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Jiande Chen - One of the best experts on this subject based on the ideXlab platform.
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Electrogastrography associated with symptomatic changes after prokinetic drug treatment for functional dyspepsia
T201203620.pdf, 2012Co-Authors: Hyun Chul Lim, Jiande Chen, Sang In Lee, Hyojin ParkAbstract:Electrogastrography associated with symptomatic changes after prokinetic drug treatment for functional dyspepsia
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multichannel Electrogastrography egg in normal subjects a multicenter study
Digestive Diseases and Sciences, 2004Co-Authors: Hrair P Simonian, Henry P Parkman, Jiande Chen, Greger Lindberg, Kashyap V Panganamamula, Chi Shao, Michael Lykke, Per Hansen, Bjorn Barner, Henrik BuhlAbstract:The aim of this study was to record gastric myoelectric activity using multichannel Electrogastrography (EGG) and to determine if there are differences due to age, gender, body mass, and study location. In 61 normal subjects from four centers, fasting multichannel EGG was recorded for 1 h, followed by two 1-h postprandial recordings after a test meal. Variables assessed included dominant frequency (DF) and its power, percentage time in 2- to 4-cpm frequency, and percentage slow-wave coupling (%SWC). There were no significant differences in EGG parameters with respect to gender or age. Subjects with a BMI >25 had a decrease in the absolute DF power but a similar increase in the postprandial DF power. Subjects with a BMI >25 had a postprandial decrease in the %SWC compared to those with a BMI <25. There was a decrease in postprandial %SWC in European/Asian centers compared to American centers. In conclusion, multichannel EGG provides assessment of electrical slow-wave coupling in addition to determining dominant frequency, power, and percentage normal rhythm. This multicenter study of normal subjects shows similar multichannel EGG values among different genders and ages. Body mass and ethnicity may impact on some of the EGG values.
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multichannel Electrogastrography egg in symptomatic patients a single center study
The American Journal of Gastroenterology, 2004Co-Authors: Hrair P Simonian, Jiande Chen, Robert S Fisher, Kashyap Panganamamula, Henry P ParkmanAbstract:OBJECTIVES: To determine the value of multichannel versus conventional single-channel Electrogastrography (EGG) and of an additional postprandial hour recording in symptomatic patients. METHODS: Eighteen normal subjects and 47 patients with upper GI symptoms underwent multichannel EGG with four cutaneous recording electrodes placed on the antral axis. Fasting EGG was recorded for 1 h, followed by meal ingestion, followed by two 1-h postprandial EGG recordings. Variables assessed: (1) dominant frequency (DF) and its power; (2) percent time in normal (2-4) cpm frequency; (3) average percent of slow wave coupling (% SWC). RESULTS: Normal values for single-channel EGG were: (1) DF from 2.5-3.3, 2.7-3.5, and 2.6-3.5 cpm in the fasting, first, and second postprandial hours; (2) percentage of time in 2-4 cpm: >50%, >65%, and >65% in the fasting, first, and second postprandial hours. Normal values for percent SWC using multichannel EGG were >50%, >55%, >55% in the fasting, first, and second postprandial hours. In the symptomatic patients, an abnormal 2-h single-channel EGG was obtained in 16 of 47 (34%) patients. Adding an additional 1 h of postprandial recording identified another 4 abnormal patients (20/47 = 43%). With multichannel EGG, abnormal results were obtained in 24 of 47 patients (51%) with the 2-h study. An additional 1 h of postprandial recording identified another 4 patients as abnormal (28/47 = 60%). CONCLUSIONS: Multichannel EGG recording improved the detection of abnormal gastric myoelectric activity in symptomatic patients. This study also demonstrates prolonging the postprandial recording to 2 h increases the diagnostic yield for both single-channel and multichannel EGG.
