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V. P. Popovych - One of the best experts on this subject based on the ideXlab platform.
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TECHNOLOGICAL ASPECTS OF TABLETS CREATION BASED ON FLAMMULINA VELUTIPES BIOMASS Dry Powder
Ukrmedknyha Publishing House, 2018Co-Authors: T. A. Butkevych, М. L. Syatynya, V. P. PopovychAbstract:The aim of the work. To study the pharmaco-technological properties of granulate and tablets based on Flammulina velutipes biomass Dry Powder, to develop the composition and technology of the medication. Materials and Methods. Research of granules and tablets pharmaco-technological properties (sieve analysis, bulk density, tapped density, compressibility index, Hausner ratio, flowability of tablet mass, average weight, resistance to crushing, friability and disintegration of tablets) was carried out in accordance to the requirements of State Pharmacopoeia of Ukraine 2nd edition. Results and Discussion. The determined pharmaco-technological parameters of the granulate indicate good values of the bulk density, tapped density, compressibility index, Hausner ratio and flowability. An intermediate product undergoes a tabletting process to produce a qualitative finished product of satisfactory appearance (plain, cylindrical tablets with a facet, yellowish-white color with brown inclusions, with a height of 4 mm, and diameter of 10 mm), a constant average mass (1.0 g), and strength (68 N). Conclusions. The pharmaco-technological properties of tablet mass (granulate) and Flammulina velutipes biomass Dry Powder tablets (sieve analysis, bulk density, tapped density, compressibility index, Hausner ratio, flowability, average weight, resistance to crushing, friability and disintegration) were studied. The composition and technology of Flammulina velutipes biomass Dry Powder tablets have been developed, pharmaco-technological parameters of their quality have been studied, technological block diagram of industrial production has been developed
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STUDY OF THE EXCIPIENTS INFLUENCE ON PHARMACO-TECHNOLOGICAL PROPERTIES OF FLAMMULINA VELUTIPES BIOMASS Dry Powder TABLETS
Ukrmedknyha Publishing House, 2017Co-Authors: T. A. Butkevych, M. L. Syatynya, V. P. PopovychAbstract:The aim of the work. Studying the impact of four groups of excipients (fillers, disintegrants, lubricants and glidants, binders) on the pharmaco-technological properties of Flammulina velutipes biomass Dry Powder tablets. Materials and Methods. Research of the impact of excipients on such parameters as surface quality, uniformity of weight, resistance to crushing, friability and disintegration of tablets was carried out in accordance to the requirements of State Pharmacopoeia of Ukraine 2nd edition using the method of mathematical experiment planning. Results and Discussion. Сonclusions about the impact of excipients on F. velutipes biomass Dry Powder tablets quality indicators were made based on comparisons of multiple levels of studied factors. When using any of representatives of the groups of excipients we obtained similar results of impact on tablet weight uniformity. Satisfactory results of tablet friability were obtained in 13 series of experiments, 5 of them had an average of less than 0.5 %. Compressed F. velutipes biomass Dry Powder tablets had different strength values, only in 9 series of experiments the index was above 50 N. 7 unsatisfactory series of the preparation were found during the study of the effect of excipients on the disintegration of tablets. Conclusions. The influence of four groups of the excipients on such pharmaco-technological properties of Flammulina velutipes biomass Dry Powder tablets as surface quality, uniformity of weight, resistance to crushing, friability and disintegration was found. Optimal representatives of the studied groups of excipients (Powdered sugar, kaolin, stearic acid, 2 % starch paste) were selected for the production of Flammulina velutipes biomass Dry Powder tablets by the wet granulation method
Christopher Marriott - One of the best experts on this subject based on the ideXlab platform.
