The Experts below are selected from a list of 120 Experts worldwide ranked by ideXlab platform
Mohammad Ibrahim - One of the best experts on this subject based on the ideXlab platform.
-
acute oral toxicity and antioxidant studies of an amine based diselenide
BMC Complementary and Alternative Medicine, 2019Co-Authors: Mohammad Ibrahim, Niaz Muhammad, Musadiq Ibrahim, Muhammad Idrees Khan, Muhammad Ishaq Ali Shah, Muhammad Said, Waliullah Khan, Jean Paul KamdemAbstract:Organochalcogen compounds have attracted the interest of a multitude of studies for their promising Pharmacological and biological activities. The antioxidant activity and acute toxicity of an organoselenium compound, 1-(2-(2-(2-(1-aminoethyl)phenyl)diselanyl)phenyl)ethanamine (APDP) was determined in mice. Mice were randomly divided into four groups, with each group comprising of seven animals. Canola oil (1ml/kg of body weight) was administered to 1st group, while 2nd, 3rd & 4th groups were administered with 10 mg/kg, 30 mg/kg & 350 mg/kg of APDP respectively. APDP was administered by Intragastric gavage as a single oral dose. The APDP oral administration was found to be safe up to 350 mg/kg of body weight and no deaths of animals were recorded. The lethal dose 50 (LD50) for APDP was determined at 72 h and was estimated to be > 350 mg/kg. After acute treatment, all mice were sacrificed by decapitation to determine the antioxidant enzymes and lipid peroxidation values for the treated mice liver. No fluctuation in lipid peroxidation, vitamin C and non protein thiol (NPSH) levels was observed due to the administration of APDP. hepatic α-ALA-D activity, catalase (CAT), superoxide dismutase (SOD) and the biochemical parameters were evaluated. Experimental observation demonstrated that APDP protected Fe(II) induced thiobarbituric acid reactive substances (TBARS) production in liver homogenate significantly (p < 0.05). The administration of APDP (an amine-based diselenide) both in vitro and in vivo clearly demonstrated that this potential compound has no acute toxicity towards mice among all the tested parameter. On the basis of experimental results, it is concluded that APDP is a potential candidate as an antioxidant compound for studying pharmacological properties.
-
Acute oral toxicity and antioxidant studies of an amine-based diselenide
BMC, 2019Co-Authors: Mohammad Ibrahim, Jean Paul Kamdem, Niaz Muhammad, Musadiq Ibrahim, Muhammad Idrees Khan, Muhammad Ishaq Ali Shah, Muhammad Said, Waliullah Khan, Joao Batista Teixeira RochaAbstract:Abstract Background Organochalcogen compounds have attracted the interest of a multitude of studies for their promising Pharmacological and biological activities. The antioxidant activity and acute toxicity of an organoselenium compound, 1-(2-(2-(2-(1-aminoethyl)phenyl)diselanyl)phenyl)ethanamine (APDP) was determined in mice. Methods Mice were randomly divided into four groups, with each group comprising of seven animals. Canola oil (1ml/kg of body weight) was administered to 1st group, while 2nd, 3rd & 4th groups were administered with 10 mg/kg, 30 mg/kg & 350 mg/kg of APDP respectively. APDP was administered by Intragastric gavage as a single oral dose. Results The APDP oral administration was found to be safe up to 350 mg/kg of body weight and no deaths of animals were recorded. The lethal dose 50 (LD50) for APDP was determined at 72 h and was estimated to be > 350 mg/kg. After acute treatment, all mice were sacrificed by decapitation to determine the antioxidant enzymes and lipid peroxidation values for the treated mice liver. No fluctuation in lipid peroxidation, vitamin C and non protein thiol (NPSH) levels was observed due to the administration of APDP. hepatic α-ALA-D activity, catalase (CAT), superoxide dismutase (SOD) and the biochemical parameters were evaluated. Experimental observation demonstrated that APDP protected Fe(II) induced thiobarbituric acid reactive substances (TBARS) production in liver homogenate significantly (p
