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Susanna C Larsson - One of the best experts on this subject based on the ideXlab platform.

  • genetically predicted circulating b vitamins in relation to Digestive System Cancers
    British Journal of Cancer, 2021
    Co-Authors: Shuai Yuan, Paul Carter, Mathew Vithayathil, Siddhartha Kar, Amy M Mason, Stephen Burgess, Susanna C Larsson
    Abstract:

    Folate, vitamin B6 and vitamin B12 have been associated with Digestive System Cancers. We conducted a two-sample Mendelian randomisation study to assess the causality of these associations. Two, one and 14 independent single nucleotide polymorphisms associated with serum folate, vitamin B6 and vitamin B12 at the genome-wide significance threshold were selected as genetic instruments. Summary-level data for the associations of the vitamin-associated genetic variants with Cancer were obtained from the UK Biobank study including 367,561 individuals and FinnGen consortium comprising up to 176,899 participants. Genetically predicted folate and vitamin B6 concentrations were not associated with overall Cancer, overall Digestive System Cancer or oesophageal, gastric, colorectal or pancreatic Cancer. Genetically predicted vitamin B12 concentrations were positively associated with overall Digestive System Cancer (ORSD, 1.12; 95% CI 1.04, 1.21, p = 0.003) and colorectal Cancer (ORSD 1.16; 95% CI 1.06, 1.26, p = 0.001) in UK Biobank. Results for colorectal Cancer were consistent in FinnGen and the combined ORSD was 1.16 (95% CI 1.08, 1.25, p < 0.001). There was no association of genetically predicted vitamin B12 with any other site-specific Digestive System Cancers or overall Cancer. These results provide evidence to suggest that elevated serum vitamin B12 concentrations are associated with colorectal Cancer.

  • Genetically predicted circulating B vitamins in relation to Digestive System Cancers
    British Journal of Cancer, 2021
    Co-Authors: Shuai Yuan, Paul Carter, Mathew Vithayathil, Siddhartha Kar, Amy M Mason, Stephen Burgess, Susanna C Larsson
    Abstract:

    Background Folate, vitamin B6 and vitamin B12 have been associated with Digestive System Cancers. We conducted a two-sample Mendelian randomisation study to assess the causality of these associations. Methods Two, one and 14 independent single nucleotide polymorphisms associated with serum folate, vitamin B6 and vitamin B12 at the genome-wide significance threshold were selected as genetic instruments. Summary-level data for the associations of the vitamin-associated genetic variants with Cancer were obtained from the UK Biobank study including 367,561 individuals and FinnGen consortium comprising up to 176,899 participants. Results Genetically predicted folate and vitamin B6 concentrations were not associated with overall Cancer, overall Digestive System Cancer or oesophageal, gastric, colorectal or pancreatic Cancer. Genetically predicted vitamin B12 concentrations were positively associated with overall Digestive System Cancer (OR_SD, 1.12; 95% CI 1.04, 1.21, p  = 0.003) and colorectal Cancer (OR_SD 1.16; 95% CI 1.06, 1.26, p  = 0.001) in UK Biobank. Results for colorectal Cancer were consistent in FinnGen and the combined OR_SD was 1.16 (95% CI 1.08, 1.25, p  

Kun Chen - One of the best experts on this subject based on the ideXlab platform.

  • a genetic variant in mir 146a modifies Digestive System Cancer risk a meta analysis
    Asian Pacific Journal of Cancer Prevention, 2014
    Co-Authors: Zhenyu Zhang, Mingjuan Jin, Yingying Mao, Fangyuan Jing, Kun Chen
    Abstract:

    MicroRNAs (miRNAs) negatively regulate gene expression and act as tumor suppressors or oncogenes in oncogenesis. The association between a single nucleotide polymorphism (SNP) in miR-146a rs2910164 and susceptibility to Digestive System Cancers was inconsistent in previous studies. In this study, we conducted a literature search of PubMed to identify all relevant studies published before August 31, 2013. A total of 21 independent case-control studies were included in this updated meta-analysis with 9,558 cases and 10,614 controls. We found that the miR-146a rs2910164 polymorphism was significantly associated with decreased risk of Digestive System Cancers in an allele model (OR=0.90, 95%CI 0.87-0.94), homozygote model (OR=0.84, 95%CI 0.77-0.91), dominant model (OR=0.90, 95%CI 0.84-0.96), and recessive model (OR=0.85, 95%CI 0.79-0.91), while in a heterozygous model (OR = 0.99, 95% CI 0.89-1.11) the association showed marginal significance. Subgroup analysis by Cancer site revealed decreased risk in colorectal Cancer above allele model (OR=0.90, 95%CI 0.83- 0.97) and homozygote model (OR=0.85, 95%CI 0.72-1.00). Similarly, decreased Cancer risk was observed when compared with allele model (OR=0.87, 95%CI 0.81-0.93) and recessive model (OR=0.81, 95%CI 0.72-0.90) in gastric Cancer. When stratified by ethnicity, genotyping methods and quality score, decreased Cancer risks were also observed. This current meta-analysis indicated that miR-146a rs2910164 polymorphism may decrease the susceptibility to Digestive System Cancers, especially in Asian populations.

  • a genetic variant in mir 196a2 increased Digestive System Cancer risks a meta analysis of 15 case control studies
    PLOS ONE, 2012
    Co-Authors: Jing Guo, Mingjuan Jin, Mingwu Zhang, Kun Chen
    Abstract:

    Background MicroRNAs (miRNAs) negatively regulate the gene expression and act as tumor suppressors or oncogenes in oncogenesis. The association between single nucleotide polymorphism (SNP) in miR-196a2 rs11614913 and the susceptibility of Digestive System Cancers was inconsistent in previous studies.

Liuguo Qing - One of the best experts on this subject based on the ideXlab platform.

  • current evidence on associations between the mmp 7 181a g polymorphism and Digestive System Cancer risk
    Asian Pacific Journal of Cancer Prevention, 2013
    Co-Authors: Huasong Wen, Miaoxiong Ying, Huocheng Long, Liuguo Qing
    Abstract:

    Matrix metalloproteinases (MMPs) degrade various components of the extracellular matrix and functional polymorphisms in encoding genes may contribute to genetic susceptibility to many Cancers. Up to now, associations between MMP-7 (-181A>G) and Digestive System Cancer risk have remained inconclusive. To better understand the role of the MMP-7 (-181A>G) genotype in Digestive Cancer development, we conducted this comprehensive meta-analysis encompassing 3,518 cases and 4,596 controls. Overall, the MMP-7 (-181A>G) polymorphism was associated with higher Digestive System Cancer risk on homozygote comparison (GG vs. AA, OR=1.21, 95% CI = 1.12-1.60) and in a dominant model (GG/GA vs. AA, OR=1.16, 95% CI =1.03-1.46). On subgroup analysis, this polymorphism was significantly linked to higher risks for gastric Cancer (GG vs. AA, OR=1.22, 95% CI = 1.021.46; GA vs. AA, OR=1.82, 95% CI =1.16-2.87; GG/GA vs. AA, OR=1.13, 95% CI =1.01-1.27; GG vs. GA/AA, OR= 1.25, 95% CI = 1.06-2.39. We also observed increased susceptibility to colorectal Cancer and esophageal SCC in both homozygote (OR = 1.13, 95% CI = 1.06-1.26) and heterozygote comparisons (OR = 1.45, 95% CI = 1.11-1.91). In the stratified analysis by controls, significant effects were only observed in population-based studies (GA vs. AA, OR=1.16, 95% CI=1.08-1.50; GA/AA vs. GG, OR=1.10, 95% CI=1.01-1.72). According to the source of ethnicity, a significantly increased risk was found among Asian populations in the homozygote model (GG vs. AA, OR=1.40, 95% CI=1.12–1.69), heterozygote model (GA vs. AA, OR=1.26, 95% CI=1.02–1.51), and dominant model (GG/GA vs. AA, OR=1.18, 95% CI=1.08–1.55). Our findings suggest that the MMP-7 (-181A>G) polymorphism may be a risk factor for Digestive System Cancer, especially among Asian populations.

