Cyst Fluid

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Karin Sundfeldt - One of the best experts on this subject based on the ideXlab platform.

  • potential tumor biomarkers identified in ovarian Cyst Fluid by quantitative proteomic analysis itraq
    Clinical Proteomics, 2013
    Co-Authors: Bjorg Kristjansdottir, Kristina Levan, Karolina Partheen, Elisabet Carlsohn, Karin Sundfeldt
    Abstract:

    Background Epithelial-derived ovarian adenocarcinoma (EOC) is the most deadly gynecologic tumor, and the principle cause of the poor survival rate is diagnosis at a late stage. Screening and diagnostic biomarkers with acceptable specificity and sensitivity are lacking. Ovarian Cyst Fluid should harbor early ovarian cancer biomarkers because of its closeness to the tumor. We investigated ovarian Cyst Fluid as a source for discovering biomarkers for use in the diagnosis of EOC.

  • Potential tumor biomarkers identified in ovarian Cyst Fluid by quantitative proteomic analysis, iTRAQ
    Clinical Proteomics, 2013
    Co-Authors: Bjorg Kristjansdottir, Kristina Levan, Karolina Partheen, Elisabet Carlsohn, Karin Sundfeldt
    Abstract:

    Background Epithelial-derived ovarian adenocarcinoma (EOC) is the most deadly gynecologic tumor, and the principle cause of the poor survival rate is diagnosis at a late stage. Screening and diagnostic biomarkers with acceptable specificity and sensitivity are lacking. Ovarian Cyst Fluid should harbor early ovarian cancer biomarkers because of its closeness to the tumor. We investigated ovarian Cyst Fluid as a source for discovering biomarkers for use in the diagnosis of EOC. Results Using quantitative mass spectrometry, iTRAQ MS, we identified 837 proteins in Cyst Fluid from benign, EOC stage I, and EOC stage III. Only patients of serous histology were included in the study. Comparing the benign (n = 5) with the malignant (n = 10) group, 87 of the proteins were significantly (p 

Bjorg Kristjansdottir - One of the best experts on this subject based on the ideXlab platform.

  • potential tumor biomarkers identified in ovarian Cyst Fluid by quantitative proteomic analysis itraq
    Clinical Proteomics, 2013
    Co-Authors: Bjorg Kristjansdottir, Kristina Levan, Karolina Partheen, Elisabet Carlsohn, Karin Sundfeldt
    Abstract:

    Background Epithelial-derived ovarian adenocarcinoma (EOC) is the most deadly gynecologic tumor, and the principle cause of the poor survival rate is diagnosis at a late stage. Screening and diagnostic biomarkers with acceptable specificity and sensitivity are lacking. Ovarian Cyst Fluid should harbor early ovarian cancer biomarkers because of its closeness to the tumor. We investigated ovarian Cyst Fluid as a source for discovering biomarkers for use in the diagnosis of EOC.

  • Potential tumor biomarkers identified in ovarian Cyst Fluid by quantitative proteomic analysis, iTRAQ
    Clinical Proteomics, 2013
    Co-Authors: Bjorg Kristjansdottir, Kristina Levan, Karolina Partheen, Elisabet Carlsohn, Karin Sundfeldt
    Abstract:

    Background Epithelial-derived ovarian adenocarcinoma (EOC) is the most deadly gynecologic tumor, and the principle cause of the poor survival rate is diagnosis at a late stage. Screening and diagnostic biomarkers with acceptable specificity and sensitivity are lacking. Ovarian Cyst Fluid should harbor early ovarian cancer biomarkers because of its closeness to the tumor. We investigated ovarian Cyst Fluid as a source for discovering biomarkers for use in the diagnosis of EOC. Results Using quantitative mass spectrometry, iTRAQ MS, we identified 837 proteins in Cyst Fluid from benign, EOC stage I, and EOC stage III. Only patients of serous histology were included in the study. Comparing the benign (n = 5) with the malignant (n = 10) group, 87 of the proteins were significantly (p 

Eleftherios P Diamandis - One of the best experts on this subject based on the ideXlab platform.

  • Prostate specific antigen — a new constituent of breast Cyst Fluid
    Breast Cancer Research and Treatment, 1996
    Co-Authors: Eleftherios P Diamandis, He Yu, Carlos López-otín
    Abstract:

    We demonstrate for the first time that prostate specific antigen (PSA) is a component of breast Cyst Fluid. At the cutoff level of 0.01 or 0.03 µg/L of PSA, 64% or 43% of Cyst Fluids are positive for PSA, respectively. PSA in Cyst Fluid, as characterized by high performance liquid chromatography, exists in almost equal concentrations as free PSA, with a molecular weight of 33 KDa, and as PSA bound to α_1-antichymotrypsin, with a molecular weight of 100 KDa. PSA presence was also characterized in Cyst Fluid by Western blot analysis. These data suggest that PSA is a frequent component of breast Cyst Fluid. More studies are needed to establish the role of this serine protease in normal breast, gross breast Cystic disease, and breast cancer.