-
in vitro evaluation of glutathione peroxidase gpx like activity and antioxidant properties of an organoselenium compound
Toxicology in Vitro, 2015Co-Authors: Mohammad Ibrahim, Anna Maria Deobald, Jean Paul Kamdem, Niaz Muhammad, Muhammad Naeem, Joao RochaAbstract:Abstract The amine based diselenide, (Z)-N-(4-methylbenzylidene)-1-(2-((2-(1-((E)-4-methyl benzylideneamino)ethyl)phenyl)diselanyl)phenyl)ethanamine ethyl)phenyl) diselanyl) phenyl) ethylimino) methyl)phenol (Compound A) an organoselenium compound that can mimic endogenous antioxidant enzymes, such as glutathione peroxidase (GPx), and diphenyl diselenide (PhSe)2 were tested against lipid peroxidation induced by sodium nitroprusside (SNP) and Fe(II) in rat brain, interaction with 1,1-diphenyl-2-picrylhydrazyl stable free radical (DPPH) and glutathione peroxidase (GPx) like antioxidant activities with H 2 O 2 or tBuOOH as substrates and with PhSH as thiol co-substrates as well as their ability to oxidize thiols were evaluated. From this study, we concluded that Compound A catalyze the reduction of H 2 O 2 with thiol was ∼2-fold more active than (PhSe)2) in both tBuOOH and H 2 O 2 systems when PhSH was used as a substrate. (PhSe)2 exhibited an increased ability to oxidize thiols while Compound A was not a good substrate for the oxidation of thiol used namely DTT and Cystine and showed DPPH radical-scavenging activity, while (PhSe)2 did not present radical scavenging activity. Compound A (amine based diselenide) presented better antioxidant profiles than (PhSe)2 against lipid peroxidation. The results clear showed that nitrogen atom in the Compound A can have a profound effect on their pharmacological properties.
-
1 2 2 2 1 aminoethyl phenyl diselanyl phenyl ethanamine an amino organoselenium compound with interesting antioxidant profile
Toxicology in Vitro, 2014Co-Authors: Mohammad Ibrahim, Anna Maria Deobald, Jean Paul Kamdem, Javed Anwar, Waseem Hassan, Diogo O. SouzaAbstract:Abstract Free radical scavenging and antioxidant activities of 1-(2-(2-(2-(1-aminoethyl)phenyl)diselanyl)phenyl)ethanamine (compound A) and diphenyl diselenide (PhSe)2 were examined and compared for inhibition of Fe(II) and sodium nitroprusside (SNP) stimulated lipid peroxidation in rat brain, interaction with 1,1-diphenyl-2-picrylhydrazyl (DPPH) stable free radical and their glutathione peroxidase (GPx) like antioxidant activities with H2O2 or tBuOOH as substrates and with PhSH as thiol co-substrates as well as their ability to oxidize mono- and di-thiols were also evaluated. This study revealed that an amino group in amino diselenide drastically enhances their catalytic activities in the aromatic thiol (PhSH) assay system. Compound A was ∼2-fold more active than (PhSe)2 in both tBuOOH and H2O2 assay systems. In addition, the present results showed that (PhSe)2 exhibited an increased ability to oxidize di-thiols, compound A was not a good substrate for the oxidation of thiol used namely DTT, cystine and DMPS. The antioxidant potency against Fe(II) and SNP-induced brain TBARS were in this order [(compound A); IC50 2 μM and 4 μM] > [(PhSe)2; IC50 19 μM and 27.5 μM. Compound A showed DPPH radical-scavenging activity. This study provides in vitro evidence anti-oxidant action of the tested organoselenium compounds, that the nitrogen atom in the organochalcogens can have a profound effect on their antioxidant activity.
Jean Paul Kamdem - One of the best experts on this subject based on the ideXlab platform.
