The Experts below are selected from a list of 306 Experts worldwide ranked by ideXlab platform
Shyam Patel - One of the best experts on this subject based on the ideXlab platform.
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dura mater regeneration with a novel synthetic bilayered nanofibrous Dural Substitute an experimental study
Nanomedicine: Nanotechnology Biology and Medicine, 2011Co-Authors: Kyle Kurpinski, Shyam PatelAbstract:Aim: To create a synthetic nanofibrous Dural Substitute that overcomes the limitations of current devices by enhancing Dural healing via biomimetic nanoscale architecture and supporting both onlaid and sutured implantation. Materials & methods: A custom electrospinning process was used to create a bilayer Dural Substitute having aligned nanofibers on one side and random nanofibers on the other. Nanoscale architecture was verified using microscopy and macroscale mechanical properties were investigated using tensile testing. Biological response to this device was investigated both in vitro and in a canine duraplasty model. Results & conclusion: Bilayer nanofiber alignment yields a graft having anisotropic mechanical properties with significantly higher strength and suturability than a commercially available collagen matrix. When implanted, the nanofibrous graft prevents leaks and brain tissue adhesions, and encourages dura mater regrowth, performing comparably to the collagen matrix. Both in vitro fibroblas...
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Dura mater regeneration with a novel synthetic, bilayered nanofibrous Dural Substitute: An experimental study
Nanomedicine, 2011Co-Authors: Kyle Kurpinski, Shyam PatelAbstract:Aim: To create a synthetic nanofibrous Dural Substitute that overcomes the limitations of current devices by enhancing Dural healing via biomimetic nanoscale architecture and supporting both onlaid and sutured implantation. Materials & methods: A custom electrospinning process was used to create a bilayer Dural Substitute having aligned nanofibers on one side and random nanofibers on the other. Nanoscale architecture was verified using microscopy and macroscale mechanical properties were investigated using tensile testing. Biological response to this device was investigated both in vitro and in a canine duraplasty model. Results & conclusion: Bilayer nanofiber alignment yields a graft having anisotropic mechanical properties with significantly higher strength and suturability than a commercially available collagen matrix. When implanted, the nanofibrous graft prevents leaks and brain tissue adhesions, and encourages dura mater regrowth, performing comparably to the collagen matrix. Both in vitro fibroblast orientation and in vivo Dural healing are enhanced by the aligned nanofibers.
Kyle Kurpinski - One of the best experts on this subject based on the ideXlab platform.
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dura mater regeneration with a novel synthetic bilayered nanofibrous Dural Substitute an experimental study
Nanomedicine: Nanotechnology Biology and Medicine, 2011Co-Authors: Kyle Kurpinski, Shyam PatelAbstract:Aim: To create a synthetic nanofibrous Dural Substitute that overcomes the limitations of current devices by enhancing Dural healing via biomimetic nanoscale architecture and supporting both onlaid and sutured implantation. Materials & methods: A custom electrospinning process was used to create a bilayer Dural Substitute having aligned nanofibers on one side and random nanofibers on the other. Nanoscale architecture was verified using microscopy and macroscale mechanical properties were investigated using tensile testing. Biological response to this device was investigated both in vitro and in a canine duraplasty model. Results & conclusion: Bilayer nanofiber alignment yields a graft having anisotropic mechanical properties with significantly higher strength and suturability than a commercially available collagen matrix. When implanted, the nanofibrous graft prevents leaks and brain tissue adhesions, and encourages dura mater regrowth, performing comparably to the collagen matrix. Both in vitro fibroblas...
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Dura mater regeneration with a novel synthetic, bilayered nanofibrous Dural Substitute: An experimental study
Nanomedicine, 2011Co-Authors: Kyle Kurpinski, Shyam PatelAbstract:Aim: To create a synthetic nanofibrous Dural Substitute that overcomes the limitations of current devices by enhancing Dural healing via biomimetic nanoscale architecture and supporting both onlaid and sutured implantation. Materials & methods: A custom electrospinning process was used to create a bilayer Dural Substitute having aligned nanofibers on one side and random nanofibers on the other. Nanoscale architecture was verified using microscopy and macroscale mechanical properties were investigated using tensile testing. Biological response to this device was investigated both in vitro and in a canine duraplasty model. Results & conclusion: Bilayer nanofiber alignment yields a graft having anisotropic mechanical properties with significantly higher strength and suturability than a commercially available collagen matrix. When implanted, the nanofibrous graft prevents leaks and brain tissue adhesions, and encourages dura mater regrowth, performing comparably to the collagen matrix. Both in vitro fibroblast orientation and in vivo Dural healing are enhanced by the aligned nanofibers.
J Guerin - One of the best experts on this subject based on the ideXlab platform.
