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Backil Sung - One of the best experts on this subject based on the ideXlab platform.

  • A rat model of radicular pain induced by chronic compression of lumbar Dorsal Root Ganglion with SURGIFLO.
    Anesthesiology, 2008
    Co-Authors: Xiaoping Gu, Shuxing Wang, Liling Yang, Qing Le Zeng, Backil Sung, Chang Yang
    Abstract:

    Background: Radicular pain is a common and debilitating clinical pain condition. To date, the mechanisms of radicular pain remain unclear, partly because of the lack of suitable preclinical models. The authors report a modified rat model of radicular pain that could mimic a subset of clinical radicular pain conditions induced by the soft tissue compression on Dorsal Root Ganglion. Methods: A rat model of radicular pain was produced by infiltrating the L5 intervertebral foramen with 60 μ1 of a hemostatic matrix (SURGIFLO™; Johnson & Johnson, Somerville, NJ) resulting in chronic compression of lumbar Dorsal Root Ganglion. Thermal hyperalgesia and mechanical allodynia were measured with or without epidural treatment with triamcinolone. Western blot was used to assess the expression of the NR1 subunit of the N-methylo-D-aspartate receptor and inhibitory factor κβ-α, an inflammatory marker, within the affected L5 Dorsal Root Ganglion and spinal cord Dorsal horn. Results: Chronic compression of lumbar Dorsal Root Ganglion resulted in: (1) persistent mechanical allodynia and thermal hyperalgesia up to 4 or 5 postoperative weeks and (2) up-regulation of the N-methyl-D-aspartate receptor and inhibitory factor κβ-α within the ipsilateral L5 Dorsal Root Ganglion and spinal cord Dorsal horn. Epidural administration of triamcinolone (6.25-100 μg) on postoperative day 3 dose-dependently attenuated both thermal hyperalgesia and mechanical allodynia in rats with chronic compression of lumbar Dorsal Root Ganglion. Conclusion: The data suggest that this modified rat model of chronic compression of lumbar Dorsal Root Ganglion may be a useful tool to explore the mechanisms as well as new therapeutic options of radicular pain.

  • A rat model of radicular pain induced by chronic compression of lumbar Dorsal Root Ganglion with SURGIFLO.
    Anesthesiology, 2008
    Co-Authors: Liling Yang, Shuxing Wang, Qing Le Zeng, Backil Sung, Chang Yang, Grewo Lim, Ji Mao, Jianren Mao
    Abstract:

    Background Radicular pain is a common and debilitating clinical pain condition. To date, the mechanisms of radicular pain remain unclear, partly because of the lack of suitable preclinical models. The authors report a modified rat model of radicular pain that could mimic a subset of clinical radicular pain conditions induced by the soft tissue compression on Dorsal Root Ganglion. Methods A rat model of radicular pain was produced by infiltrating the L5 intervertebral foramen with 60 microl of a hemostatic matrix (SURGIFLO; Johnson & Johnson, Somerville, NJ) resulting in chronic compression of lumbar Dorsal Root Ganglion. Thermal hyperalgesia and mechanical allodynia were measured with or without epidural treatment with triamcinolone. Western blot was used to assess the expression of the NR1 subunit of the N-methyl-D-aspartate receptor and inhibitory factor kappabeta-alpha, an inflammatory marker, within the affected L5 Dorsal Root Ganglion and spinal cord Dorsal horn. Results Chronic compression of lumbar Dorsal Root Ganglion resulted in: (1) persistent mechanical allodynia and thermal hyperalgesia up to 4 or 5 postoperative weeks and (2) up-regulation of the N-methyl-D-aspartate receptor and inhibitory factor kappabeta-alpha within the ipsilateral L5 Dorsal Root Ganglion and spinal cord Dorsal horn. Epidural administration of triamcinolone (6.25-100 microg) on postoperative day 3 dose-dependently attenuated both thermal hyperalgesia and mechanical allodynia in rats with chronic compression of lumbar Dorsal Root Ganglion. Conclusion The data suggest that this modified rat model of chronic compression of lumbar Dorsal Root Ganglion may be a useful tool to explore the mechanisms as well as new therapeutic options of radicular pain.