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characterization of gastric myoelectrical rhythms in patients with systemic sclerosis using multichannel surface Electrogastrography
Digestive Diseases and Sciences, 2002Co-Authors: Terry A Mcnearney, Xuemei Lin, Jharana Shrestha, Jeffrey R Lisse, Jiande ChenAbstract:The aim of this study was to characterize multichannel surface Electrogastrography (EGG) recordings in patients with systemic sclerosis (scleroderma, SSc) compared to normal controls. Ten SSc patients and 13 healthy age-matched controls were enrolled in this study. Gastric myoelectrical activity was recorded using a four-channel electrogastrograph with abdominal surface electrodes. The EGG was recorded in the morning for 1 hr in the fasting state, and 1 hr after a standardized (500 kcal) test meal. It was found that: (1) The regularity of the gastric slow wave was significantly lower in the SSc patients when compared with the normal controls in both fasting and fed states. (2) There was a significantly higher incidence of bradygastria in the SSc patients. (3) The SSc patients showed a significantly lower percentage of slow wave coupling among the four-channel EGGs than the controls. (4) In comparison with the controls, the patients showed an impaired spatial distribution of gastric slow wave power in both fasting and fed states and an impaired spatial distribution of slow wave frequency in the fasting state. It was concluded that SSc patients have an abnormal gastric slow wave as shown in the multichannel EGG as a decreased percentage of normal slow waves and impaired spatial coordination of gastric slow waves. The multichannel EGG may serve as a simple, noninvasive, and cost-effective method to assess gastric motility disorders and their relevance in patients with SSc.
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abnormal gastric slow waves in patients with functional dyspepsia assessed by multichannel Electrogastrography
American Journal of Physiology-gastrointestinal and Liver Physiology, 2001Co-Authors: Xuemei Lin, Jiande ChenAbstract:The aim of this study was to utilize multichannel Electrogastrography to investigate whether patients with functional dyspepsia had impaired propagation or coordination of gastric slow waves in the fasting state compared with healthy controls. The study was performed in 10 patients with functional dyspepsia and 11 healthy subjects. Gastric myoelectrical activity was measured by using surface Electrogastrography with a specially designed four-channel device. The study was performed for 30 min or more in the fasting state. Special computer programs were developed for the computation of the propagation and coupling of the gastric slow wave. It was found that, compared with the healthy controls, the patients showed a significantly lower percentage of slow wave propagation (58.0 ± 8.9 vs. 89.9 ± 2.6%, P < 0.002) and a significantly lower percentage of slow wave coupling (46.9 ± 4.4 vs. 61.5 ± 6.9%, P < 0.04). In addition, the patients showed inconsistencies in the frequency and regularity of the gastric slow wave among the four-channel electrogastrograms (EGGs). It was concluded that patients with functional dyspepsia have impaired slow wave propagation and coupling. Multichannel EGG has more information than single-channel EGG for the detection of gastric myoelectrical abnormalities.
Henry P Parkman - One of the best experts on this subject based on the ideXlab platform.
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multichannel Electrogastrography egg in normal subjects a multicenter study
Digestive Diseases and Sciences, 2004Co-Authors: Hrair P Simonian, Henry P Parkman, Jiande Chen, Greger Lindberg, Kashyap V Panganamamula, Chi Shao, Michael Lykke, Per Hansen, Bjorn Barner, Henrik BuhlAbstract:The aim of this study was to record gastric myoelectric activity using multichannel Electrogastrography (EGG) and to determine if there are differences due to age, gender, body mass, and study location. In 61 normal subjects from four centers, fasting multichannel EGG was recorded for 1 h, followed by two 1-h postprandial recordings after a test meal. Variables assessed included dominant frequency (DF) and its power, percentage time in 2- to 4-cpm frequency, and percentage slow-wave coupling (%SWC). There were no significant differences in EGG parameters with respect to gender or age. Subjects with a BMI >25 had a decrease in the absolute DF power but a similar increase in the postprandial DF power. Subjects with a BMI >25 had a postprandial decrease in the %SWC compared to those with a BMI <25. There was a decrease in postprandial %SWC in European/Asian centers compared to American centers. In conclusion, multichannel EGG provides assessment of electrical slow-wave coupling in addition to determining dominant frequency, power, and percentage normal rhythm. This multicenter study of normal subjects shows similar multichannel EGG values among different genders and ages. Body mass and ethnicity may impact on some of the EGG values.
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multichannel Electrogastrography egg in symptomatic patients a single center study
The American Journal of Gastroenterology, 2004Co-Authors: Hrair P Simonian, Jiande Chen, Robert S Fisher, Kashyap Panganamamula, Henry P ParkmanAbstract:OBJECTIVES: To determine the value of multichannel versus conventional single-channel Electrogastrography (EGG) and of an additional postprandial hour recording in symptomatic patients. METHODS: Eighteen normal subjects and 47 patients with upper GI symptoms underwent multichannel EGG with four cutaneous recording electrodes placed on the antral axis. Fasting EGG was recorded for 1 h, followed by meal ingestion, followed by two 1-h postprandial EGG recordings. Variables assessed: (1) dominant frequency (DF) and its power; (2) percent time in normal (2-4) cpm frequency; (3) average percent of slow wave coupling (% SWC). RESULTS: Normal values for single-channel EGG were: (1) DF from 2.5-3.3, 2.7-3.5, and 2.6-3.5 cpm in the fasting, first, and second postprandial hours; (2) percentage of time in 2-4 cpm: >50%, >65%, and >65% in the fasting, first, and second postprandial hours. Normal values for percent SWC using multichannel EGG were >50%, >55%, >55% in the fasting, first, and second postprandial hours. In the symptomatic patients, an abnormal 2-h single-channel EGG was obtained in 16 of 47 (34%) patients. Adding an additional 1 h of postprandial recording identified another 4 abnormal patients (20/47 = 43%). With multichannel EGG, abnormal results were obtained in 24 of 47 patients (51%) with the 2-h study. An additional 1 h of postprandial recording identified another 4 patients as abnormal (28/47 = 60%). CONCLUSIONS: Multichannel EGG recording improved the detection of abnormal gastric myoelectric activity in symptomatic patients. This study also demonstrates prolonging the postprandial recording to 2 h increases the diagnostic yield for both single-channel and multichannel EGG.
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measurement of gastrointestinal motility in the gi laboratory
Gastroenterology, 1998Co-Authors: Michael Camilleri, Henry P Parkman, William L Hasler, Eamonn Martin Quigley, Edy E SofferAbstract:Current tests of gastric and small intestinal motor function provide relevant physiological information, but their clinical utility is controversial. This article reviews the current procedures, indications, significance, pitfalls, and guidelines for gastrointestinal motility measurements by scintigraphy, gastroduodenojejunal manometry, and surface Electrogastrography in humans. Methods included review of literature and discussions in closed and open fora among investigators, including presentations for peer review at focused (Iowa City American Motility Society Symposium, December 1995) and national meetings (American Gastroenterological Association, May 1996, and American Motility Society, September 1996). The current tests are generally complementary; scintigraphy is typically the first test in the evaluation of gastric motor function and often confirms the clinical suspicion of dysmotility. Manometry identifies patterns suggestive of myopathy, neuropathy, or obstruction but may be most helpful when it shows entirely normal findings, because manometry helps in part to exclude dysmotility as a cause of symptoms. Electrogastrography may identify dysrhythmias or failure of signal power to increase postprandially; rhythm abnormalities may be independent of impaired emptying among dyspeptic patients. The best validated and clinically most significant results pertain to transit tests; manometry may contribute importantly to the diagnostic process; and the significance of Electrogastrography remains to be fully elucidated.
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edrophonium provocative testing during Electrogastrography egg effects on dyspeptic symptoms and the egg
Digestive Diseases and Sciences, 1998Co-Authors: Eugene S Bonapace, Henry P Parkman, Robert S FisherAbstract:The aim of this study was to determine whetheredrophonium induces dyspeptic symptoms and/or gastricmyoelectric changes in normal subjects and patients withfunctional dyspepsia. Eighteen normal controls and 28 patients with functional dyspepsiaunderwent Electrogastrography (EGG) with edrophoniumadministration. After EGG recording with 1-hr fastingand 2-hr postprandial periods, subjects received anintravenous infusion of saline (placebo) followed byedrophonium 10 mg. After each injection, the EGG wasrecorded for 15 min and symptoms scored. Patients withfunctional dyspepsia had significantly more frequent gastrointestinal symptoms in response toedrophonium than normal controls. Edrophonium had noeffect on EGG dominant frequency, but increased thepower of the dominant frequency in both controls anddyspeptic patients. In the dyspeptic patients,reproduction of the patient's symptoms was associatedwith an increase in the power of the dominant frequency,whereas when no symptoms were produced, there was nochange in power. Overall, 21 of 28 dyspeptic patients(75%) had either an abnormal baseline EGG (N = 10) or anormal EGG and positive edrophonium test (N = 11). Inconclusion, edrophonium administration can reproduce symptoms in some dyspeptic patients.Symptoms after edrophonium administration may be relatedto either more vigorous gastric contractions and/orincreased visceral perception of normal gastric contractions.
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Electrogastrography and gastric emptying scintigraphy are complementary for assessment of dyspepsia
Journal of Clinical Gastroenterology, 1997Co-Authors: Henry P Parkman, Mark A Miller, D M Trate, Linda C Knight, Jeanluc Urbain, Alan H Maurer, Robert S FisherAbstract:We have tried to correlate abnormalities in Electrogastrography (EGG) and gastric emptying (GE) with symptom severity in patients with functional dyspepsia. Seventy-two patients with functional dyspepsia underwent EGG, GE, and symptom severity quantitation. EGGs were assessed for dominant frequency (DF), percentage of time of DF in the 2 to 4 cpm range, and postprandial-fasting DF power ratio. Solid-phase GE scintigraphy was assessed for 2-hour percentage retention. Symptoms of upper abdominal discomfort, early satiety, postprandial abdominal distension, nausea, vomiting, and anorexia were graded as none (0), mild (1), moderate (2), and severe (3); the sum represented a total symptom score. The EGG was abnormal in 11 of 22 (50%) patients with delayed GE compared with 11 of 50 (22%) with normal GE (p < 0.025). The total symptom scores were higher in patients with both delayed GE and abnormal EGG compared with patients with normal GE and EGG, normal GE and abnormal EGG, and delayed GE and normal EGG. We conclude that EGG abnormalities are more common in dyspeptic patients with delayed GE. Patients with both delayed GE and abnormal EGG have more severe symptoms. Our results suggest that EGG and GE complement each other in correlating symptoms to gastric dysmotility.
Kenneth L Koch - One of the best experts on this subject based on the ideXlab platform.
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Electrogastrography for suspected gastroparesis
2021Co-Authors: Kenneth L KochAbstract:Abstract Electrogastrography is the noninvasive method for recording electrogastrograms or EGGs. EGGs measure gastric myoelectrical activity, the sum of ongoing slow wave and plateau/action potential activities of the stomach. Interstitial cells of Cajal (ICCs) are the pacemaker cells that generate the slow waves. The normal 3 cpm slow waves coordinate the plateau/action potentials that produce circular muscle contractions and the normal 3 per minute gastric peristaltic waves that result in normal gastric emptying. Gastric dysrhythmias evoked by the water load satiety test are also recorded in EGGs and are termed tachygastrias, bradygastrias, and mixed dysrhythmias. Gastric dysrhythmias are associated with depletion of ICCs, nausea, and symptoms associated with gastroparesis. Normal and hypernormal 3 cpm GMA are found in approximately 20% of patients with gastroparesis, a subtype that responds to pyloric therapies. Ingestion of poor water load volumes suggests gastric accommodation dysfunction. EGG results identify subtypes of gastroparesis with normal 3 cpm GMA or dysrhythmic GMA and guide more precise treatment approaches. Clinical indications for recording EGGs in patients with suspected gastroparesis are reviewed.
