The Experts below are selected from a list of 99 Experts worldwide ranked by ideXlab platform
Adel K Elnaggar - One of the best experts on this subject based on the ideXlab platform.
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molecular analysis of chromosome 16q regions in Dermal analogue tumors of salivary glands a genetic link to Dermal Cylindroma
The American Journal of Surgical Pathology, 2002Co-Authors: Hong Ran Choi, John G Batsakis, David L Callender, Victor G Prieto, Mario A Luna, Adel K ElnaggarAbstract:: Dermal analogue tumor, an uncommon subtype of basal cell monomorphic adenoma of the parotid gland, has a remarkable clinical and histologic resemblance to Dermal Cylindroma. Molecular studies of familial and sporadic Cylindromas have shown frequent alterations at chromosome 16q12-13 that have recently been found to house the Cylindromatosis gene (CYLD). To determine the involvement of the chromosome 16q12-13 region in Dermal analogue tumors, we performed loss of heterozygosity analysis using microsatellite markers flanking the Cylindromatosis gene locus in 21 sporadic Dermal analogue salivary tumors and 12 salivary and Dermal lesions from two sisters. Loss of heterozygosity was identified in 17 (80.9%) of the 21 sporadic tumors and in nine of the 12 Dermal and salivary gland Dermal analogue tumors from the two sisters; a parathyroid adenoma from one sister and two lymphoepithelial lesions from the second sister showed no microsatellite alterations. Microsatellite instability was only identified in three sporadic tumors at marker D16S308. Markers D16S409 (centromeric), D16S541, and D16S308 (telomeric) to the CYLD gene showed the highest incidence of loss of heterozygosity (>65%). The minimally deleted region was flanked proximally by marker D16S389 and distally by marker D16S419 and spanned the 771.5-megabase fragment that included the CYLD locus. We conclude that Dermal analogue tumor and Cylindroma share similar incidence of alterations at the 16q12-13 region, supporting a common molecular origin.
Muneo Ohkido - One of the best experts on this subject based on the ideXlab platform.
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Multiple ekkrine Spiradenome Histologische Assoziation mit Dermalem Zylindrom
Hautarzt, 1995Co-Authors: Yo Kawakubo, Mayumi Okano, Mariko Iizuka, Muneo OhkidoAbstract:A case of multiple eccrine spiradenomata is reported. One of the tumours was histopathologically associated with Dermal Cylindroma, and immunohistochemical studies showed that the Cylindroma cells differentiate towards the secreting portion of the eccrine sweat gland. The relationship among multiple eccrine spiradenomata, Dermal Cylindroma and multiple trichoepitheliomata is discussed.
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Multiple ekkrine Spiradenome Histologische Assoziation mit Dermalem Zylindrom*
Der Hautarzt, 1995Co-Authors: Yo Kawakubo, Mayumi Okano, Mariko Iizuka, Muneo OhkidoAbstract:Es wird über eine 46jährige Patientin mit multiplen ekkrinen Spiradenomen berichtet. Es zeigte sich hierbei histopathologisch die Assoziation mit einem Dermalen Zylindrom. Immunhistochemisch zeigte das Zylindrom eine Differenzierung in Richtung auf den sezernierenden Teil der ekkrinen Schweißdrüsen. Der Zusammenhang zwischen multiplen ekkrinen Spiradenomen und Dermalen Zylindromen sowie multiplen Trichoepitheliomen wird besprochen. A case of multiple eccrine spiradenomata is reported. One of the tumours was histopathologically associated with Dermal Cylindroma, and immunohistochemical studies showed that the Cylindroma cells differentiate towards the secreting portion of the eccrine sweat gland. The relationship among multiple eccrine spiradenomata, Dermal Cylindroma and multiple trichoepitheliomata is discussed.
Edward Wilson Jones - One of the best experts on this subject based on the ideXlab platform.
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Dermal Cylindroma following x ray epilation of the scalp
British Journal of Dermatology, 2006Co-Authors: M M Black, Edward Wilson JonesAbstract:SUMMARY.— Two patients are described in whom single Dermal Cylindromata on the scalp developed many years after x-ray epilation. This is believed to be the first record of this association.
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Dermal Cylindroma FOLLOWING X‐RAY EPILATION OF THE SCALP
British Journal of Dermatology, 2006Co-Authors: M M Black, Edward Wilson JonesAbstract:SUMMARY.— Two patients are described in whom single Dermal Cylindromata on the scalp developed many years after x-ray epilation. This is believed to be the first record of this association.
Hong Ran Choi - One of the best experts on this subject based on the ideXlab platform.
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molecular analysis of chromosome 16q regions in Dermal analogue tumors of salivary glands a genetic link to Dermal Cylindroma
The American Journal of Surgical Pathology, 2002Co-Authors: Hong Ran Choi, John G Batsakis, David L Callender, Victor G Prieto, Mario A Luna, Adel K ElnaggarAbstract:: Dermal analogue tumor, an uncommon subtype of basal cell monomorphic adenoma of the parotid gland, has a remarkable clinical and histologic resemblance to Dermal Cylindroma. Molecular studies of familial and sporadic Cylindromas have shown frequent alterations at chromosome 16q12-13 that have recently been found to house the Cylindromatosis gene (CYLD). To determine the involvement of the chromosome 16q12-13 region in Dermal analogue tumors, we performed loss of heterozygosity analysis using microsatellite markers flanking the Cylindromatosis gene locus in 21 sporadic Dermal analogue salivary tumors and 12 salivary and Dermal lesions from two sisters. Loss of heterozygosity was identified in 17 (80.9%) of the 21 sporadic tumors and in nine of the 12 Dermal and salivary gland Dermal analogue tumors from the two sisters; a parathyroid adenoma from one sister and two lymphoepithelial lesions from the second sister showed no microsatellite alterations. Microsatellite instability was only identified in three sporadic tumors at marker D16S308. Markers D16S409 (centromeric), D16S541, and D16S308 (telomeric) to the CYLD gene showed the highest incidence of loss of heterozygosity (>65%). The minimally deleted region was flanked proximally by marker D16S389 and distally by marker D16S419 and spanned the 771.5-megabase fragment that included the CYLD locus. We conclude that Dermal analogue tumor and Cylindroma share similar incidence of alterations at the 16q12-13 region, supporting a common molecular origin.
Yo Kawakubo - One of the best experts on this subject based on the ideXlab platform.
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Multiple ekkrine Spiradenome Histologische Assoziation mit Dermalem Zylindrom
Hautarzt, 1995Co-Authors: Yo Kawakubo, Mayumi Okano, Mariko Iizuka, Muneo OhkidoAbstract:A case of multiple eccrine spiradenomata is reported. One of the tumours was histopathologically associated with Dermal Cylindroma, and immunohistochemical studies showed that the Cylindroma cells differentiate towards the secreting portion of the eccrine sweat gland. The relationship among multiple eccrine spiradenomata, Dermal Cylindroma and multiple trichoepitheliomata is discussed.
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Multiple ekkrine Spiradenome Histologische Assoziation mit Dermalem Zylindrom*
Der Hautarzt, 1995Co-Authors: Yo Kawakubo, Mayumi Okano, Mariko Iizuka, Muneo OhkidoAbstract:Es wird über eine 46jährige Patientin mit multiplen ekkrinen Spiradenomen berichtet. Es zeigte sich hierbei histopathologisch die Assoziation mit einem Dermalen Zylindrom. Immunhistochemisch zeigte das Zylindrom eine Differenzierung in Richtung auf den sezernierenden Teil der ekkrinen Schweißdrüsen. Der Zusammenhang zwischen multiplen ekkrinen Spiradenomen und Dermalen Zylindromen sowie multiplen Trichoepitheliomen wird besprochen. A case of multiple eccrine spiradenomata is reported. One of the tumours was histopathologically associated with Dermal Cylindroma, and immunohistochemical studies showed that the Cylindroma cells differentiate towards the secreting portion of the eccrine sweat gland. The relationship among multiple eccrine spiradenomata, Dermal Cylindroma and multiple trichoepitheliomata is discussed.