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Hans R. Kricheldorf - One of the best experts on this subject based on the ideXlab platform.
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ring expansion polymerization of meso lactide catalyzed by Dibutyltin derivatives
Journal of Polymer Science Part A, 2018Co-Authors: Hans R. Kricheldorf, Steffen M. WeidnerAbstract:Meso-Lactide was polymerized in bulk at 60, 80, and 100 °C by means of three different types of catalysts: Dibutyltinsulfides (2,2-dibutyl-2-stanna-1,3-dithiolane and 2,20-dibutyl-2-stanna-1,3-dithiane), Dibutyltin derivatives of substituted cate-chols (BuCa, CyCa, and BzCa), and Dibutyltin derivatives of2,2 dihydroxybiphenyl (SnBi) and 2,2-dihydroxy-1,10-binaphthyl(SnNa. Only the latter two catalysts were active at 60 °C. The architecture of the resulting polylactides depends very much on the structure of the catalyst and on the temperature. At the lowest temperature (60 °C), SnBi and SnNa mainly yielded even-numbered linear chains, but SnNa also yielded even-numbered cycles at 100 °C and short reaction times. In contrast,BuCa, CyCa, and BzCa mainly yielded odd-numbered cycles, although the same catalysts yielded even-numbered linear chains when benzylalcohol was added.
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Ring‐expansion polymerization of meso‐lactide catalyzed by Dibutyltin derivatives
Journal of Polymer Science Part A: Polymer Chemistry, 2018Co-Authors: Hans R. Kricheldorf, Steffen M. WeidnerAbstract:Meso-Lactide was polymerized in bulk at 60, 80, and 100 °C by means of three different types of catalysts: Dibutyltinsulfides (2,2-dibutyl-2-stanna-1,3-dithiolane and 2,20-dibutyl-2-stanna-1,3-dithiane), Dibutyltin derivatives of substituted cate-chols (BuCa, CyCa, and BzCa), and Dibutyltin derivatives of2,2 dihydroxybiphenyl (SnBi) and 2,2-dihydroxy-1,10-binaphthyl(SnNa. Only the latter two catalysts were active at 60 °C. The architecture of the resulting polylactides depends very much on the structure of the catalyst and on the temperature. At the lowest temperature (60 °C), SnBi and SnNa mainly yielded even-numbered linear chains, but SnNa also yielded even-numbered cycles at 100 °C and short reaction times. In contrast,BuCa, CyCa, and BzCa mainly yielded odd-numbered cycles, although the same catalysts yielded even-numbered linear chains when benzylalcohol was added.
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Cyclic poly(l-lactide)s via simultaneous ROP and polycondensation (ROPPOC) catalyzed by Dibutyltin phenoxides
European Polymer Journal, 2018Co-Authors: Hans R. Kricheldorf, Steffen M. WeidnerAbstract:Abstract Starting from Dibutyltin oxide, four catalysts were synthesized, namely the Dibutyltin bisphenoxides of phenol (SnPh), 4-chlorophenol (SnCP), 4-hydroxybenzonitrile (SnCN) and pentafluorophenol (SnOPF). With the first three catalysts polymerizations of l -lactide at 160 °C in bulk yielded large fraction of linear chains having phenylester end groups at short reaction times. At longer times the fraction of cycles considerably increased at the expense of the linear chains, when SnCN was used as catalyst. With SnOPF only cyclic polylactides were obtained at low Lac/Cat ratios (
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Cyclic Poly(l‐lactide) via Ring‐Expansion Polymerization by Means of Dibutyltin 4‐Tert‐Butylcatecholate
Macromolecular Chemistry and Physics, 2017Co-Authors: Hans R. Kricheldorf, Steffen M. Weidner, Felix ScheligaAbstract:Five new catalysts are prepared from Dibutyltin oxide and catechol (HCa), 2,3-dihydroxynaphthalene (NaCa), 4-tert-butyl catechol (BuCa), 4-cyano catechol (CyCa), and 4-benzoyl catechol (BzCa), but only BuCa gives useful results. When benzyl alcohol is used as an initiator, linear chains having benzyl ester end groups are formed in a slow polymerization process. In contrast to cyclic or noncyclic Dibutyltin bisalkoxides, neat BuCa yields cyclic poly(l-lactide)s via a fast ring-expansion polymerization. Under certain conditions, a high-melting crystalline phase (Tm = 191 °C) is obtained. At 160 °C and short reaction times even-numbered cycles are slightly prevailing, but, surprisingly, at 120 °C, odd-numbered cycles are predominantly formed. These results definitely prove that a ring-expansion mechanism is operating.
