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Jay S Duker - One of the best experts on this subject based on the ideXlab platform.
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effect of intravitreous anti vascular endothelial growth factor therapy on choroidal thickness in neovascular age related macular degeneration using spectral domain optical coherence tomography
JAMA Ophthalmology, 2013Co-Authors: Lauren Branchini, Caio V Regatieri, Mehreen Adhi, Ignacio Floresmoreno, Varsha Manjunath, James G Fujimoto, Jay S DukerAbstract:A Critical Method of monitoring patients with neovascular age-related macular degeneration (AMD) being treated with anti–vascular endothelial growth factor (anti-VEGF) is optical coherence tomography (OCT), which uses low-coherence interferometry of light to examine the retina in vivo on a micrometer scale.1 Recent advances in spectral-domain OCT make visualization of the choroid feasible. Using image averaging and enhanced depth imaging, successful examination and measurement of choroidal thickness in normal and pathologic states have been reported.2–4 It has been hypothesized that anti-VEGF may affect choroidal vasculature.5 The goal of this study is to evaluate the effect of anti-VEGF on choroidal thickness using spectral-domain OCT in treatment-naive subjects.
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effect of intravitreous anti vascular endothelial growth factor therapy on choroidal thickness in neovascular age related macular degeneration using spectral domain optical coherence tomography
PMC, 2013Co-Authors: Lauren Branchini, Caio V Regatieri, Mehreen Adhi, Ignacio Floresmoreno, Varsha Manjunath, James G Fujimoto, Jay S DukerAbstract:Department of Ophthalmology, New England Eye Center, Tufts Medical Center, Boston (DrsBranchini, Regatieri, Adhi, Manjunath, and Duker) and Department of Electrical Engineering andComputer Science, Research Laboratory of Electronics, Massachusetts Institute of Technology,Cambridge (Dr Fujimoto); and Department of Ophthalmology, University Hospital of Albacete,Albacete, Spain (Dr Flores-Moreno).A Critical Method of monitoring patients with neovascular age-related macular degeneration(AMD) being treated with anti–vascular endothelial growth factor (anti-VEGF) is opticalcoherence tomography (OCT), which uses low-coherence interferometry of light to examinethe retina in vivo on a micrometer scale.
Lucinda F Buhse - One of the best experts on this subject based on the ideXlab platform.
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effects of deaeration Methods on dissolution testing in aqueous media a study using a total dissolved gas pressure meter
Journal of Pharmaceutical Sciences, 2006Co-Authors: Terry W Moore, William H Doub, Benjamin J. Westenberger, Lucinda F BuhseAbstract:ABSTRACT: Dissolution testing is a Critical Method for the determination of pharmaceutical product quality and bioequivalence. For some products, dissolved gases in the dissolution medium affect dissolution results thus requiring degassing of the medium prior to use. In this study, we use a total dissolved gas and oxygen meter to measure both oxygen and total gases in dissolution media before and after application of a variety of deaeration Methods. Dissolution testing results using a 10 mg Prednisone tablet (NCDA #2) are compared with the percent saturation of oxygen and total gases found in the medium. Reaeration of the medium during different stirring rates was also measured. This study confirms that measurement of total gases and not just oxygen in the medium is necessary to assess adequacy for dissolution testing. For those deaeration techniques that are performed at room temperature, the percent saturation of the total dissolved gases must be well below 100% to prevent outgassing once medium is brought to dissolution test Method temperature, typically 37°C. © 2006 Wiley-Liss, Inc. and the American Pharmacists Association.
