The Experts below are selected from a list of 108 Experts worldwide ranked by ideXlab platform
Mansun Chan - One of the best experts on this subject based on the ideXlab platform.
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32.9 nV/rt Hz -60.6 dB THD dual-band micro-electrode array signal acquisition IC
IEEE Journal of Solid-State Circuits, 2012Co-Authors: Jing Guo, Jiageng Huang, Jessica Ka Yan Law, Chi-kong Yeung, Jie Yuan, Mansun ChanAbstract:The dual-band recording of the local-field Potential (LFP, 0.1-200 Hz) and the Spike Potential (SP, 200 Hz-10 kHz) is important for physiological studies at the cellular level. Recent study shows that the LFP signal plays important roles in modulating many profound cellular mechanisms. Although various bio-signal acquisition circuits have been reported over the years, few designs are applicable to capture both LFP and SP signals. To record both signals accurately, acquisition circuits need low noise and good linearity in both bands. In this paper, we report the design of a dual-band acquisition IC for microelectrode array (MEA) recording. The novel design uses a continuous-time (CT) front-end with chopping to suppress the noise in the LFP band, and a discrete-time (DT) back-end to achieve good linearity. The acquisition channel is fully differential, which leads to a high common-mode rejection ratio (CMRR) and power supply rejection ratio (PSRR) without the 50 Hz injection. The design interfaces the microelectrode with a transistor gate, which has high input impedance. A prototype monolithic acquisition IC is fabricated in a 0.35 μm CMOS process. It includes 16 channels and an 11 bit successive-approximation (SAR) analog-to-digital converter (ADC). Every channel acquires cellular signals up to 20 mVpp with 32.9 nV/Hz0.5 and ; 110 dB) and PSRR ( >; 110 dB). The noise-efficiency factor (NEF) of the acquisition channel is 7.6. The IC is experimented to record the field Potential from cultured rat cardiomyocytes in-vitro. Overall, the new MEA acquisition channel achieves the state-of-art performance.
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32.9 nV/rt Hz ${-}$60.6 dB THD Dual-Band Micro-Electrode Array Signal Acquisition IC
IEEE Journal of Solid-State Circuits, 2012Co-Authors: Jie Yuan, Jiageng Huang, Chi-kong Yeung, Mansun ChanAbstract:The dual-band recording of the local-field Potential (LFP, 0.1-200 Hz) and the Spike Potential (SP, 200 Hz-10 kHz) is important for physiological studies at the cellular level. Recent study shows that the LFP signal plays important roles in modulating many profound cellular mechanisms. Although various bio-signal acquisition circuits have been reported over the years, few designs are applicable to capture both LFP and SP signals. To record both signals accurately, acquisition circuits need low noise and good linearity in both bands. In this paper, we report the design of a dual-band acquisition IC for microelectrode array (MEA) recording. The novel design uses a continuous-time (CT) front-end with chopping to suppress the noise in the LFP band, and a discrete-time (DT) back-end to achieve good linearity. The acquisition channel is fully differential, which leads to a high common-mode rejection ratio (CMRR) and power supply rejection ratio (PSRR) without the 50 Hz injection. The design interfaces the microelectrode with a transistor gate, which has high input impedance. A prototype monolithic acquisition IC is fabricated in a 0.35 μm CMOS process. It includes 16 channels and an 11 bit successive-approximation (SAR) analog-to-digital converter (ADC). Every channel acquires cellular signals up to 20 mVpp with 32.9 nV/Hz0.5 and ; 110 dB) and PSRR ( >; 110 dB). The noise-efficiency factor (NEF) of the acquisition channel is 7.6. The IC is experimented to record the field Potential from cultured rat cardiomyocytes in-vitro. Overall, the new MEA acquisition channel achieves the state-of-art performance.
