The Experts below are selected from a list of 2538 Experts worldwide ranked by ideXlab platform
Kanchan Kohli - One of the best experts on this subject based on the ideXlab platform.
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effect of oil and co surfactant on the formation of solutol hs 15 based colloidal drug carrier by box behnken statistical design
Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2014Co-Authors: Javed Ahmad, Showkat R. Mir, Kanchan Kohli, Saima AminAbstract:Abstract The present study provides an overview to design and optimize self-emulsifying system as colloidal drug carrier for oral delivery of hydrophobic drug using a new surfactant Solutol HS15. The formulation components i.e. surfactant, co-surfactant and oil were investigated to construct a pseudoternary phase diagram. Box–Behnken experimental design was employed as statistical tool to optimize the formulation variables, X 1 (Propylene glycol monocaprylate as oil), X 2 (Solutol HS15 as surfactant), and X 3 (Transcutol HP as Cosurfactant). Formulations were assessed for percentage transmittance, droplet size and emulsification efficacy. Transcutol HP was found to be better than other investigated Cosurfactants with Solutol HS15, to solubilize the aqueous and the oil phase. Furthermore, the results revealed the significant influence of the surfactant/Cosurfactant mass ratio ( Km ) to form self-emulsifying system of colloidal dimension. Km value 2 was observed to exert a synergistic effect. There was a good correlation between percentage transmittance of diluted self-emulsifying system and droplet size analysis ( R 2 = 0.951).
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study of Cosurfactant effect on nanoemulsifying area and development of lercanidipine loaded snedds self nanoemulsifying drug delivery system
Colloids and Surfaces B: Biointerfaces, 2011Co-Authors: Nitin Parmar, Saima Amin, Neelam Singla, Kanchan KohliAbstract:Abstract The present study deals with the development and characterization of self-nanoemulsifying drug delivery system (SNEDDS) to improve the oral bioavailability of poorly soluble third generation calcium channel blocker lercanidipine (LER). Solubility of the LER was estimated in various oils, Cosurfactants and surfactants which were grouped into two different combinations to construct pseudoternary phase diagrams. Various thermodynamic stability and dispersibility tests were performed on the formulations from phase diagram. After constructing phase diagram of two different combinations NL-I and NL-II, the effect of Cosurfactants on the nanoemulsifying area was studied and the effect of number and length of hydrophobic alkyl chains of Cosurfactant in its emulsification capacity was proved. Percentage transmittance, emulsification time, viscosity and droplet size analysis were used to characterize optimized formulations. The optimized formulation composed of Cremophor EL (45% wt/wt), (13.5% wt/wt) Caproyl 90 with (1.5% wt/wt) Transcutol® HP as per limits of inactive ingredients guidelines of FDA and Maisine oil (10% wt/wt). The mean droplet size in selected nanocarrier system was 20.01 nm. The in vitro dissolution profile of LER SNEDDS was found significant in comparison to the marketed LER (Zanidip) tablet and pure drug in pH 1.2, 4.5 and 6.8 buffers. Empty hard gelatin capsule shells were filled using Pfizer's Licap technology and charged on stability conditions of 30 °C/65% RH, 40 °C/65%RH and 50 °C/75% in glass bottles where no significant degradation ( p > 0.05) was observed in 3 months. The results indicate that SNEDDS of LER, owing to nanosized, has potential to enhance the absorption of drug.
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development and evaluation of a microemulsion formulation for transdermal delivery of terbinafine
Pda Journal of Pharmaceutical Science and Technology, 2007Co-Authors: Sanjula Baboota, Kanchan Kohli, A Alazaki, Javed Ali, Nitin Dixit, Faiyaz ShakeelAbstract:The aim of the present study is to develop and evaluate microemulsion formulations for Terbinafine (TB) with a view to enhance its permeability through the skin and provide release for 24 h. Various o/w microemulsions were prepared by the spontaneous emulsification method. Oleic acid was chosen as the oil phase, Caprylo caproyl macrogol-8- glyceride (Labrasol S) and purified diethylene glycol monoethyl ether (Transcutol P) were used as surfactant and Cosurfactant, respectively, on the basis of solubility studies. Pseudoternary phase diagrams were constructed to obtain the concentration range of oil, surfactant, Cosurfactant, and water for microemulsion formulation. The optimized microemulsion consisted of 2% w/w TB, 8% w/w oleic acid, 31% w/w labrasol S, 31% w/w transcutol P, and 30% w/w distilled water. Permeability parameters like Jss and Kp were found to be significantly higher for formulation F4 as compared to other formulations (P
Ghansham Munjapara - One of the best experts on this subject based on the ideXlab platform.
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self nanoemulsifying drug delivery system of cefpodoxime proxetil containing tocopherol polyethylene glycol succinate
Drug Development and Industrial Pharmacy, 2013Co-Authors: Amrita Bajaj, Monica R P Rao, Ishwar Khole, Ghansham MunjaparaAbstract:Context: Lipid based drug delivery systems have gained prominence in last decade for drugs with dissolution rate limited oral bioavailability.Objective: To improve the solubility, permeability and oral bioavailability of cefpodoxime proxetil, β-lactam antibiotic. It is BCS Class IV drug having solubility 400 µg/mL and 50% oral bioavailability.Materials and methods: Self-nanoemulsifying drug delivery system (SNEDDS) using various surfactant and Cosurfactants such as tween 80, tocopheryl polyethylene glycol succinate (TPGS), propylene glycol and Capmul MCM as oil phase were prepared. Ternary phase diagrams were constructed to identify stable microemulsion region. Percent transmittance studies helped to shortlist the surfactant–Cosurfactant combination.Results and discussion: Tween 80 and TPGS as surfactants and Capmul MCM as oil phase were found to produce stable nanoemulsions. Five formulations of SNEDDS had globule size of 55–60 nm and zeta potential of −4 to −11 mV. Self-emulsification time was between 2...