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cyclic poly l lactide via ring expansion polymerization by means of Dibutyltin 4 tert butylcatecholate
Macromolecular Chemistry and Physics, 2017Co-Authors: Hans R. Kricheldorf, Steffen M. Weidner, Felix ScheligaAbstract:Five new catalysts are prepared from Dibutyltin oxide and catechol (HCa), 2,3-dihydroxynaphthalene (NaCa), 4-tert-butyl catechol (BuCa), 4-cyano catechol (CyCa), and 4-benzoyl catechol (BzCa), but only BuCa gives useful results. When benzyl alcohol is used as an initiator, linear chains having benzyl ester end groups are formed in a slow polymerization process. In contrast to cyclic or noncyclic Dibutyltin bisalkoxides, neat BuCa yields cyclic poly(l-lactide)s via a fast ring-expansion polymerization. Under certain conditions, a high-melting crystalline phase (Tm = 191 °C) is obtained. At 160 °C and short reaction times even-numbered cycles are slightly prevailing, but, surprisingly, at 120 °C, odd-numbered cycles are predominantly formed. These results definitely prove that a ring-expansion mechanism is operating.
Felix Scheliga - One of the best experts on this subject based on the ideXlab platform.
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cyclic poly l lactide via ring expansion polymerization by means of Dibutyltin 4 tert butylcatecholate
Macromolecular Chemistry and Physics, 2017Co-Authors: Hans R. Kricheldorf, Steffen M. Weidner, Felix ScheligaAbstract:Five new catalysts are prepared from Dibutyltin oxide and catechol (HCa), 2,3-dihydroxynaphthalene (NaCa), 4-tert-butyl catechol (BuCa), 4-cyano catechol (CyCa), and 4-benzoyl catechol (BzCa), but only BuCa gives useful results. When benzyl alcohol is used as an initiator, linear chains having benzyl ester end groups are formed in a slow polymerization process. In contrast to cyclic or noncyclic Dibutyltin bisalkoxides, neat BuCa yields cyclic poly(l-lactide)s via a fast ring-expansion polymerization. Under certain conditions, a high-melting crystalline phase (Tm = 191 °C) is obtained. At 160 °C and short reaction times even-numbered cycles are slightly prevailing, but, surprisingly, at 120 °C, odd-numbered cycles are predominantly formed. These results definitely prove that a ring-expansion mechanism is operating.
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Cyclic Poly(l‐lactide) via Ring‐Expansion Polymerization by Means of Dibutyltin 4‐Tert‐Butylcatecholate
Macromolecular Chemistry and Physics, 2017Co-Authors: Hans R. Kricheldorf, Steffen M. Weidner, Felix ScheligaAbstract:Five new catalysts are prepared from Dibutyltin oxide and catechol (HCa), 2,3-dihydroxynaphthalene (NaCa), 4-tert-butyl catechol (BuCa), 4-cyano catechol (CyCa), and 4-benzoyl catechol (BzCa), but only BuCa gives useful results. When benzyl alcohol is used as an initiator, linear chains having benzyl ester end groups are formed in a slow polymerization process. In contrast to cyclic or noncyclic Dibutyltin bisalkoxides, neat BuCa yields cyclic poly(l-lactide)s via a fast ring-expansion polymerization. Under certain conditions, a high-melting crystalline phase (Tm = 191 °C) is obtained. At 160 °C and short reaction times even-numbered cycles are slightly prevailing, but, surprisingly, at 120 °C, odd-numbered cycles are predominantly formed. These results definitely prove that a ring-expansion mechanism is operating.