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Electrogastrography for evaluation of patients with suspected gastroparesis
2012Co-Authors: Kenneth L KochAbstract:Electrogastrography (EGG) refers to methods for recording gastric myoelectrical activity with electrodes placed on the surface of the abdomen. The signal is termed an electrogastrogram or EGG. The EGG signal reflects gastric slow-wave activity and plateau or spike potential activity from the stomach. The normal EGG rhythm is 3 cycles per minute (cpm). The amplitude of the 3 cpm EGG waves increases after meals when slow waves are coupled to plateau or spike potentials. Gastric dysrhythmias are termed tachygastrias and bradygastrias and are seen in nausea syndromes and in the majority of patients with gastroparesis. EGG recordings provide insights into the pathobiology of gastroparesis and are complementary to gastric emptying tests.
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Electrogastrography physiological basis and clinical application in diabetic gastropathy
Diabetes Technology & Therapeutics, 2001Co-Authors: Kenneth L KochAbstract:Electrogastrography is the recording and measurement of gastric myoelectrical activity from electrodes placed on the surface of the epigastrium. Normal electrogastrograms (EGGs) reflect 3 cycles per min (cpm) gastric myoelectrical activity produced by specialized pacemaker cells, the interstitial cells of Cajal, located in the muscular wall of the gastric corpus and antrum. Gastric dysrhythmias (tachygastrias and bradygastrias) are disturbances of the normal gastric pacesetter potentials and are associated with symptoms of nausea, epigastric fullness, and bloating and with hyperglycemia and delayed gastric emptying. In diabetic gastropathy, the normal 3-cpm electrical rhythm is replaced with bradygastrias, tachygastrias, and mixed or nonspecific dysrhythmias. Diagnosis of gastric dysrhythmias identifies an objective neuromuscular abnormality in diabetic patients with upper gastrointestinal (GI) symptoms. Correction of gastric dysrhythmias decreases upper GI symptoms and may improve gastric emptying all of...
Hrair P Simonian - One of the best experts on this subject based on the ideXlab platform.
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multichannel Electrogastrography egg in normal subjects a multicenter study
Digestive Diseases and Sciences, 2004Co-Authors: Hrair P Simonian, Henry P Parkman, Jiande Chen, Greger Lindberg, Kashyap V Panganamamula, Chi Shao, Michael Lykke, Per Hansen, Bjorn Barner, Henrik BuhlAbstract:The aim of this study was to record gastric myoelectric activity using multichannel Electrogastrography (EGG) and to determine if there are differences due to age, gender, body mass, and study location. In 61 normal subjects from four centers, fasting multichannel EGG was recorded for 1 h, followed by two 1-h postprandial recordings after a test meal. Variables assessed included dominant frequency (DF) and its power, percentage time in 2- to 4-cpm frequency, and percentage slow-wave coupling (%SWC). There were no significant differences in EGG parameters with respect to gender or age. Subjects with a BMI >25 had a decrease in the absolute DF power but a similar increase in the postprandial DF power. Subjects with a BMI >25 had a postprandial decrease in the %SWC compared to those with a BMI <25. There was a decrease in postprandial %SWC in European/Asian centers compared to American centers. In conclusion, multichannel EGG provides assessment of electrical slow-wave coupling in addition to determining dominant frequency, power, and percentage normal rhythm. This multicenter study of normal subjects shows similar multichannel EGG values among different genders and ages. Body mass and ethnicity may impact on some of the EGG values.
