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Ilias Katsikis - One of the best experts on this subject based on the ideXlab platform.
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Uterine volume and endometrial thickness in the Early Follicular Phase in patients with polycystic ovary syndrome.
Endocrine Practice, 2014Co-Authors: Dimitrios Panidis, Konstantinos Tziomalos, Efstathios Papadakis, Christos Vosnakis, Georgios Betsas, Ekaterini Tsourdi, Ilias KatsikisAbstract:OBJECTIVE We aimed to evaluate uterine volume and endometrial thickness during the Early Follicular Phase in patients with polycystic ovary syndrome (PCOS) and healthy controls. METHODS We studied 1,016 PCOS patients and 182 healthy controls. The anthropometric, endocrine, and metabolic characteristics of PCOS were determined. Uterine volume and endometrial thickness were also recorded. RESULTS Uterine volume progressively increased with age both in PCOS patients and controls. Patients with PCOS and body mass index (BMI) ≥25 kg/m2 had greater uterine volumes than PCOS patients with BMI
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uterine volume and endometrial thickness in the Early Follicular Phase in patients with polycystic ovary syndrome
Endocrine Practice, 2014Co-Authors: Dimitrios Panidis, Konstantinos Tziomalos, Efstathios Papadakis, Christos Vosnakis, Georgios Betsas, Ekaterini Tsourdi, Ilias KatsikisAbstract:OBJECTIVE We aimed to evaluate uterine volume and endometrial thickness during the Early Follicular Phase in patients with polycystic ovary syndrome (PCOS) and healthy controls. METHODS We studied 1,016 PCOS patients and 182 healthy controls. The anthropometric, endocrine, and metabolic characteristics of PCOS were determined. Uterine volume and endometrial thickness were also recorded. RESULTS Uterine volume progressively increased with age both in PCOS patients and controls. Patients with PCOS and body mass index (BMI) ≥25 kg/m2 had greater uterine volumes than PCOS patients with BMI <25 kg/m2 (P<.001). Patients with the classic PCOS phenotypes (i.e., with oligo-ovulation and/or anovulation [ANOV] and hyperandrogenemia [HA] with or without polycystic ovaries [PCO]) had smaller uterine volume than PCOS patients with the additional phenotypes introduced by the Rotterdam criteria (i.e., with PCO and either ANOV or HA; P = .033) and controls (P = .045). CONCLUSION Uterine volume increases progressively with age and obesity in PCOS patients. The smaller uterine volumes and endometrial thicknesses in the classic PCOS phenotypes might be attributed to the more severe HA of these patients.
Mary B. Zelinski - One of the best experts on this subject based on the ideXlab platform.
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cumulus oocyte complexes from small antral follicles during the Early Follicular Phase of menstrual cycles in rhesus monkeys yield oocytes that reinitiate meiosis and fertilize in vitro
Biology of Reproduction, 2010Co-Authors: Marina C. Peluffo, Susan L. Barrett, Richard L. Stouffer, Jon D. Hennebold, Mary B. ZelinskiAbstract:The stage at which follicle-enclosed cumulus-oocyte complexes achieve developmental competence in primates is unknown. Therefore, studies were designed to characterize the ability of oocytes in small antral follicles present during the menstrual cycle to spontaneously resume meiosis, fertilize, and support Early embryo development. Ovaries were removed from adult rhesus monkeys (n = 12) during the Early Follicular Phase (Days 3–4) of spontaneous cycles. Small antral follicles were divided into five groups according to their diameter; group I: <0.5 mm; group II: 0.5–0.99 mm; group III: 1.0–1.49 mm; group IV: 1.5–1.99 mm; and group V: 2.0–2.5 mm. The cumulus-oocyte complex from healthy small antral follicles (devoid of dark oocytes or granulosa cells) were extracted (n = 199) and cultured for 48 h under different conditions: in TALP (tyrode, albumin, lactate, pyruvate) medium alone, SAGE medium alone, or plus gonadotropins. At 48 h, oocyte meiotic status and diameter were measured after treatment of cumulus-oocyte complexes with hyaluronidase. Cumulus-oocyte complexes derived from follicles of 0.5- to 2-mm diameter contain oocytes that typically reinitiate meiosis in the absence or presence of gonadotropins and fertilize via in vitro fertilization or intracytoplasmic sperm injection. Moreover, the inseminated oocytes can reach the morula stage but arrest. Thus, the ability of these oocytes to complete maturation, as monitored from subsequent embryonic development after fertilization, is suboptimal. Further studies on primate IVM of oocytes from SAFs are warranted in order for them to be considered as an additional, novel source of gametes for fertility preservation in cancer patients.