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Cyclic Polylactides via Simultaneous Ring-Opening Polymerization and Polycondensation Catalyzed by Dibutyltin Mercaptides
Journal of Polymer Science Part A: Polymer Chemistry, 2017Co-Authors: Hans R. Kricheldorf, Steffen M. Weidner, Felix ScheligaAbstract:L-Lactide is polymerized in bulk at 160 8C either with Dibutyltin bis(benzylmercaptide) (SnSBzl), Dibutyltin bis(benzothiazole 2-mercaptide) (SnMBT), or with Dibutyltin bis(pentafluorothiophenolate) (SnSPF) as catalysts. SnSBzl yields linear polylactides having benzylthio-ester end groups in addition to cyclic polylactides, whereas SnMBT and SnSPF mainly or exclusively yield cyclic polylactides. This finding, together with model reactions, indicates that the SnS catalysts promote a combined ring-opening polymerization and polycondensation process including end-to-end cyclization. SnMBT caused slight racemization (3%–5%), when used at 160 8C. With SnSPF optically pure cyclic poly(L-lactide)s with high-molecular weights can be prepared at 160 8C.
Flora A. Milton - One of the best experts on this subject based on the ideXlab platform.
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Dibutyltin Compounds Effects on PPARγ/RXRα Activity, Adipogenesis, and Inflammation in Mammalians Cells.
Frontiers in Pharmacology, 2017Co-Authors: Flora A. Milton, Mariella G. Lacerda, Simone B. P. Sinoti, Pedro G. Mesquita, Dileesh Prakasan, Michella S. Coelho, Caroline L. De Lima, Alexandre G. Martini, Gabriela T. Pazzine, Maria De F. BorinAbstract:Organotins are a group of chemical compounds that have a tin atom covalently bound to one or more organic groups. The best-studied organotin is tributyltin chloride, which is an environmental pollutant and an endocrine disruptor. Tributyltin chloride has been shown to bind to PPARγ/RXRα and induces adipogenesis in different mammalian cells. However, there are few studies with other organotin compounds, such as Dibutyltins. The aim of this study was to investigate the effect of Dibutyltins diacetate, dichloride, dilaurate, and maleate on the transcriptional activity of the nuclear PPARγ and RXRα receptors, and on adipogenesis and inflammation. Analogous to tributyltin chloride, in reporter gene assay using HeLa cells, we observed that Dibutyltins diacetate, dichloride, dilaurate, and maleate are partial agonists of PPARγ. Unlike tributyltin chloride, which is a full agonist of RXRα, Dibutyltins dichloride and dilaurate are partial RXRα agonists. Additionally, the introduction of the C285S mutation, which disrupts tributyltin chloride binding to PPARγ, abrogated the Dibutyltin agonistic activity. In 3T3-L1 preadipocytes, all Dibutyltin induced adipogenesis, although the effect was less pronounced than that of rosiglitazone and tributyltin chloride. This adipogenic effect was confirmed by the expression of adipogenic markers Fabp4, Adipoq, and Glut4. Exposure of 3T3-L1 cells with Dibutyltin in the presence of T0070907, a specific PPARγ antagonist, reduced fat accumulation, suggesting that adipogenic effect occurs through PPARγ. Furthermore, Dibutyltins dichloride, dilaurate, and maleate inhibited the expression of proinflammatory genes in 3T3-L1 cells, such as Vcam1, Dcn, Fn1, S100a8, and Lgals9. Additionally, in RAW 264.7 macrophages, tributyltin chloride and Dibutyltin dilaurate reduced LPS-stimulated TNFα expression. Our findings indicate that Dibutyltins diacetate, dichloride, dilaurate, and maleate are PPARγ partial agonists and that Dibutyltins dichloride and dilaurate are also partial RXRα agonists. Furthermore, Dibutyltins induce adipogenesis in a PPARγ-dependent manner and repress inflammatory genes in 3T3-L1 and RAW 264.7 cells. Although Dibutyltins display some partial PPARγ/RXRα agonistic effects, the translation of cell-based results assays into in vivo effects on inflammation and insulin resistance is not entirely known. Nevertheless, further studies are necessary to address their effects in different periods of life and to elucidate the actions of organostanic compounds in whole-body context.
