The Experts below are selected from a list of 33 Experts worldwide ranked by ideXlab platform
Giuseppe Basso - One of the best experts on this subject based on the ideXlab platform.
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biological and clinical fEaturEs of b prEcursor childhood acutE lymphoblastic lEukEmia showing cd2 and or E rosEttE co ExprEssion
Haematologica, 1992Co-Authors: A Canturajnoldi, M C Putti, R Schiro, Andrea Biondi, Giorgio Cattoretti, Costante Valeggio, M Castagni, Giuseppe BassoAbstract:BACKGROUND Co-ExprEssion of thE T-associatEd markEr CD2 or E-rosEttE in non-T acutE lEukEmia has rarEly bEEn rEportEd. In this papEr thE incidEncE of such co-ExprEssion, togEthEr with its biologic fEaturEs and clinical rElEvancE, was EvaluatEd in a largE sEriEs of childhood "common" acutE lymphoblastic lEukEmia (cALL) casEs. METHODS This analysis was pErformEd rEtrospEctivEly on 306 casEs of childhood non-T ALL. CD2 and/or E-rosEttE co-ExprEssion with othEr non-T markErs was usually shown by a clEar ovErlap bEtwEEn thE pErcEntagEs of T and non-T markErs, by thE grEat diffErEncE bEtwEEn positivity for CD2 or E-rosEttE and othEr T markErs, and by doublE staining for CD2 and CD10 in onE casE. Two casEs wErE furthEr studiEd by a panEl of ninE diffErEnt CD2 monoclonal antibodiEs (MAbs) rEprEsEntativE of diffErEnt EpitopEs. DNA analysis for thE configuration of Ig and TCR gEnEs (bEta, gamma, and dElta locus) was carriEd out in thrEE casEs. RESULTS ElEvEn out of 306 casEs (3.6%) showEd CD2 and/or E-rosEttE co-ExprEssion in othErwisE typical cALL. Data obtainEd in two casEs with thE usE of ninE diffErEnt CD2 Mabs showEd a diffErEnt pattErn of rEactivity bEtwEEn lEukEmic B cElls and normal T cElls. ThE configuration of Ig and TCR gEnEs was compatiblE with B-linEagE ALL. CONCLUSIONS CD2 and/or E-rosEttE co-ExprEssion was obsErvEd in a small subsEt of acutE lEukEmias showing immunophEnotypic and gEnotypic fEaturEs of B-linEagE ALL. A pattErn of rEactivity diffErEnt from that sEEn in normal T cElls was obsErvEd in thE two casEs tEstEd with a largE panEl of CD2 MAbs. No association was found with othEr known prognostic factors, and 8 of thEsE 11 patiEnts havE bEEn in first continuous rEmission for 36-93 months.
A Canturajnoldi - One of the best experts on this subject based on the ideXlab platform.
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biological and clinical fEaturEs of b prEcursor childhood acutE lymphoblastic lEukEmia showing cd2 and or E rosEttE co ExprEssion
Haematologica, 1992Co-Authors: A Canturajnoldi, M C Putti, R Schiro, Andrea Biondi, Giorgio Cattoretti, Costante Valeggio, M Castagni, Giuseppe BassoAbstract:BACKGROUND Co-ExprEssion of thE T-associatEd markEr CD2 or E-rosEttE in non-T acutE lEukEmia has rarEly bEEn rEportEd. In this papEr thE incidEncE of such co-ExprEssion, togEthEr with its biologic fEaturEs and clinical rElEvancE, was EvaluatEd in a largE sEriEs of childhood "common" acutE lymphoblastic lEukEmia (cALL) casEs. METHODS This analysis was pErformEd rEtrospEctivEly on 306 casEs of childhood non-T ALL. CD2 and/or E-rosEttE co-ExprEssion with othEr non-T markErs was usually shown by a clEar ovErlap bEtwEEn thE pErcEntagEs of T and non-T markErs, by thE grEat diffErEncE bEtwEEn positivity for CD2 or E-rosEttE and othEr T markErs, and by doublE staining for CD2 and CD10 in onE casE. Two casEs wErE furthEr studiEd by a panEl of ninE diffErEnt CD2 monoclonal antibodiEs (MAbs) rEprEsEntativE of diffErEnt EpitopEs. DNA analysis for thE configuration of Ig and TCR gEnEs (bEta, gamma, and dElta locus) was carriEd out in thrEE casEs. RESULTS ElEvEn out of 306 casEs (3.6%) showEd CD2 and/or E-rosEttE co-ExprEssion in othErwisE typical cALL. Data obtainEd in two casEs with thE usE of ninE diffErEnt CD2 Mabs showEd a diffErEnt pattErn of rEactivity bEtwEEn lEukEmic B cElls and normal T cElls. ThE configuration of Ig and TCR gEnEs was compatiblE with B-linEagE ALL. CONCLUSIONS CD2 and/or E-rosEttE co-ExprEssion was obsErvEd in a small subsEt of acutE lEukEmias showing immunophEnotypic and gEnotypic fEaturEs of B-linEagE ALL. A pattErn of rEactivity diffErEnt from that sEEn in normal T cElls was obsErvEd in thE two casEs tEstEd with a largE panEl of CD2 MAbs. No association was found with othEr known prognostic factors, and 8 of thEsE 11 patiEnts havE bEEn in first continuous rEmission for 36-93 months.
Stroilă C - One of the best experts on this subject based on the ideXlab platform.
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Functional E rosEttE study prE and post lasEr trEatmEnt in malignant ocular mElanoma
Oftalmologia (Bucharest Romania : 1990), 1992Co-Authors: Tarnavschi R, B Cârstocea, Ciotaru D, Ursaciuc C, Antihi M, Stroilă CAbstract:For 11 patiEnts with ocular malignant mElanoma (OMM) suspicion, bEforE and aftEr lasEr photocoagulation thErapy, by E rosEttE tEst wErE studiEd. A highEr activation and sEnsitisation to OMM antigEn was obtainEd aftEr lasEr thErapy in 9 patiEnts. ThEsE rEsults suggEst thE influEncE of lasEr trEatmEnt on lymphocytE function by "rEvEaling" thE physiological rEactivity. Our rEsults point out thE "functional" E rosEttE tEst is usEful for OMM diagnosis and thErapy, as an indicator for disEasE prognosis.
Costante Valeggio - One of the best experts on this subject based on the ideXlab platform.
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biological and clinical fEaturEs of b prEcursor childhood acutE lymphoblastic lEukEmia showing cd2 and or E rosEttE co ExprEssion
Haematologica, 1992Co-Authors: A Canturajnoldi, M C Putti, R Schiro, Andrea Biondi, Giorgio Cattoretti, Costante Valeggio, M Castagni, Giuseppe BassoAbstract:BACKGROUND Co-ExprEssion of thE T-associatEd markEr CD2 or E-rosEttE in non-T acutE lEukEmia has rarEly bEEn rEportEd. In this papEr thE incidEncE of such co-ExprEssion, togEthEr with its biologic fEaturEs and clinical rElEvancE, was EvaluatEd in a largE sEriEs of childhood "common" acutE lymphoblastic lEukEmia (cALL) casEs. METHODS This analysis was pErformEd rEtrospEctivEly on 306 casEs of childhood non-T ALL. CD2 and/or E-rosEttE co-ExprEssion with othEr non-T markErs was usually shown by a clEar ovErlap bEtwEEn thE pErcEntagEs of T and non-T markErs, by thE grEat diffErEncE bEtwEEn positivity for CD2 or E-rosEttE and othEr T markErs, and by doublE staining for CD2 and CD10 in onE casE. Two casEs wErE furthEr studiEd by a panEl of ninE diffErEnt CD2 monoclonal antibodiEs (MAbs) rEprEsEntativE of diffErEnt EpitopEs. DNA analysis for thE configuration of Ig and TCR gEnEs (bEta, gamma, and dElta locus) was carriEd out in thrEE casEs. RESULTS ElEvEn out of 306 casEs (3.6%) showEd CD2 and/or E-rosEttE co-ExprEssion in othErwisE typical cALL. Data obtainEd in two casEs with thE usE of ninE diffErEnt CD2 Mabs showEd a diffErEnt pattErn of rEactivity bEtwEEn lEukEmic B cElls and normal T cElls. ThE configuration of Ig and TCR gEnEs was compatiblE with B-linEagE ALL. CONCLUSIONS CD2 and/or E-rosEttE co-ExprEssion was obsErvEd in a small subsEt of acutE lEukEmias showing immunophEnotypic and gEnotypic fEaturEs of B-linEagE ALL. A pattErn of rEactivity diffErEnt from that sEEn in normal T cElls was obsErvEd in thE two casEs tEstEd with a largE panEl of CD2 MAbs. No association was found with othEr known prognostic factors, and 8 of thEsE 11 patiEnts havE bEEn in first continuous rEmission for 36-93 months.
M C Putti - One of the best experts on this subject based on the ideXlab platform.
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biological and clinical fEaturEs of b prEcursor childhood acutE lymphoblastic lEukEmia showing cd2 and or E rosEttE co ExprEssion
Haematologica, 1992Co-Authors: A Canturajnoldi, M C Putti, R Schiro, Andrea Biondi, Giorgio Cattoretti, Costante Valeggio, M Castagni, Giuseppe BassoAbstract:BACKGROUND Co-ExprEssion of thE T-associatEd markEr CD2 or E-rosEttE in non-T acutE lEukEmia has rarEly bEEn rEportEd. In this papEr thE incidEncE of such co-ExprEssion, togEthEr with its biologic fEaturEs and clinical rElEvancE, was EvaluatEd in a largE sEriEs of childhood "common" acutE lymphoblastic lEukEmia (cALL) casEs. METHODS This analysis was pErformEd rEtrospEctivEly on 306 casEs of childhood non-T ALL. CD2 and/or E-rosEttE co-ExprEssion with othEr non-T markErs was usually shown by a clEar ovErlap bEtwEEn thE pErcEntagEs of T and non-T markErs, by thE grEat diffErEncE bEtwEEn positivity for CD2 or E-rosEttE and othEr T markErs, and by doublE staining for CD2 and CD10 in onE casE. Two casEs wErE furthEr studiEd by a panEl of ninE diffErEnt CD2 monoclonal antibodiEs (MAbs) rEprEsEntativE of diffErEnt EpitopEs. DNA analysis for thE configuration of Ig and TCR gEnEs (bEta, gamma, and dElta locus) was carriEd out in thrEE casEs. RESULTS ElEvEn out of 306 casEs (3.6%) showEd CD2 and/or E-rosEttE co-ExprEssion in othErwisE typical cALL. Data obtainEd in two casEs with thE usE of ninE diffErEnt CD2 Mabs showEd a diffErEnt pattErn of rEactivity bEtwEEn lEukEmic B cElls and normal T cElls. ThE configuration of Ig and TCR gEnEs was compatiblE with B-linEagE ALL. CONCLUSIONS CD2 and/or E-rosEttE co-ExprEssion was obsErvEd in a small subsEt of acutE lEukEmias showing immunophEnotypic and gEnotypic fEaturEs of B-linEagE ALL. A pattErn of rEactivity diffErEnt from that sEEn in normal T cElls was obsErvEd in thE two casEs tEstEd with a largE panEl of CD2 MAbs. No association was found with othEr known prognostic factors, and 8 of thEsE 11 patiEnts havE bEEn in first continuous rEmission for 36-93 months.
