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Chunchao Han - One of the best experts on this subject based on the ideXlab platform.

  • Comparison of the structures and prebiotic-like effects in vitro of polysaccharides from Coprinus comatus fruit body and mycelium
    International Journal of Biological Macromolecules, 2020
    Co-Authors: Min Sun, Yongxia Wang, Xiaoqing Cai, Yongqing Zhang, Chunchao Han
    Abstract:

    Abstract Many effects of Coprinus comatus are attributed to its polysaccharide components. Therefore, the aim of this article is to take Coprinus comatus polysaccharides as the research topic to estimate the difference between the polysaccharides of Coprinus comatus fruiting bodies (CBPs) and the intracellular polysaccharides of liquid fermentation (ICPs). The total carbohydrate contents, monosaccharide compositions, molecular weights, functional groups, microstructures and functional properties of the two prepared polysaccharides were evaluated. At the same time, the influences of the two polysaccharides on the proliferation of lactobacillus and Bifidobacterium in vitro were compared. The structural analysis exhibited that there were slight differences in the two prepared polysaccharides. However, both ICPs and CBPs could be utilized by these two strains. Furthermore, the effects of the two prepared polysaccharides on the proliferation of the selected probiotics were dose-dependent manners within the scope of the experiment, and the ICPs group and CBPs group had no significant difference (P > 0.05). Therefore, this work demonstrates that ICPs could be an equivalent replacer for CBPs.

  • Isolation and biological activity of triglycerides of the fermented mushroom of Coprinus comatus
    BMC complementary and alternative medicine, 2012
    Co-Authors: Jun Ren, Jin-li Shi, Chunchao Han, Zhenquan Liu, Jian-you Guo
    Abstract:

    Background Although many physiological functions of Coprinus comatus have been reported, there has been no report on the antinociceptive activity of Coprinus comatus. Therefore, the objective of the present study is to demonstrate the production, isolation, and biological properties of triglycerides (TFC) of the fermented mushroom of Coprinus comatus.

  • Vanadium Uptake by Biomass of Coprinus comatus and Their Effect on Hyperglycemic Mice
    Biological trace element research, 2008
    Co-Authors: Chunchao Han, Bo Cui, Yingzi Wang
    Abstract:

    The Vanadium uptake by Coprinus comatus and their co-effect on hyperglycemic mice were studied. By fermentation and AAS analysis, the optimal concentration of vanadium in medium was 0.4%, and the content of vanadium accumulated in the mycelia was 3,528.0 μg/g. At the concentration of 0.4%, the vanadium-associated toxicity was reduced, and its anti-diabetic effects were maintained.

  • Hypoglycemic activity of fermented mushroom of Coprinus comatus rich in vanadium
    Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 2006
    Co-Authors: Chunchao Han, Junhua Yuan, Yingzi Wang
    Abstract:

    Abstract The hypoglycemic activity of fermented mushroom of Coprinus comatus rich in vanadium (CCRV) was studied in this paper. Alloxan and adrenalin induced hyperglycemic mice were used in the study. The blood glucose and the HbA1c of the mice were analyzed, respectively. At the same time, the sugar tolerance of the normal mice was also determined. After the mice were administered (ig) with CCRV, the blood glucose and the HbA1c of alloxan-induced hyperglycemic mice decreased (p

Dou Yan-ping - One of the best experts on this subject based on the ideXlab platform.

Chen Jie - One of the best experts on this subject based on the ideXlab platform.

Ana Sabo - One of the best experts on this subject based on the ideXlab platform.

  • Chemical composition, nutritional profile and in vivo antioxidant properties of the cultivated mushroom Coprinus comatus.
    Royal Society open science, 2020
    Co-Authors: Nebojša Stilinović, Ivan Čapo, Saša Vukmirović, Aleksandar Rašković, Ana Tomas, Mira Popovic, Ana Sabo
    Abstract:

    This study investigated the chemical and nutritional profile and antioxidative properties of cultivated Coprinus comatus. Proximate analysis revealed that C. comatus is rich in carbohydrates, dieta...