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multichannel Electrogastrography egg in symptomatic patients a single center study
The American Journal of Gastroenterology, 2004Co-Authors: Hrair P Simonian, Jiande Chen, Robert S Fisher, Kashyap Panganamamula, Henry P ParkmanAbstract:OBJECTIVES: To determine the value of multichannel versus conventional single-channel Electrogastrography (EGG) and of an additional postprandial hour recording in symptomatic patients. METHODS: Eighteen normal subjects and 47 patients with upper GI symptoms underwent multichannel EGG with four cutaneous recording electrodes placed on the antral axis. Fasting EGG was recorded for 1 h, followed by meal ingestion, followed by two 1-h postprandial EGG recordings. Variables assessed: (1) dominant frequency (DF) and its power; (2) percent time in normal (2-4) cpm frequency; (3) average percent of slow wave coupling (% SWC). RESULTS: Normal values for single-channel EGG were: (1) DF from 2.5-3.3, 2.7-3.5, and 2.6-3.5 cpm in the fasting, first, and second postprandial hours; (2) percentage of time in 2-4 cpm: >50%, >65%, and >65% in the fasting, first, and second postprandial hours. Normal values for percent SWC using multichannel EGG were >50%, >55%, >55% in the fasting, first, and second postprandial hours. In the symptomatic patients, an abnormal 2-h single-channel EGG was obtained in 16 of 47 (34%) patients. Adding an additional 1 h of postprandial recording identified another 4 abnormal patients (20/47 = 43%). With multichannel EGG, abnormal results were obtained in 24 of 47 patients (51%) with the 2-h study. An additional 1 h of postprandial recording identified another 4 patients as abnormal (28/47 = 60%). CONCLUSIONS: Multichannel EGG recording improved the detection of abnormal gastric myoelectric activity in symptomatic patients. This study also demonstrates prolonging the postprandial recording to 2 h increases the diagnostic yield for both single-channel and multichannel EGG.
Greger Lindberg - One of the best experts on this subject based on the ideXlab platform.
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Electrogastrography poor correlation with antro duodenal manometry and doubtful clinical usefulness in adults
World Journal of Gastroenterology, 2007Co-Authors: S Abid, Greger LindbergAbstract:AIM: To investigate if there is a correlation between electrical activity measured by Electrogastrography (EGG) and contractile activity of the stomach as measured by antroduodenal manometry (ADM). We also studied whether the underlying motility disorder could be predicted from EGG parameters. METHODS: We compared 21 parameters measured from EGG with 8 parameters measured from ADM. The ability of EGG to identify the underlying diagnosis was tested by comparing EGG parameters for each diagnosis group against other patients. The study comprised recordings from 148 patients and 125 females. Their median age was 45 (range 17-76) years. RESULTS: We found few and weak correlations between EGG and ADM. Specifically the correlation between parameters reflecting the response to meal was poor (r = -0.07, P = 0.39). The discriminatory power of EGG for underlying motility disorder was also low. Patients with slow transit constipation (STC) showed a lower postprandial power in normogastric (3.7 ± 0.5 vs 4.0 ± 0.5) and tachygastric (3.5 ± 0.4 vs 3.7 ± 0.4) regions, a lower percentage of time with normogastria [87.2 (56.5-100)% vs 95.7 (0-100)%], and a higher percentage of time with tachygastria [9.3 (0-33)% vs 3.5 (0-100)%] and bradygastria [1.8 (0-20)% vs 0 (0-17.1)%]. Patients with irritable bowel syndrome had a higher percentage of time with normogastria [96.5 (62.5-100)% vs 93.3 (0-100)%] and a less unstable dominant frequency as measured by the instability coefficient [15 (3-77) vs 24 (2-72)]. CONCLUSION: EGG and ADM seem to measure different aspects of gastric motor activity but cannot show a spatial correlation. The diagnostic value of EGG is poor, but EGG may have some value for the identification of patients with STC.
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20 Electrogastrography is of limited value in the diagnosis of motility disorders
Neurogastroenterology and Motility, 2006Co-Authors: S Abid, Greger LindbergAbstract:Background: Electrogastrography (EGG) is a technique for recording gastric myoelectric activity. Conflicting results were obtained in previous studies when EGG was applied in motility disorders of the stomach associated with various systemic diseases. Aim: To investigate whether the underlying diagnosis could be predicted from EGG parameters. Material and methods: This is a retrospective analysis of patients with motility disorders who underwent EGG as part of their clinical work-up. A single bipolar channel measured the EGG. The ability of EGG to identify diagnostic groups was tested by comparing 21 EGG parameters for each diagnostic group or symptom against all other patients in the sample. Results: A total of 151 patients, 125 (83%) females, and mean age 45 ± 14 years were analysed. There were 52 patients with irritable bowel syndrome (IBS), 22 with enteric dysmotility, 26 with slow transit constipation (STC), 11 with chronic intestinal pseudo-obstruction (CIP), 13 with gastroparesis or functional dyspepsia, three post-surgical, and 24 patients with other diagnoses. In general, the discriminatory power of EGG for underlying motility disorder was low. Only those with STC showed a reasonable number of differences in EGG parameters compared to all other groups (Table). Patients with IBS had lower fasting and postprandial variability of the dominant frequency (DF) and a higher percentage of postprandial time with normogastric DF. Conclusion: The ability of EGG to identify motility disorders as well as symptoms in general was poor. EGG findings in patients with STC require validation. Table Table. Significant EGG variables in slow transit constipation (STC) EGG parameter STC (n = 26) Other diagnosis (125) Postprandial normal power (Log) 3.7 ± 0.4 4.0 ± 0.5 Postprandial tachygastria power (Log) 3.5 ± 0.4 3.7 ± 0.4 Postprandial bradygastria% median and range 2 (0–20) 0 (0–17) Postprandial normal% median and range 87 (56–100) 96 (0–100) Postprandial tachygastria% median and range 9 (0–33) 3 (0–100) Postprandial DFIC% median and range 26 (8–72) 18 (2–77) Postprandial period dominant power PDP (Log) 2.1 ± 0.6 2.4 ± 0.5 Power Ratio (Log) 0.2 ± 0.5 0.4 ± 0.5
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multichannel Electrogastrography egg in normal subjects a multicenter study
Digestive Diseases and Sciences, 2004Co-Authors: Hrair P Simonian, Henry P Parkman, Jiande Chen, Greger Lindberg, Kashyap V Panganamamula, Chi Shao, Michael Lykke, Per Hansen, Bjorn Barner, Henrik BuhlAbstract:The aim of this study was to record gastric myoelectric activity using multichannel Electrogastrography (EGG) and to determine if there are differences due to age, gender, body mass, and study location. In 61 normal subjects from four centers, fasting multichannel EGG was recorded for 1 h, followed by two 1-h postprandial recordings after a test meal. Variables assessed included dominant frequency (DF) and its power, percentage time in 2- to 4-cpm frequency, and percentage slow-wave coupling (%SWC). There were no significant differences in EGG parameters with respect to gender or age. Subjects with a BMI >25 had a decrease in the absolute DF power but a similar increase in the postprandial DF power. Subjects with a BMI >25 had a postprandial decrease in the %SWC compared to those with a BMI <25. There was a decrease in postprandial %SWC in European/Asian centers compared to American centers. In conclusion, multichannel EGG provides assessment of electrical slow-wave coupling in addition to determining dominant frequency, power, and percentage normal rhythm. This multicenter study of normal subjects shows similar multichannel EGG values among different genders and ages. Body mass and ethnicity may impact on some of the EGG values.
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24 hour ambulatory Electrogastrography in healthy volunteers
Scandinavian Journal of Gastroenterology, 1996Co-Authors: Greger Lindberg, M Iwarzon, B HammarlundAbstract:Background: Development of Electrogastrography, the recording of gastric electric rhythm from cutaneous electrodes, for clinical purposes has been hampered by methodologic problems and the lack of an ambulatory technique. We have evaluated a newly developed system for ambulatory Electrogastrography. Methods: 24-Hour recordings were obtained from 30 healthy volunteers. We used digital filtering, a Hamming window, and spectral analysis to determine the dominant frequency of successive 256-sec segments of data. Results: Low-frequency noise disturbed the primary signal. After secondary filtering a stable normogastric (2-4 cpm) rhythm was present during a median of 49% (range, 34-79%) of the recording time. The mean frequency of gastric electric activity varied from 2.92 ± 0.15 cpm (mean ± SD) at mid-day to 2.72 ± 0.13 cpm in the late night. Conclusions: Ambulatory recording of Electrogastrography needs technical improvement. The electrogastrogram shows a circadian variation in frequency.