The Experts below are selected from a list of 162 Experts worldwide ranked by ideXlab platform
J R Perry - One of the best experts on this subject based on the ideXlab platform.
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Radionuclide Diuresis pyelography.
The Journal of Urology, 1991Co-Authors: H G Mesrobian, J R PerryAbstract:AbstractRadionuclide Diuresis renography continues to be relied upon as a major diagnostic tool to differentiate obstructive and nonobstructive hydronephrosis. Controversy continues to exist with respect to methodology and interpretation of intermediate obstructive patterns. In this study radionuclide Diuresis pyelography was performed in 11 renal units with hydronephrosis and a preexisting percutaneous nephrostomy tube in place. The procedure consisted of the introduction per kidney of 20 μc./kg. 99mtechnetium-diethylenetriaxninepentaacetic acid and sterile saline as a bolus into the renal pelvis via a percutaneous nephrostomy tube to produce a volume equal to the capacity of the hydronephrotic system. The kidney was monitored with a gamma camera and computer system. Furosemide (0.3mg./kg.) was injected intravenously halfway into a 40-minute study. The time/activity curves thus generated were relatively independent of the cortical transport phase. The 2 types of curves were accelerated and constant. Anal...
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Radionuclide Diuresis pyelography.
The Journal of urology, 1991Co-Authors: H G Mesrobian, J R PerryAbstract:Radionuclide Diuresis renography continues to be relied upon as a major diagnostic tool to differentiate obstructive and nonobstructive hydronephrosis. Controversy continues to exist with respect to methodology and interpretation of intermediate obstructive patterns. In this study radionuclide Diuresis pyelography was performed in 11 renal units with hydronephrosis and a pre-existing percutaneous nephrostomy tube in place. The procedure consisted of the introduction per kidney of 20 muc./kg. 99mtechnetium-diethylenetriaminepentaacetic acid and sterile saline as a bolus into the renal pelvis via a percutaneous nephrostomy tube to produce a volume equal to the capacity of the hydronephrotic system. The kidney was monitored with a gamma camera and computer system. Furosemide (0.3 mg./kg.) was injected intravenously halfway into a 40-minute study. The time/activity curves thus generated were relatively independent of the cortical transport phase. The 2 types of curves were accelerated and constant. Analysis of these pyelogram curves revealed a strong correlation between the presence of an accelerated clearance rate response to furosemide and hydronephrosis without obstruction in 5 of 6 renal units. A constant clearance rate response to furosemide correlated with the presence of obstruction in 4 of 5 units. These observations may indicate that diuretic pyelogram curve dynamics may reflect not only the presence or absence of obstruction but also the ability of the hydronephrotic kidney to respond to the diuretic. More experience must be accumulated to determine the conditions under which Diuresis pyelography may become useful clinically.
H G Mesrobian - One of the best experts on this subject based on the ideXlab platform.
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Radionuclide Diuresis pyelography.
The Journal of Urology, 1991Co-Authors: H G Mesrobian, J R PerryAbstract:AbstractRadionuclide Diuresis renography continues to be relied upon as a major diagnostic tool to differentiate obstructive and nonobstructive hydronephrosis. Controversy continues to exist with respect to methodology and interpretation of intermediate obstructive patterns. In this study radionuclide Diuresis pyelography was performed in 11 renal units with hydronephrosis and a preexisting percutaneous nephrostomy tube in place. The procedure consisted of the introduction per kidney of 20 μc./kg. 99mtechnetium-diethylenetriaxninepentaacetic acid and sterile saline as a bolus into the renal pelvis via a percutaneous nephrostomy tube to produce a volume equal to the capacity of the hydronephrotic system. The kidney was monitored with a gamma camera and computer system. Furosemide (0.3mg./kg.) was injected intravenously halfway into a 40-minute study. The time/activity curves thus generated were relatively independent of the cortical transport phase. The 2 types of curves were accelerated and constant. Anal...
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Radionuclide Diuresis pyelography.
The Journal of urology, 1991Co-Authors: H G Mesrobian, J R PerryAbstract:Radionuclide Diuresis renography continues to be relied upon as a major diagnostic tool to differentiate obstructive and nonobstructive hydronephrosis. Controversy continues to exist with respect to methodology and interpretation of intermediate obstructive patterns. In this study radionuclide Diuresis pyelography was performed in 11 renal units with hydronephrosis and a pre-existing percutaneous nephrostomy tube in place. The procedure consisted of the introduction per kidney of 20 muc./kg. 99mtechnetium-diethylenetriaminepentaacetic acid and sterile saline as a bolus into the renal pelvis via a percutaneous nephrostomy tube to produce a volume equal to the capacity of the hydronephrotic system. The kidney was monitored with a gamma camera and computer system. Furosemide (0.3 mg./kg.) was injected intravenously halfway into a 40-minute study. The time/activity curves thus generated were relatively independent of the cortical transport phase. The 2 types of curves were accelerated and constant. Analysis of these pyelogram curves revealed a strong correlation between the presence of an accelerated clearance rate response to furosemide and hydronephrosis without obstruction in 5 of 6 renal units. A constant clearance rate response to furosemide correlated with the presence of obstruction in 4 of 5 units. These observations may indicate that diuretic pyelogram curve dynamics may reflect not only the presence or absence of obstruction but also the ability of the hydronephrotic kidney to respond to the diuretic. More experience must be accumulated to determine the conditions under which Diuresis pyelography may become useful clinically.