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Dibutyltin compounds effects on pparγ rxrα activity adipogenesis and inflammation in mammalians cells
Frontiers in Pharmacology, 2017Co-Authors: Flora A. Milton, Mariella G. Lacerda, Simone B. P. Sinoti, Pedro G. Mesquita, Dileesh Prakasan, Michella S. Coelho, Caroline L. De Lima, Alexandre G. Martini, Gabriela T. PazzineAbstract:Organotins are a group of chemical compounds that have a tin atom covalently bound to one or more organic groups. The best-studied organotin is tributyltin chloride, which is an environmental pollutant and an endocrine disruptor. Tributyltin chloride has been shown to bind to PPARγ/RXRα and induces adipogenesis in different mammalian cells. However, there are few studies with other organotin compounds, such as Dibutyltins. The aim of this study was to investigate the effect of Dibutyltins diacetate, dichloride, dilaurate, and maleate on the transcriptional activity of the nuclear PPARγ and RXRα receptors, and on adipogenesis and inflammation. Analogous to tributyltin chloride, in reporter gene assay using HeLa cells, we observed that Dibutyltins diacetate, dichloride, dilaurate, and maleate are partial agonists of PPARγ. Unlike tributyltin chloride, which is a full agonist of RXRα, Dibutyltins dichloride and dilaurate are partial RXRα agonists. Additionally, the introduction of the C285S mutation, which disrupts tributyltin chloride binding to PPARγ, abrogated the Dibutyltin agonistic activity. In 3T3-L1 preadipocytes, all Dibutyltin induced adipogenesis, although the effect was less pronounced than that of rosiglitazone and tributyltin chloride. This adipogenic effect was confirmed by the expression of adipogenic markers Fabp4, Adipoq, and Glut4. Exposure of 3T3-L1 cells with Dibutyltin in the presence of T0070907, a specific PPARγ antagonist, reduced fat accumulation, suggesting that adipogenic effect occurs through PPARγ. Furthermore, Dibutyltins dichloride, dilaurate, and maleate inhibited the expression of proinflammatory genes in 3T3-L1 cells, such as Vcam1, Dcn, Fn1, S100a8, and Lgals9. Additionally, in RAW 264.7 macrophages, tributyltin chloride and Dibutyltin dilaurate reduced LPS-stimulated TNFα expression. Our findings indicate that Dibutyltins diacetate, dichloride, dilaurate, and maleate are PPARγ partial agonists and that Dibutyltins dichloride and dilaurate are also partial RXRα agonists. Furthermore, Dibutyltins induce adipogenesis in a PPARγ-dependent manner and repress inflammatory genes in 3T3-L1 and RAW 264.7 cells. Although Dibutyltins display some partial PPARγ/RXRα agonistic effects, the translation of cell-based results assays into in vivo effects on inflammation and insulin resistance is not entirely known. Nevertheless, further studies are necessary to address their effects in different periods of life and to elucidate the actions of organostanic compounds in whole-body context.
Steffen M. Weidner - One of the best experts on this subject based on the ideXlab platform.
