The Experts below are selected from a list of 228 Experts worldwide ranked by ideXlab platform
Antonio Togni - One of the best experts on this subject based on the ideXlab platform.
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p stereogenic ferrocene based trifluoromethyl phosphanes synthesis structure coordination properties and catalysis
European Journal of Organic Chemistry, 2011Co-Authors: Aline Sondenecker, Raphael Aardoom, Jan Cvengros, Antonio TogniAbstract:Diastereoselective ortho-hydroxymethylation of (R)-(1-ferrocenylethyl)Dimethylamine and Bronsted-acid-mediated nucleophilic substitution with phenyl(trifluoromethyl)phosphane affords an epimeric mixture of P-stereogenic amine-phosphanes 4a and 4b, which are readily separated by crystallization from methanol. Subsequent substitution of the dimethylamino group with diphenylphosphane occurs without epimerization, yielding novel bis(phosphanes) 1a and 1b. These bis(phosphanes) combine three elements of chirality (C-central, P-central and planar) and bear a trifluoromethyl group at a stereogenic phosphorus atom. Their complexes with transition metals (Pd, Rh, Ir) were studied and characterized by means of NMR techniques and X-ray crystallographic analyses, and the bidentate ligands proved efficient in stereoselective catalysis.
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P‐Stereogenic Ferrocene‐Based (Trifluoromethyl)phosphanes: Synthesis, Structure, Coordination Properties and Catalysis
European Journal of Organic Chemistry, 2010Co-Authors: Aline Sondenecker, Raphael Aardoom, Jan Cvengros, Antonio TogniAbstract:Diastereoselective ortho-hydroxymethylation of (R)-(1-ferrocenylethyl)Dimethylamine and Bronsted-acid-mediated nucleophilic substitution with phenyl(trifluoromethyl)phosphane affords an epimeric mixture of P-stereogenic amine-phosphanes 4a and 4b, which are readily separated by crystallization from methanol. Subsequent substitution of the dimethylamino group with diphenylphosphane occurs without epimerization, yielding novel bis(phosphanes) 1a and 1b. These bis(phosphanes) combine three elements of chirality (C-central, P-central and planar) and bear a trifluoromethyl group at a stereogenic phosphorus atom. Their complexes with transition metals (Pd, Rh, Ir) were studied and characterized by means of NMR techniques and X-ray crystallographic analyses, and the bidentate ligands proved efficient in stereoselective catalysis.
Aline Sondenecker - One of the best experts on this subject based on the ideXlab platform.
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p stereogenic ferrocene based trifluoromethyl phosphanes synthesis structure coordination properties and catalysis
European Journal of Organic Chemistry, 2011Co-Authors: Aline Sondenecker, Raphael Aardoom, Jan Cvengros, Antonio TogniAbstract:Diastereoselective ortho-hydroxymethylation of (R)-(1-ferrocenylethyl)Dimethylamine and Bronsted-acid-mediated nucleophilic substitution with phenyl(trifluoromethyl)phosphane affords an epimeric mixture of P-stereogenic amine-phosphanes 4a and 4b, which are readily separated by crystallization from methanol. Subsequent substitution of the dimethylamino group with diphenylphosphane occurs without epimerization, yielding novel bis(phosphanes) 1a and 1b. These bis(phosphanes) combine three elements of chirality (C-central, P-central and planar) and bear a trifluoromethyl group at a stereogenic phosphorus atom. Their complexes with transition metals (Pd, Rh, Ir) were studied and characterized by means of NMR techniques and X-ray crystallographic analyses, and the bidentate ligands proved efficient in stereoselective catalysis.
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P‐Stereogenic Ferrocene‐Based (Trifluoromethyl)phosphanes: Synthesis, Structure, Coordination Properties and Catalysis
European Journal of Organic Chemistry, 2010Co-Authors: Aline Sondenecker, Raphael Aardoom, Jan Cvengros, Antonio TogniAbstract:Diastereoselective ortho-hydroxymethylation of (R)-(1-ferrocenylethyl)Dimethylamine and Bronsted-acid-mediated nucleophilic substitution with phenyl(trifluoromethyl)phosphane affords an epimeric mixture of P-stereogenic amine-phosphanes 4a and 4b, which are readily separated by crystallization from methanol. Subsequent substitution of the dimethylamino group with diphenylphosphane occurs without epimerization, yielding novel bis(phosphanes) 1a and 1b. These bis(phosphanes) combine three elements of chirality (C-central, P-central and planar) and bear a trifluoromethyl group at a stereogenic phosphorus atom. Their complexes with transition metals (Pd, Rh, Ir) were studied and characterized by means of NMR techniques and X-ray crystallographic analyses, and the bidentate ligands proved efficient in stereoselective catalysis.
Jan Cvengros - One of the best experts on this subject based on the ideXlab platform.