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Cumulus-Oocyte Complexes from Small Antral Follicles During the Early Follicular Phase of Menstrual Cycles in Rhesus Monkeys Yield Oocytes That Reinitiate Meiosis and Fertilize In Vitro
Biology of Reproduction, 2010Co-Authors: Marina C. Peluffo, Susan L. Barrett, Richard L. Stouffer, Jon D. Hennebold, Mary B. ZelinskiAbstract:The stage at which follicle-enclosed cumulus-oocyte complexes achieve developmental competence in primates is unknown. Therefore, studies were designed to characterize the ability of oocytes in small antral follicles present during the menstrual cycle to spontaneously resume meiosis, fertilize, and support Early embryo development. Ovaries were removed from adult rhesus monkeys (n = 12) during the Early Follicular Phase (Days 3–4) of spontaneous cycles. Small antral follicles were divided into five groups according to their diameter; group I:
Dimitrios Panidis - One of the best experts on this subject based on the ideXlab platform.
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Uterine volume and endometrial thickness in the Early Follicular Phase in patients with polycystic ovary syndrome.
Endocrine Practice, 2014Co-Authors: Dimitrios Panidis, Konstantinos Tziomalos, Efstathios Papadakis, Christos Vosnakis, Georgios Betsas, Ekaterini Tsourdi, Ilias KatsikisAbstract:OBJECTIVE We aimed to evaluate uterine volume and endometrial thickness during the Early Follicular Phase in patients with polycystic ovary syndrome (PCOS) and healthy controls. METHODS We studied 1,016 PCOS patients and 182 healthy controls. The anthropometric, endocrine, and metabolic characteristics of PCOS were determined. Uterine volume and endometrial thickness were also recorded. RESULTS Uterine volume progressively increased with age both in PCOS patients and controls. Patients with PCOS and body mass index (BMI) ≥25 kg/m2 had greater uterine volumes than PCOS patients with BMI
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uterine volume and endometrial thickness in the Early Follicular Phase in patients with polycystic ovary syndrome
Endocrine Practice, 2014Co-Authors: Dimitrios Panidis, Konstantinos Tziomalos, Efstathios Papadakis, Christos Vosnakis, Georgios Betsas, Ekaterini Tsourdi, Ilias KatsikisAbstract:OBJECTIVE We aimed to evaluate uterine volume and endometrial thickness during the Early Follicular Phase in patients with polycystic ovary syndrome (PCOS) and healthy controls. METHODS We studied 1,016 PCOS patients and 182 healthy controls. The anthropometric, endocrine, and metabolic characteristics of PCOS were determined. Uterine volume and endometrial thickness were also recorded. RESULTS Uterine volume progressively increased with age both in PCOS patients and controls. Patients with PCOS and body mass index (BMI) ≥25 kg/m2 had greater uterine volumes than PCOS patients with BMI <25 kg/m2 (P<.001). Patients with the classic PCOS phenotypes (i.e., with oligo-ovulation and/or anovulation [ANOV] and hyperandrogenemia [HA] with or without polycystic ovaries [PCO]) had smaller uterine volume than PCOS patients with the additional phenotypes introduced by the Rotterdam criteria (i.e., with PCO and either ANOV or HA; P = .033) and controls (P = .045). CONCLUSION Uterine volume increases progressively with age and obesity in PCOS patients. The smaller uterine volumes and endometrial thicknesses in the classic PCOS phenotypes might be attributed to the more severe HA of these patients.
Richard L. Stouffer - One of the best experts on this subject based on the ideXlab platform.
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cumulus oocyte complexes from small antral follicles during the Early Follicular Phase of menstrual cycles in rhesus monkeys yield oocytes that reinitiate meiosis and fertilize in vitro
Biology of Reproduction, 2010Co-Authors: Marina C. Peluffo, Susan L. Barrett, Richard L. Stouffer, Jon D. Hennebold, Mary B. ZelinskiAbstract:The stage at which follicle-enclosed cumulus-oocyte complexes achieve developmental competence in primates is unknown. Therefore, studies were designed to characterize the ability of oocytes in small antral follicles present during the menstrual cycle to spontaneously resume meiosis, fertilize, and support Early embryo development. Ovaries were removed from adult rhesus monkeys (n = 12) during the Early Follicular Phase (Days 3–4) of spontaneous cycles. Small antral follicles were divided into five groups according to their diameter; group I: <0.5 mm; group II: 0.5–0.99 mm; group III: 1.0–1.49 mm; group IV: 1.5–1.99 mm; and group V: 2.0–2.5 mm. The cumulus-oocyte complex from healthy small antral follicles (devoid of dark oocytes or granulosa cells) were extracted (n = 199) and cultured for 48 h under different conditions: in TALP (tyrode, albumin, lactate, pyruvate) medium alone, SAGE medium alone, or plus gonadotropins. At 48 h, oocyte meiotic status and diameter were measured after treatment of cumulus-oocyte complexes with hyaluronidase. Cumulus-oocyte complexes derived from follicles of 0.5- to 2-mm diameter contain oocytes that typically reinitiate meiosis in the absence or presence of gonadotropins and fertilize via in vitro fertilization or intracytoplasmic sperm injection. Moreover, the inseminated oocytes can reach the morula stage but arrest. Thus, the ability of these oocytes to complete maturation, as monitored from subsequent embryonic development after fertilization, is suboptimal. Further studies on primate IVM of oocytes from SAFs are warranted in order for them to be considered as an additional, novel source of gametes for fertility preservation in cancer patients.