  • Role of signals from the Dorsal Root Ganglion in neuropathic pain in a rat model.
    Neuroscience letters, 2000
    Co-Authors: Seung Keun Back, Backil Sung, Dong Jin Yoo, Seung Kil Hong
    Abstract:

    We examined whether signals from the neuroma or the Dorsal Root Ganglion of the injured segment are critical for the generation of neuropathic pain. To this aim, we used a rat model of peripheral neuropathy made by transecting the inferior and superior caudal trunks at the level between the S1 and S2 spinal nerves under enflurane anesthesia. These animals displayed tail-withdrawal responses to normally innocuous mechanical stimulation applied to the tail with a von Frey hair (2 g). Also, these animals, compared to pre-surgical value, displayed shorter tail-withdrawal latencies following immersion of the tail to warm (40°C) or cold (4°C) water. Transection of the S1 spinal nerve between the Dorsal Root Ganglion and neuroma did not change the behavioral signs of neuropathic pain. In contrast, S1 Dorsal rhizotomy significantly reduced the behavioral signs. The data suggest that signals arising from the Dorsal Root Ganglion cells of the injured segment, but not from the neuroma, are critical for the generation of neuropathic pain in this model.

Chang Yang - One of the best experts on this subject based on the ideXlab platform.

  • A rat model of radicular pain induced by chronic compression of lumbar Dorsal Root Ganglion with SURGIFLO.
    Anesthesiology, 2008
    Co-Authors: Xiaoping Gu, Shuxing Wang, Liling Yang, Qing Le Zeng, Backil Sung, Chang Yang
    Abstract:

    Background: Radicular pain is a common and debilitating clinical pain condition. To date, the mechanisms of radicular pain remain unclear, partly because of the lack of suitable preclinical models. The authors report a modified rat model of radicular pain that could mimic a subset of clinical radicular pain conditions induced by the soft tissue compression on Dorsal Root Ganglion. Methods: A rat model of radicular pain was produced by infiltrating the L5 intervertebral foramen with 60 μ1 of a hemostatic matrix (SURGIFLO™; Johnson & Johnson, Somerville, NJ) resulting in chronic compression of lumbar Dorsal Root Ganglion. Thermal hyperalgesia and mechanical allodynia were measured with or without epidural treatment with triamcinolone. Western blot was used to assess the expression of the NR1 subunit of the N-methylo-D-aspartate receptor and inhibitory factor κβ-α, an inflammatory marker, within the affected L5 Dorsal Root Ganglion and spinal cord Dorsal horn. Results: Chronic compression of lumbar Dorsal Root Ganglion resulted in: (1) persistent mechanical allodynia and thermal hyperalgesia up to 4 or 5 postoperative weeks and (2) up-regulation of the N-methyl-D-aspartate receptor and inhibitory factor κβ-α within the ipsilateral L5 Dorsal Root Ganglion and spinal cord Dorsal horn. Epidural administration of triamcinolone (6.25-100 μg) on postoperative day 3 dose-dependently attenuated both thermal hyperalgesia and mechanical allodynia in rats with chronic compression of lumbar Dorsal Root Ganglion. Conclusion: The data suggest that this modified rat model of chronic compression of lumbar Dorsal Root Ganglion may be a useful tool to explore the mechanisms as well as new therapeutic options of radicular pain.

  • A rat model of radicular pain induced by chronic compression of lumbar Dorsal Root Ganglion with SURGIFLO.
    Anesthesiology, 2008
    Co-Authors: Liling Yang, Shuxing Wang, Qing Le Zeng, Backil Sung, Chang Yang, Grewo Lim, Ji Mao, Jianren Mao
    Abstract:

    Background Radicular pain is a common and debilitating clinical pain condition. To date, the mechanisms of radicular pain remain unclear, partly because of the lack of suitable preclinical models. The authors report a modified rat model of radicular pain that could mimic a subset of clinical radicular pain conditions induced by the soft tissue compression on Dorsal Root Ganglion. Methods A rat model of radicular pain was produced by infiltrating the L5 intervertebral foramen with 60 microl of a hemostatic matrix (SURGIFLO; Johnson & Johnson, Somerville, NJ) resulting in chronic compression of lumbar Dorsal Root Ganglion. Thermal hyperalgesia and mechanical allodynia were measured with or without epidural treatment with triamcinolone. Western blot was used to assess the expression of the NR1 subunit of the N-methyl-D-aspartate receptor and inhibitory factor kappabeta-alpha, an inflammatory marker, within the affected L5 Dorsal Root Ganglion and spinal cord Dorsal horn. Results Chronic compression of lumbar Dorsal Root Ganglion resulted in: (1) persistent mechanical allodynia and thermal hyperalgesia up to 4 or 5 postoperative weeks and (2) up-regulation of the N-methyl-D-aspartate receptor and inhibitory factor kappabeta-alpha within the ipsilateral L5 Dorsal Root Ganglion and spinal cord Dorsal horn. Epidural administration of triamcinolone (6.25-100 microg) on postoperative day 3 dose-dependently attenuated both thermal hyperalgesia and mechanical allodynia in rats with chronic compression of lumbar Dorsal Root Ganglion. Conclusion The data suggest that this modified rat model of chronic compression of lumbar Dorsal Root Ganglion may be a useful tool to explore the mechanisms as well as new therapeutic options of radicular pain.