Jorge M. Diego - One of the best experts on this subject based on the ideXlab platform.
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The Polyuria of Solute Diuresis
JAMA Internal Medicine, 1997Co-Authors: James R. Oster, Lalita Thatte, Ilsa Grant-taylor, Irwin Singer, Jorge M. DiegoAbstract:Polyuria is an important symptom or sign because of its potential severity, diverse causes, and interesting pathophysiology. Whereas polyuria induced by water Diuresis is reasonably well understood and easily recognized by clinicians, that produced by solute Diuresis is more likely to cause confusion. In this article, we focus on solute Diuresis as a cause of polyuria, review the classification and pathophysiology of polyuria, and describe the clinical and laboratory studies useful for the evaluation of the polyuric patient. A stepwise, logical approach is provided (1) to determine whether a patient has a water Diuresis, a solute Diuresis, or both (concurrently), and, (2) if a solute Diuresis is present, to determine if it is caused by electrolytes (eg, sodium chloride, sodium bicarbonate), by nonelectrolytes (eg, glucose, urea), or by both. How to assess these possibilities and to determine the specific cause of the Diuresis is discussed in detail. Three representative case examples are provided. Selected causes of a solute Diuresis also are reviewed. Arch Intern Med. 1997;157:721-729
James R. Oster - One of the best experts on this subject based on the ideXlab platform.
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The Polyuria of Solute Diuresis
JAMA Internal Medicine, 1997Co-Authors: James R. Oster, Lalita Thatte, Ilsa Grant-taylor, Irwin Singer, Jorge M. DiegoAbstract:Polyuria is an important symptom or sign because of its potential severity, diverse causes, and interesting pathophysiology. Whereas polyuria induced by water Diuresis is reasonably well understood and easily recognized by clinicians, that produced by solute Diuresis is more likely to cause confusion. In this article, we focus on solute Diuresis as a cause of polyuria, review the classification and pathophysiology of polyuria, and describe the clinical and laboratory studies useful for the evaluation of the polyuric patient. A stepwise, logical approach is provided (1) to determine whether a patient has a water Diuresis, a solute Diuresis, or both (concurrently), and, (2) if a solute Diuresis is present, to determine if it is caused by electrolytes (eg, sodium chloride, sodium bicarbonate), by nonelectrolytes (eg, glucose, urea), or by both. How to assess these possibilities and to determine the specific cause of the Diuresis is discussed in detail. Three representative case examples are provided. Selected causes of a solute Diuresis also are reviewed. Arch Intern Med. 1997;157:721-729
Jeremy Weedon - One of the best experts on this subject based on the ideXlab platform.
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phenotyping nocturnal polyuria circadian and age related variations in Diuresis rate free water clearance and sodium clearance
Age and Ageing, 2020Co-Authors: Thomas F Monaghan, Donald L Bliwise, Marieastrid Denys, Ansofie Goessaert, Veerle Decalf, Candy Kumps, Johan Vande Walle, Jeffrey P Weiss, Matthew Epstein, Jeremy WeedonAbstract:Abstract Background this study compares Diuresis rate, sodium clearance and free water clearance (FWC) by age and time of day (nighttime vs. daytime) in subjects with and without nocturnal polyuria (NP) to determine whether these variables affect the phenotype of NP. Methods post hoc analysis of two prospective observational studies. Eight urine samples collected at 3-h intervals and a single blood sample were used to calculate daytime (10a/1p/4p/7p/10p) and nighttime (1a/4a/7a) Diuresis rates, sodium clearance and FWC. Three mixed linear models were constructed for Diuresis rate, sodium clearance and FWC using four predictor variables: NP status (present [nocturnal urine production g90 ml/h] vs. absent [≤90 ml/h]), time of day, age and study identification. Results subjects with NP experienced higher nighttime versus daytime Diuresis rates, sodium clearance and FWC. Regardless of NP status, increased age was accompanied by an increase in the ratio of nighttime/daytime Diuresis rate, nighttime sodium clearance and daytime sodium clearance. FWC showed a complex age effect, which was independent of time of day or NP status. Conclusions age-related increases in nighttime/daytime Diuresis rate, 24-h sodium clearance and 24-h FWC are not specific to subjects with NP. The age-related surge in either nocturnal sodium clearance or nocturnal FWC may represent the relevant substrate for behavioural or pharmacologic interventions targeting sodium Diuresis or free water Diuresis, respectively. Increases in FWC in older age groups may reflect impaired circadian rhythmicity of endogenous AVP or changes in responsiveness of the aged nephron to water clearance.