-
acute oral toxicity and antioxidant studies of an amine based diselenide
BMC Complementary and Alternative Medicine, 2019Co-Authors: Mohammad Ibrahim, Niaz Muhammad, Musadiq Ibrahim, Muhammad Idrees Khan, Muhammad Ishaq Ali Shah, Muhammad Said, Waliullah Khan, Jean Paul KamdemAbstract:Organochalcogen compounds have attracted the interest of a multitude of studies for their promising Pharmacological and biological activities. The antioxidant activity and acute toxicity of an organoselenium compound, 1-(2-(2-(2-(1-aminoethyl)phenyl)diselanyl)phenyl)ethanamine (APDP) was determined in mice. Mice were randomly divided into four groups, with each group comprising of seven animals. Canola oil (1ml/kg of body weight) was administered to 1st group, while 2nd, 3rd & 4th groups were administered with 10 mg/kg, 30 mg/kg & 350 mg/kg of APDP respectively. APDP was administered by Intragastric gavage as a single oral dose. The APDP oral administration was found to be safe up to 350 mg/kg of body weight and no deaths of animals were recorded. The lethal dose 50 (LD50) for APDP was determined at 72 h and was estimated to be > 350 mg/kg. After acute treatment, all mice were sacrificed by decapitation to determine the antioxidant enzymes and lipid peroxidation values for the treated mice liver. No fluctuation in lipid peroxidation, vitamin C and non protein thiol (NPSH) levels was observed due to the administration of APDP. hepatic α-ALA-D activity, catalase (CAT), superoxide dismutase (SOD) and the biochemical parameters were evaluated. Experimental observation demonstrated that APDP protected Fe(II) induced thiobarbituric acid reactive substances (TBARS) production in liver homogenate significantly (p < 0.05). The administration of APDP (an amine-based diselenide) both in vitro and in vivo clearly demonstrated that this potential compound has no acute toxicity towards mice among all the tested parameter. On the basis of experimental results, it is concluded that APDP is a potential candidate as an antioxidant compound for studying pharmacological properties.
-
Acute oral toxicity and antioxidant studies of an amine-based diselenide
BMC, 2019Co-Authors: Mohammad Ibrahim, Jean Paul Kamdem, Niaz Muhammad, Musadiq Ibrahim, Muhammad Idrees Khan, Muhammad Ishaq Ali Shah, Muhammad Said, Waliullah Khan, Joao Batista Teixeira RochaAbstract:Abstract Background Organochalcogen compounds have attracted the interest of a multitude of studies for their promising Pharmacological and biological activities. The antioxidant activity and acute toxicity of an organoselenium compound, 1-(2-(2-(2-(1-aminoethyl)phenyl)diselanyl)phenyl)ethanamine (APDP) was determined in mice. Methods Mice were randomly divided into four groups, with each group comprising of seven animals. Canola oil (1ml/kg of body weight) was administered to 1st group, while 2nd, 3rd & 4th groups were administered with 10 mg/kg, 30 mg/kg & 350 mg/kg of APDP respectively. APDP was administered by Intragastric gavage as a single oral dose. Results The APDP oral administration was found to be safe up to 350 mg/kg of body weight and no deaths of animals were recorded. The lethal dose 50 (LD50) for APDP was determined at 72 h and was estimated to be > 350 mg/kg. After acute treatment, all mice were sacrificed by decapitation to determine the antioxidant enzymes and lipid peroxidation values for the treated mice liver. No fluctuation in lipid peroxidation, vitamin C and non protein thiol (NPSH) levels was observed due to the administration of APDP. hepatic α-ALA-D activity, catalase (CAT), superoxide dismutase (SOD) and the biochemical parameters were evaluated. Experimental observation demonstrated that APDP protected Fe(II) induced thiobarbituric acid reactive substances (TBARS) production in liver homogenate significantly (p