Roberto S. G. M. Perez - One of the best experts on this subject based on the ideXlab platform.

  • Dorsal Root Ganglion stimulation for painful small fiber neuropathy : A case report
    Pain Physician, 2017
    Co-Authors: Paolo Maino, Eva Koetsier, Alain Kaelin-lang, Claudio Gobbi, Roberto S. G. M. Perez
    Abstract:

    Small fiber neuropathy is a disorder of the peripheral nerves with typical symptoms of burning, sharp, and shooting pain and sensory disturbances in the feet. Pain treatment depends principally on the underlying etiology with concurrent administration of antidepressants, anticonvulsants, opioids, and topical treatments like capsaicin and local anesthetics. However, treatments for pain relief in these patients frequently fail. We describe the first case of intractable painful small fiber neuropathy of the foot successfully treated with spinal cord stimulation of the left L5 Dorsal Root Ganglion. A 74-year-old man presented at our clinic with severe intractable pain, dysesthesia, and allodynia of the left foot caused by idiopathic small fiber neuropathy, confirmed by skin biopsy. His pain score was 8 on a standard 0 – 10 numeric rating scale. As the pain was not satisfactorily controlled by conventional therapy, Dorsal Root Ganglion stimulation was proposed to the patient and, after informed consent, a specifically designed percutaneous stimulation lead was placed over the left L5 Dorsal Root Ganglion and connected to an external neurostimulator. After a positive trial of 10 days, a permanent neurostimulator was implanted. Twenty months post-implantation the patient continued to experience stimulation-induced paresthesia covering the entire pain area and reported a pain rating of 4. Results from the case report demonstrate that the Dorsal Root Ganglion is a promising neural stimulation target to treat neuropathic pain due to intractable small fiber neuropathy. Prospective controlled studies are warranted to confirm the efficacy of this treatment as an option for the aforementioned condition.

  • Efficacious Dorsal Root Ganglion Stimulation for Painful Small Fiber Neuropathy: A Case Report.
    Pain physician, 2017
    Co-Authors: Paolo Maino, Eva Koetsier, Alain Kaelin-lang, Claudio Gobbi, Roberto S. G. M. Perez
    Abstract:

    Small fiber neuropathy is a disorder of the peripheral nerves with typical symptoms of burning, sharp, and shooting pain and sensory disturbances in the feet. Pain treatment depends principally on the underlying etiology with concurrent administration of antidepressants, anticonvulsants, opioids, and topical treatments like capsaicin and local anesthetics. However, treatments for pain relief in these patients frequently fail. We describe the first case of intractable painful small fiber neuropathy of the foot successfully treated with spinal cord stimulation of the left L5 Dorsal Root Ganglion.A 74-year-old man presented at our clinic with severe intractable pain, dysesthesia, and allodynia of the left foot caused by idiopathic small fiber neuropathy, confirmed by skin biopsy. His pain score was 8 on a standard 0 - 10 numeric rating scale. As the pain was not satisfactorily controlled by conventional therapy, Dorsal Root Ganglion stimulation was proposed to the patient and, after informed consent, a specifically designed percutaneous stimulation lead was placed over the left L5 Dorsal Root Ganglion and connected to an external neurostimulator. After a positive trial of 10 days, a permanent neurostimulator was implanted. Twenty months post-implantation the patient continued to experience stimulation-induced paresthesia covering the entire pain area and reported a pain rating of 4.Results from the case report demonstrate that the Dorsal Root Ganglion is a promising neural stimulation target to treat neuropathic pain due to intractable small fiber neuropathy. Prospective controlled studies are warranted to confirm the efficacy of this treatment as an option for the aforementioned condition.Key words: Dorsal Root Ganglion stimulation, small fiber neuropathy, neuropathic pain.

Eva Koetsier - One of the best experts on this subject based on the ideXlab platform.