  • prostate specific antigen a new constituent of breast Cyst Fluid
    Breast Cancer Research and Treatment, 1996
    Co-Authors: Eleftherios P Diamandis, He Yu, Carlos Lopezotin
    Abstract:

    We demonstrate for the first time that prostate specific antigen (PSA) is a component of breast Cyst Fluid. At the cutoff level of 0.01 or 0.03 µg/L of PSA, 64% or 43% of Cyst Fluids are positive for PSA, respectively. PSA in Cyst Fluid, as characterized by high performance liquid chromatography, exists in almost equal concentrations as free PSA, with a molecular weight of 33 KDa, and as PSA bound to α1-antichymotrypsin, with a molecular weight of 100 KDa. PSA presence was also characterized in Cyst Fluid by Western blot analysis. These data suggest that PSA is a frequent component of breast Cyst Fluid. More studies are needed to establish the role of this serine protease in normal breast, gross breast Cystic disease, and breast cancer.

Elisabet Carlsohn - One of the best experts on this subject based on the ideXlab platform.

  • potential tumor biomarkers identified in ovarian Cyst Fluid by quantitative proteomic analysis itraq
    Clinical Proteomics, 2013
    Co-Authors: Bjorg Kristjansdottir, Kristina Levan, Karolina Partheen, Elisabet Carlsohn, Karin Sundfeldt
    Abstract:

    Background Epithelial-derived ovarian adenocarcinoma (EOC) is the most deadly gynecologic tumor, and the principle cause of the poor survival rate is diagnosis at a late stage. Screening and diagnostic biomarkers with acceptable specificity and sensitivity are lacking. Ovarian Cyst Fluid should harbor early ovarian cancer biomarkers because of its closeness to the tumor. We investigated ovarian Cyst Fluid as a source for discovering biomarkers for use in the diagnosis of EOC.

  • Potential tumor biomarkers identified in ovarian Cyst Fluid by quantitative proteomic analysis, iTRAQ
    Clinical Proteomics, 2013
    Co-Authors: Bjorg Kristjansdottir, Kristina Levan, Karolina Partheen, Elisabet Carlsohn, Karin Sundfeldt
    Abstract:

    Background Epithelial-derived ovarian adenocarcinoma (EOC) is the most deadly gynecologic tumor, and the principle cause of the poor survival rate is diagnosis at a late stage. Screening and diagnostic biomarkers with acceptable specificity and sensitivity are lacking. Ovarian Cyst Fluid should harbor early ovarian cancer biomarkers because of its closeness to the tumor. We investigated ovarian Cyst Fluid as a source for discovering biomarkers for use in the diagnosis of EOC. Results Using quantitative mass spectrometry, iTRAQ MS, we identified 837 proteins in Cyst Fluid from benign, EOC stage I, and EOC stage III. Only patients of serous histology were included in the study. Comparing the benign (n = 5) with the malignant (n = 10) group, 87 of the proteins were significantly (p 

Karolina Partheen - One of the best experts on this subject based on the ideXlab platform.

  • potential tumor biomarkers identified in ovarian Cyst Fluid by quantitative proteomic analysis itraq
    Clinical Proteomics, 2013
    Co-Authors: Bjorg Kristjansdottir, Kristina Levan, Karolina Partheen, Elisabet Carlsohn, Karin Sundfeldt
    Abstract:

    Background Epithelial-derived ovarian adenocarcinoma (EOC) is the most deadly gynecologic tumor, and the principle cause of the poor survival rate is diagnosis at a late stage. Screening and diagnostic biomarkers with acceptable specificity and sensitivity are lacking. Ovarian Cyst Fluid should harbor early ovarian cancer biomarkers because of its closeness to the tumor. We investigated ovarian Cyst Fluid as a source for discovering biomarkers for use in the diagnosis of EOC.

  • Potential tumor biomarkers identified in ovarian Cyst Fluid by quantitative proteomic analysis, iTRAQ
    Clinical Proteomics, 2013
    Co-Authors: Bjorg Kristjansdottir, Kristina Levan, Karolina Partheen, Elisabet Carlsohn, Karin Sundfeldt
    Abstract:

    Background Epithelial-derived ovarian adenocarcinoma (EOC) is the most deadly gynecologic tumor, and the principle cause of the poor survival rate is diagnosis at a late stage. Screening and diagnostic biomarkers with acceptable specificity and sensitivity are lacking. Ovarian Cyst Fluid should harbor early ovarian cancer biomarkers because of its closeness to the tumor. We investigated ovarian Cyst Fluid as a source for discovering biomarkers for use in the diagnosis of EOC. Results Using quantitative mass spectrometry, iTRAQ MS, we identified 837 proteins in Cyst Fluid from benign, EOC stage I, and EOC stage III. Only patients of serous histology were included in the study. Comparing the benign (n = 5) with the malignant (n = 10) group, 87 of the proteins were significantly (p 

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