The Experts below are selected from a list of 159 Experts worldwide ranked by ideXlab platform
Daniel Cadarette - One of the best experts on this subject based on the ideXlab platform.
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infectious disease threats in the twenty first century strengthening the global response
Frontiers in Immunology, 2019Co-Authors: David E. Bloom, Daniel CadaretteAbstract:The world has developed an elaborate global health system as a bulwark against known and unknown infectious disease threats. The system consists of various formal and informal networks of organizations that serve different stakeholders; have varying goals, modalities, resources, and accountability; operate at different regional levels (e.g., local, national, and global); and cut across the public, private-for-profit, and private-not-for-profit sectors. The evolving global health system has done much to protect and promote human health. However, the world continues to be confronted by longstanding, emerging, and reemerging infectious disease threats. These threats differ widely in terms of severity and probability. They also have varying consequences for morbidity and mortality, as well as for a complex set of social and economic outcomes. To various degrees, they are also amenable to alternative responses, ranging from clean water provision to regulation to biomedical countermeasures. Whether the global health system as currently constituted can provide effective protection against a Dynamic Array of infectious disease threats has been called into question by recent outbreaks of Ebola, Zika, dengue, Middle East respiratory syndrome, severe acute respiratory syndrome, and influenza and by the looming threat of rising antimicrobial resistance. The concern is magnified by rapid population growth in areas with weak health systems, urbanization, globalization, climate change, civil conflict, and the changing nature of pathogen transmission between human and animal populations. There is also potential for human-originated outbreaks emanating from laboratory accidents or intentional biological attacks. This paper discusses these issues, along with the need for a (possibly self-standing) multi-disciplinary Global Technical Council on Infectious Disease Threats to address emerging global challenges with regard to infectious disease and associated social and economic risks. This Council would strengthen the global health system by improving collaboration and coordination across organizations (e.g., the WHO, Gavi, CEPI, national centers for disease control, pharmaceutical manufacturers, etc.); filling in knowledge gaps with respect to (for example) infectious disease surveillance, research and development needs, financing models, supply chain logistics, and the social and economic impacts of potential threats; and making high-level, evidence-based recommendations for managing global risks associated with infectious disease.
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infectious disease threats in the twenty first century strengthening the global response
Frontiers in Immunology, 2019Co-Authors: David E. Bloom, Daniel CadaretteAbstract:The world has developed an elaborate global health system as a bulwark against known and unknown infectious disease threats. The system consists of various formal and informal networks of organizations that serve different stakeholders; have varying goals, modalities, resources, and accountability; operate at different regional levels (i.e., local, national, regional, or global); and cut across the public, private-for-profit, and private-not-for-profit sectors. The evolving global health system has done much to protect and promote human health. However, the world continues to be confronted by longstanding, emerging, and reemerging infectious disease threats. These threats differ widely in terms of severity and probability. They also have varying consequences for morbidity and mortality, as well as for a complex set of social and economic outcomes. To various degrees, they are also amenable to alternative responses, ranging from clean water provision to regulation to biomedical countermeasures. Whether the global health system as currently constituted can provide effective protection against a Dynamic Array of infectious disease threats has been called into question by recent outbreaks of Ebola, Zika, dengue, Middle East respiratory syndrome, severe acute respiratory syndrome, and influenza and by the looming threat of rising antimicrobial resistance. The concern is magnified by rapid population growth in areas with weak health systems, urbanization, globalization, climate change, civil conflict, and the changing nature of pathogen transmission between human and animal populations. There is also potential for human-originated outbreaks emanating from laboratory accidents or intentional biological attacks. This paper discusses these issues, along with the need for a (possibly self-standing) multi-disciplinary Global Technical Council on Infectious Disease Threats to address emerging global challenges with regard to infectious disease and associated social and economic risks. This Council would strengthen the global health system by improving collaboration and coordination across organizations (e.g., the WHO, Gavi, CEPI, national centers for disease control, pharmaceutical manufacturers, etc.); filling in knowledge gaps with respect to (for example) infectious disease surveillance, research and development needs, financing models, supply chain logistics, and the social and economic impacts of potential threats; and making high-level, evidence-based recommendations for managing global risks associated with infectious disease.
David E. Bloom - One of the best experts on this subject based on the ideXlab platform.