  • current evidence on the association between mmp 7 181a g polymorphism and Digestive System Cancer risk
    Journal of Bioanalysis & Biomedicine, 2013
    Co-Authors: Huasong Wen, Miaoxiong Ying, Huocheng Long, Liuguo Qing
    Abstract:

    The matrix metalloproteinase (MMPs) can degrade various components of the extracellular matrix and its functional genetic polymorphisms may contribute to genetic susceptibility to many Cancers. Up to now, the association between MMP-7 (-181A>G) and Digestive System Cancer risk remain inconclusive. To better understand the role of MMP-7 (-181A>G) genotype in Digestive Cancer development, we conducted this comprehensive meta-analysis encompassing 3,518 cases and 4,596 controls. Overall, the MMP-7 (-181A>G) polymorphism was associated with higher Digestive System Cancer risk in homozygote comparison (GG vs. AA, OR=1.21, 95% CI=1.12-1.60) and dominant model (GG/GA vs. AA, OR=1.16, 95% CI=1.03-1.46). In subgroup analysis, this polymorphism was significantly linked to higher risks for gastric Cancer (GG vs. AA, OR=1.22, 95% CI=1.02-1.46; GA vs. AA, OR=1.82, 95% CI=1.16-2.87; GG/GA vs. AA, OR=1.13, 95% CI=1.01-1.27; GG vs. GA/AA, OR=1.25, 95% CI=1.06-2.39. We also observed increased susceptibility of colorectal Cancer and ESCC in homozygote comparison (OR=1.13, 95% CI=1.06-1.26) and heterozygote comparison (OR=1.45, 95% CI=1.11-1.91) respectively. In the stratified analysis by controls, significant effects were only observed in population-based studies (GA vs. AA, OR=1.16, 95% CI=1.08- 1.50; GA/AA vs. GG, OR=1.10, 95% CI=1.01-1.72). According to the source of ethnicity, a significantly increased risk was found among Asian populations in homozygote model (GG vs. AA, OR=1.40, 95% CI=1.12-1.69), heterozygote model (GA vs. AA, OR=1.26, 95% CI=1.02-1.51), and dominant model (GG/GA vs. AA, OR=1.18, 95% CI=1.08-1.55). Our findings suggest that the MMP-7 (-181A>G) polymorphism may be a risk factor for Digestive System Cancer, especially among Asian population.

Yang Jinhong - One of the best experts on this subject based on the ideXlab platform.

  • current evidence on the cytotoxic t lymphocyte antigen 4 49g a polymorphism and Digestive System Cancer risks a meta analysis involving 11 923 subjects
    Meta Gene, 2015
    Co-Authors: Liu Xiaolei, Yang Baohong, Ren Haipeng, Liu Shuzhen, Gao Jianfeng, Pan Xiangpo, Liu Haiyu, Yu Yuan, Zheng Dejie, Yang Jinhong
    Abstract:

    Cytotoxic T-lymphocyte antigen (CTLA-4) plays an important role in downregulating T cell activation and proliferation. The CTLA-4 + 49G > A polymorphism is one of the most commonly studied polymorphisms in this gene due to its association with many Cancer types, but the association between CTLA-4 + 49G > A polymorphism and Digestive System Cancer risks remain inconclusive. An updated meta-analysis based on 17 independent case–control studies consisting of 5176 Cancer patients and 6747 controls was performed to address this association. Overall, there was no statistically increased risk of Digestive System Cancers in every genetic comparison. In subgroup analysis, this polymorphism was significantly linked to higher risks for pancreatic Cancer (GG vs. AA, OR = 1.976, 95% CI = 1.496–2.611; GA vs. AA, OR = 1.433, 95% CI = 1.093–1.879; GG/GA vs. AA, OR = 1.668, 95% CI = 1.286–2.164; GG vs. GA/AA, OR = 1.502, 95% CI = 1.098–2.054; G vs. A, OR = 1.394, 95% CI = 1.098–1.770). We also observed increased susceptibility of hepatocellular cell carcinoma in homozygote comparison (OR = 1.433, 95% CI = 1.100–1.866) and dominant model (OR = 1.360, 95% CI = 1.059–1.746). According to the source of controls, significant effects were only observed in hospital-based studies (GA/AA vs. GG, OR = 1.257, 95% CI = 1.129–1.399). In the stratified analysis by ethnicity, no significantly increased risks were found in either Asian or Caucasian. Our findings suggest that the CTLA-4 + 49G > A polymorphism may be associated with the risk of pancreatic Cancer and hepatocellular cell carcinoma.