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Effects of Deaeration Methods on Dissolution Testing in Aqueous Media: A Study Using a Total Dissolved Gas Pressure Meter *
Journal of Pharmaceutical Sciences, 2006Co-Authors: Terry W Moore, William H Doub, Benjamin J. Westenberger, Lucinda F BuhseAbstract:ABSTRACT: Dissolution testing is a Critical Method for the determination of pharmaceutical product quality and bioequivalence. For some products, dissolved gases in the dissolution medium affect dissolution results thus requiring degassing of the medium prior to use. In this study, we use a total dissolved gas and oxygen meter to measure both oxygen and total gases in dissolution media before and after application of a variety of deaeration Methods. Dissolution testing results using a 10 mg Prednisone tablet (NCDA #2) are compared with the percent saturation of oxygen and total gases found in the medium. Reaeration of the medium during different stirring rates was also measured. This study confirms that measurement of total gases and not just oxygen in the medium is necessary to assess adequacy for dissolution testing. For those deaeration techniques that are performed at room temperature, the percent saturation of the total dissolved gases must be well below 100% to prevent outgassing once medium is brought to dissolution test Method temperature, typically 37°C. © 2006 Wiley-Liss, Inc. and the American Pharmacists Association.
Lauren Branchini - One of the best experts on this subject based on the ideXlab platform.
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effect of intravitreous anti vascular endothelial growth factor therapy on choroidal thickness in neovascular age related macular degeneration using spectral domain optical coherence tomography
JAMA Ophthalmology, 2013Co-Authors: Lauren Branchini, Caio V Regatieri, Mehreen Adhi, Ignacio Floresmoreno, Varsha Manjunath, James G Fujimoto, Jay S DukerAbstract:A Critical Method of monitoring patients with neovascular age-related macular degeneration (AMD) being treated with anti–vascular endothelial growth factor (anti-VEGF) is optical coherence tomography (OCT), which uses low-coherence interferometry of light to examine the retina in vivo on a micrometer scale.1 Recent advances in spectral-domain OCT make visualization of the choroid feasible. Using image averaging and enhanced depth imaging, successful examination and measurement of choroidal thickness in normal and pathologic states have been reported.2–4 It has been hypothesized that anti-VEGF may affect choroidal vasculature.5 The goal of this study is to evaluate the effect of anti-VEGF on choroidal thickness using spectral-domain OCT in treatment-naive subjects.
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effect of intravitreous anti vascular endothelial growth factor therapy on choroidal thickness in neovascular age related macular degeneration using spectral domain optical coherence tomography
PMC, 2013Co-Authors: Lauren Branchini, Caio V Regatieri, Mehreen Adhi, Ignacio Floresmoreno, Varsha Manjunath, James G Fujimoto, Jay S DukerAbstract:Department of Ophthalmology, New England Eye Center, Tufts Medical Center, Boston (DrsBranchini, Regatieri, Adhi, Manjunath, and Duker) and Department of Electrical Engineering andComputer Science, Research Laboratory of Electronics, Massachusetts Institute of Technology,Cambridge (Dr Fujimoto); and Department of Ophthalmology, University Hospital of Albacete,Albacete, Spain (Dr Flores-Moreno).A Critical Method of monitoring patients with neovascular age-related macular degeneration(AMD) being treated with anti–vascular endothelial growth factor (anti-VEGF) is opticalcoherence tomography (OCT), which uses low-coherence interferometry of light to examinethe retina in vivo on a micrometer scale.
Terry W Moore - One of the best experts on this subject based on the ideXlab platform.
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effects of deaeration Methods on dissolution testing in aqueous media a study using a total dissolved gas pressure meter
Journal of Pharmaceutical Sciences, 2006Co-Authors: Terry W Moore, William H Doub, Benjamin J. Westenberger, Lucinda F BuhseAbstract:ABSTRACT: Dissolution testing is a Critical Method for the determination of pharmaceutical product quality and bioequivalence. For some products, dissolved gases in the dissolution medium affect dissolution results thus requiring degassing of the medium prior to use. In this study, we use a total dissolved gas and oxygen meter to measure both oxygen and total gases in dissolution media before and after application of a variety of deaeration Methods. Dissolution testing results using a 10 mg Prednisone tablet (NCDA #2) are compared with the percent saturation of oxygen and total gases found in the medium. Reaeration of the medium during different stirring rates was also measured. This study confirms that measurement of total gases and not just oxygen in the medium is necessary to assess adequacy for dissolution testing. For those deaeration techniques that are performed at room temperature, the percent saturation of the total dissolved gases must be well below 100% to prevent outgassing once medium is brought to dissolution test Method temperature, typically 37°C. © 2006 Wiley-Liss, Inc. and the American Pharmacists Association.
