The Experts below are selected from a list of 132 Experts worldwide ranked by ideXlab platform
Gabrio Bassotti - One of the best experts on this subject based on the ideXlab platform.
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Impaired colonic motor response to cholinergic stimulation in patients with severe chronic idiopathic (slow transit type) constipation
Digestive Diseases and Sciences, 1993Co-Authors: Gabrio Bassotti, Antonio Morelli, Giuseppe Chiarioni, Bruno Pietro Imbimbo, Cesare Betti, Fabrizio Bonfante, Italo Vantini, William E. WhiteheadAbstract:Chronic idiopathic constipation, especially the slow transit type, is a troubling problem often afficting young women. The pathophysiological basis for this entity is unknown, although a defective cholinergic innervation has been postulated. We tested the hypothesis that cholinergic colonic innervation is deranged in this condition by studying colonic motor activity after strong cholinergic stimulation with Edrophonium Chloride in 14 women complaining of slow transit constipation. Unlike healthy subjects, constipated patients showed minimal or no response to Edrophonium injection. It is concluded that in slow transit constipation there is an important alteration of colonic cholinergic activity and that Edrophonium Chloride may represent a useful test drug for colonic pathophysiological investigations.
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Extensive investigation on colonic motility with pharmacological testing is useful for selecting surgical options in patients with inertia colica.
The American Journal of Gastroenterology, 1992Co-Authors: Gabrio Bassotti, C Betti, Maria Antonietta Pelli, Antonio MorelliAbstract:: Three women with idiopathic severe chronic constipation and inertia colica, who failed to respond to medical treatment, were extensively investigated for gut motor function, especially that of the colon. Twenty-four-hour manometric recordings disclosed that motility was severely reduced throughout the entire colon and response to eating was minimal. One of the patients also was tested for esophageal, gastric, and small bowel motor activity, which gave normal results. Edrophonium Chloride stimulation (10 mg iv) provoked no increase in colonic contractile activity in any patient. On these grounds, the patients were submitted to surgical intervention (total colectomy with ileorectal anastomosis two, and left hemicolectomy the other) with fairly good results at follow-up. These results indicate the wisdom of carrying out extensive functional investigations in severely constipated patients before surgery is contemplated.
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Edrophonium Chloride for testing colonic contractile activity in man
Acta Physiologica Scandinavica, 1991Co-Authors: Gabrio Bassotti, B P Imbimbo, C Betti, G S Erbella, M A Pelli, Antonio MorelliAbstract:141,289-293. Received 19 June 1990, accepted 3 October 1990. ISSN 0001-6772. Laboratorio di Motilita Intestinale, Istituto di Gastroenterologia, Universita di Perugia, Italy. The effects of cholinergic stimulation on the entire human colon are at present relatively unknown. For this reason, we evaluated the influence of a short-lived anticholinesterase agent, Edrophonium Chloride, on proximal and distal colonic contractile activity in man. Eight healthy volunteers of both sexes were studied with a multilumen manometric probe positioned with the aid of a colonoscope. Recordings were then obtained 30 minutes pre- and post-drug administration. Edrophonium Chloride (10 mg intra- venous) significantly stimulated both proximal and distal colonic contractile activity, and the maximum increase was observed within 10 minutes following injection, although some differences were observed between colonic segments in response to the drug. No important side effects were complained of after Edrophonium. Due to the potent stimulatory property on colonic smooth muscle, to its short duration of action, and
Shigefumi Suehiro - One of the best experts on this subject based on the ideXlab platform.
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Thymolipoma associated with myasthenia gravis
The Japanese Journal of Thoracic and Cardiovascular Surgery, 2007Co-Authors: Takuma Tsukioka, Kiyotoshi Inoue, Takashi Iwata, Shinjiro Mizuguchi, Ryuhei Morita, Shigefumi SuehiroAbstract:A 51-year-old woman with a 3-year history of diplopia was admitted to our hospital. Repetitive stimulation of the right median nerve revealed decreasing hand muscle responses. Edrophonium Chloride administration alleviated the symptoms. The serum anti-acetylcholine receptor antibody level was 3.3 nmol/l; thus, myasthenia gravis was diagnosed. A chest roentgenogram revealed a left inferior mediastinal mass, and a chest computed tomographic scan revealed a fat density mass partly containing soft tissue areas in the left side of the anterior mediastinum. Median sternotomy and extended thymectomy were performed. The pathology examination of the tumor revealed mature adipose tissue including islands of thymic tissue containing Hassall's corpuscles, without germinal centers. The tumor was a thymolipoma of the anterior mediastinum. Her postoperative course was good, and she is doing well at 1 year postoperatively.
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Thymolipoma associated with myasthenia gravis
General Thoracic and Cardiovascular Surgery, 2007Co-Authors: Takuma Tsukioka, Kiyotoshi Inoue, Takashi Iwata, Shinjiro Mizuguchi, Ryuhei Morita, Shigefumi SuehiroAbstract:A 51-year-old woman with a 3-year history of diplopia was admitted to our hospital. Repetitive stimulation of the right median nerve revealed decreasing hand muscle responses. Edrophonium Chloride administration alleviated the symptoms. The serum anti-acetylcholine receptor antibody level was 3.3 nmol/l; thus, myasthenia gravis was diagnosed. A chest roentgenogram revealed a left inferior mediastinal mass, and a chest computed tomographic scan revealed a fat density mass partly containing soft tissue areas in the left side of the anterior mediastinum. Median sternotomy and extended thymectomy were performed. The pathology examination of the tumor revealed mature adipose tissue including islands of thymic tissue containing Hassall's corpuscles, without germinal centers. The tumor was a thymolipoma of the anterior mediastinum. Her postoperative course was good, and she is doing well at 1 year postoperatively. The present study is the 15th reported case of thymolipoma associated with myasthenia gravis. We did not confirm a causal relationship between the thymolipoma and myasthenia gravis.
Antonio Morelli - One of the best experts on this subject based on the ideXlab platform.
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Impaired colonic motor response to cholinergic stimulation in patients with severe chronic idiopathic (slow transit type) constipation
Digestive Diseases and Sciences, 1993Co-Authors: Gabrio Bassotti, Antonio Morelli, Giuseppe Chiarioni, Bruno Pietro Imbimbo, Cesare Betti, Fabrizio Bonfante, Italo Vantini, William E. WhiteheadAbstract:Chronic idiopathic constipation, especially the slow transit type, is a troubling problem often afficting young women. The pathophysiological basis for this entity is unknown, although a defective cholinergic innervation has been postulated. We tested the hypothesis that cholinergic colonic innervation is deranged in this condition by studying colonic motor activity after strong cholinergic stimulation with Edrophonium Chloride in 14 women complaining of slow transit constipation. Unlike healthy subjects, constipated patients showed minimal or no response to Edrophonium injection. It is concluded that in slow transit constipation there is an important alteration of colonic cholinergic activity and that Edrophonium Chloride may represent a useful test drug for colonic pathophysiological investigations.
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Extensive investigation on colonic motility with pharmacological testing is useful for selecting surgical options in patients with inertia colica.
The American Journal of Gastroenterology, 1992Co-Authors: Gabrio Bassotti, C Betti, Maria Antonietta Pelli, Antonio MorelliAbstract:: Three women with idiopathic severe chronic constipation and inertia colica, who failed to respond to medical treatment, were extensively investigated for gut motor function, especially that of the colon. Twenty-four-hour manometric recordings disclosed that motility was severely reduced throughout the entire colon and response to eating was minimal. One of the patients also was tested for esophageal, gastric, and small bowel motor activity, which gave normal results. Edrophonium Chloride stimulation (10 mg iv) provoked no increase in colonic contractile activity in any patient. On these grounds, the patients were submitted to surgical intervention (total colectomy with ileorectal anastomosis two, and left hemicolectomy the other) with fairly good results at follow-up. These results indicate the wisdom of carrying out extensive functional investigations in severely constipated patients before surgery is contemplated.