-
in vitro evaluation of glutathione peroxidase gpx like activity and antioxidant properties of an organoselenium compound
Toxicology in Vitro, 2015Co-Authors: Mohammad Ibrahim, Anna Maria Deobald, Jean Paul Kamdem, Niaz Muhammad, Muhammad Naeem, Joao RochaAbstract:Abstract The amine based diselenide, (Z)-N-(4-methylbenzylidene)-1-(2-((2-(1-((E)-4-methyl benzylideneamino)ethyl)phenyl)diselanyl)phenyl)ethanamine ethyl)phenyl) diselanyl) phenyl) ethylimino) methyl)phenol (Compound A) an organoselenium compound that can mimic endogenous antioxidant enzymes, such as glutathione peroxidase (GPx), and diphenyl diselenide (PhSe)2 were tested against lipid peroxidation induced by sodium nitroprusside (SNP) and Fe(II) in rat brain, interaction with 1,1-diphenyl-2-picrylhydrazyl stable free radical (DPPH) and glutathione peroxidase (GPx) like antioxidant activities with H 2 O 2 or tBuOOH as substrates and with PhSH as thiol co-substrates as well as their ability to oxidize thiols were evaluated. From this study, we concluded that Compound A catalyze the reduction of H 2 O 2 with thiol was ∼2-fold more active than (PhSe)2) in both tBuOOH and H 2 O 2 systems when PhSH was used as a substrate. (PhSe)2 exhibited an increased ability to oxidize thiols while Compound A was not a good substrate for the oxidation of thiol used namely DTT and Cystine and showed DPPH radical-scavenging activity, while (PhSe)2 did not present radical scavenging activity. Compound A (amine based diselenide) presented better antioxidant profiles than (PhSe)2 against lipid peroxidation. The results clear showed that nitrogen atom in the Compound A can have a profound effect on their pharmacological properties.
-
1 2 2 2 1 aminoethyl phenyl diselanyl phenyl ethanamine an amino organoselenium compound with interesting antioxidant profile
Toxicology in Vitro, 2014Co-Authors: Mohammad Ibrahim, Anna Maria Deobald, Jean Paul Kamdem, Javed Anwar, Waseem Hassan, Diogo O. SouzaAbstract:Abstract Free radical scavenging and antioxidant activities of 1-(2-(2-(2-(1-aminoethyl)phenyl)diselanyl)phenyl)ethanamine (compound A) and diphenyl diselenide (PhSe)2 were examined and compared for inhibition of Fe(II) and sodium nitroprusside (SNP) stimulated lipid peroxidation in rat brain, interaction with 1,1-diphenyl-2-picrylhydrazyl (DPPH) stable free radical and their glutathione peroxidase (GPx) like antioxidant activities with H2O2 or tBuOOH as substrates and with PhSH as thiol co-substrates as well as their ability to oxidize mono- and di-thiols were also evaluated. This study revealed that an amino group in amino diselenide drastically enhances their catalytic activities in the aromatic thiol (PhSH) assay system. Compound A was ∼2-fold more active than (PhSe)2 in both tBuOOH and H2O2 assay systems. In addition, the present results showed that (PhSe)2 exhibited an increased ability to oxidize di-thiols, compound A was not a good substrate for the oxidation of thiol used namely DTT, cystine and DMPS. The antioxidant potency against Fe(II) and SNP-induced brain TBARS were in this order [(compound A); IC50 2 μM and 4 μM] > [(PhSe)2; IC50 19 μM and 27.5 μM. Compound A showed DPPH radical-scavenging activity. This study provides in vitro evidence anti-oxidant action of the tested organoselenium compounds, that the nitrogen atom in the organochalcogens can have a profound effect on their antioxidant activity.
Bernard Omondi - One of the best experts on this subject based on the ideXlab platform.