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A 38.6nV/Hz0.5 −59.6dB THD dual-band micro-electrode array signal acquisition IC
2011 IEEE Custom Integrated Circuits Conference (CICC), 2011Co-Authors: Jiageng Huang, Chi-kong Yeung, Jie Yuan, Mansun ChanAbstract:Cellular field Potential includes local field Potential (LFP, 0.1Hz~200Hz) and Spike Potential (SP, 200Hz~10kHz). SP signal has been the focus of physiological studies. Recent study shows that the LFP signal plays important roles in modulating many profound cellular mechanisms. Although many bio-signal acquisition circuits have been reported over the years, few designs are applicable for both LFP and SP signals. To record both signals accurately, acquisition circuits need low noise and good linearity in both bands. In this paper, we report the design of a dual-band acquisition IC for microelectrode array (MEA) recording. The novel design uses a continuous-time (CT) front-end with chopping to suppress the noise, and a discrete-time (DT) back-end to achieve good linearity. A prototype monolithic acquisition IC is fabricated in a 0.35um CMOS process. It has 16 acquisition channels and a 11bit successive-approximation (SAR) ADC. Every channel achieves 38.6nV/Hz0.5 noise and ;110dB) and PSRR (>;110dB). NEF of the new design is 6.4. The IC is experimented with rat cardio-myocytes recording.
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Highly Accurate Dual-Band Cellular Field Potential Acquisition For Brain–Machine Interface
IEEE Journal on Emerging and Selected Topics in Circuits and Systems, 2011Co-Authors: Jie Yuan, Jiageng Huang, Chi-kong Yeung, Mansun ChanAbstract:Cellular field Potential includes local field Potential (LFP, 0.1 Hz–200 Hz) and Spike Potential (SP, 200 Hz–10 kHz). In physiological studies of the brain, SP signal has been the focus. Various circuits have been reported to acquire SP signals in brain–machine interface (BMI) systems over the years. Recent study shows that the LFP signal plays important roles in modulating many profound neuronal mechanisms in the brain. It is important for new BMI design to record the dual-band signal accurately, which demands acquisition circuits to have low noise and good linearity in both bands. In this paper, we report the design of a dual-band acquisition integrated circuit (IC) for microelectrode recording. The novel design uses a continuous- time (CT) front-end with chopping to suppress the noise, and a discrete-time (DT) back-end to achieve good linearity. A prototype monolithic acquisition IC is fabricated in a 0.35 $\mu{\rm m}$ CMOS process. It has 16 acquisition channels and an 11 bit successive-approximation (SAR) analog-to-digital converter (ADC). Silicon measurements show that every channel has $29.2\,{\rm nV}/{\rm Hz}^{0.5}$ noise and ${ 110}~{\rm dB})$ and power-supply rejection ratio (PSRR) $({> 110}~{\rm dB})$. Noise-efficiency factor (NEF) of the acquisition channel is 6.6. The IC is experimented with rat cardio-myocytes recording.
Jie Yuan - One of the best experts on this subject based on the ideXlab platform.
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32.9 nV/rt Hz -60.6 dB THD dual-band micro-electrode array signal acquisition IC
IEEE Journal of Solid-State Circuits, 2012Co-Authors: Jing Guo, Jiageng Huang, Jessica Ka Yan Law, Chi-kong Yeung, Jie Yuan, Mansun ChanAbstract:The dual-band recording of the local-field Potential (LFP, 0.1-200 Hz) and the Spike Potential (SP, 200 Hz-10 kHz) is important for physiological studies at the cellular level. Recent study shows that the LFP signal plays important roles in modulating many profound cellular mechanisms. Although various bio-signal acquisition circuits have been reported over the years, few designs are applicable to capture both LFP and SP signals. To record both signals accurately, acquisition circuits need low noise and good linearity in both bands. In this paper, we report the design of a dual-band acquisition IC for microelectrode array (MEA) recording. The novel design uses a continuous-time (CT) front-end with chopping to suppress the noise in the LFP band, and a discrete-time (DT) back-end to achieve good linearity. The acquisition channel is fully differential, which leads to a high common-mode rejection ratio (CMRR) and power supply rejection ratio (PSRR) without the 50 Hz injection. The design interfaces the microelectrode with a transistor gate, which has high input impedance. A prototype monolithic acquisition IC is fabricated in a 0.35 μm CMOS process. It includes 16 channels and an 11 bit successive-approximation (SAR) analog-to-digital converter (ADC). Every channel acquires cellular signals up to 20 mVpp with 32.9 nV/Hz0.5 and ; 110 dB) and PSRR ( >; 110 dB). The noise-efficiency factor (NEF) of the acquisition channel is 7.6. The IC is experimented to record the field Potential from cultured rat cardiomyocytes in-vitro. Overall, the new MEA acquisition channel achieves the state-of-art performance.
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32.9 nV/rt Hz ${-}$60.6 dB THD Dual-Band Micro-Electrode Array Signal Acquisition IC
IEEE Journal of Solid-State Circuits, 2012Co-Authors: Jie Yuan, Jiageng Huang, Chi-kong Yeung, Mansun ChanAbstract:The dual-band recording of the local-field Potential (LFP, 0.1-200 Hz) and the Spike Potential (SP, 200 Hz-10 kHz) is important for physiological studies at the cellular level. Recent study shows that the LFP signal plays important roles in modulating many profound cellular mechanisms. Although various bio-signal acquisition circuits have been reported over the years, few designs are applicable to capture both LFP and SP signals. To record both signals accurately, acquisition circuits need low noise and good linearity in both bands. In this paper, we report the design of a dual-band acquisition IC for microelectrode array (MEA) recording. The novel design uses a continuous-time (CT) front-end with chopping to suppress the noise in the LFP band, and a discrete-time (DT) back-end to achieve good linearity. The acquisition channel is fully differential, which leads to a high common-mode rejection ratio (CMRR) and power supply rejection ratio (PSRR) without the 50 Hz injection. The design interfaces the microelectrode with a transistor gate, which has high input impedance. A prototype monolithic acquisition IC is fabricated in a 0.35 μm CMOS process. It includes 16 channels and an 11 bit successive-approximation (SAR) analog-to-digital converter (ADC). Every channel acquires cellular signals up to 20 mVpp with 32.9 nV/Hz0.5 and ; 110 dB) and PSRR ( >; 110 dB). The noise-efficiency factor (NEF) of the acquisition channel is 7.6. The IC is experimented to record the field Potential from cultured rat cardiomyocytes in-vitro. Overall, the new MEA acquisition channel achieves the state-of-art performance.
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A 38.6nV/Hz0.5 −59.6dB THD dual-band micro-electrode array signal acquisition IC
2011 IEEE Custom Integrated Circuits Conference (CICC), 2011Co-Authors: Jiageng Huang, Chi-kong Yeung, Jie Yuan, Mansun ChanAbstract:Cellular field Potential includes local field Potential (LFP, 0.1Hz~200Hz) and Spike Potential (SP, 200Hz~10kHz). SP signal has been the focus of physiological studies. Recent study shows that the LFP signal plays important roles in modulating many profound cellular mechanisms. Although many bio-signal acquisition circuits have been reported over the years, few designs are applicable for both LFP and SP signals. To record both signals accurately, acquisition circuits need low noise and good linearity in both bands. In this paper, we report the design of a dual-band acquisition IC for microelectrode array (MEA) recording. The novel design uses a continuous-time (CT) front-end with chopping to suppress the noise, and a discrete-time (DT) back-end to achieve good linearity. A prototype monolithic acquisition IC is fabricated in a 0.35um CMOS process. It has 16 acquisition channels and a 11bit successive-approximation (SAR) ADC. Every channel achieves 38.6nV/Hz0.5 noise and ;110dB) and PSRR (>;110dB). NEF of the new design is 6.4. The IC is experimented with rat cardio-myocytes recording.
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Highly Accurate Dual-Band Cellular Field Potential Acquisition For Brain–Machine Interface
IEEE Journal on Emerging and Selected Topics in Circuits and Systems, 2011Co-Authors: Jie Yuan, Jiageng Huang, Chi-kong Yeung, Mansun ChanAbstract:Cellular field Potential includes local field Potential (LFP, 0.1 Hz–200 Hz) and Spike Potential (SP, 200 Hz–10 kHz). In physiological studies of the brain, SP signal has been the focus. Various circuits have been reported to acquire SP signals in brain–machine interface (BMI) systems over the years. Recent study shows that the LFP signal plays important roles in modulating many profound neuronal mechanisms in the brain. It is important for new BMI design to record the dual-band signal accurately, which demands acquisition circuits to have low noise and good linearity in both bands. In this paper, we report the design of a dual-band acquisition integrated circuit (IC) for microelectrode recording. The novel design uses a continuous- time (CT) front-end with chopping to suppress the noise, and a discrete-time (DT) back-end to achieve good linearity. A prototype monolithic acquisition IC is fabricated in a 0.35 $\mu{\rm m}$ CMOS process. It has 16 acquisition channels and an 11 bit successive-approximation (SAR) analog-to-digital converter (ADC). Silicon measurements show that every channel has $29.2\,{\rm nV}/{\rm Hz}^{0.5}$ noise and ${ 110}~{\rm dB})$ and power-supply rejection ratio (PSRR) $({> 110}~{\rm dB})$. Noise-efficiency factor (NEF) of the acquisition channel is 6.6. The IC is experimented with rat cardio-myocytes recording.
Jiageng Huang - One of the best experts on this subject based on the ideXlab platform.
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32.9 nV/rt Hz -60.6 dB THD dual-band micro-electrode array signal acquisition IC
IEEE Journal of Solid-State Circuits, 2012Co-Authors: Jing Guo, Jiageng Huang, Jessica Ka Yan Law, Chi-kong Yeung, Jie Yuan, Mansun ChanAbstract:The dual-band recording of the local-field Potential (LFP, 0.1-200 Hz) and the Spike Potential (SP, 200 Hz-10 kHz) is important for physiological studies at the cellular level. Recent study shows that the LFP signal plays important roles in modulating many profound cellular mechanisms. Although various bio-signal acquisition circuits have been reported over the years, few designs are applicable to capture both LFP and SP signals. To record both signals accurately, acquisition circuits need low noise and good linearity in both bands. In this paper, we report the design of a dual-band acquisition IC for microelectrode array (MEA) recording. The novel design uses a continuous-time (CT) front-end with chopping to suppress the noise in the LFP band, and a discrete-time (DT) back-end to achieve good linearity. The acquisition channel is fully differential, which leads to a high common-mode rejection ratio (CMRR) and power supply rejection ratio (PSRR) without the 50 Hz injection. The design interfaces the microelectrode with a transistor gate, which has high input impedance. A prototype monolithic acquisition IC is fabricated in a 0.35 μm CMOS process. It includes 16 channels and an 11 bit successive-approximation (SAR) analog-to-digital converter (ADC). Every channel acquires cellular signals up to 20 mVpp with 32.9 nV/Hz0.5 and ; 110 dB) and PSRR ( >; 110 dB). The noise-efficiency factor (NEF) of the acquisition channel is 7.6. The IC is experimented to record the field Potential from cultured rat cardiomyocytes in-vitro. Overall, the new MEA acquisition channel achieves the state-of-art performance.
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32.9 nV/rt Hz ${-}$60.6 dB THD Dual-Band Micro-Electrode Array Signal Acquisition IC
IEEE Journal of Solid-State Circuits, 2012Co-Authors: Jie Yuan, Jiageng Huang, Chi-kong Yeung, Mansun ChanAbstract:The dual-band recording of the local-field Potential (LFP, 0.1-200 Hz) and the Spike Potential (SP, 200 Hz-10 kHz) is important for physiological studies at the cellular level. Recent study shows that the LFP signal plays important roles in modulating many profound cellular mechanisms. Although various bio-signal acquisition circuits have been reported over the years, few designs are applicable to capture both LFP and SP signals. To record both signals accurately, acquisition circuits need low noise and good linearity in both bands. In this paper, we report the design of a dual-band acquisition IC for microelectrode array (MEA) recording. The novel design uses a continuous-time (CT) front-end with chopping to suppress the noise in the LFP band, and a discrete-time (DT) back-end to achieve good linearity. The acquisition channel is fully differential, which leads to a high common-mode rejection ratio (CMRR) and power supply rejection ratio (PSRR) without the 50 Hz injection. The design interfaces the microelectrode with a transistor gate, which has high input impedance. A prototype monolithic acquisition IC is fabricated in a 0.35 μm CMOS process. It includes 16 channels and an 11 bit successive-approximation (SAR) analog-to-digital converter (ADC). Every channel acquires cellular signals up to 20 mVpp with 32.9 nV/Hz0.5 and ; 110 dB) and PSRR ( >; 110 dB). The noise-efficiency factor (NEF) of the acquisition channel is 7.6. The IC is experimented to record the field Potential from cultured rat cardiomyocytes in-vitro. Overall, the new MEA acquisition channel achieves the state-of-art performance.
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A 38.6nV/Hz0.5 −59.6dB THD dual-band micro-electrode array signal acquisition IC
2011 IEEE Custom Integrated Circuits Conference (CICC), 2011Co-Authors: Jiageng Huang, Chi-kong Yeung, Jie Yuan, Mansun ChanAbstract:Cellular field Potential includes local field Potential (LFP, 0.1Hz~200Hz) and Spike Potential (SP, 200Hz~10kHz). SP signal has been the focus of physiological studies. Recent study shows that the LFP signal plays important roles in modulating many profound cellular mechanisms. Although many bio-signal acquisition circuits have been reported over the years, few designs are applicable for both LFP and SP signals. To record both signals accurately, acquisition circuits need low noise and good linearity in both bands. In this paper, we report the design of a dual-band acquisition IC for microelectrode array (MEA) recording. The novel design uses a continuous-time (CT) front-end with chopping to suppress the noise, and a discrete-time (DT) back-end to achieve good linearity. A prototype monolithic acquisition IC is fabricated in a 0.35um CMOS process. It has 16 acquisition channels and a 11bit successive-approximation (SAR) ADC. Every channel achieves 38.6nV/Hz0.5 noise and ;110dB) and PSRR (>;110dB). NEF of the new design is 6.4. The IC is experimented with rat cardio-myocytes recording.
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Highly Accurate Dual-Band Cellular Field Potential Acquisition For Brain–Machine Interface
IEEE Journal on Emerging and Selected Topics in Circuits and Systems, 2011Co-Authors: Jie Yuan, Jiageng Huang, Chi-kong Yeung, Mansun ChanAbstract:Cellular field Potential includes local field Potential (LFP, 0.1 Hz–200 Hz) and Spike Potential (SP, 200 Hz–10 kHz). In physiological studies of the brain, SP signal has been the focus. Various circuits have been reported to acquire SP signals in brain–machine interface (BMI) systems over the years. Recent study shows that the LFP signal plays important roles in modulating many profound neuronal mechanisms in the brain. It is important for new BMI design to record the dual-band signal accurately, which demands acquisition circuits to have low noise and good linearity in both bands. In this paper, we report the design of a dual-band acquisition integrated circuit (IC) for microelectrode recording. The novel design uses a continuous- time (CT) front-end with chopping to suppress the noise, and a discrete-time (DT) back-end to achieve good linearity. A prototype monolithic acquisition IC is fabricated in a 0.35 $\mu{\rm m}$ CMOS process. It has 16 acquisition channels and an 11 bit successive-approximation (SAR) analog-to-digital converter (ADC). Silicon measurements show that every channel has $29.2\,{\rm nV}/{\rm Hz}^{0.5}$ noise and ${ 110}~{\rm dB})$ and power-supply rejection ratio (PSRR) $({> 110}~{\rm dB})$. Noise-efficiency factor (NEF) of the acquisition channel is 6.6. The IC is experimented with rat cardio-myocytes recording.
Chi-kong Yeung - One of the best experts on this subject based on the ideXlab platform.
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32.9 nV/rt Hz -60.6 dB THD dual-band micro-electrode array signal acquisition IC
IEEE Journal of Solid-State Circuits, 2012Co-Authors: Jing Guo, Jiageng Huang, Jessica Ka Yan Law, Chi-kong Yeung, Jie Yuan, Mansun ChanAbstract:The dual-band recording of the local-field Potential (LFP, 0.1-200 Hz) and the Spike Potential (SP, 200 Hz-10 kHz) is important for physiological studies at the cellular level. Recent study shows that the LFP signal plays important roles in modulating many profound cellular mechanisms. Although various bio-signal acquisition circuits have been reported over the years, few designs are applicable to capture both LFP and SP signals. To record both signals accurately, acquisition circuits need low noise and good linearity in both bands. In this paper, we report the design of a dual-band acquisition IC for microelectrode array (MEA) recording. The novel design uses a continuous-time (CT) front-end with chopping to suppress the noise in the LFP band, and a discrete-time (DT) back-end to achieve good linearity. The acquisition channel is fully differential, which leads to a high common-mode rejection ratio (CMRR) and power supply rejection ratio (PSRR) without the 50 Hz injection. The design interfaces the microelectrode with a transistor gate, which has high input impedance. A prototype monolithic acquisition IC is fabricated in a 0.35 μm CMOS process. It includes 16 channels and an 11 bit successive-approximation (SAR) analog-to-digital converter (ADC). Every channel acquires cellular signals up to 20 mVpp with 32.9 nV/Hz0.5 and ; 110 dB) and PSRR ( >; 110 dB). The noise-efficiency factor (NEF) of the acquisition channel is 7.6. The IC is experimented to record the field Potential from cultured rat cardiomyocytes in-vitro. Overall, the new MEA acquisition channel achieves the state-of-art performance.
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32.9 nV/rt Hz ${-}$60.6 dB THD Dual-Band Micro-Electrode Array Signal Acquisition IC
IEEE Journal of Solid-State Circuits, 2012Co-Authors: Jie Yuan, Jiageng Huang, Chi-kong Yeung, Mansun ChanAbstract:The dual-band recording of the local-field Potential (LFP, 0.1-200 Hz) and the Spike Potential (SP, 200 Hz-10 kHz) is important for physiological studies at the cellular level. Recent study shows that the LFP signal plays important roles in modulating many profound cellular mechanisms. Although various bio-signal acquisition circuits have been reported over the years, few designs are applicable to capture both LFP and SP signals. To record both signals accurately, acquisition circuits need low noise and good linearity in both bands. In this paper, we report the design of a dual-band acquisition IC for microelectrode array (MEA) recording. The novel design uses a continuous-time (CT) front-end with chopping to suppress the noise in the LFP band, and a discrete-time (DT) back-end to achieve good linearity. The acquisition channel is fully differential, which leads to a high common-mode rejection ratio (CMRR) and power supply rejection ratio (PSRR) without the 50 Hz injection. The design interfaces the microelectrode with a transistor gate, which has high input impedance. A prototype monolithic acquisition IC is fabricated in a 0.35 μm CMOS process. It includes 16 channels and an 11 bit successive-approximation (SAR) analog-to-digital converter (ADC). Every channel acquires cellular signals up to 20 mVpp with 32.9 nV/Hz0.5 and ; 110 dB) and PSRR ( >; 110 dB). The noise-efficiency factor (NEF) of the acquisition channel is 7.6. The IC is experimented to record the field Potential from cultured rat cardiomyocytes in-vitro. Overall, the new MEA acquisition channel achieves the state-of-art performance.
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A 38.6nV/Hz0.5 −59.6dB THD dual-band micro-electrode array signal acquisition IC
2011 IEEE Custom Integrated Circuits Conference (CICC), 2011Co-Authors: Jiageng Huang, Chi-kong Yeung, Jie Yuan, Mansun ChanAbstract:Cellular field Potential includes local field Potential (LFP, 0.1Hz~200Hz) and Spike Potential (SP, 200Hz~10kHz). SP signal has been the focus of physiological studies. Recent study shows that the LFP signal plays important roles in modulating many profound cellular mechanisms. Although many bio-signal acquisition circuits have been reported over the years, few designs are applicable for both LFP and SP signals. To record both signals accurately, acquisition circuits need low noise and good linearity in both bands. In this paper, we report the design of a dual-band acquisition IC for microelectrode array (MEA) recording. The novel design uses a continuous-time (CT) front-end with chopping to suppress the noise, and a discrete-time (DT) back-end to achieve good linearity. A prototype monolithic acquisition IC is fabricated in a 0.35um CMOS process. It has 16 acquisition channels and a 11bit successive-approximation (SAR) ADC. Every channel achieves 38.6nV/Hz0.5 noise and ;110dB) and PSRR (>;110dB). NEF of the new design is 6.4. The IC is experimented with rat cardio-myocytes recording.
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Highly Accurate Dual-Band Cellular Field Potential Acquisition For Brain–Machine Interface
IEEE Journal on Emerging and Selected Topics in Circuits and Systems, 2011Co-Authors: Jie Yuan, Jiageng Huang, Chi-kong Yeung, Mansun ChanAbstract:Cellular field Potential includes local field Potential (LFP, 0.1 Hz–200 Hz) and Spike Potential (SP, 200 Hz–10 kHz). In physiological studies of the brain, SP signal has been the focus. Various circuits have been reported to acquire SP signals in brain–machine interface (BMI) systems over the years. Recent study shows that the LFP signal plays important roles in modulating many profound neuronal mechanisms in the brain. It is important for new BMI design to record the dual-band signal accurately, which demands acquisition circuits to have low noise and good linearity in both bands. In this paper, we report the design of a dual-band acquisition integrated circuit (IC) for microelectrode recording. The novel design uses a continuous- time (CT) front-end with chopping to suppress the noise, and a discrete-time (DT) back-end to achieve good linearity. A prototype monolithic acquisition IC is fabricated in a 0.35 $\mu{\rm m}$ CMOS process. It has 16 acquisition channels and an 11 bit successive-approximation (SAR) analog-to-digital converter (ADC). Silicon measurements show that every channel has $29.2\,{\rm nV}/{\rm Hz}^{0.5}$ noise and ${ 110}~{\rm dB})$ and power-supply rejection ratio (PSRR) $({> 110}~{\rm dB})$. Noise-efficiency factor (NEF) of the acquisition channel is 6.6. The IC is experimented with rat cardio-myocytes recording.
Jing Guo - One of the best experts on this subject based on the ideXlab platform.
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32.9 nV/rt Hz -60.6 dB THD dual-band micro-electrode array signal acquisition IC
IEEE Journal of Solid-State Circuits, 2012Co-Authors: Jing Guo, Jiageng Huang, Jessica Ka Yan Law, Chi-kong Yeung, Jie Yuan, Mansun ChanAbstract:The dual-band recording of the local-field Potential (LFP, 0.1-200 Hz) and the Spike Potential (SP, 200 Hz-10 kHz) is important for physiological studies at the cellular level. Recent study shows that the LFP signal plays important roles in modulating many profound cellular mechanisms. Although various bio-signal acquisition circuits have been reported over the years, few designs are applicable to capture both LFP and SP signals. To record both signals accurately, acquisition circuits need low noise and good linearity in both bands. In this paper, we report the design of a dual-band acquisition IC for microelectrode array (MEA) recording. The novel design uses a continuous-time (CT) front-end with chopping to suppress the noise in the LFP band, and a discrete-time (DT) back-end to achieve good linearity. The acquisition channel is fully differential, which leads to a high common-mode rejection ratio (CMRR) and power supply rejection ratio (PSRR) without the 50 Hz injection. The design interfaces the microelectrode with a transistor gate, which has high input impedance. A prototype monolithic acquisition IC is fabricated in a 0.35 μm CMOS process. It includes 16 channels and an 11 bit successive-approximation (SAR) analog-to-digital converter (ADC). Every channel acquires cellular signals up to 20 mVpp with 32.9 nV/Hz0.5 and ; 110 dB) and PSRR ( >; 110 dB). The noise-efficiency factor (NEF) of the acquisition channel is 7.6. The IC is experimented to record the field Potential from cultured rat cardiomyocytes in-vitro. Overall, the new MEA acquisition channel achieves the state-of-art performance.