Amy M Mason - One of the best experts on this subject based on the ideXlab platform.

  • genetically predicted circulating b vitamins in relation to Digestive System Cancers
    British Journal of Cancer, 2021
    Co-Authors: Shuai Yuan, Paul Carter, Mathew Vithayathil, Siddhartha Kar, Amy M Mason, Stephen Burgess, Susanna C Larsson
    Abstract:

    Folate, vitamin B6 and vitamin B12 have been associated with Digestive System Cancers. We conducted a two-sample Mendelian randomisation study to assess the causality of these associations. Two, one and 14 independent single nucleotide polymorphisms associated with serum folate, vitamin B6 and vitamin B12 at the genome-wide significance threshold were selected as genetic instruments. Summary-level data for the associations of the vitamin-associated genetic variants with Cancer were obtained from the UK Biobank study including 367,561 individuals and FinnGen consortium comprising up to 176,899 participants. Genetically predicted folate and vitamin B6 concentrations were not associated with overall Cancer, overall Digestive System Cancer or oesophageal, gastric, colorectal or pancreatic Cancer. Genetically predicted vitamin B12 concentrations were positively associated with overall Digestive System Cancer (ORSD, 1.12; 95% CI 1.04, 1.21, p = 0.003) and colorectal Cancer (ORSD 1.16; 95% CI 1.06, 1.26, p = 0.001) in UK Biobank. Results for colorectal Cancer were consistent in FinnGen and the combined ORSD was 1.16 (95% CI 1.08, 1.25, p < 0.001). There was no association of genetically predicted vitamin B12 with any other site-specific Digestive System Cancers or overall Cancer. These results provide evidence to suggest that elevated serum vitamin B12 concentrations are associated with colorectal Cancer.

  • Genetically predicted circulating B vitamins in relation to Digestive System Cancers
    British Journal of Cancer, 2021
    Co-Authors: Shuai Yuan, Paul Carter, Mathew Vithayathil, Siddhartha Kar, Amy M Mason, Stephen Burgess, Susanna C Larsson
    Abstract:

    Background Folate, vitamin B6 and vitamin B12 have been associated with Digestive System Cancers. We conducted a two-sample Mendelian randomisation study to assess the causality of these associations. Methods Two, one and 14 independent single nucleotide polymorphisms associated with serum folate, vitamin B6 and vitamin B12 at the genome-wide significance threshold were selected as genetic instruments. Summary-level data for the associations of the vitamin-associated genetic variants with Cancer were obtained from the UK Biobank study including 367,561 individuals and FinnGen consortium comprising up to 176,899 participants. Results Genetically predicted folate and vitamin B6 concentrations were not associated with overall Cancer, overall Digestive System Cancer or oesophageal, gastric, colorectal or pancreatic Cancer. Genetically predicted vitamin B12 concentrations were positively associated with overall Digestive System Cancer (OR_SD, 1.12; 95% CI 1.04, 1.21, p  = 0.003) and colorectal Cancer (OR_SD 1.16; 95% CI 1.06, 1.26, p  = 0.001) in UK Biobank. Results for colorectal Cancer were consistent in FinnGen and the combined OR_SD was 1.16 (95% CI 1.08, 1.25, p