  • Efficacious Dorsal Root Ganglion Stimulation for Painful Small Fiber Neuropathy: A Case Report
    Pain Physician, 2017
    Co-Authors: Eva Koetsier
    Abstract:

    Small fiber neuropathy is a disorder of the peripheral nerves with typical symptoms of burning, sharp, and shooting pain and sensory disturbances in the feet. Pain treatment depends principally on the underlying etiology with concurrent administration of antidepressants, anticonvulsants, opioids, and topical treatments like capsaicin and local anesthetics. However, treatments for pain relief in these patients frequently fail. We describe the first case of intractable painful small fiber neuropathy of the foot successfully treated with spinal cord stimulation of the left L5 Dorsal Root Ganglion. A 74-year-old man presented at our clinic with severe intractable pain, dysesthesia, and allodynia of the left foot caused by idiopathic small fiber neuropathy, confirmed by skin biopsy. His pain score was 8 on a standard 0 – 10 numeric rating scale. As the pain was not satisfactorily controlled by conventional therapy, Dorsal Root Ganglion stimulation was proposed to the patient and, after informed consent, a specifically designed percutaneous stimulation lead was placed over the left L5 Dorsal Root Ganglion and connected to an external neurostimulator. After a positive trial of 10 days, a permanent neurostimulator was implanted. Twenty months post-implantation the patient continued to experience stimulation-induced paresthesia covering the entire pain area and reported a pain rating of 4. Results from the case report demonstrate that the Dorsal Root Ganglion is a promising neural stimulation target to treat neuropathic pain due to intractable small fiber neuropathy. Prospective controlled studies are warranted to confirm the efficacy of this treatment as an option for the aforementioned condition. Key words: Dorsal Root Ganglion stimulation, small fiber neuropathy, neuropathic pain

  • Dorsal Root Ganglion stimulation for painful small fiber neuropathy : A case report
    Pain Physician, 2017
    Co-Authors: Paolo Maino, Eva Koetsier, Alain Kaelin-lang, Claudio Gobbi, Roberto S. G. M. Perez
    Abstract:

    Small fiber neuropathy is a disorder of the peripheral nerves with typical symptoms of burning, sharp, and shooting pain and sensory disturbances in the feet. Pain treatment depends principally on the underlying etiology with concurrent administration of antidepressants, anticonvulsants, opioids, and topical treatments like capsaicin and local anesthetics. However, treatments for pain relief in these patients frequently fail. We describe the first case of intractable painful small fiber neuropathy of the foot successfully treated with spinal cord stimulation of the left L5 Dorsal Root Ganglion. A 74-year-old man presented at our clinic with severe intractable pain, dysesthesia, and allodynia of the left foot caused by idiopathic small fiber neuropathy, confirmed by skin biopsy. His pain score was 8 on a standard 0 – 10 numeric rating scale. As the pain was not satisfactorily controlled by conventional therapy, Dorsal Root Ganglion stimulation was proposed to the patient and, after informed consent, a specifically designed percutaneous stimulation lead was placed over the left L5 Dorsal Root Ganglion and connected to an external neurostimulator. After a positive trial of 10 days, a permanent neurostimulator was implanted. Twenty months post-implantation the patient continued to experience stimulation-induced paresthesia covering the entire pain area and reported a pain rating of 4. Results from the case report demonstrate that the Dorsal Root Ganglion is a promising neural stimulation target to treat neuropathic pain due to intractable small fiber neuropathy. Prospective controlled studies are warranted to confirm the efficacy of this treatment as an option for the aforementioned condition.

  • Efficacious Dorsal Root Ganglion Stimulation for Painful Small Fiber Neuropathy: A Case Report.
    Pain physician, 2017
    Co-Authors: Paolo Maino, Eva Koetsier, Alain Kaelin-lang, Claudio Gobbi, Roberto S. G. M. Perez
    Abstract:

    Small fiber neuropathy is a disorder of the peripheral nerves with typical symptoms of burning, sharp, and shooting pain and sensory disturbances in the feet. Pain treatment depends principally on the underlying etiology with concurrent administration of antidepressants, anticonvulsants, opioids, and topical treatments like capsaicin and local anesthetics. However, treatments for pain relief in these patients frequently fail. We describe the first case of intractable painful small fiber neuropathy of the foot successfully treated with spinal cord stimulation of the left L5 Dorsal Root Ganglion.A 74-year-old man presented at our clinic with severe intractable pain, dysesthesia, and allodynia of the left foot caused by idiopathic small fiber neuropathy, confirmed by skin biopsy. His pain score was 8 on a standard 0 - 10 numeric rating scale. As the pain was not satisfactorily controlled by conventional therapy, Dorsal Root Ganglion stimulation was proposed to the patient and, after informed consent, a specifically designed percutaneous stimulation lead was placed over the left L5 Dorsal Root Ganglion and connected to an external neurostimulator. After a positive trial of 10 days, a permanent neurostimulator was implanted. Twenty months post-implantation the patient continued to experience stimulation-induced paresthesia covering the entire pain area and reported a pain rating of 4.Results from the case report demonstrate that the Dorsal Root Ganglion is a promising neural stimulation target to treat neuropathic pain due to intractable small fiber neuropathy. Prospective controlled studies are warranted to confirm the efficacy of this treatment as an option for the aforementioned condition.Key words: Dorsal Root Ganglion stimulation, small fiber neuropathy, neuropathic pain.