  • REGENERATIVE EFFECTS OF MUSHROOM Coprinus comatus ON ISLETS OF LANGERHANS IN ALLOXAN INDUCED DIABETES MELLITUS IN RATS
    Victor Babes University of Medicine and Pharmacy Timisoara, 2017
    Co-Authors: Ivan Čapo, Nebojša Stilinović, Saša Vukmirović, Ana Sabo, Dušan Lalošević
    Abstract:

    The discovery of agents which induce regeneration\ud of pancreatic beta cells and insulin secretory potential\ud would be useful to develop new therapeutic approaches\ud to treat diabetes. We investigated effects of mushroom\ud Coprinus comatus on regeneration Langerhans islets\ud after alloxan treatment.\ud In this study, on immunohistochemically stained\ud histological preparations (insulin and glucagon) was\ud apply morphometric analysis of of rat pancreatic tissue\ud to examined: a) the degree of regenerative characteristics\ud of islets of Langerhans in alloxan induced diabetes,\ud b) the impact of mushroom Coprinus comatus on\ud pancreatic tissue and c) the impact of the mushroom\ud Coprinus comatus regenerator properties Langerhans\ud islets after administration of alloxan.\ud Suspension of mushroom Coprinus comatus\ud was applied in three time periods (7, 21, and 42 days)\ud at three different doses of 0.835, 1.67, and 3.34 g/kg.\ud Morphometric parameters were used: the volume density\ud of endocrine and exocrine part of islets per pancreatic\ud tissue; the mean corrected islet diameter , the numerical\ud density of alpha and beta cell per islet profile, the number\ud of alpha and beta cell type per islet, the corrected mean\ud nuclear diameter, and corrected mean nuclear volume.\ud The results showed that the application of\ud alloxan confirmed so far above the selective destruction\ud of beta cells with a relative degree of regeneration that\ud occurred in animals sacrificed after 4, 5, 7, 21 and 42 days\ud after application of alloxan. In the experimental group\ud of animals that received only the mushroom Coprinus\ud comatus, the application dose of 1.67 g/kg is observed\ud to increase in alpha and beta cells, while the other\ud groups showed no significant difference compared with\ud the control group. In rats which after inducing diabetes\ud with alloxan and then applied preparation mushroom\ud Coprinus comatus can be observed much greater\ud regeneration of islets compared to pure alloxan induced\ud group. Morphometric analysis revealed a proliferation\ud of alpha cells and a significant increase in beta cell\ud mass. In addition to clearly immunopositive cells were\ud observed and transitional cell forms between alpha and\ud beta cells, indicating the occurrence of the process of\ud transdifferentiation of one cell into another form.\ud Therefore, regeneration of islets covered the\ud two processes, one is the proliferation of alpha cell\ud population and the second is the appearance of new beta\ud cells for which assume that the resulting direct conversion\ud of alpha cells. Stimulating effect of mushroom Coprinus\ud comatus on the regeneration of the islets of Langerhans\ud gives us precious, so far no published data on the impact\ud of these mushrooms in vivo in living systems.\u

Yingjie Pan - One of the best experts on this subject based on the ideXlab platform.

  • Structural elucidation of a neutral fucogalactan from the mycelium of Coprinus comatus.
    Carbohydrate research, 2006
    Co-Authors: Jun-min Fan, Jingsong Zhang, Qingjiu Tang, Yanfang Liu, An-qiang Zhang, Yingjie Pan
    Abstract:

    A water-soluble fucogalactan (CMP3), with a molecular mass of 1.03 x 10(4) Da as determined by high-performance size-exclusion chromatography (HPSEC), was obtained from the crude intracellular polysaccharide of Coprinus comatus mycelium. Its chemical structure was characterized by sugar and methylation analysis along with 1H and 13C NMR spectroscopy, including NOESY and HMBC experiments for linkage and sequence analysis. The polysaccharide is composed of a pentasaccharide repeating unit with the following structure: [structure:see text].