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use of a biodegradable elastin fibrin material neuroplast as a Dural Substitute
Biomaterials, 1996Co-Authors: F Sangalli, J Guerin, G Deminiere, M RabaudAbstract:Abstract Since the new Neuroplast® biomaterial is now commonly used in several domains of restorative and curative surgery, its preliminary evaluation as a dura mater Substitute in the rabbit was performed and is described herein. Whereas the importance of prosthesis thickness was implicated and solved (0.2 rather than 1.0mm), both macroscopic examination and histological studies revealed for the neotissue an effective patency, a good continuity and especially no or almost no adherence at all. As Neuroplast® is now available for use everywhere in humans, this material is being developed in several fields of neurosurgery.
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experimental evaluation of a collagen coated vicryl mesh as a Dural Substitute
Neurosurgery, 1992Co-Authors: F Sangalli, V Darrouzet, Jeanine Rivel, C Baquey, D Ducassou, J GuerinAbstract:: Dural Substitutes must provide immediate restitution of a membranous covering for the brain without inducing any adverse reaction in the host or provoking adhesions to underlying nervous tissues. Ideally, the material should disappear completely and be replaced by tissues similar to the dura mater. In this study, parietal Dural defects were created in 12 beagle dogs and closed with a vicryl mesh prosthesis made watertight by a film of bovine collagen. Clinical and biological tolerances were satisfactory. There was one case of early local infection. Gross and microscopic examinations performed between 7 days and 9 months after implantation showed degradation of the prosthetic mesh and connective tissue growth into the implant mimicking dura mater as early as 15 days after implantation. There was no attendant inflammatory reaction or cortical adhesions or other adverse reactions. The authors conclude that collagen-embedded vicryl mesh provides satisfactory biological function and compatibility when used as a Substitute for dura mater in the dog.
Joseph M Zabramski - One of the best experts on this subject based on the ideXlab platform.
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safety and efficacy of the porcine small intestinal submucosa Dural Substitute results of a prospective multicenter study and literature review
Journal of Neurosurgery, 2007Co-Authors: Ghassan K Bejjani, Joseph M ZabramskiAbstract:Object Dural Substitutes are often needed after neurosurgical procedures to expand or replace dura mater resected during surgery. A new Dural repair material derived from porcine small intestinal submucosa (SIS) was evaluated in a prospective multicenter clinical study. Methods Between 2000 and 2003, 59 patients at five different institutions underwent Dural reconstruction with the SIS Dural Substitute, with a minimum follow up of 6 months. The primary goals of the study were to assess the efficacy and safety of the SIS Dural Substitute according to the rate of cerebrospinal fluid (CSF) leakage, infection, and meningitis. Chiari malformation Type I decompression (32 patients) and tumor resection (18 patients) were the most common procedures performed, with 81% of SIS grafts implanted in the posterior fossa or spine. There was one case of a CSF leak (1.7%), two cases of wound infection (3.4%), and no cases of bacterial meningitis (0%) in the 58 patients available for follow up. In both cases of wound infec...
F Sangalli - One of the best experts on this subject based on the ideXlab platform.
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use of a biodegradable elastin fibrin material neuroplast as a Dural Substitute
Biomaterials, 1996Co-Authors: F Sangalli, J Guerin, G Deminiere, M RabaudAbstract:Abstract Since the new Neuroplast® biomaterial is now commonly used in several domains of restorative and curative surgery, its preliminary evaluation as a dura mater Substitute in the rabbit was performed and is described herein. Whereas the importance of prosthesis thickness was implicated and solved (0.2 rather than 1.0mm), both macroscopic examination and histological studies revealed for the neotissue an effective patency, a good continuity and especially no or almost no adherence at all. As Neuroplast® is now available for use everywhere in humans, this material is being developed in several fields of neurosurgery.
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experimental evaluation of a collagen coated vicryl mesh as a Dural Substitute
Neurosurgery, 1992Co-Authors: F Sangalli, V Darrouzet, Jeanine Rivel, C Baquey, D Ducassou, J GuerinAbstract:: Dural Substitutes must provide immediate restitution of a membranous covering for the brain without inducing any adverse reaction in the host or provoking adhesions to underlying nervous tissues. Ideally, the material should disappear completely and be replaced by tissues similar to the dura mater. In this study, parietal Dural defects were created in 12 beagle dogs and closed with a vicryl mesh prosthesis made watertight by a film of bovine collagen. Clinical and biological tolerances were satisfactory. There was one case of early local infection. Gross and microscopic examinations performed between 7 days and 9 months after implantation showed degradation of the prosthetic mesh and connective tissue growth into the implant mimicking dura mater as early as 15 days after implantation. There was no attendant inflammatory reaction or cortical adhesions or other adverse reactions. The authors conclude that collagen-embedded vicryl mesh provides satisfactory biological function and compatibility when used as a Substitute for dura mater in the dog.