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infectious disease threats in the twenty first century strengthening the global response
Frontiers in Immunology, 2019Co-Authors: David E. Bloom, Daniel CadaretteAbstract:The world has developed an elaborate global health system as a bulwark against known and unknown infectious disease threats. The system consists of various formal and informal networks of organizations that serve different stakeholders; have varying goals, modalities, resources, and accountability; operate at different regional levels (e.g., local, national, and global); and cut across the public, private-for-profit, and private-not-for-profit sectors. The evolving global health system has done much to protect and promote human health. However, the world continues to be confronted by longstanding, emerging, and reemerging infectious disease threats. These threats differ widely in terms of severity and probability. They also have varying consequences for morbidity and mortality, as well as for a complex set of social and economic outcomes. To various degrees, they are also amenable to alternative responses, ranging from clean water provision to regulation to biomedical countermeasures. Whether the global health system as currently constituted can provide effective protection against a Dynamic Array of infectious disease threats has been called into question by recent outbreaks of Ebola, Zika, dengue, Middle East respiratory syndrome, severe acute respiratory syndrome, and influenza and by the looming threat of rising antimicrobial resistance. The concern is magnified by rapid population growth in areas with weak health systems, urbanization, globalization, climate change, civil conflict, and the changing nature of pathogen transmission between human and animal populations. There is also potential for human-originated outbreaks emanating from laboratory accidents or intentional biological attacks. This paper discusses these issues, along with the need for a (possibly self-standing) multi-disciplinary Global Technical Council on Infectious Disease Threats to address emerging global challenges with regard to infectious disease and associated social and economic risks. This Council would strengthen the global health system by improving collaboration and coordination across organizations (e.g., the WHO, Gavi, CEPI, national centers for disease control, pharmaceutical manufacturers, etc.); filling in knowledge gaps with respect to (for example) infectious disease surveillance, research and development needs, financing models, supply chain logistics, and the social and economic impacts of potential threats; and making high-level, evidence-based recommendations for managing global risks associated with infectious disease.
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infectious disease threats in the twenty first century strengthening the global response
Frontiers in Immunology, 2019Co-Authors: David E. Bloom, Daniel CadaretteAbstract:The world has developed an elaborate global health system as a bulwark against known and unknown infectious disease threats. The system consists of various formal and informal networks of organizations that serve different stakeholders; have varying goals, modalities, resources, and accountability; operate at different regional levels (i.e., local, national, regional, or global); and cut across the public, private-for-profit, and private-not-for-profit sectors. The evolving global health system has done much to protect and promote human health. However, the world continues to be confronted by longstanding, emerging, and reemerging infectious disease threats. These threats differ widely in terms of severity and probability. They also have varying consequences for morbidity and mortality, as well as for a complex set of social and economic outcomes. To various degrees, they are also amenable to alternative responses, ranging from clean water provision to regulation to biomedical countermeasures. Whether the global health system as currently constituted can provide effective protection against a Dynamic Array of infectious disease threats has been called into question by recent outbreaks of Ebola, Zika, dengue, Middle East respiratory syndrome, severe acute respiratory syndrome, and influenza and by the looming threat of rising antimicrobial resistance. The concern is magnified by rapid population growth in areas with weak health systems, urbanization, globalization, climate change, civil conflict, and the changing nature of pathogen transmission between human and animal populations. There is also potential for human-originated outbreaks emanating from laboratory accidents or intentional biological attacks. This paper discusses these issues, along with the need for a (possibly self-standing) multi-disciplinary Global Technical Council on Infectious Disease Threats to address emerging global challenges with regard to infectious disease and associated social and economic risks. This Council would strengthen the global health system by improving collaboration and coordination across organizations (e.g., the WHO, Gavi, CEPI, national centers for disease control, pharmaceutical manufacturers, etc.); filling in knowledge gaps with respect to (for example) infectious disease surveillance, research and development needs, financing models, supply chain logistics, and the social and economic impacts of potential threats; and making high-level, evidence-based recommendations for managing global risks associated with infectious disease.
Serdar Oztuzcu - One of the best experts on this subject based on the ideXlab platform.