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ring expansion polymerization of meso lactide catalyzed by Dibutyltin derivatives
Journal of Polymer Science Part A, 2018Co-Authors: Hans R. Kricheldorf, Steffen M. WeidnerAbstract:Meso-Lactide was polymerized in bulk at 60, 80, and 100 °C by means of three different types of catalysts: Dibutyltinsulfides (2,2-dibutyl-2-stanna-1,3-dithiolane and 2,20-dibutyl-2-stanna-1,3-dithiane), Dibutyltin derivatives of substituted cate-chols (BuCa, CyCa, and BzCa), and Dibutyltin derivatives of2,2 dihydroxybiphenyl (SnBi) and 2,2-dihydroxy-1,10-binaphthyl(SnNa. Only the latter two catalysts were active at 60 °C. The architecture of the resulting polylactides depends very much on the structure of the catalyst and on the temperature. At the lowest temperature (60 °C), SnBi and SnNa mainly yielded even-numbered linear chains, but SnNa also yielded even-numbered cycles at 100 °C and short reaction times. In contrast,BuCa, CyCa, and BzCa mainly yielded odd-numbered cycles, although the same catalysts yielded even-numbered linear chains when benzylalcohol was added.
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Ring‐expansion polymerization of meso‐lactide catalyzed by Dibutyltin derivatives
Journal of Polymer Science Part A: Polymer Chemistry, 2018Co-Authors: Hans R. Kricheldorf, Steffen M. WeidnerAbstract:Meso-Lactide was polymerized in bulk at 60, 80, and 100 °C by means of three different types of catalysts: Dibutyltinsulfides (2,2-dibutyl-2-stanna-1,3-dithiolane and 2,20-dibutyl-2-stanna-1,3-dithiane), Dibutyltin derivatives of substituted cate-chols (BuCa, CyCa, and BzCa), and Dibutyltin derivatives of2,2 dihydroxybiphenyl (SnBi) and 2,2-dihydroxy-1,10-binaphthyl(SnNa. Only the latter two catalysts were active at 60 °C. The architecture of the resulting polylactides depends very much on the structure of the catalyst and on the temperature. At the lowest temperature (60 °C), SnBi and SnNa mainly yielded even-numbered linear chains, but SnNa also yielded even-numbered cycles at 100 °C and short reaction times. In contrast,BuCa, CyCa, and BzCa mainly yielded odd-numbered cycles, although the same catalysts yielded even-numbered linear chains when benzylalcohol was added.
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Cyclic poly(l-lactide)s via simultaneous ROP and polycondensation (ROPPOC) catalyzed by Dibutyltin phenoxides
European Polymer Journal, 2018Co-Authors: Hans R. Kricheldorf, Steffen M. WeidnerAbstract:Abstract Starting from Dibutyltin oxide, four catalysts were synthesized, namely the Dibutyltin bisphenoxides of phenol (SnPh), 4-chlorophenol (SnCP), 4-hydroxybenzonitrile (SnCN) and pentafluorophenol (SnOPF). With the first three catalysts polymerizations of l -lactide at 160 °C in bulk yielded large fraction of linear chains having phenylester end groups at short reaction times. At longer times the fraction of cycles considerably increased at the expense of the linear chains, when SnCN was used as catalyst. With SnOPF only cyclic polylactides were obtained at low Lac/Cat ratios (
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Cyclic Poly(l‐lactide) via Ring‐Expansion Polymerization by Means of Dibutyltin 4‐Tert‐Butylcatecholate
Macromolecular Chemistry and Physics, 2017Co-Authors: Hans R. Kricheldorf, Steffen M. Weidner, Felix ScheligaAbstract:Five new catalysts are prepared from Dibutyltin oxide and catechol (HCa), 2,3-dihydroxynaphthalene (NaCa), 4-tert-butyl catechol (BuCa), 4-cyano catechol (CyCa), and 4-benzoyl catechol (BzCa), but only BuCa gives useful results. When benzyl alcohol is used as an initiator, linear chains having benzyl ester end groups are formed in a slow polymerization process. In contrast to cyclic or noncyclic Dibutyltin bisalkoxides, neat BuCa yields cyclic poly(l-lactide)s via a fast ring-expansion polymerization. Under certain conditions, a high-melting crystalline phase (Tm = 191 °C) is obtained. At 160 °C and short reaction times even-numbered cycles are slightly prevailing, but, surprisingly, at 120 °C, odd-numbered cycles are predominantly formed. These results definitely prove that a ring-expansion mechanism is operating.