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Cumulus-Oocyte Complexes from Small Antral Follicles During the Early Follicular Phase of Menstrual Cycles in Rhesus Monkeys Yield Oocytes That Reinitiate Meiosis and Fertilize In Vitro
Biology of Reproduction, 2010Co-Authors: Marina C. Peluffo, Susan L. Barrett, Richard L. Stouffer, Jon D. Hennebold, Mary B. ZelinskiAbstract:The stage at which follicle-enclosed cumulus-oocyte complexes achieve developmental competence in primates is unknown. Therefore, studies were designed to characterize the ability of oocytes in small antral follicles present during the menstrual cycle to spontaneously resume meiosis, fertilize, and support Early embryo development. Ovaries were removed from adult rhesus monkeys (n = 12) during the Early Follicular Phase (Days 3–4) of spontaneous cycles. Small antral follicles were divided into five groups according to their diameter; group I:
Jon D. Hennebold - One of the best experts on this subject based on the ideXlab platform.
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cumulus oocyte complexes from small antral follicles during the Early Follicular Phase of menstrual cycles in rhesus monkeys yield oocytes that reinitiate meiosis and fertilize in vitro
Biology of Reproduction, 2010Co-Authors: Marina C. Peluffo, Susan L. Barrett, Richard L. Stouffer, Jon D. Hennebold, Mary B. ZelinskiAbstract:The stage at which follicle-enclosed cumulus-oocyte complexes achieve developmental competence in primates is unknown. Therefore, studies were designed to characterize the ability of oocytes in small antral follicles present during the menstrual cycle to spontaneously resume meiosis, fertilize, and support Early embryo development. Ovaries were removed from adult rhesus monkeys (n = 12) during the Early Follicular Phase (Days 3–4) of spontaneous cycles. Small antral follicles were divided into five groups according to their diameter; group I: <0.5 mm; group II: 0.5–0.99 mm; group III: 1.0–1.49 mm; group IV: 1.5–1.99 mm; and group V: 2.0–2.5 mm. The cumulus-oocyte complex from healthy small antral follicles (devoid of dark oocytes or granulosa cells) were extracted (n = 199) and cultured for 48 h under different conditions: in TALP (tyrode, albumin, lactate, pyruvate) medium alone, SAGE medium alone, or plus gonadotropins. At 48 h, oocyte meiotic status and diameter were measured after treatment of cumulus-oocyte complexes with hyaluronidase. Cumulus-oocyte complexes derived from follicles of 0.5- to 2-mm diameter contain oocytes that typically reinitiate meiosis in the absence or presence of gonadotropins and fertilize via in vitro fertilization or intracytoplasmic sperm injection. Moreover, the inseminated oocytes can reach the morula stage but arrest. Thus, the ability of these oocytes to complete maturation, as monitored from subsequent embryonic development after fertilization, is suboptimal. Further studies on primate IVM of oocytes from SAFs are warranted in order for them to be considered as an additional, novel source of gametes for fertility preservation in cancer patients.
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Cumulus-Oocyte Complexes from Small Antral Follicles During the Early Follicular Phase of Menstrual Cycles in Rhesus Monkeys Yield Oocytes That Reinitiate Meiosis and Fertilize In Vitro
Biology of Reproduction, 2010Co-Authors: Marina C. Peluffo, Susan L. Barrett, Richard L. Stouffer, Jon D. Hennebold, Mary B. ZelinskiAbstract:The stage at which follicle-enclosed cumulus-oocyte complexes achieve developmental competence in primates is unknown. Therefore, studies were designed to characterize the ability of oocytes in small antral follicles present during the menstrual cycle to spontaneously resume meiosis, fertilize, and support Early embryo development. Ovaries were removed from adult rhesus monkeys (n = 12) during the Early Follicular Phase (Days 3–4) of spontaneous cycles. Small antral follicles were divided into five groups according to their diameter; group I:
