETCOc among Coombs' Test-positive infants. The 50 Coombs' Test-negative infants had ETCOc = 1.6 +/- 0.45 ppm. Serial ETCOc measurements were performed in 14 Coombs' Test-positive infants: in all but 1 infant ETCOc values declined over time. There is a good correlation between ETCOc and RC in Coombs' Test-positive infants. ETCOc >2.5 ppm predicts a significant elevation of RC in 90% of Coombs' Test-positive infants.

  • corrected end tidal carbon monoxide closely correlates with the corrected reticulocyte count in Coombs Test positive term neonates
    Pediatrics, 2003
    Co-Authors: Maria Cristina Javier, Alfred N Krauss, Mirjana Nesin
    Abstract:

    Objective. To evaluate clinical usefulness of corrected end-tidal carbon monoxide (ETCOc) measurements in healthy, term, Coombs’ Test-positive neonates and correlate it to the corrected reticulocyte count (RC). Methods. ETCOc and RC were determined (at 36 ± 12 hours of age) in 50 Coombs’ Test-positive neonates and compared with the ETCOc values of 50 Coombs’ Test-negative neonates. Results. Fifty percent of Coombs’ Test-positive infants had RCs 8% and ETCOc = 4.52 ± 0.83 ppm. There was an almost linear correlation ( r = 0.86) between the RC and the ETCOc among Coombs’ Test-positive infants. The 50 Coombs’ Test-negative infants had ETCOc = 1.6 ± 0.45 ppm. Serial ETCOc measurements were performed in 14 Coombs’ Test-positive infants: in all but 1 infant ETCOc values declined over time. Conclusions. There is a good correlation between ETCOc and RC in Coombs’ Test-positive infants. ETCOc >2.5 ppm predicts a significant elevation of RC in 90% of Coombs’ Test-positive infants.

Hironari Hanaoka - One of the best experts on this subject based on the ideXlab platform.

N Grunnet - One of the best experts on this subject based on the ideXlab platform.

  • positive Coombs Test associated with ulcerative colitis a prevalence study
    Acta Medica Scandinavica, 2009
    Co-Authors: Lene O Poulsen, Leif Freund, Kirsten Lylloff, N Grunnet
    Abstract:

    : Among 112 patients with ulcerative colitis (UC), a positive Coombs' Test was detected in two cases. The immunoglobulins were IgG and no complement could be detected on the red cells. None of the two patients showed laboratory evidence of hemolysis, although reduced red cell survival was suspected in one patient with a 6-year history of UC, previous autoimmune hemolytic anemia and a positive in vitro monocyte-macrophage phagocytosis Test. The HLA-antigens in the two patients were different except for the common antigen HLA-A1.