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Particulate Interactions in Dry Powder Formulation
2013Co-Authors: Xian Ming Zeng, Gary Peter Martin, Christopher MarriottAbstract:Particulate Interactions in Dry Powder Formulation , Particulate Interactions in Dry Powder Formulation , کتابخانه دیجیتال جندی شاپور اهواز
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Deposition of Disodiun Cromoglycate and Salbutamol from a multiple-dose Dry Powder inhaler device
Journal of Pharmaceutical and Allied Sciences, 2011Co-Authors: Jo Onyechi, Christopher Marriott, David GandertonAbstract:Inhalation of drugs offers the opportunity to treat diseases of the respiratory tract. The use of Dry Powder inhalers is preferred to metered dose inhalers and nebulizers in this mode of drug delivery delivery. A multi-dose Dry Powder inhaler device, KCHALER TM device, which delivers drugs passively into the respiratory tract, was developed in our laboratories. In this study, we report the deposition pattern of disodium cromoglycate and salbutamol obtained with the device in the Twin Impinger BP. The effect of type of mouthpiece attached to the KCHALER TM device, on respirable fraction obtained with the Twin Impinger BP was also evaluated. The surface texture of carrier particles used in the formulation of the inhalation mixes and type of mouthpiece, affected the respirable fraction obtained in mixtures containing salbutamol and disodium cromoglycate. Keywords: Dry Powder inhalers, multiple-dose Dry Powder inhaler device, salbutamol deposition, Twin impinger BP Journal of Pharmaceutical and Allied Sciences , Vol. 7 No. 1 (2010)
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Particulate Interactions in Dry Powder Formulations for Inhalation
2000Co-Authors: Xian Ming Zeng, Gary Peter Martin, Christopher MarriottAbstract:Particulate interactions in Dry Powder formulations for inhalation , Particulate interactions in Dry Powder formulations for inhalation , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
Anthony J Hickey - One of the best experts on this subject based on the ideXlab platform.
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Fundamentals of Dry Powder Inhaler Technology
Particles and Nanoparticles in Pharmaceutical Products, 2018Co-Authors: Anthony J HickeyAbstract:Dry Powders and their delivery devices are an alternative to pressurized metered dose inhalers for the administration of aerosols to the lungs. Use of Powders would reduce the necessity of employing global warming propellants; however further developments are needed in the technology required to disperse Dry Powders as aerosols if there is to be an alternative to pMDI as the primary means of aerosol delivery. For progress to occur the following factors influencing Dry Powder dispensing and dispersion must be considered. (1) The way in which particles are prepared may influence their subsequent behavioral characteristics. These preparative techniques fall in the general categories of constructive and destructive methods. (2) Specific morphological characteristics of particles such as size, shape, and rugosity may influence their interaction. In addition, particles may interact with each other or with surrounding surfaces. Among the underlying forces giving rise to these interactions are electrostatic, van der Waals, capillary and mechanical interlocking forces. (3) Powder may be dispersed by laboratory equipment, Dry dust and fluidized bed generators, or small hand held devices designed for delivery of drugs to the lung. A development program requires selection of optimal conditions for each of these steps in the delivery of drugs to the lungs. The following description of Dry-Powder production, dispersion in air and particulate interactions discusses some of the difficulties that must be overcome for systems to advance as alternative to MDIs.
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In vitro Dry Powder inhaler formulation performance considerations
Journal of Controlled Release, 2014Co-Authors: Susanne Ziffels, Norman L. Bemelmans, Phillip Durham, Anthony J HickeyAbstract:Abstract It has long been desired to match airflow conditions during formulation evaluation to those of relevance to lung deposition. In this context several strategies have been adopted involving sampling at different: flow rate (without consideration of flow conditions, e.g. shear, Reynolds number, work function); pressure drop (with and without consideration of flow conditions) and; flow rate and pressure drop. Performance testing has focused on the influence of these sampling conditions on delivered dose uniformity and aerodynamic particle size distribution. However, in order to be physiologically relevant it is also important to know when the drug was delivered with respect to initiation of airflow as variation in this parameter would influence lung deposition. A light obscuration method of detecting the dose delivered from a Dry Powder inhaler while sampling for aerodynamic particle size distributions (APSD) by inertial impaction has been developed. Four formulations of albuterol sulfate and budesonide in sieved and milled lactose, respectively, were dispersed and their rate of delivery monitored. The differences observed have the potential to impact the site of delivery in the lungs. The rate of delivery of drug is clearly an important companion measurement to delivered dose and APSD if the intent is to predict the similarity of in vivo performance of Dry Powder inhaler products.
Stephen P. Newman - One of the best experts on this subject based on the ideXlab platform.
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Drug delivery to the lungs from Dry Powder inhalers.
Current Opinion in Pulmonary Medicine, 2003Co-Authors: Stephen P. NewmanAbstract:When asthma is being treated, it is essential that sufficient drug is deposited at the site(s) where it is needed. In recent years, many Dry Powder inhalers have been developed by the pharmaceutical industry. Drug delivery to the lung from Dry Powder inhalers is dependent upon the patient's peak inhaled flow rate, and so it is very important to be able to assess the amount and location of drug delivered from different devices. Lung deposition has recently been assessed from a new Dry Powder inhaler, the Novolizer® (ASTA Medica, now VIATRIS GmbH & Co. KG, subsidiary Sofotec GmbH & Co. KG, Frankfurt, Germany), using gamma scintigraphy. It was shown that the Novolizer® deposited significantly more budesonide in the lungs than a Turbuhaler® used either at similar inspiratory flow rates or with similar inspiratory effort. Equivalent clinical efficacy and safety profiles have also been shown in asthmatic patients treated with budesonide from each device.
Hakkim Chan - One of the best experts on this subject based on the ideXlab platform.
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Dry Powder inhalable formulations for anti-tubercular therapy.
Advanced drug delivery reviews, 2016Co-Authors: Thaigarajan Parumasivam, Rachel Yoon Kyung Chang, Sharif Abdelghany, Warwick J. Britton, Hakkim ChanAbstract:Tuberculosis (TB) is an intracellular infectious disease caused by the airborne bacterium, Mycobacterium tuberculosis. Despite considerable research efforts, the treatment of TB continues to be a great challenge in part due to the requirement of prolonged therapy with multiple high-dose drugs and associated side effects. The delivery of pharmacological agents directly to the respiratory system, following the natural route of infection, represents a logical therapeutic approach for treatment or vaccination against TB. Pulmonary delivery is non-invasive, avoids first-pass metabolism in the liver and enables targeting of therapeutic agents to the infection site. Inhaled delivery also potentially reduces the dose requirement and the accompanying side effects. Dry Powder is a stable formulation of drug that can be stored without refrigeration compared to liquids and suspensions. The Dry Powder inhalers are easy to use and suitable for high-dose formulations. This review focuses on the current innovations of inhalable Dry Powder formulations of drug and vaccine delivery for TB, including the Powder production method, preclinical and clinical evaluations of inhaled Dry Powder over the last decade. Finally, the risks associated with pulmonary therapy are addressed. A novel Dry Powder formulation with high percentages of respirable particles coupled with a cost effective inhaler device is an appealing platform for TB drug delivery.
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inhalation of Dry Powder mannitol increases mucociliary clearance
European Respiratory Journal, 1997Co-Authors: Evangelia Daviskas, Sandra D Anderson, John D Brannan, Hakkim Chan, Stefan Eberl, George J BautovichAbstract:Inhalation of hypertonic saline stimulates mucociliary clearance (MCC) in healthy subjects and those with obstructive lung disease. We investigated the effect of inhaling the osmotic agent mannitol on MCC. We used a Dry-Powder preparation of mannitol British Pharmacopea (BP) which was encapsulated and delivered using a Dinkihaler. MCC was measured for 75 min in six asthmatic and six healthy subjects on two occasions before and after the mannitol inhalation or its control, using 99mTc-sulphur colloid and a gamma camera. The inhaled dose of mannitol was 267+/-171 mg (mean+/-SD) and 400 mg and the percentage fall in forced expiratory volume in one second (FEV1) was 22+/-3 and 4+/-2% in the asthmatic and healthy subjects, respectively. The total clearance in the whole right lung for the 60 min from the start of inhalation of mannitol was greater by 263+/-11.9% in the asthmatic and 18.1+/-4.9% in the healthy subjects compared to the control. The total clearance over 75 min was 54.7+/-9.6% and 33.6+/-9.4% on the mannitol and control day (p<0.002), respectively, in the asthmatic subjects and 40.5+/-7.1% and 24.8+/-7.8% (p<0.002) in the healthy subjects. In conclusion, inhalation of Dry-Powder mannitol increases mucociliary clearance in asthmatic and healthy subjects and may benefit patients with abnormal mucociliary clearance.
