The Experts below are selected from a list of 225 Experts worldwide ranked by ideXlab platform
Jae-hee Hyun - One of the best experts on this subject based on the ideXlab platform.
-
c29 sterols with a Cyclopropane Ring at c 25 and 26 from the vietnamese marine sponge ianthella sp and their anticancer properties
Bioorganic & Medicinal Chemistry Letters, 2009Co-Authors: Huu Tung Nguyen, Van Minh Chau, Thu Ha Tran, Van Kiem Phan, Thanh Huong Hoang, Tien Dat Nguyen, Xuan Nhiem Nguyen, Bui Huu Tai, Jae-hee HyunAbstract:Two new C(29) sterols with a Cyclopropane Ring at C-25 and C-26, petrosterol-3,6-dione (1) and 5alpha,6alpha-epoxy-petrosterol (2), along with petrosterol (3), were isolated from the Vietnamese marine sponge Ianthella sp. The structures of the new compounds were elucidated by comprehensive spectroscopic analyses. Compounds 1-3 showed cytotoxic activities on A549, HL-60, MCF-7, SK-OV-3, and U937 cancer cell lines with IC(50) in the range of 8.4-22.6 microM, whereas compounds 1-3 exhibited only weak cytotoxic activities on HT-29 cell. After HL-60 cells were treated with the compounds, several apoptosis events like chromatin condensation and the increase of the population of sub-G1 hypodiploid cells were observed. These data supported that the compounds might have potential for leukemia treatment.
-
A new C29-sterol with a Cyclopropane Ring at C-25 and 26 from the Vietnamese marine sponge lanthella sp.
Archives of pharmacal research, 2009Co-Authors: Nguyen Huu Tung, Chau Van Minh, Phan Van Kiem, Hoang Thanh Huong, Nguyen Tien Dat, Nguyen Xuan Nhiem, Nguyen Xuan Cuong, Jae-hee Hyun, Hee-kyoung KangAbstract:One new C29 sterol with a Cyclopropane Ring at C-25 and C-26, aragusteroketal B (1), and aragusterol B (2) were isolated from the Vietnamese marine sponge Ianthella sp. Their structures were elucidated by extensive spectroscopic analyses. Both 1 and 2 showed moderate cytotoxic activity against MCF-7, SK-Hep-1, and HeLa cell lines with IC50 in the range of 12.8–27.8 μM.
Jacek Stalewski - One of the best experts on this subject based on the ideXlab platform.
-
The Vicarious Nucleophilic Substitution of Hydrogen Proceeding via a Cyclopropane Ring‐Opening.
ChemInform, 2010Co-Authors: Jacek StalewskiAbstract:Abstract 1-Cyano-2,2-diethoxycarbonyl Cyclopropane was reacted with several nitroarenes under basic conditions. The reaction proceeded according to the vicarious nucleophilic substitution of hydrogen scheme; i.e. the initially formed σ-adducts underwent base-induced elimination, resulting in cleavage of the Cyclopropane Ring. The ortho -substituted products can be directly transformed into substituted N -hydroxyindoles.
-
the vicarious nucleophilic substitution of hydrogen proceeding via a Cyclopropane Ring opening
Tetrahedron Letters, 1998Co-Authors: Jacek StalewskiAbstract:Abstract 1-Cyano-2,2-diethoxycarbonyl Cyclopropane was reacted with several nitroarenes under basic conditions. The reaction proceeded according to the vicarious nucleophilic substitution of hydrogen scheme; i.e. the initially formed σ-adducts underwent base-induced elimination, resulting in cleavage of the Cyclopropane Ring. The ortho -substituted products can be directly transformed into substituted N -hydroxyindoles.
Hee-kyoung Kang - One of the best experts on this subject based on the ideXlab platform.
-
A new C29-sterol with a Cyclopropane Ring at C-25 and 26 from the Vietnamese marine sponge lanthella sp.