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Effects of Deaeration Methods on Dissolution Testing in Aqueous Media: A Study Using a Total Dissolved Gas Pressure Meter *
Journal of Pharmaceutical Sciences, 2006Co-Authors: Terry W Moore, William H Doub, Benjamin J. Westenberger, Lucinda F BuhseAbstract:ABSTRACT: Dissolution testing is a Critical Method for the determination of pharmaceutical product quality and bioequivalence. For some products, dissolved gases in the dissolution medium affect dissolution results thus requiring degassing of the medium prior to use. In this study, we use a total dissolved gas and oxygen meter to measure both oxygen and total gases in dissolution media before and after application of a variety of deaeration Methods. Dissolution testing results using a 10 mg Prednisone tablet (NCDA #2) are compared with the percent saturation of oxygen and total gases found in the medium. Reaeration of the medium during different stirring rates was also measured. This study confirms that measurement of total gases and not just oxygen in the medium is necessary to assess adequacy for dissolution testing. For those deaeration techniques that are performed at room temperature, the percent saturation of the total dissolved gases must be well below 100% to prevent outgassing once medium is brought to dissolution test Method temperature, typically 37°C. © 2006 Wiley-Liss, Inc. and the American Pharmacists Association.
Ignacio Floresmoreno - One of the best experts on this subject based on the ideXlab platform.
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effect of intravitreous anti vascular endothelial growth factor therapy on choroidal thickness in neovascular age related macular degeneration using spectral domain optical coherence tomography
JAMA Ophthalmology, 2013Co-Authors: Lauren Branchini, Caio V Regatieri, Mehreen Adhi, Ignacio Floresmoreno, Varsha Manjunath, James G Fujimoto, Jay S DukerAbstract:A Critical Method of monitoring patients with neovascular age-related macular degeneration (AMD) being treated with anti–vascular endothelial growth factor (anti-VEGF) is optical coherence tomography (OCT), which uses low-coherence interferometry of light to examine the retina in vivo on a micrometer scale.1 Recent advances in spectral-domain OCT make visualization of the choroid feasible. Using image averaging and enhanced depth imaging, successful examination and measurement of choroidal thickness in normal and pathologic states have been reported.2–4 It has been hypothesized that anti-VEGF may affect choroidal vasculature.5 The goal of this study is to evaluate the effect of anti-VEGF on choroidal thickness using spectral-domain OCT in treatment-naive subjects.
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effect of intravitreous anti vascular endothelial growth factor therapy on choroidal thickness in neovascular age related macular degeneration using spectral domain optical coherence tomography
PMC, 2013Co-Authors: Lauren Branchini, Caio V Regatieri, Mehreen Adhi, Ignacio Floresmoreno, Varsha Manjunath, James G Fujimoto, Jay S DukerAbstract:Department of Ophthalmology, New England Eye Center, Tufts Medical Center, Boston (DrsBranchini, Regatieri, Adhi, Manjunath, and Duker) and Department of Electrical Engineering andComputer Science, Research Laboratory of Electronics, Massachusetts Institute of Technology,Cambridge (Dr Fujimoto); and Department of Ophthalmology, University Hospital of Albacete,Albacete, Spain (Dr Flores-Moreno).A Critical Method of monitoring patients with neovascular age-related macular degeneration(AMD) being treated with anti–vascular endothelial growth factor (anti-VEGF) is opticalcoherence tomography (OCT), which uses low-coherence interferometry of light to examinethe retina in vivo on a micrometer scale.