The Experts below are selected from a list of 12 Experts worldwide ranked by ideXlab platform

Michel M Maharbiz - One of the best experts on this subject based on the ideXlab platform.

  • an actuated neural probe architecture for reducing gliosis induced recording degradation
    IEEE Transactions on Nanobioscience, 2019
    Co-Authors: Travis L Massey, Leane S Kuo, Jiang Lan Fan, Michel M Maharbiz
    Abstract:

    Glial encapsulation of chronically implanted neural probes inhibits recording and stimulation, and this signal loss is a significant factor limiting the clinical viability of most neural implant topologies for decades-long implantation. We demonstrate a mechanical proof of concept for silicon shank-style neural probes intended to minimize gliosis near the recording sites. Compliant whiskers on the edges of the probe fold inward to minimize tissue damage during insertion. Once implanted to the target depth and retracted slightly, these whiskers splay outward. The splayed tips, on which recording sites could be patterned, extend beyond the typical 50–100 $\mu \text{m}$ radius of a glial scar. The whiskers are micrometer-scale to minimize or avoid glial scarring. Electrically inactive devices with whiskers of varying widths and curvature were designed and monolithically fabricated from a 5- $\mu \text{m}$ silicon-on-insulator (SOI) wafer, and their mechanical functionality was demonstrated in a 0.6% agar brain phantom. Deflection was plotted versus Deflection Speed, and those that were most compliant actuated successfully. This probe requires no preparation for use beyond what is typical for a shank-style silicon probe.

  • an actuated neural probe architecture for reducing gliosis induced recording degradation
    bioRxiv, 2018
    Co-Authors: Travis L Massey, Leane S Kuo, Jiang Lan Fan, Michel M Maharbiz
    Abstract:

    Glial encapsulation of chronically implanted neural probes inhibits recording and stimulation, and this signal loss is a significant factor limiting the clinical viability of most neural implant topologies for decades-long implantation. We demonstrate a mechanical proof of concept for silicon shank-style neural probes intended to minimize gliosis near the recording sites. Compliant whiskers on the edges of the probe fold inward to minimize tissue damage during insertion. Once implanted to the target depth and retracted slightly, these whiskers splay outward. The splayed tips, on which recording sites could be patterned, extend beyond the typical 50-100 micron radius of a glial scar. The whiskers are micron-scale to minimize or avoid glial scarring. Electrically inactive devices with whiskers of varying widths and curvature were designed and monolithically fabricated from a five-micron silicon-on-insulator (SOI) wafer, and their mechanical functionality was demonstrated in a 0.6% agar brain phantom. Deflection was plotted versus Deflection Speed, and those that were most compliant actuated successfully. This probe requires no preparation for use beyond what is typical for a shank-style silicon probe.

Travis L Massey - One of the best experts on this subject based on the ideXlab platform.

  • an actuated neural probe architecture for reducing gliosis induced recording degradation
    IEEE Transactions on Nanobioscience, 2019
    Co-Authors: Travis L Massey, Leane S Kuo, Jiang Lan Fan, Michel M Maharbiz
    Abstract:

    Glial encapsulation of chronically implanted neural probes inhibits recording and stimulation, and this signal loss is a significant factor limiting the clinical viability of most neural implant topologies for decades-long implantation. We demonstrate a mechanical proof of concept for silicon shank-style neural probes intended to minimize gliosis near the recording sites. Compliant whiskers on the edges of the probe fold inward to minimize tissue damage during insertion. Once implanted to the target depth and retracted slightly, these whiskers splay outward. The splayed tips, on which recording sites could be patterned, extend beyond the typical 50–100 $\mu \text{m}$ radius of a glial scar. The whiskers are micrometer-scale to minimize or avoid glial scarring. Electrically inactive devices with whiskers of varying widths and curvature were designed and monolithically fabricated from a 5- $\mu \text{m}$ silicon-on-insulator (SOI) wafer, and their mechanical functionality was demonstrated in a 0.6% agar brain phantom. Deflection was plotted versus Deflection Speed, and those that were most compliant actuated successfully. This probe requires no preparation for use beyond what is typical for a shank-style silicon probe.

  • an actuated neural probe architecture for reducing gliosis induced recording degradation
    bioRxiv, 2018
    Co-Authors: Travis L Massey, Leane S Kuo, Jiang Lan Fan, Michel M Maharbiz
    Abstract:

    Glial encapsulation of chronically implanted neural probes inhibits recording and stimulation, and this signal loss is a significant factor limiting the clinical viability of most neural implant topologies for decades-long implantation. We demonstrate a mechanical proof of concept for silicon shank-style neural probes intended to minimize gliosis near the recording sites. Compliant whiskers on the edges of the probe fold inward to minimize tissue damage during insertion. Once implanted to the target depth and retracted slightly, these whiskers splay outward. The splayed tips, on which recording sites could be patterned, extend beyond the typical 50-100 micron radius of a glial scar. The whiskers are micron-scale to minimize or avoid glial scarring. Electrically inactive devices with whiskers of varying widths and curvature were designed and monolithically fabricated from a five-micron silicon-on-insulator (SOI) wafer, and their mechanical functionality was demonstrated in a 0.6% agar brain phantom. Deflection was plotted versus Deflection Speed, and those that were most compliant actuated successfully. This probe requires no preparation for use beyond what is typical for a shank-style silicon probe.

Leane S Kuo - One of the best experts on this subject based on the ideXlab platform.

  • an actuated neural probe architecture for reducing gliosis induced recording degradation
    IEEE Transactions on Nanobioscience, 2019
    Co-Authors: Travis L Massey, Leane S Kuo, Jiang Lan Fan, Michel M Maharbiz
    Abstract:

    Glial encapsulation of chronically implanted neural probes inhibits recording and stimulation, and this signal loss is a significant factor limiting the clinical viability of most neural implant topologies for decades-long implantation. We demonstrate a mechanical proof of concept for silicon shank-style neural probes intended to minimize gliosis near the recording sites. Compliant whiskers on the edges of the probe fold inward to minimize tissue damage during insertion. Once implanted to the target depth and retracted slightly, these whiskers splay outward. The splayed tips, on which recording sites could be patterned, extend beyond the typical 50–100 $\mu \text{m}$ radius of a glial scar. The whiskers are micrometer-scale to minimize or avoid glial scarring. Electrically inactive devices with whiskers of varying widths and curvature were designed and monolithically fabricated from a 5- $\mu \text{m}$ silicon-on-insulator (SOI) wafer, and their mechanical functionality was demonstrated in a 0.6% agar brain phantom. Deflection was plotted versus Deflection Speed, and those that were most compliant actuated successfully. This probe requires no preparation for use beyond what is typical for a shank-style silicon probe.

  • an actuated neural probe architecture for reducing gliosis induced recording degradation
    bioRxiv, 2018
    Co-Authors: Travis L Massey, Leane S Kuo, Jiang Lan Fan, Michel M Maharbiz
    Abstract:

    Glial encapsulation of chronically implanted neural probes inhibits recording and stimulation, and this signal loss is a significant factor limiting the clinical viability of most neural implant topologies for decades-long implantation. We demonstrate a mechanical proof of concept for silicon shank-style neural probes intended to minimize gliosis near the recording sites. Compliant whiskers on the edges of the probe fold inward to minimize tissue damage during insertion. Once implanted to the target depth and retracted slightly, these whiskers splay outward. The splayed tips, on which recording sites could be patterned, extend beyond the typical 50-100 micron radius of a glial scar. The whiskers are micron-scale to minimize or avoid glial scarring. Electrically inactive devices with whiskers of varying widths and curvature were designed and monolithically fabricated from a five-micron silicon-on-insulator (SOI) wafer, and their mechanical functionality was demonstrated in a 0.6% agar brain phantom. Deflection was plotted versus Deflection Speed, and those that were most compliant actuated successfully. This probe requires no preparation for use beyond what is typical for a shank-style silicon probe.

Jiang Lan Fan - One of the best experts on this subject based on the ideXlab platform.

  • an actuated neural probe architecture for reducing gliosis induced recording degradation
    IEEE Transactions on Nanobioscience, 2019
    Co-Authors: Travis L Massey, Leane S Kuo, Jiang Lan Fan, Michel M Maharbiz
    Abstract:

    Glial encapsulation of chronically implanted neural probes inhibits recording and stimulation, and this signal loss is a significant factor limiting the clinical viability of most neural implant topologies for decades-long implantation. We demonstrate a mechanical proof of concept for silicon shank-style neural probes intended to minimize gliosis near the recording sites. Compliant whiskers on the edges of the probe fold inward to minimize tissue damage during insertion. Once implanted to the target depth and retracted slightly, these whiskers splay outward. The splayed tips, on which recording sites could be patterned, extend beyond the typical 50–100 $\mu \text{m}$ radius of a glial scar. The whiskers are micrometer-scale to minimize or avoid glial scarring. Electrically inactive devices with whiskers of varying widths and curvature were designed and monolithically fabricated from a 5- $\mu \text{m}$ silicon-on-insulator (SOI) wafer, and their mechanical functionality was demonstrated in a 0.6% agar brain phantom. Deflection was plotted versus Deflection Speed, and those that were most compliant actuated successfully. This probe requires no preparation for use beyond what is typical for a shank-style silicon probe.

  • an actuated neural probe architecture for reducing gliosis induced recording degradation
    bioRxiv, 2018
    Co-Authors: Travis L Massey, Leane S Kuo, Jiang Lan Fan, Michel M Maharbiz
    Abstract:

    Glial encapsulation of chronically implanted neural probes inhibits recording and stimulation, and this signal loss is a significant factor limiting the clinical viability of most neural implant topologies for decades-long implantation. We demonstrate a mechanical proof of concept for silicon shank-style neural probes intended to minimize gliosis near the recording sites. Compliant whiskers on the edges of the probe fold inward to minimize tissue damage during insertion. Once implanted to the target depth and retracted slightly, these whiskers splay outward. The splayed tips, on which recording sites could be patterned, extend beyond the typical 50-100 micron radius of a glial scar. The whiskers are micron-scale to minimize or avoid glial scarring. Electrically inactive devices with whiskers of varying widths and curvature were designed and monolithically fabricated from a five-micron silicon-on-insulator (SOI) wafer, and their mechanical functionality was demonstrated in a 0.6% agar brain phantom. Deflection was plotted versus Deflection Speed, and those that were most compliant actuated successfully. This probe requires no preparation for use beyond what is typical for a shank-style silicon probe.

J T L Thong - One of the best experts on this subject based on the ideXlab platform.

  • improving the Speed of scanning electron microscope Deflection systems
    Measurement Science and Technology, 1999
    Co-Authors: K W Lee, J T L Thong
    Abstract:

    A simple technique to characterize the response of a SEM Deflection system is described. By measuring the delay in the SEM video signal as the primary beam is deflected and swept over a knife-edge, the transient Deflection response can be mapped out. The transfer function of the beam Deflection is then approximated by exponential functions and appropriate analogue filters are designed to pre-emphasise the Deflection coil drive signal in order to increase the Deflection Speed. This technique is used to decrease the Deflection response time from typically ~6 µs to ~0.5 µs, thereby allowing the implementation of non-raster scanning schemes that require fast point-to-point Deflection.