Archives of pharmacal research, 2009Co-Authors: Nguyen Huu Tung, Chau Van Minh, Phan Van Kiem, Hoang Thanh Huong, Nguyen Tien Dat, Nguyen Xuan Nhiem, Nguyen Xuan Cuong, Jae-hee Hyun, Hee-kyoung KangAbstract:One new C29 sterol with a Cyclopropane Ring at C-25 and C-26, aragusteroketal B (1), and aragusterol B (2) were isolated from the Vietnamese marine sponge Ianthella sp. Their structures were elucidated by extensive spectroscopic analyses. Both 1 and 2 showed moderate cytotoxic activity against MCF-7, SK-Hep-1, and HeLa cell lines with IC50 in the range of 12.8–27.8 μM.
Dzmitry Kananovich - One of the best experts on this subject based on the ideXlab platform.
-
Divergent Access to Histone Deacetylase Inhibitory Cyclopeptides via a Late-Stage Cyclopropane Ring Cleavage Strategy. Short Synthesis of Chlamydocin
Organic letters, 2019Co-Authors: Gabor Zoltan Elek, Kaur Koppel, Dzmitry Zubrytski, Nele Konrad, Ivar Järving, Margus Lopp, Dzmitry KananovichAbstract:A unified step-economical strategy for accessing histone deacetylase inhibitory peptides is proposed, based on the late-stage installation of multiple zinc-binding functionalities via the cleavage of the strained Cyclopropane Ring in the common pluripotent cyclopropanol precursor. The efficacy of the proposed diversity-oriented approach has been validated by short stereoselective synthesis of natural product chlamydocin, containing a challenging-to-install fragment of (2S,9S)-2-amino-8-oxo-9,10-epoxydecanoic acid (Aoe) and a range of its analogues, derivatives of 2-amino-8-oxodecanoic and 2-aminosuberic acids.
-
Divergent Access to Histone Deacetylase Inhibitory Cyclopeptides via Late- Stage Cyclopropane Ring Cleavage Strategy. Short Synthesis of Chlamydocin
2019Co-Authors: Gabor Zoltan Elek, Kaur Koppel, Dzmitry Zubrytski, Nele Konrad, Ivar Järving, Margus Lopp, Dzmitry KananovichAbstract:We present a unified step-economical strategy to access histone deacetylase inhibitory peptides, based on late-stage installation of zinc-binding functionalities via the cleavage of the strained Cyclopropane Ring in the common pluripotent cyclopropanol precursor. The efficacy of the proposed diversity-oriented approch has been validated by short stereoselective synthesis of a natural product chlamydocin and a number of its analogs.<br>
Satoshi Obika - One of the best experts on this subject based on the ideXlab platform.
-
Synthesis and properties of 2′-O,4′-C-spirocyclopropylene bridged nucleic acid (scpBNA), an analogue of 2′,4′-BNA/LNA beaRing a Cyclopropane Ring
Chemical communications (Cambridge England), 2015Co-Authors: Takao Yamaguchi, Masahiko Horiba, Satoshi ObikaAbstract:2′-O,4′-C-Spirocyclopropylene bridged nucleic acid (scpBNA), an analogue of 2′-O,4′-C-methylene bridged nucleic acid (2′,4′-BNA/LNA) beaRing a Cyclopropane Ring at the 6′-position, was synthesized and successfully incorporated into oligonucleotides. The scpBNA-modified oligonucleotides showed excellent duplex-forming ability with complementary single-stranded RNA and exhibited increased enzymatic stability as compared to the corresponding natural and 2′,4′-BNA/LNA-modified oligonucleotides. Our results demonstrate the potential of scpBNA for gene therapeutics, such as antisense technology.
-
synthesis and properties of 2 o 4 c spirocyclopropylene bridged nucleic acid scpbna an analogue of 2 4 bna lna beaRing a Cyclopropane Ring
Chemical Communications, 2015Co-Authors: Takao Yamaguchi, Masahiko Horiba, Satoshi ObikaAbstract:2′-O,4′-C-Spirocyclopropylene bridged nucleic acid (scpBNA), an analogue of 2′-O,4′-C-methylene bridged nucleic acid (2′,4′-BNA/LNA) beaRing a Cyclopropane Ring at the 6′-position, was synthesized and successfully incorporated into oligonucleotides. The scpBNA-modified oligonucleotides showed excellent duplex-forming ability with complementary single-stranded RNA and exhibited increased enzymatic stability as compared to the corresponding natural and 2′,4′-BNA/LNA-modified oligonucleotides. Our results demonstrate the potential of scpBNA for gene therapeutics, such as antisense technology.