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cyclic poly l lactide via ring expansion polymerization by means of Dibutyltin 4 tert butylcatecholate
Macromolecular Chemistry and Physics, 2017Co-Authors: Hans R. Kricheldorf, Steffen M. Weidner, Felix ScheligaAbstract:Five new catalysts are prepared from Dibutyltin oxide and catechol (HCa), 2,3-dihydroxynaphthalene (NaCa), 4-tert-butyl catechol (BuCa), 4-cyano catechol (CyCa), and 4-benzoyl catechol (BzCa), but only BuCa gives useful results. When benzyl alcohol is used as an initiator, linear chains having benzyl ester end groups are formed in a slow polymerization process. In contrast to cyclic or noncyclic Dibutyltin bisalkoxides, neat BuCa yields cyclic poly(l-lactide)s via a fast ring-expansion polymerization. Under certain conditions, a high-melting crystalline phase (Tm = 191 °C) is obtained. At 160 °C and short reaction times even-numbered cycles are slightly prevailing, but, surprisingly, at 120 °C, odd-numbered cycles are predominantly formed. These results definitely prove that a ring-expansion mechanism is operating.
Gabriela T. Pazzine - One of the best experts on this subject based on the ideXlab platform.
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Dibutyltin Compounds Effects on PPARγ/RXRα Activity, Adipogenesis, and Inflammation in Mammalians Cells.
Frontiers in Pharmacology, 2017Co-Authors: Flora A. Milton, Mariella G. Lacerda, Simone B. P. Sinoti, Pedro G. Mesquita, Dileesh Prakasan, Michella S. Coelho, Caroline L. De Lima, Alexandre G. Martini, Gabriela T. Pazzine, Maria De F. BorinAbstract:Organotins are a group of chemical compounds that have a tin atom covalently bound to one or more organic groups. The best-studied organotin is tributyltin chloride, which is an environmental pollutant and an endocrine disruptor. Tributyltin chloride has been shown to bind to PPARγ/RXRα and induces adipogenesis in different mammalian cells. However, there are few studies with other organotin compounds, such as Dibutyltins. The aim of this study was to investigate the effect of Dibutyltins diacetate, dichloride, dilaurate, and maleate on the transcriptional activity of the nuclear PPARγ and RXRα receptors, and on adipogenesis and inflammation. Analogous to tributyltin chloride, in reporter gene assay using HeLa cells, we observed that Dibutyltins diacetate, dichloride, dilaurate, and maleate are partial agonists of PPARγ. Unlike tributyltin chloride, which is a full agonist of RXRα, Dibutyltins dichloride and dilaurate are partial RXRα agonists. Additionally, the introduction of the C285S mutation, which disrupts tributyltin chloride binding to PPARγ, abrogated the Dibutyltin agonistic activity. In 3T3-L1 preadipocytes, all Dibutyltin induced adipogenesis, although the effect was less pronounced than that of rosiglitazone and tributyltin chloride. This adipogenic effect was confirmed by the expression of adipogenic markers Fabp4, Adipoq, and Glut4. Exposure of 3T3-L1 cells with Dibutyltin in the presence of T0070907, a specific PPARγ antagonist, reduced fat accumulation, suggesting that adipogenic effect occurs through PPARγ. Furthermore, Dibutyltins dichloride, dilaurate, and maleate inhibited the expression of proinflammatory genes in 3T3-L1 cells, such as Vcam1, Dcn, Fn1, S100a8, and Lgals9. Additionally, in RAW 264.7 macrophages, tributyltin chloride and Dibutyltin dilaurate reduced LPS-stimulated TNFα expression. Our findings indicate that Dibutyltins diacetate, dichloride, dilaurate, and maleate are PPARγ partial agonists and that Dibutyltins dichloride and dilaurate are also partial RXRα agonists. Furthermore, Dibutyltins induce adipogenesis in a PPARγ-dependent manner and repress inflammatory genes in 3T3-L1 and RAW 264.7 cells. Although Dibutyltins display some partial PPARγ/RXRα agonistic effects, the translation of cell-based results assays into in vivo effects on inflammation and insulin resistance is not entirely known. Nevertheless, further studies are necessary to address their effects in different periods of life and to elucidate the actions of organostanic compounds in whole-body context.
