The Experts below are selected from a list of 210 Experts worldwide ranked by ideXlab platform
C. Stephen Foster - One of the best experts on this subject based on the ideXlab platform.
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Hypertrophic Discoid Lupus Erythematosus of the conjunctiva.
American Journal of Ophthalmology, 1999Co-Authors: Harvey S. Uy, Wasee Polcharoen, Roberto Pineda, Frederick Albert Jakobiec, John W Shore, C. Stephen FosterAbstract:Abstract PURPOSE: To report the ophthalmic manifestations of hypertrophic Discoid Lupus Erythematosus of the conjunctiva. METHOD: Case report and review of biopsy results. RESULTS: A 58-year-old woman with a history of chronic blepharoconjunctivitis presented with an unusual raised conjunctival lesion. Previous biopsy slides were reviewed and interpreted as diagnostic of Discoid Lupus Erythematosus, hypertrophic or verrucous type. Both blepharoconjunctivitis and the raised conjunctival lesion resolved with hydroxychloroquine therapy. CONCLUSIONS: A raised conjunctival mass in the context of refractory blepharoconjunctivitis should elicit suspicion for Discoid Lupus Erythematosus. The hypertrophic variant of this disease can affect the conjunctiva.
Lars Molin - One of the best experts on this subject based on the ideXlab platform.
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Discoid Lupus Erythematosus treated with cryotherapy
The Journal of dermatological treatment, 2003Co-Authors: Lars Molin, M TarstedtAbstract:A female is presented with multiple longstanding hypertrophic Discoid Lupus Erythematosus lesions resistant to topical and systemic therapy for years. She suffered severe itching and pain localized to the lesions. Treatment with cryosurgery resulted in complete healing of the lesions, leaving slightly hypopigmented soft scars. There was no tendency of relapse during a follow-up period of ten years.
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Discoid Lupus Erythematosus Lesions Treated with Cryosurgery
Advances in experimental medicine and biology, 1999Co-Authors: Lars MolinAbstract:A case is presented in whom therapy resistent Discoid Lupus Erythematosus (DLE) lesions were successfully treated with cryosurgery.
Hisashi Takahashi - One of the best experts on this subject based on the ideXlab platform.
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Keratin and involucrin expression in Discoid Lupus Erythematosus and lichen planus.
Archives of Dermatological Research, 1997Co-Authors: Eiko Ichikawa, S. Watanabe, Hisashi TakahashiAbstract:In the present study, keratin and involucrin expression were studied in cutaneous lesions of Discoid Lupus Erythematosus and lichen planus in order to gain a better understanding of the abnormal differentiation or maturation of the epidermal cells in these dermatoses. Ten specimens each from Discoid Lupus Erythematosus and lichen planus were analyzed by immunohistochemical techniques, using a panel of monoclonal antikeratin antibodies and polyclonal anti-involucrin antibody, and five specimens each were analyzed by one- and two-dimensional gel electrophoresis and immunoblot analysis using three antikeratin antibodies. No significant difference was found between the dermatoses. The expression of differentiation-specific keratins showed a similar pattern to that in normal epidermis, and involucrin was expressed even in the lower part of the stratum spinosum. Keratins 6 and 16, which are characteristic markers of hyperproliferative states, and keratin 17 were detected in nonhyperproliferative and atrophic epidermis with hydropic degeneration and inflammatory infiltrates in the dermis. These results suggest that expression of keratins 6, 16 and 17 in Discoid Lupus Erythematosus and lichen planus may reflect a wound healing response to the damage to the basal cell layer, or may be under the control of cytokines produced by infiltrating inflammatory cells in the dermis.
Shyamala C. Huilgol - One of the best experts on this subject based on the ideXlab platform.
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Discoid Lupus Erythematosus presenting as madarosis.
American Journal of Ophthalmology, 2003Co-Authors: Dinesh Selva, Celia S. Chen, Craig James, Shyamala C. HuilgolAbstract:Abstract Purpose Discoid Lupus Erythematosus (DLE) is an autoimmune disorder that usually affects the sun–exposed skin. Periocular involvement occurs uncommonly and may progress from eyelid erythema to scarring and madarosis. Method Observational case report. Result A case of DLE that presented with madarosis alone in the absence of preceding skin erythema and scarring. Conclusion Our case demonstrates that DLE may present with madarosis alone in the absence of a history of preceding erythema and scarring. Discoid Lupus Erythematosus should therefore be considered as a differential diagnosis in chronic blepharitis that persists despite usual medical management and eyelid hygiene. Biopsy should be considered in the presence of clinical features such as erythematous scale on the face and alopecia and sent for direct immunofluorescence staining.
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Discoid Lupus Erythematosus presenting as madarosis.
American Journal of Ophthalmology, 2003Co-Authors: Dinesh Selva, Celia S. Chen, Craig James, Shyamala C. HuilgolAbstract:Abstract Purpose Discoid Lupus Erythematosus (DLE) is an autoimmune disorder that usually affects the sun–exposed skin. Periocular involvement occurs uncommonly and may progress from eyelid erythema to scarring and madarosis. Method Observational case report. Result A case of DLE that presented with madarosis alone in the absence of preceding skin erythema and scarring. Conclusion Our case demonstrates that DLE may present with madarosis alone in the absence of a history of preceding erythema and scarring. Discoid Lupus Erythematosus should therefore be considered as a differential diagnosis in chronic blepharitis that persists despite usual medical management and eyelid hygiene. Biopsy should be considered in the presence of clinical features such as erythematous scale on the face and alopecia and sent for direct immunofluorescence staining.
Harvey S. Uy - One of the best experts on this subject based on the ideXlab platform.
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Hypertrophic Discoid Lupus Erythematosus of the conjunctiva.
American Journal of Ophthalmology, 1999Co-Authors: Harvey S. Uy, Wasee Polcharoen, Roberto Pineda, Frederick Albert Jakobiec, John W Shore, C. Stephen FosterAbstract:Abstract PURPOSE: To report the ophthalmic manifestations of hypertrophic Discoid Lupus Erythematosus of the conjunctiva. METHOD: Case report and review of biopsy results. RESULTS: A 58-year-old woman with a history of chronic blepharoconjunctivitis presented with an unusual raised conjunctival lesion. Previous biopsy slides were reviewed and interpreted as diagnostic of Discoid Lupus Erythematosus, hypertrophic or verrucous type. Both blepharoconjunctivitis and the raised conjunctival lesion resolved with hydroxychloroquine therapy. CONCLUSIONS: A raised conjunctival mass in the context of refractory blepharoconjunctivitis should elicit suspicion for Discoid Lupus Erythematosus. The hypertrophic variant of this disease can affect the conjunctiva.