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p stereogenic ferrocene based trifluoromethyl phosphanes synthesis structure coordination properties and catalysis
European Journal of Organic Chemistry, 2011Co-Authors: Aline Sondenecker, Raphael Aardoom, Jan Cvengros, Antonio TogniAbstract:Diastereoselective ortho-hydroxymethylation of (R)-(1-ferrocenylethyl)Dimethylamine and Bronsted-acid-mediated nucleophilic substitution with phenyl(trifluoromethyl)phosphane affords an epimeric mixture of P-stereogenic amine-phosphanes 4a and 4b, which are readily separated by crystallization from methanol. Subsequent substitution of the dimethylamino group with diphenylphosphane occurs without epimerization, yielding novel bis(phosphanes) 1a and 1b. These bis(phosphanes) combine three elements of chirality (C-central, P-central and planar) and bear a trifluoromethyl group at a stereogenic phosphorus atom. Their complexes with transition metals (Pd, Rh, Ir) were studied and characterized by means of NMR techniques and X-ray crystallographic analyses, and the bidentate ligands proved efficient in stereoselective catalysis.
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P‐Stereogenic Ferrocene‐Based (Trifluoromethyl)phosphanes: Synthesis, Structure, Coordination Properties and Catalysis
European Journal of Organic Chemistry, 2010Co-Authors: Aline Sondenecker, Raphael Aardoom, Jan Cvengros, Antonio TogniAbstract:Diastereoselective ortho-hydroxymethylation of (R)-(1-ferrocenylethyl)Dimethylamine and Bronsted-acid-mediated nucleophilic substitution with phenyl(trifluoromethyl)phosphane affords an epimeric mixture of P-stereogenic amine-phosphanes 4a and 4b, which are readily separated by crystallization from methanol. Subsequent substitution of the dimethylamino group with diphenylphosphane occurs without epimerization, yielding novel bis(phosphanes) 1a and 1b. These bis(phosphanes) combine three elements of chirality (C-central, P-central and planar) and bear a trifluoromethyl group at a stereogenic phosphorus atom. Their complexes with transition metals (Pd, Rh, Ir) were studied and characterized by means of NMR techniques and X-ray crystallographic analyses, and the bidentate ligands proved efficient in stereoselective catalysis.
Raphael Aardoom - One of the best experts on this subject based on the ideXlab platform.
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p stereogenic ferrocene based trifluoromethyl phosphanes synthesis structure coordination properties and catalysis
European Journal of Organic Chemistry, 2011Co-Authors: Aline Sondenecker, Raphael Aardoom, Jan Cvengros, Antonio TogniAbstract:Diastereoselective ortho-hydroxymethylation of (R)-(1-ferrocenylethyl)Dimethylamine and Bronsted-acid-mediated nucleophilic substitution with phenyl(trifluoromethyl)phosphane affords an epimeric mixture of P-stereogenic amine-phosphanes 4a and 4b, which are readily separated by crystallization from methanol. Subsequent substitution of the dimethylamino group with diphenylphosphane occurs without epimerization, yielding novel bis(phosphanes) 1a and 1b. These bis(phosphanes) combine three elements of chirality (C-central, P-central and planar) and bear a trifluoromethyl group at a stereogenic phosphorus atom. Their complexes with transition metals (Pd, Rh, Ir) were studied and characterized by means of NMR techniques and X-ray crystallographic analyses, and the bidentate ligands proved efficient in stereoselective catalysis.
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P‐Stereogenic Ferrocene‐Based (Trifluoromethyl)phosphanes: Synthesis, Structure, Coordination Properties and Catalysis
European Journal of Organic Chemistry, 2010Co-Authors: Aline Sondenecker, Raphael Aardoom, Jan Cvengros, Antonio TogniAbstract:Diastereoselective ortho-hydroxymethylation of (R)-(1-ferrocenylethyl)Dimethylamine and Bronsted-acid-mediated nucleophilic substitution with phenyl(trifluoromethyl)phosphane affords an epimeric mixture of P-stereogenic amine-phosphanes 4a and 4b, which are readily separated by crystallization from methanol. Subsequent substitution of the dimethylamino group with diphenylphosphane occurs without epimerization, yielding novel bis(phosphanes) 1a and 1b. These bis(phosphanes) combine three elements of chirality (C-central, P-central and planar) and bear a trifluoromethyl group at a stereogenic phosphorus atom. Their complexes with transition metals (Pd, Rh, Ir) were studied and characterized by means of NMR techniques and X-ray crystallographic analyses, and the bidentate ligands proved efficient in stereoselective catalysis.
Abdel-aziz M. Wahbi - One of the best experts on this subject based on the ideXlab platform.
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Reversed phase-liquid chromatography of primary and secondary aliphatic amines after derivatization combined with electrochemical detection☆
Analytica Chimica Acta, 1995Co-Authors: Reinhold Wintersteiger, Magda H. Barary, Fawzy A. El-yazbi, Suzy M. Sabry, Abdel-aziz M. WahbiAbstract:Abstract An analytical procedure has been developed for the determination of primary and secondary aliphatic amines by liquid chromatography with electrochemical detection (LC-ECD). Aliphatic amines, such as propylamine (PA), butylamine (BA), 2-pentylamine (2-PA), Dimethylamine (DMA), diethylamine (DEA) and dipropylamine (DPA) react readily with salicylic acid chloride (SAC) to produce electroactive amide derivatives with good chemical stability. The isocratic elution pattern of synthetic mixtures of the investigated amines on a reversed-phase column is shown. Hydrodynamic voltammograms of standard compounds are presented. The detection limits monitored with an EC detector are compared with those of an UV detector. The method was sensitive enough to detect the derivatives in the picomol range. The method was also applied for the determination of amines in plasma and urine using 2-PA and DPA as model substances. Following a solid phase extraction and derivatization, the compounds could be detected in the lower ng range/ml biological material.