Caixia Wen - One of the best experts on this subject based on the ideXlab platform.
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self microemulsifying drug delivery system improves curcumin dissolution and bioavailability
Drug Development and Industrial Pharmacy, 2011Co-Authors: Xiuwang Huang, Caixia WenAbstract:Background: Curcumin has a wide spectrum of biological and pharmacological activities, but it has not yet been approved as a therapeutic agent because of its low solubility and stability in aqueous solution, and the relatively low bioavailability in vivo. To overcome these limitations, self-microemulsifying drug delivery system (SMEDDS) of curcumin was developed. Method: Various oils, surfactants, and Cosurfactants were selected to optimize the formulation. Pseudoternary phase diagrams were constructed and orthogonal design was used to compare the oil-in-water (o/w) microemulsion-forming capacity of different oils/ surfactants/Cosurfactants. The solubility of curcumin in various oils and Cosurfactants was determined to find suitable ingredients with a good solubilizing capacity. Droplet size was measured to obtain the concentration of oil, surfactant, and Cosurfactant for forming stable microemulsion. Furthermore, its quality and bioavailability in mice were assessed. Results: Pseudoternary phase diagrams and solubility test showed that the formulation of SMEDDS composed of 20% ethanol, 60% Cremophor RH40 ® , and 20% isopropyl myristate, in which the concentration of curcumin reached 50 mg/mL. Curcumin was released completely from SMEDDS at 10 minutes. The developed SMEDDS formulation improved the oral bioavailability of curcumin significantly, and the relative oral bioavailability of SMEDDS compared with curcumin suspension was 1213%. Conclusion: The SMEDDS can significantly increase curcumin dissolution in vitro and bioavailability in vivo.
F. J. Schork - One of the best experts on this subject based on the ideXlab platform.
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Lauroyl peroxide as a Cosurfactant in miniemulsion polymerization
Industrial & Engineering Chemistry Research, 1997Co-Authors: J. L. Reimers, F. J. SchorkAbstract:Miniemulsion polymerizations have been carried out using only an oil-soluble initiator (lauroyl peroxide) as the Cosurfactant. Diffusional instability was reduced to the point where nucleation in the monomer droplets and polymerization could be carried out before significant diffusional degradation of the droplets took place. The polymerization behavior was that expected in miniemulsion polymerization with more conventional Cosurfactants.
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Miniemulsion polymerization of styrene with chain transfer agent as Cosurfactant
Journal of Polymer Science Part A: Polymer Chemistry, 1997Co-Authors: Shou‐ting Wang, Gary W. Poehlein, F. J. SchorkAbstract:Miniemulsion polymerization of styrene with the chain transfer agent n-dodecyl mercaptan (DDM) used as Cosurfactant was studied. Droplet size and shelf life for unpolymerized miniemulsions were measured and compared with those of equivalent macroemulsions. The miniemulsion monomer droplets with dodecyl mercaptan as Cosurfactant were very stable. Shelf lives were from 17 h to 3 months. The kinetics of miniemulsion polymerization were studied. Unlike other miniemulsion systems where the Cosurfactant does not act as a chain transfer agent, the polymerization rate falls with Cosurfactant level because the chain transfer agent enhances radical desorption from the particles. The polymerization rate in all the miniemulsions was lower than that of the corresponding macroemulsions. Polymerized particles were larger than in the corresponding macroemulsions, but molecular weights were lower. Results indicate that DDM can serve as an effective Cosurfactant as well as a chain transfer agent. The fact that the molecular weights are lower in the miniemulsion reactions indicates predominant droplet nucleation. © 1997 John Wiley & Sons, Inc.
Darshana Deepak Hegde - One of the best experts on this subject based on the ideXlab platform.
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development and characterization of self microemulsifying drug delivery system of tacrolimus for intravenous administration
Drug Development and Industrial Pharmacy, 2009Co-Authors: Vivek Baban Borhade, Hema Ajit Nair, Darshana Deepak HegdeAbstract:Tacrolimus (FK 506), a poorly soluble immunosuppressant is currently formulated in nonaqueous vehicle containing hydrogenated castor oil derivative for intravenous administration. Hydrogenated castor oil derivatives are associated with acute anaphylactic reactions. This proposes to overcome the problems of poor aqueous solubility of the drug and the toxicity associated with currently used excipients by the development of a new parenterally acceptable formulation using self-microemulsifying drug delivery system (SMEDDS). Solubility of FK 506 in various oils, surfactants, and Cosurfactants was determined to identify SMEDDS components. Phase diagrams were constructed at different ratios of surfactants: Cosurfactant (Km) to determine microemulsion existence area. Influence of oily phase content, Km, aqueous phase composition, dilution, and incorporation of drug on mean globule size of microemulsions was studied. SMEDDSs were developed using ethyl oleate as oily phase and Solutol HS 15 as surfactant. Glycofuro...
