The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
André B. Charette - One of the best experts on this subject based on the ideXlab platform.
-
one pot synthesis of 3 4 5 trisubstituted 1 2 4 triazoles via the addition of hydrazides to activated secondary amides
Organic Letters, 2015Co-Authors: William S Bechara, Inna S Khazhieva, Elsa Rodriguez, André B. CharetteAbstract:A general approach has been developed for the one-pot synthesis of 3,4,5-trisubstituted 1,2,4-triazoles from secondary amides and hydrazides via triflic anhydride activation followed by microwave-induced Cyclodehydration. In addition, the 1,2,4-triazole moiety is shown to be a useful directing group for Ru-catalyzed C–H arylation. Access to 1,2,4-triazolophenanthridine can be achieved from the reaction products using a Pd-catalyzed intramolecular C–H functionalization reaction.
-
triflic anhydride mediated synthesis of imidazo 1 5 a azines
ChemInform, 2013Co-Authors: Guillaume Pelletier, André B. CharetteAbstract:A wide range of imidazo[1,5-a]azines is constructed using a mild Cyclodehydration/aromatization reaction triggered by the use of triflic anhydride and 2-methoxypyridine.
-
triflic anhydride mediated synthesis of imidazo 1 5 a azines
Organic Letters, 2013Co-Authors: Guillaume Pelletier, André B. CharetteAbstract:Imidazo[1,5-a]azines are synthesized in moderate to excellent yields using a mild Cyclodehydration/aromatization reaction triggered by the use of triflic anhydride (Tf2O) and 2-methoxypyridine (2-MeOPyr). Various substitution patterns and functional groups were found to be compatible under the optimized conditions. In addition, a 5-bromo-3-aryl derivative was also shown to be active in a Sonogashira cross-coupling and direct arylation reactions. A tertiary amide was compatible as a substrate leading to the synthesis of an imidazo[1,5-a]pyridinium triflate.
Riyuan Tang - One of the best experts on this subject based on the ideXlab platform.
-
nh4pf6 promoted Cyclodehydration of α amino carbonyl compounds efficient synthesis of pyrrolo 3 2 1 ij quinoline and indole derivatives
ChemInform, 2015Co-Authors: Shujuan Zhou, Chenliang Deng, Fan Chen, Riyuan TangAbstract:Title compounds (II), (IV), and (VI) are efficiently and conveniently synthesized by a metal-free Cyclodehydration strategy.
-
nh4pf6 promoted Cyclodehydration of α amino carbonyl compounds efficient synthesis of pyrrolo 3 2 1 ij quinoline and indole derivatives
RSC Advances, 2014Co-Authors: Shujuan Zhou, Chenliang Deng, Fan Chen, Riyuan TangAbstract:NH4PF6 is an inexpensive, safe, and low-toxicity inorganic salt; it was found to promote the Cyclodehydration of α-amino carbonyl compounds in the absence of metal reagents. This simple Cyclodehydration strategy enables highly atom-economic formation of pyrrolo[3,2,1-ij]quinoline and indole derivatives, which are significant pharmacophores.
William S Bechara - One of the best experts on this subject based on the ideXlab platform.
-
one pot synthesis of 3 4 5 trisubstituted 1 2 4 triazoles via the addition of hydrazides to activated secondary amides
Organic Letters, 2015Co-Authors: William S Bechara, Inna S Khazhieva, Elsa Rodriguez, André B. CharetteAbstract:A general approach has been developed for the one-pot synthesis of 3,4,5-trisubstituted 1,2,4-triazoles from secondary amides and hydrazides via triflic anhydride activation followed by microwave-induced Cyclodehydration. In addition, the 1,2,4-triazole moiety is shown to be a useful directing group for Ru-catalyzed C–H arylation. Access to 1,2,4-triazolophenanthridine can be achieved from the reaction products using a Pd-catalyzed intramolecular C–H functionalization reaction.
Christopher Hulme - One of the best experts on this subject based on the ideXlab platform.
-
ugi robinson gabriel reactions directed toward the synthesis of 2 4 5 trisubstituted oxazoles
Tetrahedron Letters, 2012Co-Authors: Arthur Y Shaw, Christopher HulmeAbstract:This Letter discloses a novel concise synthesis of a series of 2,4,5-trisubstituted oxazoles via a tandem Ugi/Robinson–Gabriel sequence. Herein, 2,4-dimethoxybenzylamine 1 was used as an ammonia equivalent in combination with arylglyoxal 3 and supporting Ugi reagents, an isonitrile and carboxylic acid. As such the product of the acid treated Ugi intermediate is ideally configured to undergo a Robinson–Gabriel Cyclodehydration reaction to yield the desired oxazole scaffold 5.
Shujuan Zhou - One of the best experts on this subject based on the ideXlab platform.
-
nh4pf6 promoted Cyclodehydration of α amino carbonyl compounds efficient synthesis of pyrrolo 3 2 1 ij quinoline and indole derivatives
ChemInform, 2015Co-Authors: Shujuan Zhou, Chenliang Deng, Fan Chen, Riyuan TangAbstract:Title compounds (II), (IV), and (VI) are efficiently and conveniently synthesized by a metal-free Cyclodehydration strategy.
-
nh4pf6 promoted Cyclodehydration of α amino carbonyl compounds efficient synthesis of pyrrolo 3 2 1 ij quinoline and indole derivatives
RSC Advances, 2014Co-Authors: Shujuan Zhou, Chenliang Deng, Fan Chen, Riyuan TangAbstract:NH4PF6 is an inexpensive, safe, and low-toxicity inorganic salt; it was found to promote the Cyclodehydration of α-amino carbonyl compounds in the absence of metal reagents. This simple Cyclodehydration strategy enables highly atom-economic formation of pyrrolo[3,2,1-ij]quinoline and indole derivatives, which are significant pharmacophores.
