The Experts below are selected from a list of 183 Experts worldwide ranked by ideXlab platform

Roberto Pontremoli - One of the best experts on this subject based on the ideXlab platform.

  • Creatinine Clearance and signs of end-organ damage in primary hypertension
    Journal of human hypertension, 2004
    Co-Authors: Giovanna Leoncini, Francesca Viazzi, Denise Parodi, Elena Ratto, Simone Vettoretti, Valentina Vaccaro, Maura Ravera, Cinzia Tomolillo, Giacomo Deferrari, Roberto Pontremoli
    Abstract:

    A reduction in renal function is associated with high cardiovascular morbidity and mortality in hypertension. The aim of the present study was to investigate the relationship between Creatinine Clearance and subclinical organ damage in 957 never previously treated, middle-aged patients with primary hypertension. Renal function was estimated by means of the serum Creatinine level using the Cockcroft–Gault formula; left ventricular hypertrophy (LVH) was determined according to electrocardiographic criteria; and retinal vascular changes were evaluated by direct ophthalmoscopy. Creatinine Clearance was, on the average, 83±21.2 ml/min, and the prevalence of LVH and retinopathy was 13 and 49%, respectively. Creatinine Clearance was inversely related to the duration of disease (r=−0.132, P

Pietro Anastasio - One of the best experts on this subject based on the ideXlab platform.

M. Sato - One of the best experts on this subject based on the ideXlab platform.

Leonard G. Feld - One of the best experts on this subject based on the ideXlab platform.

  • Endogenous Creatinine Clearance in the rat : strain variation
    Life sciences, 1993
    Co-Authors: Judith B. Van Liew, Marianna J. Zamlauski-tucker, Leonard G. Feld
    Abstract:

    Abstract The Clearance of endogenous Creatinine was examined in five strains of rats (Wistar, Wistar Kyoto, Spontaneously Hypertensive Rats, Biobreeding/ Worcester diabetic prone and diabetic resistant rats). Creatinine Clearance was compared with inulin Clearance as the standard. Conditions for Clearance measurements were also varied (anesthesia with constant infusion, overnight collection of urine, fed vs. unfed state, single-injection technique). The Clearance of Creatinine adequately reflects the glomerular filtration rate in three strains (Wistar, Wistar-Kyoto and the spontaneously Hypertensive Rat). In the two strains of the Biobreeding/ Worcester rat Creatinine Clearance is consistently lower than the inulin Clearance. When Creatinine Clearance is measured from an overnight collection of urine with food withheld it is always lower than when food is present. This Clearance should always be validated by comparison with inulin Clearance measured simultaneously or under comparable conditions. The ease with which endogenous Creatinine Clearance can be measured makes it a reasonable method when large numbers of repeated determinations of glomerular filtration rate are required.

Antonio Siciliano - One of the best experts on this subject based on the ideXlab platform.