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Dibutyltin compounds effects on pparγ rxrα activity adipogenesis and inflammation in mammalians cells
Frontiers in Pharmacology, 2017Co-Authors: Flora A. Milton, Mariella G. Lacerda, Simone B. P. Sinoti, Pedro G. Mesquita, Dileesh Prakasan, Michella S. Coelho, Caroline L. De Lima, Alexandre G. Martini, Gabriela T. PazzineAbstract:Organotins are a group of chemical compounds that have a tin atom covalently bound to one or more organic groups. The best-studied organotin is tributyltin chloride, which is an environmental pollutant and an endocrine disruptor. Tributyltin chloride has been shown to bind to PPARγ/RXRα and induces adipogenesis in different mammalian cells. However, there are few studies with other organotin compounds, such as Dibutyltins. The aim of this study was to investigate the effect of Dibutyltins diacetate, dichloride, dilaurate, and maleate on the transcriptional activity of the nuclear PPARγ and RXRα receptors, and on adipogenesis and inflammation. Analogous to tributyltin chloride, in reporter gene assay using HeLa cells, we observed that Dibutyltins diacetate, dichloride, dilaurate, and maleate are partial agonists of PPARγ. Unlike tributyltin chloride, which is a full agonist of RXRα, Dibutyltins dichloride and dilaurate are partial RXRα agonists. Additionally, the introduction of the C285S mutation, which disrupts tributyltin chloride binding to PPARγ, abrogated the Dibutyltin agonistic activity. In 3T3-L1 preadipocytes, all Dibutyltin induced adipogenesis, although the effect was less pronounced than that of rosiglitazone and tributyltin chloride. This adipogenic effect was confirmed by the expression of adipogenic markers Fabp4, Adipoq, and Glut4. Exposure of 3T3-L1 cells with Dibutyltin in the presence of T0070907, a specific PPARγ antagonist, reduced fat accumulation, suggesting that adipogenic effect occurs through PPARγ. Furthermore, Dibutyltins dichloride, dilaurate, and maleate inhibited the expression of proinflammatory genes in 3T3-L1 cells, such as Vcam1, Dcn, Fn1, S100a8, and Lgals9. Additionally, in RAW 264.7 macrophages, tributyltin chloride and Dibutyltin dilaurate reduced LPS-stimulated TNFα expression. Our findings indicate that Dibutyltins diacetate, dichloride, dilaurate, and maleate are PPARγ partial agonists and that Dibutyltins dichloride and dilaurate are also partial RXRα agonists. Furthermore, Dibutyltins induce adipogenesis in a PPARγ-dependent manner and repress inflammatory genes in 3T3-L1 and RAW 264.7 cells. Although Dibutyltins display some partial PPARγ/RXRα agonistic effects, the translation of cell-based results assays into in vivo effects on inflammation and insulin resistance is not entirely known. Nevertheless, further studies are necessary to address their effects in different periods of life and to elucidate the actions of organostanic compounds in whole-body context.