-
Triethylammonium hexa-μ2-acetato-κ12O:O′-diacetato-κ2O-aqua-μ3-oxido-triferrate(III) toluene monosolvate
International Union of Crystallography, 2011Co-Authors: Andrew R. Burgoyne, Reinout Meijboom, Alfred Muller, Bernard OmondiAbstract:The title compound, (C6H16N)[Fe3(CH3CO2)8O(H2O)]·C7H8, was serendipitously crystallized from a reaction of disilanol with iron(II) acetate. The trinuclear acetatoferrate(III) anion has a triethylammonium cation as the counterion. The three Fe atoms lie on the vertices of a regular triangle and are octahedrally coordinated. The complete coordination of the anion includes shared ligands among the three metal ions: a central tribridging O atom and six bidentate bridging acetyl groups. The six-coordinations of two of the metal ions are completed by a monodentate acetate ligand, whereas that of the third metal ion is completed by a water molecule. The uncoordinated triethylammonium cation is involved in N—H...O hydrogen bonding to a singly coordinated acetyl group. The coordinated aqua molecule is involved in bifurcated O—H...O hydrogen bonding. C—H...O interactions are also observed. The toluene solvent molecule is disordered over two sets of sites in a 0.609 (11):0.391 (11) ratio
-
O-aqua-l3-oxidotriferrate(III) toluene monosolvate
2011Co-Authors: Triethylammonium Hexa-l-acetatoj, Andrew R. Burgoyne, Reinout Meijboom, Alfred Muller, Bernard OmondiAbstract:disorder in solvent or counterion; R factor = 0.040; wR factor = 0.099; data-toparameter ratio = 13.0. The title compound, (C6H16N)[Fe3(CH3CO2)8O(H2O)] C7H8, was serendipitously crystallized from a reaction of disilanol with iron(II) acetate. The trinuclear acetatoferrate(III) anion has a triethylammonium cation as the counterion. The three Fe atoms lie on the vertices of a regular triangle and are octahedrally coordinated. The complete coordination of the anion includes shared ligands among the three metal ions: a central tribridging O atom and six bidentate bridging acetyl groups. The six-coordinations of two of the metal ions are completed by a monodentate acetate ligand, whereas that of the third metal ion is completed by a water molecule. The uncoordinated triethylammonium cation is involved in N— H O hydrogen bonding to a singly coordinated acetyl group. The coordinated aqua molecule is involved in bifurcated O— H O hydrogen bonding. C—H O interactions are also observed. The toluene solvent molecule is disordered over two sets of sites in a 0.609 (11):0.391 (11) ratio. Related literature For exchange-coupled structural fragments or exchange cluster
Burgoyne, Andrew R. - One of the best experts on this subject based on the ideXlab platform.
-
Triethylammonium hexa-l2-acetatoj 12O:O0-diacetato-j2O-aqua-l3-oxidotriferrate( III) toluene monosolvate
2011Co-Authors: Omondi, Bernard O., Muller Alfred, Meijboom Reinout, Burgoyne, Andrew R.Abstract:The title compound, (C6H16N)[Fe3(CH3CO2)8O(H2O)] C7H8, was serendipitously crystallized from a reaction of disilanol with iron(II) acetate. The trinuclear acetatoferrate(III) anion has a triethylammonium cation as the counterion. The three Fe atoms lie on the vertices of a regular triangle and are octahedrally coordinated. The complete coordination of the anion includes shared ligands among the three metal ions: a central tribridging O atom and six bidentate bridging acetyl groups. The six-coordinations of two of the metal ions are completed by a monodentate acetate ligand, whereas that of the third metal ion is completed by a water molecule. The uncoordinated triethylammonium cation is involved in N— H O hydrogen bonding to a singly coordinated acetyl group. The coordinated aqua molecule is involved in bifurcated O— H O hydrogen bonding. C—H O interactions are also observed. The toluene solvent molecule is disordered over two sets of sites in a 0.609 (11):0.391 (11) ratio.National Research Foundation of South Africa (NRF