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Edrophonium Chloride for testing colonic contractile activity in man
Acta Physiologica Scandinavica, 1991Co-Authors: Gabrio Bassotti, B P Imbimbo, C Betti, G S Erbella, M A Pelli, Antonio MorelliAbstract:141,289-293. Received 19 June 1990, accepted 3 October 1990. ISSN 0001-6772. Laboratorio di Motilita Intestinale, Istituto di Gastroenterologia, Universita di Perugia, Italy. The effects of cholinergic stimulation on the entire human colon are at present relatively unknown. For this reason, we evaluated the influence of a short-lived anticholinesterase agent, Edrophonium Chloride, on proximal and distal colonic contractile activity in man. Eight healthy volunteers of both sexes were studied with a multilumen manometric probe positioned with the aid of a colonoscope. Recordings were then obtained 30 minutes pre- and post-drug administration. Edrophonium Chloride (10 mg intra- venous) significantly stimulated both proximal and distal colonic contractile activity, and the maximum increase was observed within 10 minutes following injection, although some differences were observed between colonic segments in response to the drug. No important side effects were complained of after Edrophonium. Due to the potent stimulatory property on colonic smooth muscle, to its short duration of action, and
W J Feuer - One of the best experts on this subject based on the ideXlab platform.
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the effect of Edrophonium Chloride on muscle balance in normal subjects and those with nonmyasthenic strabismus
Journal of Neuro-ophthalmology, 1997Co-Authors: R M Siatkowski, L Shah, W J FeuerAbstract:: Because the Lancaster red-green test and the Hess screen are not widely used by most ophthalmologists, we used the alternate prism-cover test to study the effect of intravenous Edrophonium Chloride (Tensilon) on the ocular alignment of 30 normal subjects and 14 individuals with nonmyasthenic strabismus. After measurement of their baseline phorias and tropias, patients received an intravenous injection of Tensilon via the incremental dose technique until autonomic effects of the drug were noted or until 10 mg was administered. Another set of measurements of muscle balance was taken immediately postinjection and 2 and 5 min later. Apart from a small increase (mean, 2 prism dipoters; p = 0.004) in their exophoria at near, normal subjects exhibited no significant change in their phorias after Tensilon injection. One third to one half of the nonmyasthenic strabismics, however, showed a change in their vertical deviation after Tensilon (46% at distance and 38% at near), with the majority of them increasing their angle of squint. These changes were small (mean, 1.7 prism diopters; maximum, 5 prism diopters). In only one case did reversal of the direction of deviation occur. Tensilon produces a statistically significant increase in near exophorias of normal subjects and in vertical distance deviations of nonmyasthenic strabismics. These changes, however, are clinically insignificant and should not be considered to constitute a positive Tensilon test.
Pinhas M Livne - One of the best experts on this subject based on the ideXlab platform.
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the effect of cholinergic enhancement during filling cystometry can Edrophonium Chloride be used as a provocative test for overactive bladder
The Journal of Urology, 2001Co-Authors: Ofer Yossepowitch, Gabriel Gillon, Jack Baniel, D Engelstein, Pinhas M LivneAbstract:Purpose: Overactive bladder, a highly prevalent disorder, is suspected of having a low detection rate due to the lack of sensitive diagnostic tools. Recent studies imply the involvement of the cholinergic system in the pathophysiological mechanism underlying overactive bladder. We determined whether in vivo enhancement of cholinergic activity with Edrophonium Chloride, a potent cholinesterase inhibitor, would serve as a provocative maneuver to increase the sensitivity of filling cystometry.Materials and Methods: A total of 27 patients underwent a multichannel video urodynamic evaluation, followed by filling cystometry with the intravenous administration of 10 mg. Edrophonium Chloride. The response to Edrophonium was defined as a significant change in sensation and decreased bladder capacity, the induction or amplification of involuntary detrusor contractions, or significantly decreased detrusor compliance. Findings were compared in responders and nonresponders.Results: We identified 11 responders and 16 n...