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Evidence for elevated (LIMK2 and CFL1) and suppressed (ICAM1, EZR, MAP2K2, and NOS3) gene expressions in metabolic syndrome
Endocrine, 2016Co-Authors: Suzan Tabur, Serdar Oztuzcu, Seniz Demiryürek, Mesut Ozkaya, Elif Oguz, Hasan Dagli, Belgin Alasehirli, Abdullah T DemiryurekAbstract:The metabolic syndrome (MetS) is a common multicomponent condition including abdominal obesity, dyslipidemia, hypertension, and hyperglycaemia. The aim of this study was to investigate the associations of the expression of a panel of signalling genes with the MetS in a Turkish population. A total of 54 MetS patients and 42 healthy controls with similar age and sex were included to this study. mRNA from blood samples was extracted, and real-time polymerase chain reaction was performed for gene expressions using a BioMark 96.96 Dynamic Array system. We observed marked increases in LIM kinase 2 ( LIMK2 ) and cofilin 1 ( CFL1 ) gene expressions in MetS patients. However, there were significant decreases in intercellular adhesion molecules 1 ( ICAM1 ), ezrin ( EZR ), mitogen-activated protein kinase kinase 2 ( MAP2K2 ), and nitric oxide synthase 3 ( NOS3 ) gene expressions in MetS patients. Additionally, no marked changes were noted in other 15 genes studied. This is the first study to provide evidence that activation of LIMK2/CFL1 pathway may play an important role in MetS.
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association of trpm channel gene polymorphisms with systemic sclerosis
in Vivo, 2015Co-Authors: Serdar Oztuzcu, Ahmet Mesut Onat, Yavuz Pehlivan, Salim Dönmez, Gözde Çetin, Servet Yolbas, Ibrahim Bozgeyik, Neslihan Yilmaz, Fatma Alibazoner, Metin OzgenAbstract:BACKGROUND/AIM Systemic sclerosis (SSc) is an inflammatory disease characterized by vascular abnormalities and fibrosis. The aim of the present study was to investigate the possible role of transient receptor potential melastatin (TRPM) channel genes in the susceptibility and phenotype expression of SSc. MATERIALS AND METHODS A total of 339 patients with SSc and 302 healthy controls were studied. Genomic DNA was extracted from leukocytes of the peripheral blood, and 25 single nucleotide polymorphisms in the TRPM channel genes were analyzed by the BioMark HD Dynamic Array system. RESULTS There were marked increases in the CC genotype (94.7% vs 81.8%, p<0.0001) and C allele frequencies (97.0% vs. 90.1%, p<0.0001) in the TRPM3 rs1328142, and TT genotype (19.0% vs. 7.8%, p=0.0002) in TRPM5 rs34551253 (Ala456Thr) polymorphism in SSc patients when compared to controls. TRPM3 gene rs1328142 polymorphism was also markedly associated with disease phenotype. However, no associations with the other 23 polymorphisms studied were found. CONCLUSION This is the first study to examine the involvement of TRPM channel gene variations on the risk of SSc incidence. Our results suggest roles of TRPM3 and TRPM5 gene variants in the susceptibility to or clinical expression of SSc in the Turkish population.
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role of the transient receptor potential trp channel gene expressions and trp melastatin trpm channel gene polymorphisms in obesity related metabolic syndrome
European Review for Medical and Pharmacological Sciences, 2015Co-Authors: Suzan Tabur, Serdar Oztuzcu, Ayten Eraydin, S Eroglu, Mesut Ozkaya, Abdullah T DemiryurekAbstract:OBJECTIVE: Metabolic syndrome (MetS) is correlated with increased cardiovascu - lar risk and characterized by several factors, in - cluding visceral obesity, hypertension, dyslipi - demia, and insulin resistance. The etiology of MetS is complex, and can be influenced by ge - netic susceptibility.The aim of this study was to investigate a possible association of transient receptor potential (TRP) channels gene expres - sions andTRP melastatin (TRPM) gene polymor - phisms with MetS in aTurkish population. PATIENTS AND METHODS: A total of 142 pa - tients with obesity-related MetS and 166 healthy controls with similar age and sex were enrolled to this study. For polymorphism studies, genom - ic DNA from the participants was analyzed by a BioMark 96.96 Dynamic Array system (Fluidigm, South San Francisco, CA, USA). For gene ex - pression studies, mRNA from blood samples was extracted, and real time polymerase chain reaction on the BioMark HD system was per - formed. RESULTS: There was an increase in A allele (64.6% in patients vs. 49.5% in controls) and de - crease in G allele frequencies (35.4% in patients vs. 50.5% in control, p = 0.0019) of the TRPM5 gene rs4929982 (Arg578Gln) polymorphism. We also observed that the distribution of genotype and allele frequencies of the TRPM8 gene rs12472151 in MetS patients were significantly different from controls ( p < 0.0001). Although there were marked decreases in TRPC1, TRPC3, TRPM2,TRPM5,TRPV4,TRPV5,TRPV6, MCOLN2 (TRPML2), and MCOLN3 (TRPML3) gene expres - sions, an augmentation was noted in TRPC6 gene expression. CONCLUSIONS : Genetic polymorphisms in TRPM5 and TRPM8 genes may modify individual susceptibility to MetS in the Turkish population.
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the effects of nigella sativa ns anthemis hyalina ah and citrus sinensis cs extracts on the replication of coronavirus and the expression of trp genes family
Molecular Biology Reports, 2014Co-Authors: Mustafa Ulasli, Serdar Oztuzcu, Onder Yumrutas, Recep Bayraktar, Serdar Abidin Gurses, Mehri Igci, Yusuf Ziya Igci, Ecir Ali Cakmak, Ahmet ArslanAbstract:Extracts of Anthemis hyalina (Ah), Nigella sativa (Ns) and peels of Citrus sinensis (Cs) have been used as folk medicine to fight antimicrobial diseases. To evaluate the effect of extracts of Ah, Ns and Cs on the replication of coronavirus (CoV) and on the expression of TRP genes during coronavirus infection, HeLa-CEACAM1a (HeLa-epithelial carcinoembryonic antigen-related cell adhesion molecule 1a) cells were inoculated with MHV-A59 (mouse hepatitis virus–A59) at moi of 30. 1/50 dilution of the extracts was found to be the safe active dose. ELISA kits were used to detect the human IL-8 levels. Total RNA was isolated from the infected cells and cDNA was synthesized. Fluidigm Dynamic Array nanofluidic chip 96.96 was used to analyze the mRNA expression of 21 TRP genes and two control genes. Data was analyzed using the BioMark digital Array software. Determinations of relative gene expression values were carried out by using the 2−∆∆Ct method (normalized threshold cycle (Ct) value of sample minus normalized Ct value of control). TCID50/ml (tissue culture infectious dose that will produce cytopathic effect in 50 % of the inoculated tissue culture cells) was found for treatments to determine the viral loads. The inflammatory cytokine IL-8 level was found to increase for both 24 and 48 h time points following Ns extract treatment. TRPA1, TRPC4, TRPM6, TRPM7, TRPM8 and TRPV4 were the genes which expression levels changed significantly after Ah, Ns or Cs extract treatments. The virus load decreased when any of the Ah, Ns or Cs extracts was added to the CoV infected cells with Ah extract treatment leading to undetectable virus load for both 6 and 8hpi. Although all the extract treatments had an effect on IL-8 secretion, TRP gene expression and virus load after CoV infection, it was the Ah extract treatment that showed the biggest difference in virus load. Therefore Ah extract is the best candidate in our hands that contains potential treatment molecule(s).
Seniz Demiryürek - One of the best experts on this subject based on the ideXlab platform.
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Leukocyte TRP channel gene expressions in patients with non-valvular atrial fibrillation
Scientific reports, 2017Co-Authors: Irfan Veysel Duzen, Fethi Yavuz, Ertan Vuruşkan, Erhan Saraçoğlu, Fatih Poyraz, Hüseyin Göksülük, Basar Candemir, Seniz DemiryürekAbstract:Atrial fibrillation (AF) is the most common arrhythmia in clinical practice and is a major cause of morbidity and mortality. The upregulation of TRP channels is believed to mediate the progression of electrical remodelling and the arrhythmogenesis of the diseased heart. However, there is limited data about the contribution of the TRP channels to development of AF. The aim of this study was to investigate leukocyte TRP channels gene expressions in non-valvular atrial fibrillation (NVAF) patients. The study included 47 NVAF patients and 47 sex and age matched controls. mRNA was extracted from blood samples, and real-time polymerase chain reaction was performed for gene expressions by using a Dynamic Array system. Low levels of TRP channel expressions in the controls were markedly potentiated in NVAF group. We observed marked increases in MCOLN1 (TRPML1), MCOLN2 (TRPML2), MCOLN3 (TRPML3), TRPA1, TRPM1, TRPM2, TRPM3, TRPM4, TRPM5, TRPM6, TRPM7, TRPM8, TRPC1, TRPC2, TRPC3, TRPC4, TRPC5, TRPC6, TRPC7, TRPV1, TRPV2, TRPV3, TRPV4, TRPV5, TRPV6, and PKD2 (TRPP2) gene expressions in NVAF patients (P
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Evidence for elevated (LIMK2 and CFL1) and suppressed (ICAM1, EZR, MAP2K2, and NOS3) gene expressions in metabolic syndrome
Endocrine, 2016Co-Authors: Suzan Tabur, Serdar Oztuzcu, Seniz Demiryürek, Mesut Ozkaya, Elif Oguz, Hasan Dagli, Belgin Alasehirli, Abdullah T DemiryurekAbstract:The metabolic syndrome (MetS) is a common multicomponent condition including abdominal obesity, dyslipidemia, hypertension, and hyperglycaemia. The aim of this study was to investigate the associations of the expression of a panel of signalling genes with the MetS in a Turkish population. A total of 54 MetS patients and 42 healthy controls with similar age and sex were included to this study. mRNA from blood samples was extracted, and real-time polymerase chain reaction was performed for gene expressions using a BioMark 96.96 Dynamic Array system. We observed marked increases in LIM kinase 2 ( LIMK2 ) and cofilin 1 ( CFL1 ) gene expressions in MetS patients. However, there were significant decreases in intercellular adhesion molecules 1 ( ICAM1 ), ezrin ( EZR ), mitogen-activated protein kinase kinase 2 ( MAP2K2 ), and nitric oxide synthase 3 ( NOS3 ) gene expressions in MetS patients. Additionally, no marked changes were noted in other 15 genes studied. This is the first study to provide evidence that activation of LIMK2/CFL1 pathway may play an important role in MetS.
Jinhong Yuan - One of the best experts on this subject based on the ideXlab platform.
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a Dynamic Array of subArrays architecture and hybrid precoding algorithms for terahertz wireless communications
IEEE Journal on Selected Areas in Communications, 2020Co-Authors: Longfei Yan, Chong Han, Jinhong YuanAbstract:Terahertz (THz) communications are envisioned as a key technology for 6G wireless systems, owing to an unprecedented promised multi-GHz bandwidth. While THz band suffers from huge propagation losses, large Arrays of sub-millimeter wavelength antennas can be realized in ultra-massive multiple-input multiple-output (UM-MIMO) systems to enhance the received power and overcome the distance limitation. In this paper, a Dynamic Array-of-subArrays (DAoSA) hybrid precoding architecture is proposed to reduce the power consumption while meeting the data rate requirement in THz UM-MIMO systems. The connections between RF chains and subArrays are intelligently adjusted through a network of switches. First, to solve the intractable DAoSA hybrid precoding problem, element-by-element (EBE) and vectorization-based (VEC) algorithms are derived. Moreover, to determine the connections of the switches, near-optimal progressive stage-by-stage (PSBS), low-complexity alternating-selection (AS) and block-diagonal-search (BDS) algorithms are developed. Extensive simulation results show that both the EBE and VEC algorithms have higher spectral efficiency than existing hybrid precoding algorithms. Furthermore, the power consumption of the DAoSA architecture is substantially lessened, with PSBS, AS and BDS algorithms, respectively. The developed DAoSA architecture associated with proposed hybrid precoding and switch network design algorithms demonstrates a superior capability on balancing the spectral efficiency and power consumption.
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a Dynamic Array of sub Array architecture for hybrid precoding in the millimeter wave and terahertz bands
International Conference on Communications, 2019Co-Authors: Longfei Yan, Chong Han, Jinhong YuanAbstract:In this paper, a Dynamic Array of sub-Array (DAoSA) architecture is proposed for hybrid precoding in the millimeter wave (mmWave) and Terahertz (THz) bands. Switches are inserted in the hybrid precoding architecture, to Dynamically adjust the connection between RF chains and sub-Arrays, i.e., each RF chain connects to m sub-Arrays. In particular, the fully-connected (FC) and Array of sub-Array (AoSA) architectures can be realized by setting m as the number of RF chains and 1, respectively. Based on the DAoSA architecture, the intractable precoding problem is decomposed into multiple tractable FC precoding problems, to which the solutions are developed based on a low-complexity column-by-column (CBC) algorithm. In the mmWave and THz wireless channel, simulation results show that compared with the FC architecture, the power consumption of the DAoSA architecture can be substantially reduced with a negligible spectral efficiency loss. In contrast to the AoSA architecture, the spectral efficiency is significantly improved.