-
Triethylammonium hexa-μ2-acetato-κ12 O:O′-diacetato-κ2 O-aqua-μ3-oxido-triferrate(III) toluene monosolvate
International Union of Crystallography, 2026Co-Authors: Burgoyne, Andrew R., Meijboom Reinout, Muller Alfred, Omondi, Bernard O.Abstract:The title compound, (C6H16N)[Fe3(CH3CO2)8O(H2O)]·C7H8, was serendipitously crystallized from a reaction of disilanol with iron(II) acetate. The trinuclear acetatoferrate(III) anion has a triethylammonium cation as the counterion. The three Fe atoms lie on the vertices of a regular triangle and are octahedrally coordinated. The complete coordination of the anion includes shared ligands among the three metal ions: a central tribridging O atom and six bidentate bridging acetyl groups. The six-coordinations of two of the metal ions are completed by a monodentate acetate ligand, whereas that of the third metal ion is completed by a water molecule. The uncoordinated triethylammonium cation is involved in N—H⋯O hydrogen bonding to a singly coordinated acetyl group. The coordinated aqua molecule is involved in bifurcated O—H⋯O hydrogen bonding. C—H⋯O interactions are also observed. The toluene solvent molecule is disordered over two sets of sites in a 0.609 (11):0.391 (11) ratio
Omondi, Bernard O. - One of the best experts on this subject based on the ideXlab platform.
-
Triethylammonium hexa-l2-acetatoj 12O:O0-diacetato-j2O-aqua-l3-oxidotriferrate( III) toluene monosolvate
2011Co-Authors: Omondi, Bernard O., Muller Alfred, Meijboom Reinout, Burgoyne, Andrew R.Abstract:The title compound, (C6H16N)[Fe3(CH3CO2)8O(H2O)] C7H8, was serendipitously crystallized from a reaction of disilanol with iron(II) acetate. The trinuclear acetatoferrate(III) anion has a triethylammonium cation as the counterion. The three Fe atoms lie on the vertices of a regular triangle and are octahedrally coordinated. The complete coordination of the anion includes shared ligands among the three metal ions: a central tribridging O atom and six bidentate bridging acetyl groups. The six-coordinations of two of the metal ions are completed by a monodentate acetate ligand, whereas that of the third metal ion is completed by a water molecule. The uncoordinated triethylammonium cation is involved in N— H O hydrogen bonding to a singly coordinated acetyl group. The coordinated aqua molecule is involved in bifurcated O— H O hydrogen bonding. C—H O interactions are also observed. The toluene solvent molecule is disordered over two sets of sites in a 0.609 (11):0.391 (11) ratio.National Research Foundation of South Africa (NRF
-
Triethylammonium hexa-μ2-acetato-κ12 O:O′-diacetato-κ2 O-aqua-μ3-oxido-triferrate(III) toluene monosolvate
International Union of Crystallography, 2026Co-Authors: Burgoyne, Andrew R., Meijboom Reinout, Muller Alfred, Omondi, Bernard O.Abstract:The title compound, (C6H16N)[Fe3(CH3CO2)8O(H2O)]·C7H8, was serendipitously crystallized from a reaction of disilanol with iron(II) acetate. The trinuclear acetatoferrate(III) anion has a triethylammonium cation as the counterion. The three Fe atoms lie on the vertices of a regular triangle and are octahedrally coordinated. The complete coordination of the anion includes shared ligands among the three metal ions: a central tribridging O atom and six bidentate bridging acetyl groups. The six-coordinations of two of the metal ions are completed by a monodentate acetate ligand, whereas that of the third metal ion is completed by a water molecule. The uncoordinated triethylammonium cation is involved in N—H⋯O hydrogen bonding to a singly coordinated acetyl group. The coordinated aqua molecule is involved in bifurcated O—H⋯O hydrogen bonding. C—H⋯O interactions are also observed. The toluene solvent molecule is disordered over two sets of sites in a 0.609 (11):0.391 (11) ratio