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David Crews - One of the best experts on this subject based on the ideXlab platform.
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Effect of incubation temperature and androgens on Dopaminergic Activity in the leopard gecko, Eublepharis macularius.
Developmental Neurobiology, 2007Co-Authors: Brian G. Dias, Ramona Sousan Ataya, David Rushworth, Jun Zhao, David CrewsAbstract:Male leopard geckos that hatch from eggs incubated at a female-biased temperature (Tf) behave differently when compared with males hatching at a temperature which produces a male-biased sex ratio (Tm). We investigated the effect of incubation temperature and androgen implantation on aspects of the Dopaminergic system of Tf and Tm males. Our data suggest that more dopamine (DA) is stored in the nucleus accumbens of naive Tf males compared with naive Tm males when they encounter a receptive female conspecific across a barrier. No difference was measured in the preoptic area and the ventral tegmental area (VTA). This difference in intracellular DA levels in a motivation-related brain nucleus might be correlated with differences in sociosexual behavior observed between the two morphs. There were no differences in tyrosine hydroxylase (TH) expressing cell numbers in the VTA of cholesterol (CH)-implanted naive castrated Tf and Tm males. Only Tf males implanted with testosterone had significantly higher TH immunopositive cell numbers in the VTA compared with CH- and dihydrotestosterone-implanted Tf males. These data indicate that both the embryonic environment as well as the circulating hormonal milieu can modulate neurochemistry, which might in turn be a basis for individual variation in behavior. © 2007 Wiley Periodicals, Inc. Develop Neurobiol, 2007
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Effect of Incubation Temperature and Androgens on Dopaminergic Activity in the Leopard Gecko,
2006Co-Authors: Eublepharis Macularius, Brian G. Dias, Ramona Sousan Ataya, David Rushworth, Jun Zhao, David CrewsAbstract:Male leopard geckos that hatch from eggs incubated at a female-biased temperature (T f) behave differently when compared with males hatching at a temperature which produces a male-biased sex ratio (T m). We investigated the effect of incubation temperature and androgen implantation on aspects of the Dopaminergic system of Tf and Tm males. Our data suggest that more dopamine (DA) is stored in the nucleus accumbens of naive Tf males compared with naïve Tm males when they encounter a receptive female conspecific across a barrier. No difference was measured in the preoptic area and the ventral tegmental area (VTA). This difference in intracellular DA levels in a motivationrelated brain nucleus might be correlated with differences in sociosexual behavior observed between the tw
Gregory M. Miller - One of the best experts on this subject based on the ideXlab platform.
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the emerging role of trace amine associated receptor 1 in the functional regulation of monoamine transporters and Dopaminergic Activity
Journal of Neurochemistry, 2011Co-Authors: Gregory M. MillerAbstract:It is now recognized that trace amine associated-receptor 1 (TAAR1) plays a functional role in the regulation of brain monoamines and the mediation of action of amphetamine-like psychostimulants. Accordingly, research on TAAR1 opens the door to a new avenue of approach for medications development to treat drug addiction as well as the spectrum of neuropsychiatric disorders hallmarked by aberrant regulation of brain monoamines. This overview focuses on recent studies which reveal a role for TAAR1 in the functional regulation of monoamine transporters and the neuronal regulatory mechanisms that modulate Dopaminergic Activity.
Mark A Stein - One of the best experts on this subject based on the ideXlab platform.
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plasma homovanillic acid correlates inversely with history of learning problems in healthy volunteer and personality disordered subjects
Psychiatry Research-neuroimaging, 2007Co-Authors: Emil F Coccaro, Sharon L Hirsch, Mark A SteinAbstract:Central Dopaminergic Activity is critical to the functioning of both motor and cognitive systems. Based on the therapeutic action of Dopaminergic agents in treating attention deficit hyperActivity disorder (ADHD), ADHD symptoms may be related to a reduction in central Dopaminergic Activity. We tested the hypothesis that Dopaminergic Activity, as reflected by plasma homovanillic acid (pHVA), may be related to dimensional aspects of ADHD in adults. Subjects were 30 healthy volunteer and 39 personality disordered subjects, in whom morning basal pHVA concentration and a dimensional measure of childhood ADHD symptoms (Wender Utah Rating Scale: WURS) were obtained. A significant inverse correlation was found between WURS Total score and pHVA concentration in the total sample. Among WURS factor scores, a significant inverse relationship was noted between pHVA and history of "childhood learning problems". Consistent with the Dopaminergic dysfunction hypothesis of ADHD and of cognitive function, pHVA concentrations were correlated with childhood history of ADHD symptoms in general and with history of "learning problems" in non-ADHD psychiatric patients and controls. Replication is needed in treated and untreated ADHD samples to confirm these initial results.
Hakan Wikstrom - One of the best experts on this subject based on the ideXlab platform.
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a novel synthesis and pharmacological evaluation of a potential dopamine d1 d2 agonist 1 propyl 1 2 3 4 4a 5 10 10a octahydrobenzo g quinoline 6 7 diol
Bioorganic & Medicinal Chemistry, 2008Co-Authors: Danyang Liu, Durk Dijkstra, Jan B De Vries, Hakan WikstromAbstract:Previously, we have demonstrated that enone prodrugs of Dopaminergic catecholamines represent a new type of dopamine (DA) agonist. Trans-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinoline-6,7-diol (TL-334), the active form of trans-1-propyl-2,3,4,4a,5,7,8,9,10,10a-decahydro-1H-benzo[g]quinolin-6-one (GMC-6650), in vivo showed an extremely potent Dopaminergic Activity. Here, we report a novel synthesis and a pharmacological evaluation of TL-334 by means of microdialysis.
Lawrence D Wise - One of the best experts on this subject based on the ideXlab platform.
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aryl 1 but 3 ynyl 4 phenyl 1 2 3 6 tetrahydropyridines as potential antipsychotic agents synthesis and structure Activity relationships
Journal of Medicinal Chemistry, 1996Co-Authors: Shelly A Glase, Robert G Mackenzie, Hyacinth C Akunne, Thomas G Heffner, Juan C Jaen, Leonard T Meltzer, Thomas A Pugsley, Sarah Jane Smith, Lawrence D WiseAbstract:A novel series of aryl 1-but-3-ynyl-4-phenyl-1,2,3,6-tetrahydropyridines with Dopaminergic Activity is described. The structure−Activity relationships of this series were studied by synthesis of an...