The Experts below are selected from a list of 90 Experts worldwide ranked by ideXlab platform
Elisabeth Aberer - One of the best experts on this subject based on the ideXlab platform.
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CXCL13 Chemokine in pediatric and adult neuroborreliosis
Acta Neurologica Scandinavica, 2011Co-Authors: Nora Wutte, Andrea Berghold, S. Löffler, Werner Zenz, E. Daghofer, I. Krainberger, G. Kleinert, Elisabeth AbererAbstract:Wutte N, Berghold A, Loffler S, Zenz W, Daghofer E, Krainberger I, Kleinert G, Aberer E. CXCL13 Chemokine in pediatric and adult neuroborreliosis. Acta Neurol Scand: 2011: 124: 321–328. © 2011 John Wiley & Sons A/S. Objectives – Diagnosis of Lyme neuroborreliosis (NB) depends on the proof of intrathecal antibody production against Borrelia burgdorferi. CXCL13 has been seen to be elevated early in NB, before antibody production has started. In this study, we determined the diagnostic role of the CXCL13 Chemokine in cerebrospinal fluid (CSF) and serum for the first time in pediatric NB patients as well as in adults, compared to controls and blood donors (BD). Material and methods – CXCL13 levels were measured in CSF and serum of 33 children and 42 adult patients. Serum CXCL13 was measured in 300 BD. Results – CSF CXCL13 levels were significantly elevated in definite and probable acute NB in children and adults compared to seropositive and seronegative neurological controls (P < 0.001). Serum CXCL13 levels showed great fluctuations and were not significantly elevated in NB patients. Conclusions – Our study suggests that CSF CXCL13 can be used as a diagnostic marker for NB in children as well. In contrast, CXCL13 serum levels show great variance even in the healthy population and are not indicative of active NB.
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CXCL13 Chemokine in pediatric and adult neuroborreliosis
Acta neurologica Scandinavica, 2011Co-Authors: Nora Wutte, Andrea Berghold, S. Löffler, Werner Zenz, E. Daghofer, I. Krainberger, G. Kleinert, Elisabeth AbererAbstract:Wutte N, Berghold A, Loffler S, Zenz W, Daghofer E, Krainberger I, Kleinert G, Aberer E. CXCL13 Chemokine in pediatric and adult neuroborreliosis. Acta Neurol Scand: 2011: 124: 321–328. © 2011 John Wiley & Sons A/S. Objectives – Diagnosis of Lyme neuroborreliosis (NB) depends on the proof of intrathecal antibody production against Borrelia burgdorferi. CXCL13 has been seen to be elevated early in NB, before antibody production has started. In this study, we determined the diagnostic role of the CXCL13 Chemokine in cerebrospinal fluid (CSF) and serum for the first time in pediatric NB patients as well as in adults, compared to controls and blood donors (BD). Material and methods – CXCL13 levels were measured in CSF and serum of 33 children and 42 adult patients. Serum CXCL13 was measured in 300 BD. Results – CSF CXCL13 levels were significantly elevated in definite and probable acute NB in children and adults compared to seropositive and seronegative neurological controls (P
Nora Wutte - One of the best experts on this subject based on the ideXlab platform.
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CXCL13 Chemokine in pediatric and adult neuroborreliosis
Acta Neurologica Scandinavica, 2011Co-Authors: Nora Wutte, Andrea Berghold, S. Löffler, Werner Zenz, E. Daghofer, I. Krainberger, G. Kleinert, Elisabeth AbererAbstract:Wutte N, Berghold A, Loffler S, Zenz W, Daghofer E, Krainberger I, Kleinert G, Aberer E. CXCL13 Chemokine in pediatric and adult neuroborreliosis. Acta Neurol Scand: 2011: 124: 321–328. © 2011 John Wiley & Sons A/S. Objectives – Diagnosis of Lyme neuroborreliosis (NB) depends on the proof of intrathecal antibody production against Borrelia burgdorferi. CXCL13 has been seen to be elevated early in NB, before antibody production has started. In this study, we determined the diagnostic role of the CXCL13 Chemokine in cerebrospinal fluid (CSF) and serum for the first time in pediatric NB patients as well as in adults, compared to controls and blood donors (BD). Material and methods – CXCL13 levels were measured in CSF and serum of 33 children and 42 adult patients. Serum CXCL13 was measured in 300 BD. Results – CSF CXCL13 levels were significantly elevated in definite and probable acute NB in children and adults compared to seropositive and seronegative neurological controls (P < 0.001). Serum CXCL13 levels showed great fluctuations and were not significantly elevated in NB patients. Conclusions – Our study suggests that CSF CXCL13 can be used as a diagnostic marker for NB in children as well. In contrast, CXCL13 serum levels show great variance even in the healthy population and are not indicative of active NB.
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CXCL13 Chemokine in pediatric and adult neuroborreliosis
Acta neurologica Scandinavica, 2011Co-Authors: Nora Wutte, Andrea Berghold, S. Löffler, Werner Zenz, E. Daghofer, I. Krainberger, G. Kleinert, Elisabeth AbererAbstract:Wutte N, Berghold A, Loffler S, Zenz W, Daghofer E, Krainberger I, Kleinert G, Aberer E. CXCL13 Chemokine in pediatric and adult neuroborreliosis. Acta Neurol Scand: 2011: 124: 321–328. © 2011 John Wiley & Sons A/S. Objectives – Diagnosis of Lyme neuroborreliosis (NB) depends on the proof of intrathecal antibody production against Borrelia burgdorferi. CXCL13 has been seen to be elevated early in NB, before antibody production has started. In this study, we determined the diagnostic role of the CXCL13 Chemokine in cerebrospinal fluid (CSF) and serum for the first time in pediatric NB patients as well as in adults, compared to controls and blood donors (BD). Material and methods – CXCL13 levels were measured in CSF and serum of 33 children and 42 adult patients. Serum CXCL13 was measured in 300 BD. Results – CSF CXCL13 levels were significantly elevated in definite and probable acute NB in children and adults compared to seropositive and seronegative neurological controls (P
Julian L. Ambrus - One of the best experts on this subject based on the ideXlab platform.
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Early Covert Appearance of Marginal Zone B Cells in Salivary Glands of Sjögren's Syndrome-Susceptible Mice: Initiators of Subsequent Overt Clinical Disease.
International journal of molecular sciences, 2021Co-Authors: Ammon B. Peck, Cuong Q. Nguyen, Julian L. AmbrusAbstract:The C57BL/6.NOD-Aec1Aec2 mouse model has been extensively studied to define the underlying cellular and molecular bioprocesses critical in the onset of primary Sjogren’s Syndrome (pSS), a human systemic autoimmune disease characterized clinically as the loss of lacrimal and salivary gland functions leading to dry eye and dry mouth pathologies. This mouse model, together with several gene knockout mouse models of SS, has indicated that B lymphocytes, especially marginal zone B (MZB) cells, are necessary for development and onset of clinical manifestations despite the fact that destruction of the lacrimal and salivary gland cells involves a classical T cell-mediated autoimmune response. Because migrations and functions of MZB cells are difficult to study in vivo, we have carried out ex vivo investigations that use temporal global RNA transcriptomic analyses to profile autoimmunity as it develops within the salivary glands of C57BL/6.NOD-Aec1Aec2 mice. Temporal profiles indicate the appearance of Notch2-positive cells within the salivary glands of these SS-susceptible mice concomitant with the early-phase appearance of lymphocytic foci (LF). Data presented here identify cellular bioprocesses occurring during early immune cell migrations into the salivary glands and suggest MZB cells are recruited to the exocrine glands by the upregulated CXCL13 Chemokine where they recognize complement (C´)-decorated antigens via their sphingosine-1-phosphate (S1P) and B cell (BC) receptors. Based on known MZB cell behavior and mobility, we propose that MZB cells activated in the salivary glands migrate to splenic follicular zones to present antigens to follicular macrophages and dendritic cells that, in turn, promote a subsequent systemic cell-mediated and autoantibody-mediated autoimmune T cell response that targets exocrine gland cells and functions. Overall, this study uses the power of transcriptomic analyses to provide greater insight into several molecular events defining cellular bioprocesses underlying SS that can be modelled and more thoroughly studied at the cellular level.
Werner Zenz - One of the best experts on this subject based on the ideXlab platform.
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CXCL13 Chemokine in pediatric and adult neuroborreliosis
Acta Neurologica Scandinavica, 2011Co-Authors: Nora Wutte, Andrea Berghold, S. Löffler, Werner Zenz, E. Daghofer, I. Krainberger, G. Kleinert, Elisabeth AbererAbstract:Wutte N, Berghold A, Loffler S, Zenz W, Daghofer E, Krainberger I, Kleinert G, Aberer E. CXCL13 Chemokine in pediatric and adult neuroborreliosis. Acta Neurol Scand: 2011: 124: 321–328. © 2011 John Wiley & Sons A/S. Objectives – Diagnosis of Lyme neuroborreliosis (NB) depends on the proof of intrathecal antibody production against Borrelia burgdorferi. CXCL13 has been seen to be elevated early in NB, before antibody production has started. In this study, we determined the diagnostic role of the CXCL13 Chemokine in cerebrospinal fluid (CSF) and serum for the first time in pediatric NB patients as well as in adults, compared to controls and blood donors (BD). Material and methods – CXCL13 levels were measured in CSF and serum of 33 children and 42 adult patients. Serum CXCL13 was measured in 300 BD. Results – CSF CXCL13 levels were significantly elevated in definite and probable acute NB in children and adults compared to seropositive and seronegative neurological controls (P < 0.001). Serum CXCL13 levels showed great fluctuations and were not significantly elevated in NB patients. Conclusions – Our study suggests that CSF CXCL13 can be used as a diagnostic marker for NB in children as well. In contrast, CXCL13 serum levels show great variance even in the healthy population and are not indicative of active NB.
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CXCL13 Chemokine in pediatric and adult neuroborreliosis
Acta neurologica Scandinavica, 2011Co-Authors: Nora Wutte, Andrea Berghold, S. Löffler, Werner Zenz, E. Daghofer, I. Krainberger, G. Kleinert, Elisabeth AbererAbstract:Wutte N, Berghold A, Loffler S, Zenz W, Daghofer E, Krainberger I, Kleinert G, Aberer E. CXCL13 Chemokine in pediatric and adult neuroborreliosis. Acta Neurol Scand: 2011: 124: 321–328. © 2011 John Wiley & Sons A/S. Objectives – Diagnosis of Lyme neuroborreliosis (NB) depends on the proof of intrathecal antibody production against Borrelia burgdorferi. CXCL13 has been seen to be elevated early in NB, before antibody production has started. In this study, we determined the diagnostic role of the CXCL13 Chemokine in cerebrospinal fluid (CSF) and serum for the first time in pediatric NB patients as well as in adults, compared to controls and blood donors (BD). Material and methods – CXCL13 levels were measured in CSF and serum of 33 children and 42 adult patients. Serum CXCL13 was measured in 300 BD. Results – CSF CXCL13 levels were significantly elevated in definite and probable acute NB in children and adults compared to seropositive and seronegative neurological controls (P
S. Löffler - One of the best experts on this subject based on the ideXlab platform.
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CXCL13 Chemokine in pediatric and adult neuroborreliosis
Acta Neurologica Scandinavica, 2011Co-Authors: Nora Wutte, Andrea Berghold, S. Löffler, Werner Zenz, E. Daghofer, I. Krainberger, G. Kleinert, Elisabeth AbererAbstract:Wutte N, Berghold A, Loffler S, Zenz W, Daghofer E, Krainberger I, Kleinert G, Aberer E. CXCL13 Chemokine in pediatric and adult neuroborreliosis. Acta Neurol Scand: 2011: 124: 321–328. © 2011 John Wiley & Sons A/S. Objectives – Diagnosis of Lyme neuroborreliosis (NB) depends on the proof of intrathecal antibody production against Borrelia burgdorferi. CXCL13 has been seen to be elevated early in NB, before antibody production has started. In this study, we determined the diagnostic role of the CXCL13 Chemokine in cerebrospinal fluid (CSF) and serum for the first time in pediatric NB patients as well as in adults, compared to controls and blood donors (BD). Material and methods – CXCL13 levels were measured in CSF and serum of 33 children and 42 adult patients. Serum CXCL13 was measured in 300 BD. Results – CSF CXCL13 levels were significantly elevated in definite and probable acute NB in children and adults compared to seropositive and seronegative neurological controls (P < 0.001). Serum CXCL13 levels showed great fluctuations and were not significantly elevated in NB patients. Conclusions – Our study suggests that CSF CXCL13 can be used as a diagnostic marker for NB in children as well. In contrast, CXCL13 serum levels show great variance even in the healthy population and are not indicative of active NB.
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CXCL13 Chemokine in pediatric and adult neuroborreliosis
Acta neurologica Scandinavica, 2011Co-Authors: Nora Wutte, Andrea Berghold, S. Löffler, Werner Zenz, E. Daghofer, I. Krainberger, G. Kleinert, Elisabeth AbererAbstract:Wutte N, Berghold A, Loffler S, Zenz W, Daghofer E, Krainberger I, Kleinert G, Aberer E. CXCL13 Chemokine in pediatric and adult neuroborreliosis. Acta Neurol Scand: 2011: 124: 321–328. © 2011 John Wiley & Sons A/S. Objectives – Diagnosis of Lyme neuroborreliosis (NB) depends on the proof of intrathecal antibody production against Borrelia burgdorferi. CXCL13 has been seen to be elevated early in NB, before antibody production has started. In this study, we determined the diagnostic role of the CXCL13 Chemokine in cerebrospinal fluid (CSF) and serum for the first time in pediatric NB patients as well as in adults, compared to controls and blood donors (BD). Material and methods – CXCL13 levels were measured in CSF and serum of 33 children and 42 adult patients. Serum CXCL13 was measured in 300 BD. Results – CSF CXCL13 levels were significantly elevated in definite and probable acute NB in children and adults compared to seropositive and seronegative neurological controls (P