Liling Yang - One of the best experts on this subject based on the ideXlab platform.

  • A rat model of radicular pain induced by chronic compression of lumbar Dorsal Root Ganglion with SURGIFLO.
    Anesthesiology, 2008
    Co-Authors: Xiaoping Gu, Shuxing Wang, Liling Yang, Qing Le Zeng, Backil Sung, Chang Yang
    Abstract:

    Background: Radicular pain is a common and debilitating clinical pain condition. To date, the mechanisms of radicular pain remain unclear, partly because of the lack of suitable preclinical models. The authors report a modified rat model of radicular pain that could mimic a subset of clinical radicular pain conditions induced by the soft tissue compression on Dorsal Root Ganglion. Methods: A rat model of radicular pain was produced by infiltrating the L5 intervertebral foramen with 60 μ1 of a hemostatic matrix (SURGIFLO™; Johnson & Johnson, Somerville, NJ) resulting in chronic compression of lumbar Dorsal Root Ganglion. Thermal hyperalgesia and mechanical allodynia were measured with or without epidural treatment with triamcinolone. Western blot was used to assess the expression of the NR1 subunit of the N-methylo-D-aspartate receptor and inhibitory factor κβ-α, an inflammatory marker, within the affected L5 Dorsal Root Ganglion and spinal cord Dorsal horn. Results: Chronic compression of lumbar Dorsal Root Ganglion resulted in: (1) persistent mechanical allodynia and thermal hyperalgesia up to 4 or 5 postoperative weeks and (2) up-regulation of the N-methyl-D-aspartate receptor and inhibitory factor κβ-α within the ipsilateral L5 Dorsal Root Ganglion and spinal cord Dorsal horn. Epidural administration of triamcinolone (6.25-100 μg) on postoperative day 3 dose-dependently attenuated both thermal hyperalgesia and mechanical allodynia in rats with chronic compression of lumbar Dorsal Root Ganglion. Conclusion: The data suggest that this modified rat model of chronic compression of lumbar Dorsal Root Ganglion may be a useful tool to explore the mechanisms as well as new therapeutic options of radicular pain.

  • A rat model of radicular pain induced by chronic compression of lumbar Dorsal Root Ganglion with SURGIFLO.
    Anesthesiology, 2008
    Co-Authors: Liling Yang, Shuxing Wang, Qing Le Zeng, Backil Sung, Chang Yang, Grewo Lim, Ji Mao, Jianren Mao
    Abstract:

    Background Radicular pain is a common and debilitating clinical pain condition. To date, the mechanisms of radicular pain remain unclear, partly because of the lack of suitable preclinical models. The authors report a modified rat model of radicular pain that could mimic a subset of clinical radicular pain conditions induced by the soft tissue compression on Dorsal Root Ganglion. Methods A rat model of radicular pain was produced by infiltrating the L5 intervertebral foramen with 60 microl of a hemostatic matrix (SURGIFLO; Johnson & Johnson, Somerville, NJ) resulting in chronic compression of lumbar Dorsal Root Ganglion. Thermal hyperalgesia and mechanical allodynia were measured with or without epidural treatment with triamcinolone. Western blot was used to assess the expression of the NR1 subunit of the N-methyl-D-aspartate receptor and inhibitory factor kappabeta-alpha, an inflammatory marker, within the affected L5 Dorsal Root Ganglion and spinal cord Dorsal horn. Results Chronic compression of lumbar Dorsal Root Ganglion resulted in: (1) persistent mechanical allodynia and thermal hyperalgesia up to 4 or 5 postoperative weeks and (2) up-regulation of the N-methyl-D-aspartate receptor and inhibitory factor kappabeta-alpha within the ipsilateral L5 Dorsal Root Ganglion and spinal cord Dorsal horn. Epidural administration of triamcinolone (6.25-100 microg) on postoperative day 3 dose-dependently attenuated both thermal hyperalgesia and mechanical allodynia in rats with chronic compression of lumbar Dorsal Root Ganglion. Conclusion The data suggest that this modified rat model of chronic compression of lumbar Dorsal Root Ganglion may be a useful tool to explore the mechanisms as well as new therapeutic options of radicular pain.